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Phosphorylation & G-Protein Mediated Signaling Networks
Gordon Research Conference

New Druggable Targets Underlying Structural and Spatial Aspects of Signaling in Metabolic, Inflammatory, and Other Stress-Related Disease Pathways

Dates

June 5-10, 2016

Location

University of New England
Biddeford, ME

Organizers

Chair:
Carmen W. Dessauer

Vice Chair:
Anton Bennett

Meeting Description

The Gordon Research Conference on "Phosphorylation and G Protein Mediated Signaling Networks" was established in 1970 and fostered by Nobel Laureates Earl Sutherland, Edwin Krebs, Edmond Fischer and Al Gilman and many other leaders in the signal transduction field. While the conference title has expanded along with our knowledge of cell signaling ("Cyclic AMP", "Cyclic Nucleotides", "Second Messengers and Protein Phosphorylation"), the conference remains a premier venue for cutting-edge discoveries in diverse areas of signal transduction, with particular emphasis on protein kinase, phosphatase and heterotrimeric G protein-dependent networks that mediate the actions of cell-surface receptors.

The 2016 conference will bring together leading innovators, global experts, and early stage investigators to facilitate the exchange of ideas, challenge dogma, develop collaborations, and accelerate the pace of research. Sessions will emphasize structural, spatial, and temporal dynamics of signaling and the contribution of these molecular mechanisms to disease. Particular focus will include the identification of druggable targets and new technology that can be applied to signaling networks in metabolic, inflammatory, and stress-related pathways in disease. Rewiring of these signaling pathways can lead to pathologies in a range of heritable and environmentally-driven diseases, including obesity, diabetes, heart disease, cancer and depression. This meeting draws an enthusiastic and engaged group of students, postdoctoral fellows and faculty at all stages to create an exciting and collegial atmosphere that makes it the "go-to" event on the beautiful coast of Maine.

Related Meeting

This GRC was held in conjunction with the "Phosphorylation & G-Protein Mediated Signaling Networks" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: G Proteins, Kinases, and Phosphatases - Druggable Targets
The third talk in this session, selected from the GRS, is presented in memory of Dr. Alfred G. Gilman.
Discussion Leader: Anton Bennett (Yale University, USA)
7:40 pm - 8:10 pmGary Johnson (University of North Carolina School of Medicine, USA)
"Chromatin Remodeling and Transcriptome Changes Drive the Adaptive Response to Targeted Kinase Inhibition"
8:10 pm - 8:25 pmDiscussion
8:25 pm - 8:55 pmTracy Handel (University of California, San Diego, USA)
"Structure, Activation Mechanisms and Inhibition of Chemokine Receptors"
8:55 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmAndre Lazar (University of California, San Francisco, USA)
"Regulation of Adenylyl Cyclase by Isoform-Specific Endocytosis"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSpatial and Temporal Dynamics of Cellular Signaling
Discussion Leader: Eileen Kennedy (University of Georgia, USA)
9:00 am - 9:25 amJohn Scott (University of Washington, USA)
"Guiding Signals Through Anchored Enzyme Complexes"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amJin Zhang (University of California, San Diego, USA)
"New Fluorescent Biosensors for Visualizing Live-Cell Biochemical Activities at Superresolution"
10:00 am - 10:10 amDiscussion
10:10 am - 10:25 amThomas Rich (University of South Alabama, USA)
"Hyperspectral Imaging Approaches to Measure Localized cAMP Signals"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:10 amBandarigoda Somatilaka (University of Texas Southwestern Medical Center, USA)
"Subcellular Trafficking of Adenylyl Cyclases: Primary Cilia and Beyond"
11:10 am - 11:15 amDiscussion
11:15 am - 11:40 amNarasimhan Gautam (Washington University in St. Louis School of Medicine, USA)
"Dissecting Cell Behavior with Subcellular Optogenetics"
11:40 am - 11:50 amDiscussion
11:50 am - 12:15 pmKirill Martemyanov (The Scripps Research Institute, USA)
"Organization of the G Protein Signaling Cascade of the First Visual Synapse"
12:15 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLipid Modifications and Signaling
Discussion Leader: Maurine Linder (Cornell University, USA)
7:30 pm - 7:55 pmJonathan Backer (Albert Einstein College of Medicine, USA)
"The p85/p110beta PI 3-Kinase as a Mediator of G-Protein Signaling"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmIlya Levental (McGovern Medical School, University of Texas Health Science Center at Houston, USA)
"Greasing the Way: Protein Lipidation and Lipidomics in Membrane Targeting"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmCarol Williams (Medical College of Wisconsin, USA)
"Repurposing GPCR-Targeted Drugs to Regulate the Prenylation and Membrane Localization of Rap, Ras, and Rho Small GTPases in Cancer: Signaling Mechanisms and Therapeutic Strategies"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSivaraj Sivaramakrishnan (University of Minnesota Twin Cities, USA)
"The Kinase Toolbox: Probing the Regulation of Kinase Function Through Multi-Domain Coordination"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmStructural Organization of Cellular Signaling
Discussion Leader: Stephen Sprang (University of Montana, USA)
9:00 am - 9:30 amNicholas Tonks (Cold Spring Harbor Laboratory, USA)
"Drugging the Undruggable: New Approaches to Exploiting the Protein Tyrosine Phosphatases as Therapeutic Targets"
9:30 am - 9:45 amDiscussion
9:45 am - 10:10 amJohn Tesmer (University of Michigan, USA)
"Molecular Mechanisms of Effector Regulation by Heterotrimeric G Proteins and Lipids"
10:10 am - 10:20 amDiscussion
10:20 am - 10:30 amEileen Kennedy (University of Georgia, USA)
"Targeting Allosteric Activation of EGFR"
10:30 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:30 amAnne-Claude Gingras (Lunenfeld-Tanenbaum Research Institute, Canada)
"Spatio-Temporal Organization of Signaling Using Quantitative Mass Spectrometry"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmRoger Sunahara (University of California, San Diego, USA)
"The G Protein- and Agonist-Bound GPCR Conformation: Is This Really the Activated State or Are We Missing Something?"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmMatthew Torres (Georgia Institute of Technology, USA)
"The N-Terminal Tails of G Gamma Subunits Are Well-Conserved Targets of Phosphorylation that Regulate G Protein Signaling in Saccharomyces cerevisiae"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmRegulation of G Protein Networks
Discussion Leader: Kendall Blumer (Washington University in St. Louis, USA)
7:30 pm - 7:55 pmJohn Hepler (Emory University, USA)
"RGS14 at the Interface of Hippocampal Signaling and Synaptic Plasticity"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmVenetia Zachariou (Icahn School of Medicine at Mount Sinai, USA)
"RGS Proteins as Targets for the Treatment of Chronic Pain and Depression"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmMikel Garcia-Marcos (Boston University, USA)
"Alternative Signaling Mechanisms via a New Class of G Protein Activators"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmMeral Tunc Ozdemir (University of North Carolina at Chapel Hill, USA)
"Leucine-Rich Repeat Receptor-Like Kinases (LRR RLKs) Provide Signal Discrimination for Activation of Heterotrimeric G Protein Complex"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSignaling Networks in Nutrient Sensing and Metabolism
Discussion Leader: Rebecca Berdeaux (University of Texas Health Science Center at Houston, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amAnton Bennett (Yale University, USA)
"Signaling Mechanisms in Disease by MAP Kinase Dephosphorylation"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amKun-Liang Guan (University of California, San Diego, USA)
"The Hippo Pathway in Cell Growth and Cancer"
10:05 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 11:10 amStefan Offermanns (Max Planck Institute for Heart and Lung Research, Germany)
"Regulation of Metabolism and Immune Functions Through Metabolite GPCRs"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amTony Tiganis (Monash University, Australia)
"Phosphatases and Obesity"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pmMelanie Cobb (University of Texas Southwestern Medical Center, USA)
"ERKonomics of Lung Cancer"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmNew Twists on Cyclic Nucleotide Signaling
Discussion Leader: Carmen Dessauer (McGovern Medical School, USA)
7:30 pm - 7:55 pmMark Von Zastrow (University of California, San Francisco, USA)
"GPCR Signaling from Internal Membrane Compartments"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmXiaodong Cheng (McGovern Medical School, USA)
"EPAC Proteins: Structure, Function and Therapeutics"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmRebecca Berdeaux (University of Texas Health Science Center at Houston, USA)
"cAMP Regulated Signaling in Myogenesis"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmJochen Buck (Weill Cornell Medical College, USA)
"Soluble Adenylyl Cyclase Is Essential for Proper Lysosomal Acidification"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSignaling Networks in Times of Stress
Discussion Leader: Melanie Cobb (University of Texas Southwestern Medical Center, USA)
9:00 am - 9:25 amSilvio Gutkind (University of California, San Diego, USA)
"Novel G-Protein Regulated Signaling Networks in Stem Cell Fate Decisions and Cancer"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amBarry Willardson (Brigham Young University, USA)
"Chaperone-Mediated Assembly of the mTORC1 Complex"
10:00 am - 10:10 amDiscussion
10:10 am - 10:20 amNatalia Riobo (University of Leeds, United Kingdom)
"Non-Canonical Hedgehog Signalling Regulates Autophagy"
10:20 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amHenrik Dohlman (University of North Carolina at Chapel Hill, USA)
"Metabolomics Analysis of Stress-Dependent Second Messengers"
11:20 am - 11:30 amDiscussion
11:30 am - 11:55 amGregory Tall (University of Michigan, USA)
"Receptor Tyrosine Kinase Pathway Tuning of Heterotrimeric G Protein Signaling by G Protein Abundance Modulation"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:15 pmYonghao Yu (University of Texas Southwestern Medical Center, USA)
"Navigating Downstream of mTOR: A Quantitative Proteomic Approach"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSignaling Networks in Cardiac Stress and Disease
Discussion Leader: Natalia Riobo (University of Leeds, United Kingdom)
7:30 pm - 7:55 pmMaria Kontaridis (Harvard Medical School, USA)
"Role of SHP2 Phosphatase in Cardiac Development and Disease"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmAlan Smrcka (University of Rochester School of Medicine, USA)
"Intracellular Phospholipase C Signaling Networks in Cardiac Function and Disease"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmJoan Heller Brown (University of California, San Diego, USA)
"GPCR and RhoA-Mediated Transcriptional Regulation in Cell Proliferation and Survival"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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