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Biology of Spirochetes
Gordon Research Conference

Spirochetes: Environmental, Endosymbiotic, Invasive, and Persistent

Dates

January 10-15, 2016

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chair:
Justin D. Radolf

Vice Chair:
Jenifer L. Coburn

Meeting Description

Spirochetes comprise a unique phylogenetic group of eubacteria taxonomically defined by their helical or sinusoidal shape, double membrane ultrastructure, and motility apparatus located entirely within the periplasmic space. Collectively and individually, spirochetes pose enormous and growing global threats to animal and human health. Pathogenic spirochetes include the agents of Lyme disease, relapsing fever, syphilis, leptospirosis, periodontal disease, digital dermatitis and dysentery. The biennial Gordon Research Conference on the Biology of Spirochetes brings together basic and translational researchers who study this diverse and remarkably successful group of bacteria. The highly interactive format, with its focus on cutting edge, unpublished results, generates intense discussion and productive, often lifelong, collaborations between investigators representing a wide spectrum of backgrounds, interests, and experimental approaches. The conference also provides an optimal setting for trainees and early career scientists to introduce themselves and their research to the spirochete community and to interact with established investigators. Critical to our mission of enhancing career development is the Gordon Research Seminar on the weekend immediately preceding the GRC, which provides a relaxed, but stimulating, environment for graduate students and postdoctoral fellows to present their work, discuss their findings, and build collaborations. Please note that in order to be considered for oral presentations, abstracts must be submitted by October 23, 2015.

Acceptance of applications will begin September 10, 2015.

Related Meeting

This GRC was held in conjunction with the "Biology of Spirochetes" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmSpirochetes: Diverse and Unique
Discussion Leader: Linda Bockenstedt (Yale School of Medicine, USA)
7:40 pm - 8:20 pmJorge Benach (Stony Brook University, USA)
"The Characteristics of the Outer Membrane of Borrelia burgdorferi Determine Its Ability to Thrive in Different Environments"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 9:00 pmBen Adler (Monash University, Australia)
"Leptospira Has Unique, but Largely Unknown, Virulence Factors and Cross-Protective Antigens"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmNatasha Arora (Zurich Institute of Forensic Medicine, Switzerland)
"Genomics of Syphilis"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmInteractions of Spirochetes with the Host
Discussion Leader: David Haake (VA Greater Los Angeles Healthcare System / University of California, Los Angeles, USA)
9:00 am - 9:20 amElsio Wunder (Yale School of Public Health, USA)
"Novel Leptospiral Protein Involved in Dissemination and Virulence"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amTara Moriarty (University of Toronto, Canada)
"Vascular Interaction Mechanisms of B. burgdorferi"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amPatricia Rosa (Rocky Mountain Labs / National Institute of Allergy and Infectious Diseases, NIH, USA)
"The Inexplicably Conserved OspC Signal Peptide: Form Ever Follows Function?"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amCoffee Break
10:50 am - 11:05 amBrigette Church (University of Victoria, Canada)
"Interaction of Treponema pallidum Pallilysin (Tp0751) with Human Platelets"
11:05 am - 11:10 amDiscussion
11:10 am - 11:30 amUtpal Pal (University of Maryland, College Park, USA)
"Tick Immunity Impacting Persistence of Lyme Disease Pathogens"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amJennifer Caine (Medical College of Wisconsin, USA)
"Borrelia burgdorferi Outer Surface Protein C Inhibits the Classical Complement Cascade by Binding C4b"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmHui Zhi (Texas A&M Health Science Center, USA)
"Borrelia burgdorferi BbK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmImmune Evasion and Persistence
Discussion Leader: Janis Weis (University of Utah, USA)
7:30 pm - 7:50 pmPeter Kraiczy (University Hospital of Frankfurt, Germany)
"How Lyme Disease Spirochetes Trick Innate Immunity to Resist Complement Attack"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmNicole Baumgarth (University of California, Davis, USA)
"B Cell Response Subversion Following Infection with Borrelia burgdorferi"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmRobert Lochhead (Massachusetts General Hospital / Harvard Medical School, USA)
"Innate and Adaptive Immune Activation in Antibiotic-Refractory Lyme Arthritis Illumintated by High-Throughput RNA and microRNA Sequencing of Patient Synovial Tissue"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmAdriana Marques (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Searching for Persistence in Lyme Disease"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmEnvironmental Sensing and Responses
Discussion Leader: Scott Samuels (University of Montana, USA)
9:00 am - 9:20 amMathieu Picardeau (Institut Pasteur, France)
"Comprehensive Analysis of Leptospiral Exoproteins"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amRichard Marconi (Virginia Commonwealth University Medical Center, USA)
"Unraveling the Genetic Regulatory Mechanisms of Treponema denticola: Insight into Its Unique Ability to Thrive in Periodontal Pockets"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amPaula Schlax (Bates College, USA)
"mRNA Sequence and Structure Influences Translational Regulation and mRNA Decay in Borrelia burgdorferi and Leptospira interrogans"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amCoffee Break
10:50 am - 11:05 amAriel Mechaly (Institut Pasteur de Montevideo, Uruguay)
"Crystal Structure of the Hybrid Response Regulator LIC11708, a Virulence Factor of Leptospira interrogans"
11:05 am - 11:10 amDiscussion
11:10 am - 11:30 amBrian Stevenson (University of Kentucky, USA)
"Metabolic Sensing, Signal Transduction, and Gene Regulation by the Lyme Disease Spirochete"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amNadia Benaroudj (Institut Pasteur, France)
"The Peroxide Stress Regulator PerR of Leptospira interrogans Is a New Paradigm for Oxidative Stress Sensing and Adaptation"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmChristian Eggers (Quinnipiac University, USA)
"Phage-Mediated Exchange of Both Phage and Non-Phage DNA Among Borrelia burgdorferi Isolates"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPhysiology, Membrane Biology, and Structural Biology
Discussion Leader: Melissa Caimano (University of Connecticut, USA)
7:30 pm - 7:50 pmAlejandro Buschiazzo (Institut Pasteur de Montevideo, Uruguay)
"An Extra Twist in Leptospira Flagella: Filament Structure, Flagellin, and Beyond"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmChristine Jacobs-Wagner (Yale University, USA)
"Insights into the Cell Biology of Borrelia burgdorferi"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmMichael Norgard (University of Texas Southwestern Medical Center, USA)
"Biophysical and Biochemical Approaches for Discerning Unique Features of the Treponema pallidum Periplasm and Their Relationship to Syphilis Pathogenesis"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:15 pmChris Kenyon (Institute of Tropical Medicine Antwerp, Belgium)
"Phosphorylations and Methylations in the Treponema pallidum Proteome"
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAttachment, Invasion, Dissemination, and Persistence
Discussion Leader: Sven Bergstrom (Umeå University, Sweden)
9:00 am - 9:20 amJohn Leong (Tufts University School of Medicine, USA)
"Role of the Major Outer Surface Protein OspC During Mammalian Infection by the Lyme Disease Spirochete"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amKristel Lourdault (University of California, Los Angeles / VA Greater Los Angeles Healthcare System, USA)
"Using Tn-Seq to Identify Novel Leptospira interrogans Virulence Factors"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amJenny Hyde (Texas A&M Health Science Center, USA)
"Elucidation of B. burgdorferi In Vivo Gene Expression"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amCoffee Break
10:50 am - 11:10 amJob Lopez (Baylor College of Medicine, USA)
"Understanding Salivary Gland Colonization and Transmission of Relapsing Fever Spirochetes"
11:10 am - 11:20 amDiscussion
11:20 am - 11:35 amCélia Fontana (Merial / Institut Pasteur, France)
"A Spontaneous Mutation in fliM Causes an Endoflagella Assembly Defect Resulting in Loss of Both Motility and Virulence in Leptospira interrogans"
11:35 am - 11:40 amDiscussion
11:40 am - 11:55 amMichael Curtis (Medical College of Wisconsin, USA)
"Exploring the Roles of P66 During Borrelia burgdorferi Mammalian Infection"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmTao Lin (University of Texas Health Science Center at Houston, USA)
"Borrelia burgdorferi Flagella Export Apparatus and Virulence: Insights into Type III Secretion System"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmPathogen Recognition and Inflammation
Discussion Leader: Peter Kraiczy (University Hospital of Frankfurt, Germany)
7:30 pm - 7:50 pmCatherine Werts (Institut Pasteur, France)
"Leptospiral Cell Wall Specificities as Means of Escape from TLR and NLR Innate Immune Responses"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmKishore Alugupalli (Thomas Jefferson University, USA)
"Altered Recognition of Borrelia hermsii Results in Dysregulated Inflammation and Lethality During Relapsing Fever"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmTanja Petnicki-Ocwieja (Tufts University School of Medicine, USA)
"AP-3 Mediated Trafficking of B. burgdorferi Controls Specificity of Inflammatory Responses but Not TLR2 Adaptor Complex Assembly"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmJoao Pedra (University of Maryland School of Medicine, USA)
"Non-Canonical Activation of the Immune Deficiency Pathway in Ticks"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSpirochete Interception and Disease Prevention
Discussion Leader: Adriana Marques (National Institute of Allergy and Infectious Diseases, NIH, USA)
9:00 am - 9:20 amLinden Hu (Tufts University, USA)
"Vector Targeted Approaches to Prevention of Lyme Disease"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amCaroline Cameron (University of Victoria, Canada)
"Protection from Syphilis Infection: Could It Be Mission Possible?"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amKathryn Hacker (Yale University, USA)
"Rodent Population Dynamics and Leptospirosis Infection in Urban Slum Environments"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amCoffee Break
10:50 am - 11:05 amLee Oliver (Virginia Commonwealth University, USA)
"An OspA and OspC Epitope Based 'Chimeritope' Provides Protection Against Tick Challenge in Canines: Progress Towards the Development of a Vaccine for Lyme Disease in Humans"
11:05 am - 11:10 amDiscussion
11:10 am - 11:25 amAlan McBride (Federal University of Pelotas (UFPel), Brazil)
"LigB Subunit Vaccine Against Leptospirosis Confers Sterilizing Immunity in Hamsters"
11:25 am - 11:30 amDiscussion
11:30 am - 11:50 amJoppe Hovius (Academic Medical Center, The Netherlands)
"In Search of an Antidote Against Tick-Borne Diseases"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmHari Hara Potula (University of Tennessee Health Science Center, USA)
"Vaccination with LigA-Expressing Lactobacillus Rescues Disease Readouts in a Sublethal Mouse Model of Infection and Suggests that Leptospira Infection May Prevent Expansion of Memory Cells"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSpirochetes as Members of Microbial Consortia
Discussion Leader: Jared Leadbetter (California Institute of Technology, USA)
7:30 pm - 7:50 pmDavid Hampson (Murdoch University, Australia)
"Brachyspira: Spirochetes that Chose the Colon"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmSukanya Narasimhan (Yale University, USA)
"'Micro' Management in the Tick Gut - Impact on Borrelia burgdorferi"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmChris Li (State University of New York at Buffalo, USA)
"Flagellar Glycosylation - A New Tale of Treponema denticola"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:15 pmJae Min Shin (University of Michigan School of Dentistry, USA)
"Behavior of Green Fluorescence-Expressing Treponema denticola in Oral Biofilms"
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13AI122289-01 from the National Institute of Allergy and Infections Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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