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Cell Death
Gordon Research Conference

New Concepts in Cell Death Research: From Basic Mechanisms to Clinical Opportunities

Dates

July 3-8, 2016

Location

PGA Catalunya Business and Convention Centre
Girona, Spain

Organizers

Chair:
Henning Walczak

Vice Chair:
Marion MacFarlane

Meeting Description

Many diseases are frequently associated with excessive, reduced or inappropriate cell death. The 2016 Gordon Research Conference on Cell Death will foster unencumbered scientific exchange, focusing on mechanisms that specify cell death in normal development and in various pathologies. The conference will accelerate discovery in these areas and will also advance new opportunities for therapeutic intervention in the many diseases that are caused by mis-regulated cell death, such as cancer, auto-immune diseases, neurodegeneration and other age-associated disorders. The Conference will gather established experts who are leaders in the field as well as junior scientists, postdocs and graduate students to share discoveries and exchange ideas. Some poster presenters will be selected for oral presentations. The intimate format and collegial atmosphere of this Conference is designed to enable brainstorming and promote collaborations.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Perspectives on Cell Death and Survival
Discussion Leader: Henning Walczak (UCL Cancer Institute, United Kingdom)
7:40 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:20 pmEric Baehrecke (University of Massachusetts Medical School, USA)
"Autophagy, Cell Health and Cell Death"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 8:40 pmIntroduction by Discussion Leader
8:40 pm - 9:15 pmDouglas Green (St. Jude Children's Research Hospital, USA)
"Death and Undeath: To the Edge of Necroptosis and Back"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCell Signalling, Survival and Death
Discussion Leader: Marion MacFarlane (Medical Research Council Toxicology Unit, United Kingdom)
9:00 am - 9:15 amVishva Dixit (Genentech, Inc., USA)
"Cell Death in Inflammation"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amSelected from Poster Abstracts: Hamsa Puthalakath (La Trobe University, Australia)
"Identification of a Novel Death Receptor (FUMR) Responsible for Immune Cell Death During Sepsis"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amSeamus Martin (Trinity College Dublin, Ireland)
"Exploring the Interface Between Cell Death and Inflammation"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amPascal Meier (The Institute of Cancer Research, United Kingdom)
"Ubiquitin-Dependent Regulation of TNF-Induced Cell Death"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amSelected from Poster Abstracts: Sebastian Kupka (University College London, United Kingdom)
"LUBAC and LUBAC-Associated Proteins in Cell Death and Inflammation"
10:35 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:25 amHao Wu (Harvard Medical School / Boston Children's Hospital, USA)
"Molecular Elucidation of Inflammasome Activation and Regulation"
11:25 am - 11:30 amDiscussion
11:30 am - 11:45 amSelected from Poster Abstracts: Astrid Fauster (CeMM Research Center for Molecular Medicine, Austrian Academy of Sciences, Austria)
"A Combined Chemical, Proteomic and Genetic Approach Identifies Novel Inhibitors and Targets for TNF-Induced Necroptosis"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmSelected from Poster Abstracts: Matous Hrdinka (University of Oxford, United Kingdom)
"RIPK2 Active Conformation, but Not Its Kinase Activity, Is Essential for Pro-Inflammatory Signalling"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmDomagoj Vucic (Genentech, Inc., USA)
"Regulation of Inflammatory and Cell Death Signaling by RIP Kinases"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Marion MacFarlane (Medical Research Council Toxicology Unit, United Kingdom)
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmMitochondria and Cell Death in Cancer
Discussion Leader: Andreas Strasser (Walter and Eliza Hall Institute of Medical Research, Australia)
6:00 pm - 6:15 pmJoseph Opferman (St. Jude Children's Research Hospital, USA)
"Revealing MCL-1's Role(s) During Differentiation"
6:15 pm - 6:20 pmDiscussion
6:20 pm - 6:35 pmSelected from Poster Abstracts: Andrew Gilmore (Wellcome Trust Centre for Cell/Matrix Research, United Kingdom)
"Differential Binding Between BH3-Only and Anti-Apoptotic Bcl-2 Proteins Monitored by Protein Dynamics in Live Imaging Shows Single Cell Heterogeneity in Apoptotic Priming"
6:35 pm - 6:40 pmDiscussion
6:40 pm - 6:55 pmSelected from Poster Abstracts: Kelvin Cain (MRC Toxicology Unit, United Kingdom)
"Bioenergetic Reprogramming Induces Profound Changes in the Mitochondrial Proteome, 3D Mitochondrial Structure and Proteins that Regulate Death"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:15 pmSelected from Poster Abstracts: Grant Dewson (Walter and Eliza Hall Institute of Medical Research, Australia)
"VDAC2 Is a Critical Promoter of Bax Apoptotic Function"
7:15 pm - 7:20 pmDiscussion
7:20 pm - 7:35 pmAna Garcia-Saez (University of Tübingen, Germany)
"Bax Pores, One Particle at a Time"
7:35 pm - 7:40 pmDiscussion
7:40 pm - 7:55 pmSelected from Poster Abstracts: Evripidis Gavathiotis (Albert Einstein College of Medicine, USA)
"Structural and Functional Insights into the Regulation of Bax Activation"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmMitochondria and Cell Death in Neurodegeneration and Autoimmunity
Discussion Leader: Douglas Green (St. Jude Children's Research Hospital, USA)
9:00 am - 9:15 amDanielle Sliter (National Institute of Neurological Disorders and Stroke, NIH, USA)
"Mitochondria, Autophagy and Ubiquitin Phosphorylation"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amSelected from Poster Abstracts: Frank Edlich (University of Freiburg, Germany)
"Parkin Promotes Proteasomal Degradation of Misregulated Bax"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amJ. Marie Hardwick (Johns Hopkins University, USA)
"Alternate Functions of BCL-xL and BAX"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amSelected from Poster Abstracts: Solange Desagher (CNRS, France)
"Characterization of a Novel Pathway Regulating α-Synuclein Expression and Neuronal Death in Parkinson's Disease"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amSelected from Poster Abstracts: Lian Li (Emory University School of Medicine, USA)
"PINK1-Mediated Mitochondrial Signaling Against Neurodegeneration"
10:35 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:25 amAtan Gross (Weizmann Institute of Science, Israel)
"Mitochondria Metabolism at the Crossroads of Life and Death"
11:25 am - 11:30 amDiscussion
11:30 am - 11:45 amSelected from Poster Abstracts: Stephen Tait (Beatson Institute, Cancer Research UK, United Kingdom)
"Targeting Cancer by Inhibiting Apoptosis"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmSelected from Poster Abstracts: Juan Sanchez (Imperial College London, United Kingdom)
"Mitochondrial Dynamics Regulate the Apoptotic Threshold During the Onset of Embryonic Differentiation"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmNika Danial (Harvard Medical School, USA)
"Metabolic Control of Beta-Cell Survival"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmCell Death Networks and Clearance
Discussion Leader: John Abrams (University of Texas Southwestern Medical Center, USA)
6:00 pm - 6:15 pmShigekazu Nagata (Osaka University, Japan)
"Molecular Mechanism of Apoptotic Phosphatidylserine Exposure"
6:15 pm - 6:20 pmDiscussion
6:20 pm - 6:35 pmSelected from Poster Abstracts: Barbara Conradt (Ludwig Maximilians University of Munich, Germany)
"How Do C. elegans Engulfment Pathways Promote Apoptosis?"
6:35 pm - 6:40 pmDiscussion
6:40 pm - 6:55 pmInna Lavrik (Otto-von-Guericke University Magdeburg, Germany)
"Molecular Crosstalk of CD95 and TNFR1 Signaling Networks"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:15 pmGuy Salvesen (Sanford Burnham Prebys Medical Discovery Institute, USA)
"Proteolytic Cross-Talk in Cell Death Networks"
7:15 pm - 7:20 pmDiscussion
7:20 pm - 7:35 pmWill Wood (University of Bristol, United Kingdom)
"Detecting Death and Damage in Drosophila"
7:35 pm - 7:40 pmDiscussion
7:40 pm - 7:55 pmSelected from Poster Abstracts: Francesco Dazzi (King's College London, United Kingdom)
"Mesenchymal Stromal Cell Apoptosis in Graft-Versus-Host Disease"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCell Survival and Death in Cancer
Discussion Leader: Atan Gross (Weizmann Institute of Science, Israel)
9:00 am - 9:15 amMarcus Peter (Northwestern University, USA)
"Killing Cancer Cells by DICE"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amSelected from Poster Abstracts: Dagmar Kulms (Experimental Dermatology, Germany)
"Caspase-8 Promotes Uncontrolled Progression of Cancer Cells"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amSelected from Poster Abstracts: Gemma Kelly (Walter and Eliza Hall Institute of Medical Research, Australia)
"Investigating the Impact of TP53 Mutations/Loss on the Potential of MCL-1 Targeting for MYC-Driven Lymphoma Therapy"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amSelected from Poster Abstracts: Mads Daugaard (University of British Columbia, Canada)
"Glycosaminoglycans as Novel Cancer Targets"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amSelected from Poster Abstracts: Gerry Melino (Medical Research Council, United Kingdom)
"The E3 Ubiquitin Ligase WWP1 Sustains the Growth of Acute Myeloid Leukemia"
10:35 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:25 amAndreas Villunger (Medical University of Innsbruck, Austria)
"Caspase-2, Enigma No More"
11:25 am - 11:30 amDiscussion
11:30 am - 11:45 amSelected from Poster Abstracts: Delphine Merino (Walter and Eliza Hall Institute of Medical Research, Australia)
"Breast Cancer and Metastasis: New Insights into Cell Death Pathways"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmSelected from Poster Abstracts: Kirill Rosen (Dalhousie University, Canada)
"ErbB2 as a Regulator of Cancer Cell Survival"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Julian Pardo (University of Zaragoza, Spain)
"The Dual Role of Inflammatory and Apoptotic Granzymes During Colorectal Carcinoma Development"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmNon-Canonical Death Pathways and Model Organisms
Discussion Leader: Eric Baehrecke (University of Massachusetts Medical School, USA)
6:00 pm - 6:15 pmChristine Watson (University of Cambridge, United Kingdom)
"Non-Apoptotic Cell Death in Mammary Epithelial Cells"
6:15 pm - 6:20 pmDiscussion
6:20 pm - 6:35 pmSelected from Poster Abstracts: Michelle Riegman (Memorial Sloan Kettering Cancer Center, USA)
"Ferroptotic Cell Death Has Non-Cell-Autonomous Properties"
6:35 pm - 6:40 pmDiscussion
6:40 pm - 6:55 pmJohn Abrams (University of Texas Southwestern Medical Center, USA)
"Death and 'Transposopathy'"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:15 pmSelected from Poster Abstracts: Rebekah Kells (University of Edinburgh, United Kingdom)
"Environmental Stress-Related 'Stem-Ness' in Aggressive B Cell Lymphoma"
7:15 pm - 7:20 pmDiscussion
7:20 pm - 7:35 pmSharad Kumar (University of South Australia, Australia)
"Regulation of Autophagy-Dependent Midgut Degradation in Drosophila"
7:35 pm - 7:40 pmDiscussion
7:40 pm - 7:55 pmScott Lowe (Memorial Sloan Kettering Cancer Center, USA)
"Tumor Suppressor and Tumor Maintenance Genes"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmProgrammed Necrosis and Inflammation
Discussion Leader: Guy Salvesen (Sanford Burnham Prebys Medical Discovery Institute, USA)
9:00 am - 9:15 amKim Newton (Genentech, Inc., USA)
"Exploring the Pro-Survival Function of RIPK1"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amSelected from Poster Abstracts: Ben Croker (Boston Children's Hospital, USA)
"Effector Functions of Necroptosis"
9:35 am - 9:40 amDiscussion
9:40 am - 9:55 amPeter Vandenabeele (VIB, University of Ghent, Belgium)
"Role of RIPK3 in Cell Death and Inflammation"
9:55 am - 10:00 amDiscussion
10:00 am - 10:15 amJunying Yuan (Harvard Medical School, USA)
"The Role of RIPK1 in Necroptosis and Inflammation"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amSelected from Poster Abstracts: Andrew Oberst (University of Washington, USA)
"RIPK3 Coordinates Neuroinflammatory Defense Against Viral Infection Independent of Necroptosis"
10:35 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:25 amFrancis Chan (University of Massachusetts Medical School, USA)
"Targeted Strike: Compartmentalized Function of RIPK3 in Inflammation"
11:25 am - 11:30 amDiscussion
11:30 am - 11:45 amSelected from Poster Abstracts: Diego Rodriguez (St. Jude Children's Research Hospital, USA)
"Non-Canonical Activation of Necroptosis: MLKL-Dependent Cell Death in Absence of RIPK3"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmManolis Pasparakis (University of Cologne, Germany)
"RIPK1 in Cell Death and Inflammation"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmJohn Silke (Walter and Eliza Hall Institute of Medical Research, Australia)
"Cell Death and Inflammation in the Skin"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmTranslating Cell Death Discoveries Towards the Clinic
Discussion Leader: J. Marie Hardwick (Johns Hopkins University, USA)
6:00 pm - 6:15 pmKristopher Sarosiek (Harvard T.H. Chan School of Public Health, USA)
"Dynamic Regulation of Apoptosis in Healthy Tissues"
6:15 pm - 6:20 pmDiscussion
6:20 pm - 6:35 pmSelected from Poster Abstracts: Andreas Linkermann (University of Kiel, Germany)
"MLKL Mediates Necroptosis in Humans"
6:35 pm - 6:40 pmDiscussion
6:40 pm - 6:55 pmSelected from Poster Abstracts: Maria Guicciardi (Mayo Clinic, USA)
"A Novel Murine Model of SMAC Mimetic-Induced Acute Sclerosing Cholangitis"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:15 pmSelected from Poster Abstracts: Loren Walensky (Dana-Farber Cancer Institute, USA)
"Translating Pro-Apoptotic Peptide Helices to the Clinic"
7:15 pm - 7:20 pmDiscussion
7:20 pm - 7:35 pmSandra Zinkel (Vanderbilt University School of Medicine, USA)
"Regulation of Cell Death Decisions in Hematopoietic Differentiation and Stem Cell Function"
7:35 pm - 7:40 pmDiscussion
7:40 pm - 7:55 pmAndreas Strasser (Walter and Eliza Hall Institute of Medical Research, Australia)
"Life Without Intrinsic Apoptosis: Consequences of Embryonic Development in the Combined Absence of BAX, BAK and BOK"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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