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Neurotrophic Factors
Gordon Research Conference

From Cellular Mechanisms to Function in Behavior and Disease

Dates

June 4-9, 2017

Location

Salve Regina University
Newport, RI Site Information

Organizers

Chair:
Wilma J. Friedman

Vice Chair:
Philip A. Barker

Meeting Description

The thirteenth Gordon Research Conference (GRC) on Neurotrophic Factors will provide a multidisciplinary and intimate environment for discussing the latest advances in the field of neurotrophic factors. The 2017 meeting is based upon the idea that if we can understand basic cellular and molecular mechanisms of neurotrophic factor actions, then we can employ those lessons to understand how these factors influence behavior and disease. The meeting therefore includes sessions on the basic biology of neurotrophic factors (neurotrophin signaling, regulation of PNS and CNS development by neurotrophic factors, growth factors and neural stem cells, intracellular trafficking and local signaling, and mechanisms of axonal growth and degeneration), together with sessions describing their involvement in plasticity, behavior and disease. In addition, this meeting will provide opportunities for young investigators to present their data to the neurotrophic factors community through posters and talks. The overarching goal of this meeting is to bring together scientists working on these different aspects of neurotrophic factor biology, and that this will lead to new intellectual insights, collaborations, and a fuller understanding of how neurotrophic factors impact neural development and function.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmNeurotrophin Signaling Mechanisms
Discussion Leader: Michael Greenberg (Harvard Medical School, USA)
7:40 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:10 pmCarlos Ibanez (Karolinska Institute, Sweden)
"Mechanism-Based Pharmacology of the p75 Neurotrophin Receptor"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmFernanda Ledda (University of Buenos Aires, Argentina)
"Pea3 Transcription Family Members and Neuronal Differentiation in Response to Neurotrophins"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmRejji Kuruvilla (Johns Hopkins University, USA)
"Axonal Targeting Mechanisms for Neurotrophin Receptors"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNeurotrophin Effects on Nervous System Development
Discussion Leader: Barbara Hempstead (Weill Cornell Medicine, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:50 amAlexander M. Cruickshank Lecture: Liqun Luo (Stanford University, USA)
"Neurotrophin Signaling in Competitive Dendrite Morphogenesis"
9:50 am - 10:00 amDiscussion
10:00 am - 10:30 amElizabeth Coulson (University of Queensland, Australia)
"Regulation of Cholinergic Basal Forebrain Function and Dysfunction by p75"
10:30 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:40 amDavid Ginty (Howard Hughes Medical Institute / Harvard Medical School, USA)
"Development and Organization of Low-Threshold Mechanosensory Neurons"
11:40 am - 11:50 amDiscussion
11:50 am - 12:20 pmLloyd Greene (Columbia University, USA)
"What Is ATF4 Doing in the Brain and Why Should Neurotrophiners Care?"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Rosalind Segal (Harvard Medical School / Dana-Farber Cancer Institute, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPlasticity
Discussion Leader: Moses Chao (New York University, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:10 pmMartin Korte (Braunschweig University of Technology, Germany)
"Role of Ligand-Independent TrkB Transactivation in Controlling Dendritic Architecture of Interneurons, Granule Cells and Pyramidal Neurons"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmMartha Escobar (Autonomous University of Mexico, Mexico)
"Neurotrophins in Plasticity and Metaplasticity"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmMarco Canossa (European Brain Research Institute (EBRI), Italy)
"Peri-Synaptic Glia Recycles Brain-Derived Neurotrophic Factor for LTP Stabilization and Memory Retention"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmNeurotrophic Factors in Disease
Discussion Leader: Louis Reichardt (Simons Foundation, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amHelen Scharfman (Nathan Kline Institute for Psychiatric Research, USA)
"The Role of BDNF in Epilepsy"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amWilliam Mobley (University of California, San Diego, USA)
"Neurotrophins and Neurodegenerative Disease"
10:10 am - 10:20 amDiscussion
10:20 am - 10:45 amCoffee Break
10:45 am - 11:10 amCheryl Dreyfus (Robert Wood Johnson Medical School, Rutgers University, USA)
"Enhancing Recovery from a Demyelinating Lesion Through the Actions of BDNF: The Role of Astrocytes and Metabotropic Glutamate Receptors"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amMichael Sendtner (University of Wuerzburg, Germany)
"Altered Axonal Actin Dynamics in Spinal Muscular Atrophy and Amyotrophic Lateral Sclerosis"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pmPatrick Mantyh (University of Arizona Cancer Center, USA)
"NGF and Skeletal Pain"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmIntracellular Trafficking and Local Signaling
Discussion Leader: Francisca Bronfman (Pontificia Universidad Catolica de Chile, Chile)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:05 pmGiampietro Schiavo (University College London, United Kingdom)
"Functional Characterisation of Axonal Signalling Endosomes in Motor Neurons"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:40 pmEnrico Tongiorgi (University of Trieste, Italy)
"Spatial and Quantitative Regulation of Local BDNF Synthesis in Dendrites"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmJeffery Twiss (University of South Carolina, USA)
"Signaling to Stress Granules Alters Axon Regeneration"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCellular Mechanisms of Neurotrophin Function
Discussion Leader: Mark Bothwell (University of Washington, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amAnton Maximov (Scripps Research Institute, USA)
"Molecular Mechanisms of Peptidergic Vesicle Exocytosis"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amTonis Timmusk (Tallinn University of Technology, Estonia)
"Regulation of BDNF Gene Transcription and Translation in Neuronal and Non-Neuronal Cells"
10:10 am - 10:20 amDiscussion
10:20 am - 10:45 amCoffee Break
10:45 am - 11:10 amMollie Meffert (Johns Hopkins University School of Medicine, USA)
"Post-Transcriptional Control of Trophic Responses"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amMladen-Roko Rasin (Robert Wood Johnson Medical School, Rutgers University, USA)
"Ribosome Signature, RNA Binding Proteins and Trophic Factors in Neurogenesis"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pmLino Tessarollo (National Cancer Institute, NIH, USA)
"Physiological Roles and Signaling of Truncated Trk Receptors"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmNeurotrophins and Behavior
Discussion Leader: Lloyd Greene (Columbia University, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:10 pmThomas Carew (New York University, USA)
"Using a Simple System to Explore a Complex Question: The Role(s)? of Growth Factor Signaling in Memory Formation in Aplysia"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmFrancis Lee (Weill Cornell Medicine, USA)
"Neurotrophic Factors and OCD-Like Phenotypes"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmEero Castren (University of Helsinki, Finland)
"TrkB Signaling Activated by Drugs"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAxonal Growth, Degeneration and Signaling
Discussion Leader: Bruce Carter (Vanderbilt University School of Medicine, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amMike Fainzilber (Weizmann Institute of Science, Israel)
"Acting Locally to Grow Globally – Localized Mechanisms in Neuron Growth Regulation"
9:35 am - 9:45 amDiscussion
9:45 am - 10:10 amRosalind Segal (Harvard Medical School / Dana-Farber Cancer Institute, USA)
"RNA Transport Granules and Axonal Degeneration"
10:10 am - 10:20 amDiscussion
10:20 am - 10:45 amCoffee Break
10:45 am - 11:10 amEran Perlson (Tel Aviv University, Israel)
"Spatial Effect of Neurotrophic Factors on Motoneuron Health"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amDavid Simon (The Rockefeller University, USA)
"Control of Sensory Axon Degeneration by the Neuronal Cell Body"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pmAvraham Yaron (Weizmann Institute of Science, Israel)
"Mechanisms of Axonal Pruning"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmStem Cell Regulation by Neurotrophic Factors
Discussion Leader: David Kaplan (Hospital for Sick Children, Canada)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:10 pmFreda Miller (University of Toronto, Canada)
"Growth Factors and Cell Genesis in the Developing Mammalian Brain"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:50 pmIsabel Farinas (University of Valencia, Spain)
"Adult Neural Stem Cell Regulation by Neurotrophins"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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