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Carotenoids
Gordon Research Conference

Carotenoid Biosynthesis, Functions, and Application to Human Health

Dates

May 22-27, 2016

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chair:
Johannes Von Lintig

Vice Chair:
Giovanni Giuliano

Meeting Description

Carotenoids delight our senses as colorful pigments and exert vital physiological functions in all kingdoms of living nature. These lipids have been the focus of research efforts in the fields of chemistry, plant biology, biochemistry, physiology, nutrition, and medicine for over a century. The Gordon Research Conference on Carotenoids has been held triennially since 1992. The 2016 9th Gordon Research Conference on Carotenoids will uphold the tradition of bringing together multidisciplinary investigators at the forefront of carotenoid science. The conference will showcase exciting developments and updates with presentations on carotenoid biosynthesis and regulation; carotenoids in photosynthesis and plastids, breeding and metabolic engineering for human health; apocarotenoid biogenesis and functions; pro-vitamin A biology, carotenoids and disease prevention and aging; and carotenoids in vision and retinal health. Academic, industrial and government participants are welcome and all are strongly encouraged to present their most recent unpublished findings as posters for which ample time has been allotted. Selected posters will be chosen for short oral presentations during the conference.

This conference is an outstanding opportunity to promote growth, development, and open communication of frontier developments in carotenoid science. The collegial atmosphere of this conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides a forum for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations between carotenoid researchers world-wide. Applications are welcome from postdoctoral fellows and graduate students and it is anticipated that travel awards will be available to selected participants. Early application is recommended as attendance is limited. This year's GRC will be again preceded by a Gordon Research Seminar (GRS) on carotenoids specifically geared for postdoctoral fellows and graduate students. GRS participants are invited to also apply to attend the GRC to further network and interact with the larger carotenoid community.

Related Meeting

This GRC was held in conjunction with the "Carotenoids" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmPathway Engineering
Discussion Leader: Norihiko Misawa (Ishikawa Prefectural University, Japan)
7:40 pm - 7:45 pmOpening Remarks
7:45 pm - 8:00 pmIntroduction by Discussion Leader
8:00 pm - 8:20 pmPaul Christou (Universitat de Lleida, Spain)
"Field-Grown Engineered Maize Hybrids with Diverse Carotenoid Profiles Reveal the Complex Interplay Between Synthetic and Endogenous Metabolic Pathways"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmPaul Fraser (Royal Holloway University of London, United Kingdom)
"Engineering the Carotenoid Pathway in Solanaceae for Renewable Sources of Nutritional and Industrial Carotenoids"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmRalf Welsch (University of Freiburg, Germany)
"Novel Avenues for Controlling Carotenoid Homeostasis in Plant Tissues"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCarotenoid Biosynthesis
Discussion Leader: Barry Pogson (Australian National University, Australia)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amDean Dellapenna (Michigan State University, USA)
"Insights into Carotenoid Accumulation from Quantitative Genetics/Genomics Approaches"
9:35 am - 9:50 amDiscussion
9:50 am - 10:15 amLi Li (Agricultural Research Service, USDA / Cornell University, USA)
"Dual Functions of OR in Regulating Carotenoid Biosynthesis and Chromoplast Biogenesis"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:15 amMonica Schmidt (University of Arizona, USA)
"Enhanced Accumulation of β-Carotene in Seeds of Both Soybean and Camelina Result in Increased Levels of Seed Protein Content"
11:15 am - 11:20 amDiscussion
11:20 am - 11:45 amManuel Rodriguez-Concepcion (Centre for Research in Agricultural Genomics (CRAG), Spain)
"Control of Plant Carotenoid Biosynthesis by Light Signals"
11:45 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmClaudia Stange (University of Chile, Chile)
"Abscisic Acid and DcPSY2 Modulation During Salt Stress Tolerance in Daucus carota"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Eleanore Wurtzel (Lehman College, City University of New York, USA) and Loredana Quadro (Rutgers University, USA)
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmCarotenoids in Health and Disease
Discussion Leader: Helmut Sies (Heinrich Heine University Dusseldorf, Germany)
6:00 pm - 6:15 pmIntroduction by Discussion Leader
6:15 pm - 6:40 pmGeorge Lietz (Newcastle University, United Kingdom)
"Characterisation of the Low Responder Phenotype"
6:40 pm - 6:50 pmDiscussion
6:50 pm - 7:15 pmSherry Tanumihardjo (University of Wisconsin-Madison, USA)
"Vitamin A Liver Status Influences Provitamin A Bioconversion to Retinol and Tissue Accumulation of Carotenoids"
7:15 pm - 7:25 pmDiscussion
7:25 pm - 7:50 pmNancy Moran (Ohio State University Wexner Medical Center, USA)
"Gene-Tomato Carotenoid Interactions Impacting Carotenoid Biodistribution and Anti-Cancer Activity"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmApocarotenoid Synthesis and Functions
Discussion Leader: Salim Al-Babili (King Abdullah University of Science and Technology, Saudi Arabia)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amHarro Bouwmeester (Wageningen University, The Netherlands)
"Biosynthesis, Structural Diversity and Biological Function of Strigolactones"
9:35 am - 9:50 amDiscussion
9:50 am - 10:15 amEarl Harrison (Ohio State University, USA)
"Substrate Specificity and Mechanism of Vertebrate Carotenoid Cleavage Oxygenases"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amPhilip Kiser (Case Western Reserve University, USA)
"Biophysical Characterization of the Non-Heme Iron Center of Carotenoid Cleavage Oxygenases"
11:25 am - 11:40 amDiscussion
11:40 am - 12:05 pmMaria Jesus-Rodrigo (Institute of Agrochemistry and Food Technology (IATA-CSIC), Spain)
"Coloration Diversity in Citrus Fruits: Determining the Role of Carotenoid Cleavage Oxygenases"
12:05 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmCarotenoids and Disease Prevention
Discussion Leader: Jose Canas (Nemours Children's Health System, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:35 pmYoav Sharoni (Ben-Gurion University, Israel)
"Carotenoids and Their Derivatives Synergize with Other Phytonutrients to Produce Enhanced Anti-Cancer and Anti-Inflammatory Effects"
6:35 pm - 6:45 pmDiscussion
6:45 pm - 7:00 pmIvan Petyaev (Lycotec, United Kingdom)
"Lycopene and Lutein Clinical and Nutritional Challenges"
7:00 pm - 7:05 pmDiscussion
7:05 pm - 7:30 pmElizabeth Johnson (Tufts University, USA)
"The Role of Lutein in Cognitive Function: Mechanisms of Action"
7:30 pm - 7:40 pmDiscussion
7:40 pm - 7:55 pmAntonio Melendez-Martinez (Universidad de Sevilla, Spain)
"The Colorless Carotenoid Phytoene and Phytofluene: From Chemistry to Health-Promoting Biological Actions"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPhotosynthesis and Plastids
Discussion Leader: Krishna Niyogi (HHMI / University of California, Berkeley / Lawrence Berkeley National Laboratory, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amRoberto Bassi (University of Verona, Italy)
"Functions of Xanthophylls in Regulating Photosynthetic Light Use Efficiency"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amCheryl Kerfeld (Michigan State University / Lawrence Berkeley National Laboratory, USA)
"Red Carotenoid Proteins – Structure, Diversity, and Evolution of an Expanded Family of Soluble Carotenoid Binding Proteins in Cyanobacteria"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:05 amManuel Llansola-Portoles (University of Paris-Saclay, France)
"Triplet Formation Mechanism in Natural and Artificial Lycopene Aggregates"
11:05 am - 11:10 amDiscussion
11:10 am - 11:35 amRalph Bock (Max-Planck-Institute of Molecular Plant Physiology, Germany)
"Engineering Isoprenoid Metabolism in Plastid"
11:35 am - 11:45 amDiscussion
11:45 am - 12:10 pmDiana Kirilovsky (Institute of Integrative Biology of the Cell (I2BC), Université Paris Saclay, France)
"Distinct Activities of the Homologs of the N-Terminal Domain of the OCP"
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmApocarotenoid Metabolism
Discussion Leader: Loredana Quadro (Rutgers University, USA)
6:00 pm - 6:15 pmIntroduction by Discussion Leader
6:15 pm - 6:40 pmAlexander Moise (University of Kansas, USA)
"DHRS3 and Its Role in the Metabolism of Apocarotenoids"
6:40 pm - 6:50 pmDiscussion
6:50 pm - 7:15 pmXiang-Dong Wang (Tufts University, USA)
"Differential Mechanisms of Action of Apocarotenoids and Carotenoids"
7:15 pm - 7:25 pmDiscussion
7:25 pm - 7:50 pmOlivia Costantina Demurtas (ENEA Casaccia Research Centre, Italy)
"Crocin Biosynthesis in Saffron Stigmas: A Tale of Three Compartments"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmCarotenoids in Vision
Discussion Leader: John Landrum (Florida International University, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amPaul Bernstein (University of Utah, USA)
"Biosynthesis of Meso-Zeaxanthin"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amJohn Nolan (Waterford Institute of Technology, Ireland)
"Enrichment of Macular Pigment Enhances Visual Performance and Cognitive Function in Subjects Free of Retinal Disease: The Central Retinal Enrichment Supplementation Trials (CREST)"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:05 amTrevor McGill (Oregon Health and Science University, USA)
"The Role of Xanthophylls and Omega-3 Fatty Acids in Retinal Aging and Macular Disease: Insights from a Monkey Model"
11:05 am - 11:10 amDiscussion
11:10 am - 11:35 amDarwin Babino (Case Western Reserve University, USA)
"Carotenoid Cleavage Oxygenases in Animal Vision"
11:35 am - 11:45 amDiscussion
11:45 am - 12:10 pmJoseph Corbo (Washington University School of Medicine in St. Louis, USA)
"The Mechanistic Basis of Seeing Red and Being Red"
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmRegulation of the Carotenoid Biosynthetic Pathway
Discussion Leader: Joseph Hirschberg (Hebrew University of Jerusalem, Israel)
6:00 pm - 6:15 pmIntroduction by Discussion Leader
6:15 pm - 6:40 pmEleanore Wurtzel (Lehman College, City University of New York, USA)
"A Novel Gate-Keeper of Carotenoid Biosynthesis in Plants"
6:40 pm - 6:50 pmDiscussion
6:50 pm - 7:15 pmPatricia Leon-Mejia (Instituto de Biotecnologia UNAM, Mexico)
"The Role of Linear Carotenoids in the Leaf Development"
7:15 pm - 7:25 pmDiscussion
7:25 pm - 7:50 pmRyan McQuinn (Australian National University, Australia)
"Exploiting Genetic Diversity for Characterization of Carotenoid Regulation in Tomato Fruit"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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