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Polyamines
Gordon Research Conference

Polyamine Metabolism in Disease and Polyamine-Targeted Therapies

Dates

June 25-30, 2017

Location

Waterville Valley
Waterville Valley, NH

Organizers

Chairs:
Susan K. Gilmour & Alex R. Khomutov

Vice Chair:
Keith T. Wilson

Meeting Description

The 2017 Gordon Research Conference (GRC) on Polyamines will feature cutting edge studies on the regulation and roles of polyamines in cellular homeostasis and disease. The Polyamine GRC is the preeminent meeting in this field and will cover a wide range of topics in basic, translational and clinical research. The Polyamine Gordon conference will be held at the Waterville Valley Resort in Waterville Valley, New Hampshire from June 25-30, 2017. A major focus of the 2017 Polyamine GRC is targeting polyamine pathways in cancer and in other pathogenic and infectious diseases. The meeting will also emphasize several new areas of basic polyamine research including provocative findings relating polyamines to circadian clock control, inflammation, pathogenic virulence, and novel polyamine-targeted therapies. New insights into the mechanisms by which normal polyamine metabolism contributes to cell growth control and autophagy and how these regulatory circuits are disabled or hijacked in other pathological states (e.g., in cancers, infection with parasites or bacteria, and neurodegenerative disorders) will be discussed. This GRC is attended by biologists, chemists, structural biologists and clinicians, and investigators from academia, biotech and pharmaceutical sectors. The variety of scientific disciplines and organisms represented at the Polyamine GRC is unique among GRCs and creates an intellectually stimulating environment. The highly collegial and collaborative atmosphere of this Conference, with programmed discussion sessions and ample opportunities for informal gatherings in the afternoons and evenings, provides the perfect environment for scientists to discuss and share ideas and to foster collaborations in the research areas represented. The Polyamine GRC will be held in conjunction with the sixth Gordon Research Seminar (GRS) on Polyamines. The GRS will be held from June 24-25, and students and postdocs participating in the GRS will be expected to also attend the regular GRC meeting, which immediately follows.

Related Meeting

This GRC was held in conjunction with the "Polyamines" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmNew Polyamine Frontiers
Discussion Leader: Takami Oka (Wakunaga Pharmaceutical Co., Ltd., Japan)
7:40 pm - 7:45 pmOpening Remarks
7:45 pm - 8:10 pmRobert Casero (Johns Hopkins University School of Medicine, USA)
"Spermine Oxidase: A Link Between Infection/Inflammation and Cancer"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmGad Asher (Weizmann Institute of Science, Israel)
"Circadian Clock Control by Polyamine Levels Through a Mechanism that Declines with Age"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmDavid Christianson (University of Pennsylvania, USA)
"Structure, Mechanism, and Specificity of the Eukaryotic Cytoplasmic Polyamine Deacetylase"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmImpact of Polyamine Metabolism in Cancer Development
Discussion Leader: John Cleveland (Moffitt Cancer Center, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:40 amGianluca Canettieri (Sapienza University of Rome, Italy)
"Translational Control of the ODC-Polyamine Axis by a Developmental Regulator and Its Pathophysiological Relevance to Cancer"
9:40 am - 9:50 amDiscussion
9:50 am - 10:20 amNoriyuki Murai (Jikei University School of Medicine, Japan)
"Antizyme-Interacting Proteins in Cancer Cells"
10:20 am - 10:30 amDiscussion
10:30 am - 10:55 amGroup Photo / Coffee Break
10:55 am - 11:25 amUrsula Grohmann (University of Perugia, Italy)
"Polyamines as Two-Sided Nodes in the Immunoregulatory Intersection Between Arginine and Tryptophan Metabolism"
11:25 am - 11:35 amDiscussion
11:35 am - 12:05 pmPearlie Epling-Burnette (Moffitt Cancer Center, USA)
"Cereblon-Directed Control of Polyamines Regulates Anti-Tumor T-Cell Immunity"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Heather Wallace (University of Aberdeen, United Kingdom)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPolyamine Regulation of Translation and Cell Growth
Discussion Leader: Kazuei Igarashi (Chiba University, Japan)
7:30 pm - 8:00 pmChaim Kahana (Weizmann Institute of Science, Israel)
"Cellular and Molecular Consequences of Polyamine Depletion"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmJoseph Shiloach (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
"Improving Recombinant Protein Expression from Mammalian Cells by Utilizing Non-Coding RNA and Identification of Antizyme-1 as a Possible Enhancer"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmKeiko Kashiwagi (Chiba Institute of Science, Japan)
"Polyamine Modulon Whose Synthesis Is Enhanced by Polyamines at the Level of Translation"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPolyamines in Cellular Homeostasis and Physiology
Discussion Leader: Jian-Ying Wang (University of Maryland School of Medicine, USA)
9:00 am - 9:10 amOpening Remarks
9:10 am - 9:40 amLeah Vardy (Institute of Medical Biology, A*STAR, Singapore)
"Polyamine Mediated Regulation of Wound Healing"
9:40 am - 9:50 amDiscussion
9:50 am - 10:20 amMisha Nikiforov (Roswell Park Cancer Institute, USA)
"Regulators of Polyamine Levels as Antineoplastic Drug Targets"
10:20 am - 10:30 amDiscussion
10:30 am - 10:55 amCoffee Break
10:55 am - 11:25 amTeresa Mastracci (Indiana Biosciences Research Institute, USA)
"Polyamine and Hypusine Biosynthesis Is Required for Proper Pancreas Development"
11:25 am - 11:35 amDiscussion
11:35 am - 12:05 pmSalim Merali (Temple University School of Pharmacy, USA)
"The 6,000 Calorie Question"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmLaurence von Kalm (University of Central Florida, USA)
"The Polyamigo Gene: A Human ATP13A3 Ortholog Required for Polyamine Transport in Drosophila"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPolyamines and Their Pleiotropic Effects
Discussion Leader: Sigrid Roberts (Pacific University, USA)
7:30 pm - 8:00 pmMargaret Phillips (University of Texas Southwestern Medical Center, USA)
"Regulation of Polyamine Biosynthesis in Trypanosomatid Parasites"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmDan Zilberstein (Technion - Israel Institute of Technology, Israel)
"Arginine Sensing and Its Role in Virulence of the Human Pathogen Leishmania"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmCarol Colton (Duke University, USA)
"Immune-Mediated Polyamine Pathway Flux in Neurodegenerative Disease"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNovel Cancer Therapies Targeting Polyamine Pathways
Discussion Leader: Andre Bachmann (Michigan State University, USA)
9:00 am - 9:10 amOpening Remarks
9:10 am - 9:40 amDominic Smiraglia (Roswell Park Cancer Institute, USA)
"Therapeutic Potential of Polyamine Catabolism Activation in Combination with Methionine Salvage"
9:40 am - 9:50 amDiscussion
9:50 am - 10:20 amEric Alexander (Lankenau Institute for Medical Research, USA)
"Anti-Tumor Effects of Novel Arylpolyamine Drugs"
10:20 am - 10:30 amDiscussion
10:30 am - 10:55 amCoffee Break
10:55 am - 11:25 amMichael Hogarty (University of Pennsylvania, USA)
"Depleting Polyamines to Target MYC-Driven Cancers and Their Immunosuppressive Microenvironment"
11:25 am - 11:35 amDiscussion
11:35 am - 12:05 pmAlexander Ivanov (Engelhardt Institute of Molecular Biology, Russia)
"Regulation of Antizyme Biosynthesis by Polyamines and Their Analogues"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmMetabolic Diversity of Polyamine Function
Discussion Leader: Anthony Michael (University of Texas Southwestern Medical Center, USA)
7:30 pm - 8:00 pmCarolina Sierra (Vanderbilt University, USA)
"Role of Polyamines and DFMO in Helicobacter pylori-Induced Gastric Carcinogenesis"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmTiffany Lowe-Power (USA)
"How Putrescine Increases Host Susceptibility to the Plant Pathogenic Bacterium Ralstonia solanacearum"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmAutar Mattoo (U.S. Department of Agriculture, USA)
"Higher Polyamines Revive Metabolic Memory and Upregulate Bioactive and Chemopreventive Molecules in Transgenic Tomato Fruit"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDrug Discovery and Development
Discussion Leader: Otto Phanstiel (University of Central Florida, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:40 amPatrick Woster (Medical University of South Carolina, USA)
"Polyamine Analogues as Anti-Infective Agents for Wild-Type and Resistant Organisms"
9:40 am - 9:50 amDiscussion
9:50 am - 10:20 amBianca Verlinden (University of Pretoria, South Africa)
"Multitarget Anti-Malarial Polyamine Analogues: Resisting Resistance"
10:20 am - 10:30 amDiscussion
10:30 am - 10:55 amCoffee Break
10:55 am - 11:25 amMichael Walker (Sun BioPharma, Inc., USA)
"The Clinical Development of SBP-101, a Polyamine Analogue for the Treatment of Pancreatic Cancer and Pancreatitis"
11:25 am - 11:35 amDiscussion
11:35 am - 12:05 pmEugene Gerner (Cancer Prevention Pharmaceuticals, USA)
"Developing Drugs Targeting the Polyamine Pathway to Treat Cancer Risk Factors"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmThomas Dever (National Institutes of Health, USA)
"Polyamine Inhibition of eIF5A Induces Ribosome Queuing and Promotes Near Cognate Initiation on the AZIN1 mRNA"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmKeynote Session: Why Can't Eukaryotic Cells Live Without Polyamines?
Discussion Leaders: Keith Wilson (Vanderbilt University Medical Center, USA) and Enzo Agostinelli (Sapienza University of Rome, Italy)
5:30 pm - 5:40 pmYuri Ishii (Kwansei-Gakuin University, Japan)
"Polyamines in Vinegar Are Key Compounds for Effective Trapping of Spotted Wing Drosophila"
5:40 pm - 5:45 pmDiscussion
5:45 pm - 5:55 pmSpencer Rosario (Roswell Park Cancer Institute, USA)
"In Silico Identification of Polyamine Metabolic Dysregulation Across Cancers"
5:55 pm - 6:00 pmDiscussion
6:00 pm - 6:10 pmAkram Da'dara (Tufts University, USA)
"Polyamine Uptake: A Potential Therapeutic Target for Schistosomiasis"
6:10 pm - 6:15 pmDiscussion
6:15 pm - 6:20 pmIntroduction by Discussion Leader
6:20 pm - 7:05 pmMyung-Hee Park (National Institute of Dental and Craniofacial Research, NIH, USA)
"Why Can't Eukaryotic Cells Live Without Polyamines?"
7:05 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmUriel Bachrach (Hebrew University of Jerusalem, Israel)
"Closing Remarks: Historical and Future Perspectives"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13CA216980-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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