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Tetrapyrroles, Chemistry & Biology of
Gordon Research Conference

Biology of Heme, Chlorophyll, Porphyrins, Chlorins and Bilins - The Pigments of Life

Dates

July 17-22, 2016

Location

Salve Regina University
Newport, RI

Organizers

Chair:
John Phillips

Vice Chair:
Iqbal Hamza

Meeting Description

The 2016 Chemistry and Biology of Tetrapyrroles Gordon Research Conference is the 50th anniversary of this conference. The focus of this meeting will be to provide a forum for scientists with a research focus on tetrapyrroles (heme, chlorophyll, B12, corrins, bilins) to learn where the field is moving and to interact in ways that establish new cross-disciplinary collaborations. Sessions will be led by leaders in their respective fields with speakers representing an international group of individuals, ranging from senior investigators to junior scientists. Cutting-edge talks on tetrapyrrole chemistry, heme metabolism in normal and disease states, heme and iron acquisition by parasitic organisms, tetrapyrrole metabolism in photosynthetic organisms and microorganisms, and heme metabolism related to human physiology and disease will be presented. The speakers will be present throughout the week so that attendees will have ample opportunities for individual and group discussions.

The 2016 meeting will build upon a long and rich tradition of Chemistry and Biology of Tetrapyrrole Gordon Research Conferences in bringing together a group of scientists with diverse interests and strengths. It will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. Based upon submitted abstracts, short talks will be identified for each session to ensure that the most recent advances in the field are presented. The collegial atmosphere of this conference, with programmed discussions, poster sessions and opportunities for informal gatherings in the afternoons and evenings, provides an excellent venue to renew/enhance/develop collaborative science.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmChlorophyll, Light Harvesting Systems and Tetrapyrroles that Produce Energy
Discussion Leader: Neil Hunter (University of Sheffield, United Kingdom)
7:40 pm - 8:10 pmGongfang Hu (North Carolina State University, USA)
"Panchromatic Light-Harvesting Architecture: New Designs for Tetrapyrroles in Artificial Photosynthesis"
8:10 pm - 8:25 pmDiscussion
8:25 pm - 8:55 pmRoman Sobotka (Institute of Microbiology, Czech Academy of Sciences, Czech Republic)
"Corralling the Colours: Regulation of Photosynthetic Tetrapyrroles"
8:55 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmToni Mingers (Braunschweig University of Technology, Germany)
"Late Steps in Tetrapyrrole Synthesis and Heme Transport"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Chemistry of Tetrapyrroles
Discussion Leader: Kara Bren (University of Rochester, USA)
9:00 am - 9:35 amEkaterina Pletneva (Dartmouth College, USA)
"The Role of Conformational Dynamics in Defining Redox Function of Cytochrome c"
9:35 am - 9:45 amDiscussion
9:45 am - 10:20 amMatthew Liptak (University of Vermont, USA)
"Non-Canonical Heme Oxygenases: A New Chapter of Heme-Oxygen Chemistry"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:35 amRicardo Louro (ITQB, Universidade Nova de Lisboa, Portugal)
"NMR Studies of Multiheme Cytochromes c from Anaerobic Bacteria that Use Metals to Sustain Their Bioenergetic Metabolism"
11:35 am - 11:45 amDiscussion
11:45 am - 12:00 pmElisa Tomat (University of Arizona, USA)
"Urinary Biopyrrins: From Heme Metabolites to Redox-Active Ligands"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmAmit Redddi (Georgia Institute of Technology, USA)
"Heme Gazing: Elucidating Heme Trafficking, Dynamics, and Signaling with Fluorescent Heme Sensors"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLinear Tetrapyrroles in Biology
Discussion Leader: J. Clark Lagarias (University of California, Davis, USA)
7:30 pm - 8:00 pmJeff Tabor (Rice University, USA)
"Optogenetic Applications of Bilin-Based Light Sensors"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmBeronda Montgomery (Michigan State University, USA)
"Tetrapyrrole-Binding Tryptophan-Rich Sensory Protein (TSPO) Is Involved in Stress-Related and Light-Dependent Processes in the Cyanobacterium Fremyella diplosiphon"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmJoanne Blanchfield (University of Queensland, Australia)
"Mechanistic Evaluation of the Inhibition of Polyaromatic Mutagens by Endogenous Bile Pigments"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmEdson Rocha (Brody School of Medicine, East Carolina University, USA)
"Heme-Iron Utilization in the Gut Commensal and Opportunistic Anaerobe Pathogen Bacteroides fragilis Is Dependent on the Ferrous Iron Transporter FeoAB"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmThe Next 50 Years of Chlorophyll
Discussion Leader: Samuel Beale (Brown University, USA)
9:00 am - 9:35 amRobert Blankenship (Washington University in St. Louis, USA)
"Neutron Crystal Structure and Redox-Activated Quenching of the FMO Photosynthetic Antenna Protein"
9:35 am - 9:45 amDiscussion
9:45 am - 10:20 amFei Gan (The Scripps Research Institute, USA)
"FaRLiP and LoLiP: Alternative Mechanisms for Acclimation to Far Red and Low Light in Terrestrial Cyanobacteria"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:35 amRobert Willows (Macquarie University, Australia)
"New Regulatory Mechanisms in Chlorophyll Biosynthesis"
11:35 am - 11:45 amDiscussion
11:45 am - 12:00 pmGunhild Layer (Leipzig University, Germany)
"Enzymatic In Vitro Synthesis of Cofactor F430"
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:20 pmAmanda Brindley (University of Sheffield, United Kingdom)
"Unravelling Protein-Protein Interactions Within the Magnesium Chelatase Enzyme Complex"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Synthesis, Biology and Use of Cobalamine
Discussion Leader: Amy Medlock (University of Georgia, USA)
7:30 pm - 8:00 pmMartin Warren (Unversity of Kent, United Kingdom)
"Developing a Synthetic B12 Pathway"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmMarkos Koutmos (Uniformed Services University of the Health Sciences, USA)
"A Structural Look at Cytosolic B12 Metabolism"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmMolly Sutherland (Washington University in St. Louis, USA)
"Heme Trafficking and Modifications in the Prokaryotic Cytochrome c Biogenesis Pathways"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmAlhosna Benjdia (INRA / Université Paris Saclay, France)
"TsrM, a Unique B12-Dependent Radical SAM Enzyme: Catalysis of Unprecedented Methyl Transfer Reaction in Thiostrepton A Biosynthesis"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHeme Biosynthesis in Disease
Discussion Leader: Robert Desnick (Icahn School of Medicine at Mount Sinai, USA)
9:00 am - 9:35 amMarcelo Bozza (Universidade Federal do Rio de Janeiro, Brazil)
"Heme Activates Macrophages Through Innate Immune Receptors and ROS"
9:35 am - 9:45 amDiscussion
9:45 am - 10:20 amBill Querbes (Alnylam Pharmaceuticals, USA)
"A Novel siRNA for Acute Intermittent Porphyria"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:35 amTania Baker (Massachusetts Institute of Technology, USA)
"Managing the Rate Limiting Step in Heme Biosynthesis by ClipX"
11:35 am - 11:45 amDiscussion
11:45 am - 12:00 pmBarbara Wegiel (Beth Israel Deaconess Medical Center, USA)
"Heme Activates Cancer Metastases via Modulation of DNA Secondary Structures"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmXiaojing Yuan (University of Maryland, College Park, USA)
"Regulation of Intracellular Heme Trafficking Revealed by Subcellular Reporters"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmThe Pathobiology of Heme: Tetrapyrroles and Host Microbe Interactions
Discussion Leader: Miguel Soares (Fundação Calouste Gulbenkian, Instituto Gulbenkian Ciência, Portugal)
7:30 pm - 8:00 pmSolomon Ofori-Acquah (University of Pittsburgh, USA)
"Role and Mechanism of Heme in the Pathogenesis of Acute Lung Injury in Sickle Cell Anemia"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmMalay Haldar (Perelman School of Medicine, University of Pennsylvania, USA)
"Heme Activation of SPI-C"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmJan Perner (Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Czech Republic)
"Acquisition of Exogenous Haem Is Essential for Tick Reproduction"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmJose Maria Perez-Victoria (Instituto de Parasitologia y Biomedicina "Lopez-Neyra", CSIC, Spain)
"Trypanosomatid Parasites Rescue Heme from Endocytosed Hemoglobin Through Lysosomal HRG Transporters"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSynthesis and Optimal Use of Vitamin B12
Discussion Leader: Michiko Taga (University of California, Berkeley, USA)
9:00 am - 9:35 amOlivier Berteau (Micalis Institute, INRA, France)
"Radically New Reactions: Emergence of the B12 / Radical SAM Enzymes"
9:35 am - 9:45 amDiscussion
9:45 am - 10:20 amMontserrat Elias-Arnanz (University of Murcia, Spain)
"Light Regulation of Gene Expression by a B12-Dependent Photoreceptor"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:35 amWyatt Yue (University of Oxford, United Kingdom)
"Journey of Vitamin B12 Through the Human Processing and Trafficking Pathways"
11:35 am - 11:45 amDiscussion
11:45 am - 12:00 pmJulia Cricco (National University of Rosario, Argentina)
"Trypanosoma cruzi, a Heme Auxotroph Parasite, Could Restrict the Intracellular Heme Content Through Its Transport"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmFlorian Widner (Institute of Organic Chemistry, University of Innsbruck, Austria)
"Functional Misfit in the Goblin Vitamin – Revelations from the Rhodium-Analogue of Coenzyme B12"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Diseases of Heme and Porphyrin Biosynthesis
Discussion Leader: Sylvia Bottomley (University of Oklahoma College of Medicine, USA)
7:30 pm - 8:40 pmMichael Marletta (University of California, Berkeley, USA)
"Heme in Chemistry, Medicine and Biology"
8:40 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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