Gordon Research Conferences
Meeting Details
Search:
  GO

Protein Processing, Trafficking & Secretion
Gordon Research Conference

Secretory and Endocytic Pathways in Health and Disease

Dates

July 24-29, 2016

Location

Colby-Sawyer College
New London, NH

Organizers

Chair:
Paul H. Taghert

Vice Chair:
Klaudia Brix

Meeting Description

The 2016 Gordon Conference on Protein Processing Trafficking and Secretion will feature cutting-edge research on the cell biology of the secretory and endocytic pathways, with fundamental implications that address many areas of human health and development. Invited talks will cover a wide range of topics including the biology of PCSK9, PC1/2s, cathepsins and other important proteases; Regulated Intramembrane Proteolysis; generation of endosomes and multi-vesicular bodies; the sorting and trafficking of dense core vesicles; inter-organelle communication and autophagy; and the mechanisms of neuropeptide secretion. A strength of this Gordon Conference is the multidisciplinary nature of the research reported, drawing on methodological advances in areas ranging from high-throughput genetics and proteomics, to enzymology and super-resolution microscopy. Attendance by under-represented minorities, students, postdoctoral fellows, junior faculty, and faculty from primarily undergraduate institutions is highly encouraged.

In addition to the 31 invited talks, approximately 12 short talks will be presented by Conference participants selected on the basis of submitted abstracts. All applicants are therefore encouraged to submit a brief abstract describing their work and to indicate whether they would like their abstract to be considered for one of the short talks. For full consideration, applicants interested in presenting a short talk should submit their application by June 6, 2016. Alternatively, ample space and time will be afforded for the presentation and discussion of posters by all Conference attendees.

The Conference will be preceded by the third affiliated Gordon Research Seminar, in which students and postdoctoral researchers will have the opportunity to present their work in talks and posters and to build collaborations and informal networks with their peers prior to the arrival of senior investigators. Klaudia Brix (Jacobs Univ) will present the keynote address and a Mentoring Component will feature technical advances to study secretory and endocytic pathways. Interested trainees can find more information on the associated GRS web page (see "Related Meeting" section below).

Related Meeting

This GRC was held in conjunction with the "Protein Processing, Trafficking & Secretion" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Next-Gen Protein Processing
This session is dedicated in memorium for Dr. Donald F. Steiner, M.D., who co-founded this GRC 22 years ago, and who passed away since the 2014 Conference.
Discussion Leader: Iris Lindberg (University of Maryland School of Medicine, USA)
7:40 pm - 7:50 pmIntroduction by Discussion Leader: The Legacy of Don Steiner
7:50 pm - 8:15 pmPeter Arvan (University of Michigan Medical School, USA)
"The Story of Proinsulin Continues to Unfold"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmRobert Day (Université de Sherbrooke, Canada)
"PCSK6 Undergoes an Oncogenic Alternative Splicing Switch in Cancer"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmBertrand Cariou (L'Institut du Thorax, Centre Hospitalier Universitaire (CHU) de Nantes, France)
"The Biology and Genetics of PCSK9"
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGeneration of the Endolysosomal Pathway
Discussion Leader: Richard Mains (University of Connecticut Health Center, USA)
9:00 am - 9:25 amAvital Rodal (Brandeis University, USA)
"The Lowe Syndrome Phosphoinositide Phosphatase dORCL Maintains Innate Immunity Quiescence by Regulating Endosomal Trafficking"
9:25 am - 9:30 amDiscussion
9:30 am - 9:55 amErik Jorgensen (Howard Hughes Medical Institute / University of Utah, USA)
"Ultrafast Endocytosis"
9:55 am - 10:00 amDiscussion
10:00 am - 10:25 amPhyllis Hanson (Washington University School of Medicine in St. Louis, USA)
"ESCRT-III Function in Endosomal Trafficking"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amRobert Fuller (University of Michigan, USA)
"Molecular Functions and Structural Features of Vps13 and Its Role in Diverse Membrane Transactions"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amMelkam Kebede (University of Sydney, Australia)
"A Single Nucleotide Polymorphism in the Pro-Domain of Sorcs1 Affects Sorcs1 Protein Processing"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amMajid Khatib (INSERM / University of Bordeaux, France)
"Proprotein Convertases (PCs) Mediate Epstein-Barr Virus Infection Through Glycoprotein B Cleavage: Amplification and Positive Feedback Loop"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmEdward Anderson (Brown University, USA)
"Effect of Alternative BMP Processing on Signaling Activity, Prodomain Complexes, and Development"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Betty Eipper (University of Connecticut Health Center, USA) and Avital Rodal (Brandeis University, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNew Views on Peptide Processing and Release
Discussion Leader: Kelly Ten Hagen (National Institutes of Health, USA)
7:30 pm - 7:55 pmRobert Edwards (University of California, San Francisco, USA)
"Membrane Protein Sorting to the Regulated Secretory Pathway"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmSeung Kim (Stanford University School of Medicine / Howard Hughes Medical Institute, USA)
"Suppression of Insulin Output by the Decretin Hormones Limostatin and Neuromedin U"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:55 pmJonathan Sweedler (University of Illinois at Urbana-Champaign, USA)
"Heterogeneity in Peptide Processing Measured via High Throughput Single Cell Mass Spectrometry"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmDuy Tran (National Institutes of Health, USA)
"Imaging Secretory Granule Dynamics and Regulated Exocytosis In Vivo"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRegulated Intramembrane Proteolysis
Discussion Leader: Nabil Seidah (Institut de Recherches Cliniques de Montréal (IRCM), Canada)
9:00 am - 9:25 amRegina Fluhrer (BioMedizinische Zentrum der LMU München, Germany)
"SPPL3 - An Intramembrane Aspartyl Protease with Exciting Properties"
9:25 am - 9:30 amDiscussion
9:30 am - 9:55 amMichael Glickman (Memorial Sloan-Kettering Cancer Center, USA)
"Role of the Rip1 Intramembrane Protease in M. tuberculosis Stress Resistance"
9:55 am - 10:00 amDiscussion
10:00 am - 10:25 amJoanne Lemieux (University of Alberta, Canada)
"Rhomboid-Mediated Intramembrane Proteolysis in the Mitochondrion"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amGroup Photo / Coffee Break
11:00 am - 11:10 amBernd Schroder (Christian-Albrechts-Universität zu Kiel, Germany)
"SPPL2-Mediated Intramembrane Proteolysis Controls Pro-Atherogenic Signaling of the Receptor LOX-1"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amCamilla Gustafsen (Aarhus University, Denmark)
"Role for Mosaic Receptor SorLA/LR11 in Regulation of Extra-Hepatic PCSK9 Activity"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amSarah Neuman (University of Wisconsin-Madison, USA)
"A Screen for Systemic Growth Regulators Reveals Hobbit, a Novel and Conserved Regulator of Insulin Secretion"
11:40 am - 11:45 amDiscussion
11:45 am - 12:00 pmGeneral Discussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmInter-Organelle Communication
Discussion Leader: Kristi Wharton (Brown University, USA)
7:30 pm - 7:55 pmLoydie Jerome-Majewska (McGill University, Canada)
"Protein Transport by TMED2 Is Required for Liver Homeostasis"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmRajini Rao (Johns Hopkins University School of Medicine, USA)
"Endosomal NHE: Linking Luminal pH to Cargo Fate in Neurological Disorders"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:55 pmGary Thomas (University of Pittsburgh, USA)
"Endosome Trafficking Meets the Nuclear Transcriptional Machinery"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmJulia Von Blume (Max Planck Institute of Biochemistry, Germany)
"Cargo Sorting During Protein Secretion"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMolecular Takes on Dense Core Vesicles
Discussion Leader: Alan Attie (University of Wisconsin-Madison, USA)
9:00 am - 9:25 amMichele Solimena (Universität Dresden, Germany)
"Insulin Granule Aging and Rejuvenation"
9:25 am - 9:30 amDiscussion
9:30 am - 9:55 amAdam Linstedt (Carnegie Mellon University, USA)
"Targeting Golgi Processing for Novel Therapeutics"
9:55 am - 10:00 amDiscussion
10:00 am - 10:25 amBetty Eipper (University of Connecticut Health Center, USA)
"Biosynthetic and Endocytic Roles for PAM"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amHeather Brohier (Case Western Reserve University, USA)
"Linking DCV Exocytosis to Synapse Formation"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amNaushad Moti (Duke-NUS Graduate Medical School, Singapore)
"Site of Action of Wntless Revealed by Live Cell Imaging of Wnt Secretion"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amXingmin Zhang (University of Wisconsin-Madison, USA)
"BAIAP3, a C2 Domain-Containing Munc13 Protein, Regulates Endosome Recycling to the Golgi and Affects the Early Secretory Pathway"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmAntonio Santos (Centre for Genomic Regulation (CRG), Spain)
"The Novel Chimeric Protein Mia2/cTAGE5 Loads Pre-Chylomicrons/VLDLs at Endoplasmic Reticulum Exit Sites for Their Export"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmProcessing Enzymes in the Secretory and Endocytic Pathways
Discussion Leader: Lloyd Fricker (Albert Einstein College of Medicine, USA)
7:30 pm - 7:55 pmGalia Blum (Hebrew University of Jerusalem, Israel)
"Where Do Proteases Function During Stress?"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmJohn Creemers (KU Leuven, Belgium)
"The Role of PREPL in Regulated Secretion"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:55 pmKlaudia Brix (Jacobs University Bremen, Germany)
"Interactions Between Cysteine Cathepsins and GPCRs in Thyroid Hormone Mediated Endocrine Regulation"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:15 pmMichael Ailion (University of Washington, USA)
"The EARP Complex Controls Cargo Sorting to Dense-Core-Vesicles"
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFeeding into Autophagosomes and Lysosomes
Discussion Leader: Indira Mysorekar (Washington University School of Medicine, USA)
9:00 am - 9:25 amSharon Tooze (Francis Crick Institute, United Kingdom)
"Molecular Pathways and Vesicular Traffic During Autophagosome Formation"
9:25 am - 9:30 amDiscussion
9:30 am - 9:55 amRoberto Zoncu (University of California, Berkeley, USA)
"The Lysosome in Nutrient Sensing and Cellular Growth Control"
9:55 am - 10:00 amDiscussion
10:00 am - 10:25 amAna Maria Cuervo (Albert Einstein College of Medicine, USA)
"Chaperone-Mediated Autophagy: Crossing the Lysosomal Membrane Becomes Challenging in Neurodegeneration"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amJason Mills (Washington University School of Medicine in St. Louis, USA)
"Mist 1: A Single Transcription Factor that Is Necessary/Sufficient to Block Autophagy and Build a Secretory Cell"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amCristina Mazuski (Washington University in St. Louis, USA)
"Decoding the Firing Patterns of SCN VIP Neurons"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amStephanie Duval (Institut de Recherche Clinique de Montreal (IRCM), Université de Montréal, Canada)
"Defining the Functions of the Type II-Transmembrane Proteins GPP130 and casc4: Shedding at Common and Distinct Sites by PC7 and Furin"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmGholson Lyon (Cold Spring Harbor Laboratory, USA)
"The X-Linked Ogden Syndrome Involving NAA10 and the Amino-Terminal Acetylation of Proteins in Human Biology and Disease"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTo Image Trafficking and Secretion
Discussion Leader: Ronald Holz (University of Michigan Medical School, USA)
7:30 pm - 7:55 pmEdwin Levitan (University of Pittsburgh, USA)
"Presynaptic Dense-Core Vesicle Traffic: Effects of Neuron Type, Activity and Injury"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmMatthijs Verhage (Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, The Netherlands)
"Trafficking and Fusion of Dense Core Vesicles in Mammalian Neurons"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 8:55 pmPatrik Verstreken (VIB, KU Leuven, Belgium)
"Sleep Defects in Parkinson's Disease"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:25 pmEdwin Chapman (Howard Hughes Medical Institute / University of Wisconsin-Madison, USA)
"Ca2+ Sensors that Regulate the Release of Hormones from the Anterior Pituitary"
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS096766. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

This material is based upon work supported by the Air Force Office of Scientific Research under award number FA9550-16-1-0123. Any opinions, finding, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the United States Air Force.
© 2017 Gordon Research Conferences Search | Contact | Terms of Use | Privacy Policy | Follow us: Facebook Twitter