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Quantitative Genetics & Genomics
Gordon Research Conference

Exploiting Context and Increasing Predictive Value in Complex Trait Genetics

Dates

February 26 - March 3, 2017

Location

Hotel Galvez
Galveston, TX

Organizers

Chair:
Ann E. Stapleton

Vice Chair:
Mike Goddard

Meeting Description

Quantitative genetics is the body of knowledge fundamental to the application of genomic and environmental information to feed our growing global population and deliver on the promise of genomics for improved health of people and their associated natural systems. This meeting will bring outstanding new science and scientists into a strong existing community of quantitative genetics researchers. The 16th conference on Quantitative Genetics and Genomics will bring together leaders in quite different fields to discuss areas of shared interest and cutting edge developments with the potential to affect all researchers within the broad field of quantitative genetics. The meeting will integrate theory and experimental approaches to fully leverage large-scale data and expanded capacity for computationally intense data analyses. Increased quality and quantity of collaborations and development of new directions in research are also key goals for this meeting.

A broad perspective on quantitative genetics and genomics will be especially valuable in early 2017. Genomic selection has revolutionized animal and plant breeding and these methodologies are likely to have a major impact in human medicine as well -- yet scientists already face what appear to be potential limitations of the technology. How to overcome these limitations, via a deeper understanding of the interactions between environmental context and the genetic architecture of complex traits, will be one of the major discussion points of the 2017 GRC. Sequencing and precise editing technologies are advancing at an accelerating pace and this is bound to profoundly impact agricultural and medical practices. How best to capitalize on these emerging technologies will also be a focus of discussion.

Related Meeting

This GRC was held in conjunction with the "Quantitative Genetics & Genomics" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmStatistical Predictions and Models: Causality, Scale and Experimental Connections
Discussion Leader: Chris-Carolin Schoen (Technical University of Munich, Germany)
7:40 pm - 7:55 pmIntroduction by Discussion Leader
7:55 pm - 8:25 pmSylvia Richardson (University of Cambridge, United Kingdom)
"Statistical Modelling and Analysis of Complex Phenotypes in Genomics"
8:25 pm - 8:45 pmDiscussion
8:45 pm - 9:15 pmEric Green (National Human Genome Research Institute, NIH, USA)
"From the Human Genome Project to Precision Medicine: A Journey to Advance Human Health"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmGenetics of Risk and Prediction – Applications
Discussion Leader: Rebecca Doerge (Carnegie Mellon University, USA)
9:00 am - 9:20 amIntroduction by Discussion Leader
9:20 am - 9:50 amNatalia De Leon (University of Wisconsin-Madison, USA)
"The Effect of Artificial Selection on Phenotypic Plasticity in Maize"
9:50 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:15 amIona MacLeod (AgriBio, University of Melbourne, Australia)
"Exploiting Prior Biological Knowledge for Genomic Prediction and Mapping of Causal Variants"
11:15 am - 11:40 amDiscussion
11:40 am - 12:10 pmDavid Heckerman (Microsoft Research, USA)
"Surprises in the Statistical Analysis of Associations"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Susan Lamont (Iowa State University, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEvolutionary Contexts for Prediction and Selection
Discussion Leader: Josephine Pemberton (University of Edinburgh, United Kingdom)
7:30 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:20 pmJohn Novembre (University of Chicago, USA)
"Evaluating Polygenic Signatures of Selection in Ancient DNA"
8:20 pm - 8:40 pmDiscussion
8:40 pm - 9:10 pmNicholas Barton (Institute of Science and Technology Austria, Austria)
"Epistasis and the Limits to Selection"
9:10 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenetic Context – Making Sense of Multivariate Phenotypes
Discussion Leader: Lauren McIntyre (University of Florida, USA)
9:00 am - 9:20 amIntroduction by Discussion Leader
9:20 am - 9:50 amBarbara Engelhardt (Princeton University, USA)
"Heritability, Effect Sizes, and Pleiotropy in Expression QTLs Across Tissues"
9:50 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:15 amEleazar Eskin (University of California, Los Angeles, USA)
"Fine Mapping and Allelic Heterogeneity"
11:15 am - 11:40 amDiscussion
11:40 am - 12:10 pmBin Yu (University of California, Berkeley, USA)
"Spatial Gene Expression Patterns in Drosophila: Mapping a Cell's Destiny"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmModeling of Context – Interaction Terms and Beyond
Discussion Leader: Bruce Walsh (University of Arizona, USA)
7:30 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:20 pmIan Ehrenreich (Translational Imaging Center, University of Southern California, USA)
"Genetic Architectures of a Complex Trait Across Backgrounds and Environments"
8:20 pm - 8:40 pmDiscussion
8:40 pm - 9:10 pmPaul Magwene (Duke University, USA)
"Exploring Pleiotropy and Epistasis Using a Novel Yeast Mapping Panel"
9:10 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLate-Breaking Topics
Discussion Leader: Peter Visscher (University of Queensland, Australia)
9:00 am - 9:20 amIntroduction by Discussion Leader
9:20 am - 9:50 amGustavo Stolovitsky (Translational Systems Biology and Nanobiotechnology Group, IBM, USA)
"Crowdsourcing Biological Network Inference, Drug Synergy Prediction and Beyond: The DREAM Challenges"
9:50 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:15 amMatthew Webster (Uppsala University, Sweden)
"The Genomic Basis of Local Adaptation in Honeybees"
11:15 am - 11:40 amDiscussion
11:40 am - 12:10 pmAlexis Battle (Johns Hopkins University, USA)
"Predicting the Complex and Cascading Impact of Non-Coding Variation"
12:10 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmContext – Drugs, Weather and the Systems to Integrate Genotypes and Environments
Discussion Leader: Ed Buckler (Agricultural Research Service, USDA / Cornell University, USA)
7:30 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:20 pmMark Cooper (DuPont Pioneer, USA)
"Crop Modeling and Genomic Prediction"
8:20 pm - 8:40 pmDiscussion
8:40 pm - 9:10 pmSally Aitken (University of British Columbia, Canada)
"How Does Adjusting for Population Structure Alter Polygenic Signals of Local Adaptation to Climate?"
9:10 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmQuantitative Perspectives on Gene Editing – Why to Edit What
Discussion Leader: Ann Stapleton (University of North Carolina at Wilmington, USA)
9:00 am - 9:20 amIntroduction by Discussion Leader
9:20 am - 9:50 amKevin Esvelt (Massachusetts Institute of Technology, USA)
"Daisy Drives for Grassroots Ecological Engineering"
9:50 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:10 amMattheos Koffas (Rensselaer Polytechnic Institute, USA)
"Rewiring Cellular Metabolism Using Metabolic Flux Analysis Models for Chemical Production"
11:10 am - 11:30 amDiscussion
11:30 am - 11:45 amShort Talk Selected from Poster Abstracts
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNext Generation Quantitative Genetics and Genomics
Discussion Leader: Mike Goddard (University of Melbourne, Australia)
7:30 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:20 pmChristine Queitsch (University of Washington, USA)
"Hyper-Variable Genetic Elements in Complex Trait Genetics"
8:20 pm - 8:40 pmDiscussion
8:40 pm - 9:10 pmJeff Leek (Johns Hopkins Bloomberg School of Public Health, USA)
"What Can We Learn from Analyzing Every Human RNA-Seq Sample Ever Collected Together?"
9:10 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13 HG009449-01 from the National Human Genome Research Institute (NHGRI). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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