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Chromosome Dynamics
Gordon Research Conference

The Cellular, Molecular and Physical Biology of Chromosomes

Dates

May 21-26, 2017

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy Site Information

Organizers

Chair:
Rebecca Heald

Vice Chair:
John F. Marko

Application Deadline

Applications for this meeting must be submitted by April 23, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

Chromosomes provide the blueprint for all life. Because of its fundamental importance, chromosome biology is currently investigated by a large and diverse set of researchers using many different organisms, model systems, and approaches. The primary goal of this Gordon Research Conference on "Chromosome Dynamics" is to bring together a cross section of these researchers who represent the breadth and highest scientific standards within the field. Many discoveries have occurred and new technologies have developed in recent years at a very rapid pace. This conference allows researchers in diverse areas to learn about the current approaches and the latest experiments, and to develop interdisciplinary interactions and collaborations.

Related Meeting

This GRC will be held in conjunction with the "Chromosome Dynamics" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Diverse Views of Chromosome Biology
Discussion Leader: Rebecca Heald (University of California, Berkeley, USA)
7:40 pm - 7:45 pmOpening Remarks
7:45 pm - 8:10 pmTatsuya Hirano (RIKEN, Japan)
"Condensin-Based Chromosome Organization"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmDaniela Barilla (University of York, United Kingdom)
"Chromosome Segregation in Archaea"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmXiaowei Zhuang (Harvard University / Howard Hughes Medical Institute, USA)
"Imaging the Three-Dimensional Genome Organization in Single Cells"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChromosome Organization
Discussion Leader: David Sherratt (University of Oxford, United Kingdom)
9:00 am - 9:20 amIsabelle Vallet-Gely (Institut de Biologie Intégrative de la Cellule (I2BC), CNRS, France)
"Interplay Between Chromosome Segregation, Replication and Cell Division in Pseudomonas aeruginosa"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMichael Laub (Massachusetts Institute of Technology, USA)
"Regulation of Transcription and Replication by Nucleoid-Associated Proteins"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amNancy Kleckner (Harvard University, USA)
"Global Chromosome Dynamics from Bacteria to Mammalian Cells"
10:20 am - 10:30 amDiscussion
10:30 am - 10:40 amShort Talk Selected from Poster Abstracts
10:40 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:35 amWendy Bickmore (MRC Human Genetics Unit, United Kingdom)
"Chromosome Unfolding and Gene Regulation by Distant Enhancers"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmKiyoshi Mizuuchi (National Institutes of Health, USA)
"Intracellular Long-Range Communication and Chromosomal Positioning Mechanisms in Cell Division"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Abby Dernburg (University of California, Berkeley, USA)
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmCentromeres, Telomeres and Chromosome Stability
Discussion Leader: Susan Lovett (Brandeis University, USA)
6:00 pm - 6:20 pmJulie Cooper (National Cancer Institute, NIH, USA)
"Novel Anti-Cancer Strategies that Harness Non-Canonical Roles of Telomeres and Centromeres"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmVirginia Zakian (Princeton University, USA)
"The Role of Pif1 Family Helicases in Promoting Genome Stability"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmMichael Lampson (University of Pennsylvania, USA)
"Preventing Chromosome Instability: Molecular Mechanisms of Mitotic Error correction"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:40 pmShort Talk Selected from Poster Abstracts
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmShort Talk Selected from Poster Abstracts
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmChromosome Biophysics
Discussion Leader: Douglas Koshland (University of California, Berkeley, USA)
9:00 am - 9:20 amSophie Dumont (University of California, San Francisco, USA)
"Mechanical Architecture and Function of the Mammalian Spindle"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJohan Elf (Uppsala University, Sweden)
"Coordination of Replication and Division Cycles"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amGeeta Narlikar (University of California, San Francisco, USA)
"Phase-Separation Behavior of Heterochromatin Suggests New Avenues for Cancer Therapeutics"
10:20 am - 10:30 amDiscussion
10:30 am - 10:40 amShort Talk Selected from Poster Abstracts
10:40 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:35 amPaul Wiggins (University of Washington, USA)
"Modeling Replication Conflicts and Segregation Dynamics"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmSunney Xie (Harvard University, USA)
"Single Molecule Studies of Chromosome Biology"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmGenome Structure and Dynamics
Discussion Leader: Frederic Boccard (Institut de Biologie Intégrative de la Cellule (I2BC), CNRS, France)
6:00 pm - 6:20 pmHoura Merrikh (University of Washington, USA)
"Replication-Transcription Conflicts"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmJade Wang (University of Wisconsin-Madison, USA)
"The Nature of Mutations Induced by Replication-Transcription Conflict"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmBarbara Meyer (Howard Hughes Medical Institute / University of California, Berkeley, USA)
"Role of Chromosome Structure in the Regulation of X-Chromosome-Wide Gene Expression"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:40 pmShort Talk Selected from Poster Abstracts
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmShort Talk Selected from Poster Abstracts
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChromosome Dynamics and Cancer
Discussion Leader: John Marko (Northwestern University, USA)
9:00 am - 9:20 amJob Dekker (University of Massachusetts Medical School, USA)
"Folding and Segregating Chromosomes: Implications for Genome Stability and Epigenetic Inheritance"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amTarun Kapoor (The Rockefeller University, USA)
"New Chemical Tools to Dissect Cell Division Mechanisms and Selectively Target Cancer Cells"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amGary Karpen (Lawrence Berkeley National Laboratory, USA)
"Centromere Protein Overexpression Predicts Cancer Patient Outcomes and Response to Adjuvant Therapies"
10:20 am - 10:30 amDiscussion
10:30 am - 10:40 amShort Talk Selected from Poster Abstracts
10:40 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:35 amThomas Maresca (University of Massachusetts Amherst, USA)
"Avoiding Aneuploidy and Cancer: Characterizing Error Correction Pathways in Cell Division"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmAaron Straight (Stanford University Medical School, USA)
"RNA Dependent Control of Chromatin Silencing and Its Deregulation in Breast Cancer"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmMeiosis
Discussion Leader: Hironori Funabiki (Rockefeller University, USA)
6:00 pm - 6:20 pmElcin Unal (University of California, Berkeley, USA)
"Kinetochore Remodeling During Meiosis Through the Regulation of Hec1"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmScott Keeney (Memorial Sloan Kettering Cancer Center, USA)
"Formation and Repair of Protein-Linked DNA Double-Strand Breaks in Meiosis and Anti-Cancer Chemotherapy"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmTomoya Kitajima (RIKEN Center for Developmental Biology, Japan)
"The Causes of Chromosome Segregation Errors in Mammalian Oocytes"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:40 pmShort Talk Selected from Poster Abstracts
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmShort Talk Selected from Poster Abstracts
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmChromosome Cohesion and Condensation
Discussion Leader: Kerry Bloom (University of North Carolina at Chapel Hill, USA)
9:00 am - 9:20 amFrank Uhlmann (The Francis Crick Institute, United Kingdom)
"The Mechanism of the Chromosomal Cohesin Complex in Preventing Aneuploidies"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amDavid Rudner (Harvard Medical School, USA)
"Processive Enlargement of DNA Loops by SMC Condensin Complexes"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amKim Nasmyth (University of Oxford, United Kingdom)
"The Role of Scc2/Nipbl in Loading and Maintaining Cohesin on Chromosomes"
10:20 am - 10:30 amDiscussion
10:30 am - 10:40 amShort Talk Selected from Poster Abstracts
10:40 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:35 amCamilla Sjogren (Karolinska Institute, Sweden)
"The Smc5/6 Complex; Protecting the Genome Against Cancer-Promoting Aberrations"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmDaniel Gerlich (Institute of Molecular Biotechnology, Austria)
"The Cancer Proliferation Marker Ki-67 Mediates Mitotic Chromosome Separation"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmChromosome Replication and Repair
Discussion Leader: Jorge Schvartzman (Spanish National Research Council (CSIC), Spain)
6:00 pm - 6:20 pmStephen D. Bell (Indiana University, USA)
"Regulation and Mechanism of Eukaryotic DNA Replication Initiation"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmAbby Dernburg (University of California, Berkeley, USA)
"Genome-Wide Control of DNA Break Repair"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmStephen P. Bell (Howard Hughes Medical Institute / Massachusetts Institute of Technology, USA)
"The Initiation of DNA Replication in Prokaryotes"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:40 pmShort Talk Selected from Poster Abstracts
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmShort Talk Selected from Poster Abstracts
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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