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Staphylococcal Diseases
Gordon Research Conference

Staphylococcal Biology, Pathogenesis, Infections and Treatment

Dates

August 6-11, 2017

Location

Waterville Valley
Waterville Valley, NH Site Information

Organizers

Chairs:
Eric P. Skaar & Tammy L. Kielian

Vice Chairs:
Andreas Peschel & Ross Fitzgerald

Application Deadline

Applications for this meeting must be submitted by July 9, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

The 2017 Staphylococcal Diseases Gordon Research Conference (GRC) and its associated Gordon Research Seminar (GRS) will be held at Waterville Valley, New Hampshire, USA with the GRS being held on August 5-6 and the GRC immediately following on August 6-11, 2017. This will be the 3rd meeting of the GRS, the specific purpose of which is to promote the development of the next generation of staphylococcal investigators and the active participation of these trainees and their integration into the broader research community. The overall goal of the GRC and its associated GRS is to bring the world's leading scientists and the most promising young investigators and trainees together in a collegial and supportive environment. The specific goals are to: 1) provide a forum for the presentation of unpublished, cutting-edge research and both formal and informal discussions of the manner in which these results advance the field, 2) include investigators focusing on diverse staphylococcal species and the impact of these species on the overall problem of staphylococcal infection in both humans and animals, 3) include investigators focusing on all aspects of staphylococcal disease and provide these investigators with a forum to expand the boundaries of their own work, and 4) ensure development and integration of young investigators into the broader research community in a meaningful and interactive way. The collegial atmosphere will include organized discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, thus providing an ideal setting for scientists from different disciplines to exchange ideas and foster cross-disciplinary collaborations both among themselves and the next generation of staphylococcal investigators. Thus, the GRC will provide a unique and fundamentally important opportunity to bring together the world's leading staphylococcal investigators in a format designed for the free exchange of research results and ideas covering all aspects of staphylococcal biology and its relationship to disease and, together with the GRS, it will do so in a manner specifically designed to promote the development of promising young investigators in the field and their integration into the larger research community. In the short term, this will significantly enhance the ability of investigators around the world to address critical problems in staphylococcal disease, while in the long term it will ensure the continued success of their efforts and those of the next generation of investigators.

Related Meeting

This GRC will be held in conjunction with the "Staphylococcal Diseases" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmUnique Approaches for Combating Staphylococcal Infections
Discussion Leader: Anthony Lynch (Janssen Research & Development, LLC, USA)
7:40 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:10 pmWouter Hazenbos (Genentech, Inc., USA)
"Therapeutic Targeting of Staphylococcus aureus by an Antibody-Antibiotic Conjugate"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmSuzanne Walker (Harvard Medical School, USA)
"Teichoic Acids as Targets"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmBret Sellman (MedImmune, LLC, USA)
"Monoclonal Antibody-Mediated Toxin Neutralization Promotes a Protective Immune Response"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMetabolism: Fueling the Way
Discussion Leader: Paul Fey (University of Nebraska Medical Center, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amVinai Thomas (University of Nebraska Medical Center, USA)
"Metabolic Control of Regulated Cell Death in Staphylococcus aureus"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amAnthony Richardson (University of Pittsburgh, USA)
"Glucose Import and Nitric Oxide Resistance in Staphylococcus aureus"
10:05 am - 10:15 amDiscussion
10:15 am - 10:40 amGroup Photo / Coffee Break
10:40 am - 11:05 amKelly Rice (University of Florida, USA)
"Contributions of Bacterial Nitric Oxide Synthase to Staphylococcus aureus Metabolism"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amNeal Hammer (Michigan State University, USA)
"IspA Supports Small Colony Development by Alleviating Oxidative Stress"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Jean Lee (Brigham and Women's Hospital / Harvard Medical School, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStaphylococcal Virulence Determinants
Discussion Leader: Jean Lee (Brigham and Women's Hospital / Harvard Medical School, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:00 pmJames O'Gara (NUI Galway, Ireland)
"Redeploying β-Lactam Antibiotics as a Novel Anti-Virulence and Anti-Persister Strategy for the Treatment of MRSA Infections"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmRuth Massey (University of Bath, United Kingdom)
"What Can Genome Sequencing Tell Us About Staphylococcal Pathogenicity"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:10 pmJose Penades (University of Glasgow, United Kingdom)
"The Right Move"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHost vs. Staphylococci: The Battle Continues
Discussion Leader: Juliane Bubeck Wardenburg (University of Chicago, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amJim Cassat (Vanderbilt University Medical Center, USA)
"Hypoxic Responses at the Staphylococcal-Host Interface"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amOlaf Schneewind (University of Chicago, USA)
"Staphylococcus aureus Manipulation of B Cell Responses During Infection"
10:05 am - 10:15 amDiscussion
10:15 am - 10:40 amCoffee Break
10:40 am - 11:05 amMary O'Riordan (University of Michigan Medical School, USA)
"A Mitochondrial Sirtuin Protects Phagocytes from Oxidative Destruction During MRSA Infection"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amAnna Norrby-Teglund (Karolinska Institute, Sweden)
"Severe S. aureus Infections of Human Lung and Skin: Determinants of Tissue Pathology"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStaphylococcal Interactions with Other Bacterial Species
Discussion Leader: George O'Toole (Dartmouth College, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:00 pmMarvin Whiteley (University of Texas at Austin, USA)
"Co-Infecting Microbes Impact the S. aureus Essential Genome"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmKimberly Kline (Nanyang Technological University, Singapore)
"Enterococcus faecalis-Staphylococcus aureus Interactions During Wound Infection"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:10 pmAmanda Olgesbie-Sherrouse (University of Maryland School of Pharmacy, USA)
"Impacts of Iron on Interactions Between Staphylococcus aureus and Pseudomonas aeruginosa"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmImmune Evasive Strategies of Staphylococci
Discussion Leader: Rachel McLoughlin (Trinity College, Dublin, Ireland)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amGeorge Liu (Cedars-Sinai Medical Center, USA)
"Host Immune Response to S. aureus Peptidoglycan"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amFrancis Alonzo (Loyola University Chicago, USA)
"Intersections of Metabolism and Host Immunity: A Staphylococcus aureus Metabolic Cofactor that Suppresses Inflammation"
10:05 am - 10:15 amDiscussion
10:15 am - 10:40 amCoffee Break
10:40 am - 11:05 amSuzan Rooijakkers (University Medical Center Utrecht, The Netherlands)
"Molecular Interactions Between S. aureus and the Human Immune System"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amJoaquin Madrenas (Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, USA)
"Disease Tolerance to S. aureus Infection"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmRegulation
Discussion Leader: Thomas Kehl-Fie (University of Illinois at Urbana-Champaign, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:00 pmKim Lewis (Northeastern University, USA)
"Persisters in S. aureus"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmAlexander Horswill (University of Iowa, USA)
"Regulation of Clumping and Virulence in Staphylococcus aureus"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:10 pmAngelika Grundling (Imperial College London, United Kingdom)
"Regulation of Cyclic-di-AMP Synthesis in Staphylococcus aureus – What Makes, Breaks and Triggers Its Production"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStaphylococcal Infections and Clinical Considerations
Discussion Leader: Jessica Snowden (University of Nebraska Medical Center, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amPaul Kubes (University of Calgary, Canada)
"Imaging the Interplay Between S. aureus and Innate Immunity"
9:30 am - 9:40 amDiscussion
9:40 am - 10:05 amBo Shopsin (New York Universtity School of Medicine, USA)
"Adaptation of S. aureus to the Host and Hospital Environment"
10:05 am - 10:15 amDiscussion
10:15 am - 10:40 amCoffee Break
10:40 am - 11:05 amKeisuke (Chris) Nagao (National Institutes of Health, USA)
"Mechanisms of Immunity Against Staphylococcus aureus in the Skin"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amPaul Dunman (University of Rochester, USA)
"Targeting the GIANTS - Gram-Positive Indispensable Accessories of Bacterial Nucleic Acid Metabolism and Translational Systems"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmLate-Breaking Topics
Discussion Leaders: Andreas Peschel (University of Tübingen, Germany) and Ross Fitzgerald (University of Edinburgh, United Kingdom)
5:30 pm - 5:40 pmShort Talk Selected from Poster Abstracts
5:40 pm - 5:45 pmDiscussion
5:45 pm - 5:55 pmShort Talk Selected from Poster Abstracts
5:55 pm - 6:00 pmDiscussion
6:00 pm - 6:10 pmShort Talk Selected from Poster Abstracts
6:10 pm - 6:15 pmDiscussion
6:15 pm - 6:25 pmShort Talk Selected from Poster Abstracts
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:40 pmShort Talk Selected from Poster Abstracts
6:40 pm - 6:45 pmDiscussion
6:45 pm - 6:55 pmShort Talk Selected from Poster Abstracts
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:10 pmShort Talk Selected from Poster Abstracts
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmShort Talk Selected from Poster Abstracts
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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