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Peptides, Chemistry & Biology of
Gordon Research Conference

Crossing Barriers by Peptide Science for Health and Wellness

Dates

February 21-26, 2016

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chairs:
Philip E. Dawson & Anna Maria Papini

Vice Chairs:
Jennifer R. Cochran & James S. Nowick

Meeting Description

Peptides are molecules, ubiquitous in Nature, that play critical roles in biomedicine, agriculture, material and food science, etc. As a mature field of investigation, many basic properties and applications involving peptides have already been explored in detail. In order to continue advancing peptide science, barriers will have to be overcome with respect to predicting, synthesizing and testing, the structure and function of peptides. Future advances in peptide science will require researchers to overcome the physical barriers of the gut, brain and cellular membranes and also the technological, social, diversity and conceptual barriers that that currently limit scientists’ ability to realize the full potential of peptide science in the -omics era. To do this, the GRC will bring together scientists from academia and industry, and across all aspects of peptide chemistry, biology, and technology to critically evaluate the current state of the art, and future prospects of areas such as peptide drugs, vaccines, immunology, diagnostics, nutraceutics, cosmetics. The conference will also explore the frontiers of synthetic methodologies for the design, production, analysis, delivery of complex peptides and peptide-like polymers.The 2016 program will feature invited talks from leaders in the field from around the world; as well as talks from early career scientists; poster sessions; and, of course in the GRC tradition, plenty of time for discussion, scientific exchanges, and for continuing to building the peptide-science community across barriers. The GRC has several programs to encourage and support attendance by underrepresented groups, which we endorse and encourage application.

Related Meeting

This GRC was held in conjunction with the "Peptides, Chemistry & Biology of" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Crossing the Barrier from Academics to Industry (and Back)
Discussion Leaders: Philip Dawson (The Scripps Research Institute, USA) and Anna Maria Papini (University of Florence, Italy / University of Cergy-Pontoise, France)
7:40 pm - 8:20 pmRichard DiMarchi (Indiana University, USA)
"Peptide-Based Therapeutics: From Hormones to Polypharmacy"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmPeter Kim (Stanford University School of Medicine, USA)
"Toward an HIV Vaccine"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPeptide Discovery: Biological and Chemical Libraries
Discussion Leaders: Kit Lam (UC Davis School of Medicine, USA) and John Nuss (Ferring Research Institute, USA)
9:00 am - 9:20 amIntroduction by Discussion Leader
9:20 am - 9:45 amThomas Kodadek (The Scripps Research Institute, Scripps Florida, USA)
"Synthesis and Screening of Large Libraries of Conformationally Restricted Oligomers"
9:45 am - 10:00 amDiscussion
10:00 am - 10:25 amRichard Roberts (University of Southern California, USA)
"Directed Evolution of Scanning Unnatural Protease Resistant (SUPR) Peptides for In Vivo Applications"
10:25 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:35 amRatmir Derda (University of Alberta, Canada)
"Novel Chemical and Genetics Approaches Chemically-Modified Peptide Libraries"
11:35 am - 11:50 amDiscussion
11:50 am - 12:15 pmJames Heath (California Institute of Technology, USA)
"Precise Epitope Targeting of Synthetic Macrocyclic Peptides for Biomedical Applications"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Jennifer Cochran (Stanford University, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPeptide Discovery: Where to Look Next
Discussion Leaders: Paul Alewood (The University of Queensland, Australia) and Natia Tsomaia (Ipsen, USA)
7:30 pm - 7:55 pmRoderich Sussmuth (Technische Universität Berlin, Germany)
"Peptide Antibiotics from Pathogenic Microorganisms - Structure, Biosynthesis and Engineering"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmMohamed Marahiel (Philipps-Universität Marburg, Germany)
"Insights into the Biosynthesis and Structural Diversity of Bacterial Lasso Peptides"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmRichard Lewis (The University of Queensland, Australia)
"Unique Defensive and Predatory Envenomation Strategies in Cone Snails"
9:15 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmPosttranslationally Modified Proteins and Conjugates
Discussion Leaders: Jeffery Kelly (The Scripps Research Institute, USA) and Geoffrey Wahl (The Salk Institute, USA)
9:00 am - 9:25 amHilal Lashuel (École Polytechnique Fédérale de Lausanne, Switzerland)
"Posttranslational Modifications in Neurodegenerative Disease"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amMatthew Pratt (University of Southern California, USA)
"Investigating the Side-Specific Effects of Posttranslational Modifications with Protein Chemistry"
10:05 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amChristian Becker (University of Vienna, Austria)
"Semisynthesis of Posttranslationally Modified Proteins"
11:15 am - 11:30 amDiscussion
11:30 am - 11:45 amJianmin Gao (Boston College, USA)
"Application of Iminoboronate Chemistry in Targeting Biomolecules and Peptide Cyclization"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmJennifer Stockdill (Wayne State University, USA)
"Progress Toward a Universal Strategy for the Controlled Folding of Disulfide-Rich Peptides"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmJoshua Price (Brigham Young University, USA)
"Predictive Structure-Based Guidelines for Identifying Optimal Protein PEGylation Sites"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPeptides in the Immune System
Discussion Leaders: Charles Deber (University of Toronto, Canada) and Thomas Nielsen (Novo Nordisk, Denmark)
7:30 pm - 7:55 pmHuib Ovaa (The Netherlands Cancer Institute, The Netherlands)
"Chemistry of MHC Class I Antigen Presentation"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmDana Ault-Riche (Reflexion Pharmaceuticals, USA)
"Immunological Evaluation of Mirror Image Protein Therapeutics"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmMichael Chorev (Harvard Medical School, USA)
"Glycated CD59: A Novel, Disease Relevant Biomarker in Diabetes"
9:15 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCritical Analysis of Cell Penetrating Peptides
Discussion Leader: Joel Schneider (National Cancer Institute, NIH, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader: Critical Analysis of Cell Penetrating Peptides
9:10 am - 9:35 amNiels Geijsen (Hubrecht Institute, The Netherlands)
"iTOP, a Novel Method for the Intracellular Delivery of Native Proteins"
9:35 am - 9:50 amDiscussion
9:50 am - 10:15 amLoren Walensky (Dana-Farber Cancer Institute, USA)
"Biophysical Determinants for Cellular Uptake of Hydrocarbon-Stapled Peptides"
10:15 am - 10:30 amDiscussion
10:30 am - 10:50 amCoffee Break
10:50 am - 11:15 amDehua Pei (The Ohio State University, USA)
"Drugging Undruggable Targets with Macrocycles"
11:15 am - 11:30 amDiscussion
11:30 am - 11:55 amYao-Cheng Leo Li (The Salk Institute for Biological Studies, USA)
"ReBiL, a Powerful Platform Technology for Detecting Protein-Protein Interactions and for Identifying Specific Antagonists"
11:55 am - 12:10 pmDiscussion
12:10 pm - 12:25 pmHenry Herce (Technische Universitat Darmstadt, Germany)
"Drugs Design and Delivery Using Cell-Penetrating Peptides: A Journey from Molecular Mechanisms to In Vivo Applications"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmPeptide Vaccines
Discussion Leaders: Peter Kim (Stanford University School of Medicine, USA) and Michael Kay (University of Utah, USA)
7:30 pm - 7:55 pmElisabetta Bianchi (IRBM Science Park S.p.A., Italy)
"Strategies for the Development of Effective Peptide Vaccines"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmMichael Zwick (The Scripps Research Institute, USA)
"Recognition Requirements of Membrane-Proximal 'Linear' Epitopes on HIV-1 gp41"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmRegan Anderson (Victoria University of Wellington, New Zealand)
"Synthetic Peptide Vaccines Based on Glycolipid-Peptide Conjugates"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmJonathan Lai (Albert Einstein College of Medicine, USA)
"Engineered Dengue Virus EDIIIs as Immunogen (Vaccine) Candidates"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPeptides in Epigenetic Regulation
Discussion Leaders: Dewey McCafferty (Duke University, USA) and Christian Adam Olsen (University of Copenhagen, Denmark)
9:00 am - 9:25 amChampak Chatterjee (University of Washington, USA)
"Learning the Language of Histone Modifications with Semisynthetic Tools"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amDanica Fujimori (University of California, San Francisco, USA)
"Crossttalk Between Chromatin Reader and Eraser Domains in Histone Demethylases"
10:05 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amBeat Fierz (École Polytechnique Fédérale de Lausanne, Switzerland)
"Probing the Dynamic Function of Histone PTMs, One Molecule at a Time"
11:15 am - 11:30 amDiscussion
11:30 am - 11:45 amDaniel Baxter (University of Bath, United Kingdom)
"Cell-Permeable Helix-Constrained Peptides Inhibit Activator Protein-1 and Reduce Cancer Cell Viability"
11:45 am - 11:50 amDiscussion
11:50 am - 12:15 pmBrian Strahl (University of North Carolina, USA)
"Using Peptide Arrays to Uncover New Insights into Chromatin Regulation"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmIntelligent Materials and Nanoparticles
Discussion Leaders: Jennifer Cochran (Stanford University, USA) and James Nowick (University of California, Irvine, USA)
7:30 pm - 7:55 pmNicole Steinmetz (Case Western Reserve University School of Medicine, USA)
"Virus Based Therapeutics and Contrast Agents"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmKamaljit Kaur (University of Alberta, Canada)
"Microcantilever Arrays Functionalized with a Breast Cancer Targeting Peptide as Detection Platforms for Circulating Tumor Cells"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmAnnelise Barron (Stanford University, USA)
"Deceptively Simple? Peptides that Form Toxin-Antitoxin Complexes"
9:15 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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