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Bioorganic Chemistry
Gordon Research Conference

Bio-Graphic Chemistry: Stories of Molecules that Shape Human Biology

Dates

June 11-16, 2017

Location

Proctor Academy
Andover, NH Site Information

Organizers

Chairs:
Paramjit S. Arora & Frank W. Kotch

Vice Chairs:
Paul R. Thompson & Erik C. Hett

Application Deadline

Applications for this meeting must be submitted by May 14, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

The Bioorganic Chemistry Gordon Research Conference (GRC), established in 1992, brings together interdisciplinary scientists pursuing challenges at the interface of chemistry and biology. Attendees from industry, academia and other research institutions convene annually to discuss the latest molecular approaches and tools to understand, probe and modulate biological complexity. The 2017 edition will broadly focus on the structure-function relationships in biomolecular recognition with an emphasis on the role of weak forces and dynamics, with specific sessions on biopharmaceuticals, conformational disorder in recognition, and translation of chemical biology approaches to new drugs and materials. Conferees are encouraged to present posters. Poster presenters should submit an abstract with their applications on the GRC web site. A number of poster presenters will be invited to present short talks. As this meeting usually oversubscribes, submission of applications in early 2017 is strongly encouraged.

Related Meeting

This GRC will be held in conjunction with the "Bioorganic Chemistry" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmIntra and Extracellular Biomolecular Recognition
Discussion Leader: Richard Cheng (National Taiwan University, Taiwan)
7:40 pm - 8:05 pmJames Wells (University of California, San Francisco, USA)
"Discovering and Modulating How Cell Surfaceomes Change in Cancer"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmRonald Breaker (Yale University, USA)
"Riboswitches that Respond to RNA-Like Signaling Molecules Reveal Ancient Regulatory Pathways"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmLaura Kiessling (University of Wisconsin-Madison, USA)
"Glycans as Cell IDs"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProtein Disorder and Dynamics
Discussion Leader: Michelle Farkas (University of Massachusetts Amherst, USA)
9:00 am - 9:30 amJane Clarke (University of Cambridge, United Kingdom)
"Analyses of Folding and Binding of Intrinsically Disordered Proteins"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amAnna Mapp (University of Michigan, USA)
"From Fuzzy to Function: The New Frontier of Protein-Protein Interactions"
10:10 am - 10:20 amDiscussion
10:20 am - 10:40 amCoffee Break
10:40 am - 11:10 amKevin Gardner (CUNY Advanced Science Research Center, USA)
"Ligand-Controlled Conformational Plasticity: Lessons Learned from Natural and Artificial Control of Protein-Protein Interactions"
11:10 am - 11:20 amDiscussion
11:20 am - 11:50 amDustin Maly (University of Washington, USA)
"Engineered Protein Switches for Studying Intracellular Signaling Dynamics"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk Selected from Poster Abstracts
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Anna Mapp (University of Michigan, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTranslational Chemical Biology
Discussion Leader: Derek Tan (Memorial Sloan Kettering Cancer Center, USA)
7:30 pm - 8:00 pmJerry Adams (GlaxoSmithKline, USA)
"Harnessing the Immune System to Fight Cancer: What Will Be the Role of Small Molecule Drug Discovery"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmJeanne Magram (Northern Biologics, Canada)
"Targeting the Tumor Microenvironment with Antibody Therapeutics"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmPeter Schultz (The Scripps Research Institute, USA)
"A Chemist's Foray into Translational Research - From Stem Cells to Neglected Disease"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmChallenges in Nucleic Acids Recognition and Therapeutics
Discussion Leader: Louise Charkoudian (Haverford College, USA)
9:00 am - 9:30 amYamuna Krishnan (University of Chicago, USA)
"Fluorescent DNA Nanodevices to Quantitate Protein Activity in Living Systems"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amAseem Ansari (University of Wisconsin-Madison, USA)
"Cosmic-Seq Based Surprises on How Synthetic Genome Readers Engage Chromatinized Genomes in Live Human Stem Cells"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amJoshua Brooks (Ionis Pharmaceuticals, USA)
"Process Development in Antisense Oligonucleotides"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amShort Talk Selected from Poster Abstracts
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTarget and Organism-Based Drug Discovery
Discussion Leader: Paola Castaldi (AstraZeneca, USA)
7:30 pm - 8:00 pmMatthew Schiffler (Eli Lilly and Company, USA)
"mPGES-1 Inhibitors from Start to Finish"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmStacie S. Canan (Celgene Global Health, USA)
"In Vitro Whole Organism SAR Coupled with Rapid Advancement to In Vivo Proof-of-Concept Studies to Drive Anti-Malarial Drug Discovery"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmShort Talk Selected from Poster Abstracts
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmUnderstanding and Exploiting the Immune System
Discussion Leader: Marina Rubini (University College Dublin, Ireland)
9:00 am - 9:30 amCatherine Leimkuhler Grimes (University of Delaware, USA)
"Breaking Down and Remodeling Bacterial Cell Walls"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amSteve Kolodziej (Pfizer, USA)
"Oligosaccharide Models to Study Regioselectivity of Chemical Activation and Protein Conjugation for Conjugate Vaccines"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amCarston Wagner (University of Minnesota, USA)
"Chemically Self-Assembled Nanorings: From CARS to PARS"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amShort Talk Selected from Poster Abstracts
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmProtein Recognition and Function
Discussion Leader: Emily Derbyshire (Duke University, USA)
7:30 pm - 8:00 pmMarcey Waters (University of North Carolina at Chapel Hill, USA)
"Strategies for Sensing Histone Post-Translational Modifications"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmJason Gestwicki (University of California, San Francisco, USA)
"Targeting Protein-Protein Interactions in the Molecular Chaperone Network"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmTarun Kapoor (The Rockefeller University, USA)
"Chemical Approaches to Dissect the Diverse Functions of Proteins in the AAA+ Superfamily"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLabeling, Folding and Degrading Proteins
Discussion Leader: Brian McNaughton (Colorado State University, USA)
9:00 am - 9:30 amAndy Crew (Arvinas, Inc., USA)
"Proteolysis-Targeting Chimera (PROTACs) as Potent and Selective Degraders of Pathological Proteins"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amGeorge Rose (Johns Hopkins University, USA)
"Protein Folding: Non-Specific Interactions Can Promote Highly Specific Chain Organization"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amRonald Raines (University of Wisconsin-Madison, USA)
"Diazo Compounds: Versatile Tools for Chemical Biology"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amShort Talk Selected from Poster Abstracts
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmRecent Advances in Chemical Biology
Discussion Leader: Jennifer Ottesen (Ohio State University, USA)
7:30 pm - 8:00 pmHiroaki Suga (University of Tokyo, Japan)
"One-Pot Synthesis and Screening of Pseudo-Natural Peptides and Products"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmDavid Breslauer (Bolt Threads, USA)
"Using Industrial Biotechnology to Make Spider Silk and Other Protein-Based Fibers"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmAlanna Schepartz (Yale University, USA)
"Seeing and Engineering Inside Cells"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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