Gordon Research Conferences
Meeting Details
Search:
  GO

Proteins
Gordon Research Conference

Exploring the Role of Proteins as Cellular Organizers by Combining Experiment and Theory

Dates

June 18-23, 2017

Location

Holderness School
Holderness, NH

Organizers

Chairs:
Catherine A. Royer & Vijay S. Pande

Vice Chairs:
Charles L. Brooks & Elizabeth M. Meiering

Meeting Description

The 2017 Proteins Gordon Research Conference has been conceived with two underlying leitmotifs. The first is to highlight proteins as cellular organizers, while the second and equally central theme of the meeting is the interplay between experiment and theory and modeling in modern protein research. Recent major advances in electron and optical microscopy have revealed amazing structural and spatial organization at the level of protein complexes and protein interactions. These advances will be featured by Andre Hoelz of CalTech who will describe the structure of the nuclear pore complex in the opening Keynote address. Our closing Keynote speaker, Carol Post of Purdue University, will address a combined computational and experimental approach to understanding the regulation of a tyrosine kinase. Several sessions will follow up on the theme of proteins as cellular organizers. Session 3 will address new super-resolution imaging of nuclear organization, while Session 4 will speak to the dynamic aspects of proteins as organizers in vesicle sorting and membrane remodeling. Two other sessions, one on the role of intrinsically disordered proteins and the other on protein biogenesis and interactions in vivo will weave in this leitmotif, as well. Given the ever increasing level of integration of experimental and theoretical approaches in protein science, both theory and experiment have been included in each session. In several cases, individual invited speakers will address both experimental and computational aspects of protein research. In other sessions, a combination of talks, some theoretical and others experimental, will address similar topics. Of the 24 invited speakers, we have worked to achieve a near complete balance between theoretical and experimental protein science. The topics for each session correspond to very exciting areas of protein research, in which major advances are currently being achieved. We believe that the combination of these crucial topics and combined approaches, with outstanding scientists who will speak to their work in these areas will make for a very stimulating conference.

Related Meeting

This GRC was held in conjunction with the "Proteins" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: The Structure of the Nuclear Pore Complex
Discussion Leader: Catherine Royer (Rensselaer Polytechnic Institute, USA)
7:40 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:50 pmAndre Hoelz (California Institute of Technology, USA)
"Structure of the Nuclear Pore Complex"
8:50 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmShape-Shifters – Functional Mechanisms of Intrinsically Disordered Proteins
Discussion Leaders: Julie Forman-Kay (The Hospital for Sick Children, Canada) and Jianhan Chen (University of Massachusetts Amherst, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amMartin Blackledge (Institute for Structural Biology, CNRS, France)
"NMR Studies of the Role of Protein Dynamics in Molecular Recognition - From Fundamental Biophysics to Biological Function"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amGeorge Makhatadze (Rensselaer Polytechnic Institute, USA)
"Novel Fluorescent Probes of Amyloid Fibrils"
9:55 am - 10:00 amDiscussion
10:00 am - 10:25 amJoan-Emma Shea (University of California, Santa Barbara, USA)
"Regulation and Aggregation of Intrinsically Disordered Proteins"
10:25 am - 10:35 amDiscussion
10:35 am - 10:50 amCoffee Break
10:50 am - 11:15 amRohit Pappu (Washington University in St. Louis, USA)
"Regulation of Protein Function Through Intrinsically Disordered Regions"
11:15 am - 11:25 amDiscussion
11:25 am - 11:40 amCarlos Castaneda (Syracuse University, USA)
"Phase Separation of UBQLN2 Is Modulated by Oligomerization and Ubiquitin Binding"
11:40 am - 11:45 amDiscussion
11:45 am - 12:10 pmJane Dyson (The Scripps Research Institute, USA)
"Interaction Champions: Intrinsically Disordered Viral Proteins"
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmHigh Resolution Visualization of Nuclear Organization
Discussion Leaders: Jacqueline Cherfils (ENS Paris-Saclay, CNRS, France) and Mala Radhakrishnan (Wellesley College, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:00 pmMarcelo Nollmann (INSERM / CNRS, France)
"Chromosome Structure and Remodelling at Super-Resolution"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmAlessandro Borgia (University of Zurich, Switzerland)
"Two Intrinsically Disordered, Chromatic-Remodeling Proteins Binding with Picomolar Affinity Without Grain of Structure"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmSagar Khare (Rutgers University, USA)
"Large-Scale Prediction, Characterization and Modulation of Protease Enzyme Specificity Using Computation and Experiment"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmElizabeth Villa (University of California, San Diego, USA)
"Opening Windows into the Nucleus: Bringing Structure to Cellular Biophysics"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNew Protein Functions by Design or Evolution
Discussion Leaders: Joan-Emma Shea (University of California, Santa Barbara, USA) and Thomas Magliery (Ohio State University, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amBrian Kuhlman (University of North Carolina at Chapel Hill, USA)
"SEWING: Designing New Structures and Complexes from Protein Pieces"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amDaša Lipovšek (Bristol-Myers Squibb, USA)
"Adnectin Conjugates for Specific Delivery of Payloads"
9:55 am - 10:00 amDiscussion
10:00 am - 10:25 amTanja Kortemme (University of California, San Francisco, USA)
"Reshaping and Reprogramming Proteins for New Functions"
10:25 am - 10:35 amDiscussion
10:35 am - 10:50 amCoffee Break
10:50 am - 11:15 amLynne Regan (Yale University, USA)
"Novel Supra-Molecular Structures and Materials from Proteins"
11:15 am - 11:25 amDiscussion
11:25 am - 11:40 amTijana Grove (Virginia Tech, USA)
"Protein Engineering - From Nature to Nanotechnology"
11:40 am - 11:45 amDiscussion
11:45 am - 12:10 pmMichael Harms (University of Oregon, USA)
"'Marty, You're Not Thinking Fourth Dimensionally!', High-Order Epistasis in Protein Evolution"
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmVesicle Sorting and Membrane Remodeling
Discussion Leaders: Lila Gierasch (University of Massachusetts Amherst, USA) and Yu-Shan Lin (Tufts University, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:00 pmJacqueline Cherfils (ENS Paris-Saclay, CNRS, France)
"Allosteric Regulation of Small GTPases at the Membrane-Cytosol Interface"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmKristin Low (The Hospital for Sick Children, Canada)
"Identification of an Inner Membrane Subcomplex Required for Alignate Biosynthesis and Acetylation"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmHector Garcia Seisdedos (Weizmann Institute of Science, Israel)
"Proteins Evolve on the Edge of Supramolecular Self-Assembly"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmGregory Voth (University of Chicago, USA)
"Membrane Remodeling by Proteins: Insights and Surprises from Multiscale Computer Simulation"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMolecular Mechanisms Underlying Protein Dynamics and Allostery
Discussion Leaders: K.C. Huang (Stanford University, USA) and Lucas Bleicher (Federal University of Minas Gerais, Brazil)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amBryan Roth (University of North Carolina at Chapel Hill, USA)
"New Insights into the Role of Allosteric Sodium in GPCR Structure and Function"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amChris Neale (Los Alamos National Laboratory, USA)
"Allosteric Stabilization of a GPCR by Membrane Lipids"
9:55 am - 10:00 amDiscussion
10:00 am - 10:25 amRommie Amaro (University of California, San Diego, USA)
"Multi-Scale Dynamics: Molecules to Cells"
10:25 am - 10:35 amDiscussion
10:35 am - 10:50 amCoffee Break
10:50 am - 11:15 amLiskin Swint-Kruse (University of Kansas Medical Center, USA)
"Rheostats and Toggle Switches for Modulating Protein Function"
11:15 am - 11:25 amDiscussion
11:25 am - 11:40 amRoberto Chica (University of Ottawa, Canada)
"Rational Design of Proteins that Exchange on Functional Timescales"
11:40 am - 11:45 amDiscussion
11:45 am - 12:10 pmJosh Wand (University of Pennsylvania, USA)
"Dynamics and Entropy in Protein Function"
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmStructural Modeling and Sparse Data
Discussion Leaders: Martin Blackledge (Institute for Structural Biology, CNRS, France) and Charles Matthews (University of Massachusetts Medical School, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:00 pmJulie Forman-Kay (The Hospital for Sick Children, Canada)
"Characterization of Disordered Proteins and Their Dynamic Complexes by Combined Experimental and Computational Approaches"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmAkram Alian (Technion - Israel Institute of Technology, Israel)
"Molecular and Structural Basis of Protein Evolution During Viral Adaptation"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmLauren Porter (Howard Hughes Medical Institute, USA)
"Protein Fold Switching Is Widespread"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmNikolas Sgourakis (University of California, Santa Cruz, USA)
"Modelling the Structures of Protein Complexes Using Sparse NMR Data"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProtein Biogenesis and Interactions In Vivo
Discussion Leaders: Jane Dyson (The Scripps Research Institute, USA) and Andreas Lehmann (Biogen, Inc., USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amLila Gierasch (University of Massachusetts Amherst, USA)
"The Hsp70 Allosteric Chaperone Machine"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amCaitlin Davis (University of Illinois at Urbana-Champaign, USA)
"Spliceosomal U1A Protein-SL2 RNA Binding Affinity Decreases in Cells"
9:55 am - 10:00 amDiscussion
10:00 am - 10:25 amBerndt Bukau (University of Heidelberg, Germany)
"Chaperone-Assisted Folding and Assembly of Newly Synthesized Proteins"
10:25 am - 10:35 amDiscussion
10:35 am - 10:50 amCoffee Break
10:50 am - 11:15 amK.C. Huang (Stanford University, USA)
"Cytoskeletal Coordination of Bacterial Growth"
11:15 am - 11:25 amDiscussion
11:25 am - 11:40 amGlenna Foight (University of Washington, USA)
"Bio-Orthogonal Chemically Induced Dimerizers Based on HCV Protease and Its Inhibitors"
11:40 am - 11:45 amDiscussion
11:45 am - 12:10 pmMarina Rodnina (Max Planck Institute for Biophysical Chemistry, Germany)
"Co-Translational Protein Folding on the Ribosome"
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: Understanding Regulation of Syk Tyrosine Kinase Interaction with Receptor ITAM, from Solution NMR to Computer Simulation
Discussion Leader: Vijay Pande (Stanford University, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:40 pmCarol Post (Purdue University, USA)
"Understanding Regulation of Syk Tyrosine Kinase Interaction with Receptor ITAM: From Solution NMR to Computer Simulation"
8:40 pm - 9:10 pmDiscussion
9:10 pm - 9:20 pmGeneral Discussion
9:20 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
© 2017 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter