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Nitric Oxide
Gordon Research Conference

Reactive Nitrogen Signaling: Mechanism to Medicine

Dates

February 19-24, 2017

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chair:
Sruti Shiva

Vice Chair:
Neil Hogg

Meeting Description

Thirty years ago nitric oxide (NO) was discovered as a predominant physiological vasodilator. Since then, it has become apparent that NO signaling is significant not only in the cardiovascular system but involved in the maintenance of homeostasis in other organ systems as well as modulating the pathogenesis of a number of diseases. Even though the Nobel Prize was awarded for the discovery of NO in 1998, the field continues to expand with new discoveries leading to novel targeting of the NO pathway for therapeutic development.

The 2017 NO Gordon Research Conference (GRC) is designed to be a cross-disciplinary meeting to facilitate interaction between cutting-edge NO scientists whose expertise range from biochemical and molecular mechanisms to models of disease processes and ultimately to clinical investigation. Morning sessions will focus on advances in basic mechanisms in the areas of chemical biology, protein modification, signal transduction and interaction with other gasotransmitters. These sessions will be complimented by evening sessions focused on the role of NO in specific disease processes and translation of basic science to the clinic. The conference will encompass 33 talks by junior and senior leaders in the field from academia, government and industry and 9 talks selected from submitted abstracts. Keynote lectures by Drs. Joseph Loscalzo and Rafael Radi will kick off and end the conference respectively. Poster sessions will be held each afternoon, including a "reverse" poster session in which senior leaders in the field will be asked to present posters in order to encourage interaction between junior and senior investigators. This year for the first time the NO GRC will be preceded by a Gordon Research Seminar (GRS) organized solely for trainees by trainees (chaired by Drs. Courtney Sparacino-Watkins and Filip Larsen).

Related Meeting

This GRC was held in conjunction with the "Nitric Oxide" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Physiological NO Signaling
Discussion Leader: Serpil Erzurum (The Cleveland Clinic Foundation, USA)
7:40 pm - 7:55 pmOpening Remarks
7:55 pm - 8:55 pmJoseph Loscalzo (Harvard Medical School, USA)
"Vascular Redox State Regulation and Nitric Oxide"
8:55 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCanonical and Non-Canonical Signaling Through sGC
Discussion Leaders: Elsa Garcin (University of Maryland, Baltimore County, USA) and Miriam Cortese-Krott (Heinrich Heine University Dusseldorf, Germany)
9:00 am - 9:20 amGreg Thatcher (College of Pharmacy, University of Illinois at Chicago, USA)
"NO Memory Is a Good Memory, Except When It's a Headache"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAdam Straub (University of Pittsburgh, USA)
"Cyb5R3 and cGMP Signaling"
9:50 am - 10:00 amDiscussion
10:00 am - 10:15 amArnab Gosh (Cleveland Clinic, USA)
"Soluble Guanylate Cyclase Dysfuction in Asthma"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amJessica Wales (University of Arizona, USA)
"Discovery of a Conserved Stimulator Binding Site in the β1 H-NOX Domain of Soluble Guanylate Cyclase"
10:35 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:30 amAnnie Beuve (New Jersey Medical School, Rutgers University, USA)
"A Well-Connected NO-Guanylyl Cyclase in the Cardiovascular System"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmEmmanuel Buys (Harvard Medical School, USA)
"Targeting NO-Signaling: A Novel Therapeutic Approach for Glaucoma"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmKatrina Miranda (University of Arizona, USA)
"Nitroxyl Signaling"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNO, Mitochondria and Metabolic Syndrome
Discussion Leaders: Victor Darley-Usmar (University of Alabama at Birmingham, USA) and Martin Feelisch (University of Southampton, United Kingdom)
7:30 pm - 7:50 pmJane Reusch (University of Colorado Denver, USA)
"Deconstructing the Exercise Impairments in Diabetes: Molecular Targeting of NOS for Reconstruction"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJason Allen (Institute of Sport, Exercise and Active Living (ISEAL), Victoria University, Australia)
"Nitrate Supplementation as an Ergogenic Aid in Cardiovascular Disease"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmBrad Hill (University of Louisville, USA)
"Endothelial NOS in Obesity and Exercise"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmBryndon Oleson (Medical College of Wisconsin, USA)
"Nitric Oxide Says 'NO' to DNA Damage-Dependent Apoptosis in β-cells"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmNO Signaling via Post-Translational Modifications
Discussion Leaders: Andrew Gow (Rutgers University, USA) and Rakesh Patel (University of Alabama at Birmingham, USA)
9:00 am - 9:20 amLisa Palmer (University of Virginia, USA)
"S-Nitrosylation and the Regulation of Intracellular Transport: Implications for Gender Difference in the Development of Pulmonary Arterial Hypertension"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amPaschalis-Thomas Doulias (Children's Hospital of Philadelphia, USA)
"Regulation of Mitochondrial Fatty Acid Oxidation by Nitric Oxide. Mechanistic Insights and Therapeutic Interventions"
9:50 am - 10:00 amDiscussion
10:00 am - 10:15 amMark Kohr (Johns Hopkins Bloomberg School of Public Health, USA)
"S-Nitrosation and Ischemia-Reperfusion Injury: New Insights from the Female Heart"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amTara Deboer (University of California, Berkeley, USA)
"Peroxynitrite-Generating Platforms and Resulting Post-Translational Modifications"
10:35 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:30 amJoshua Hare (University of Miami, USA)
"Regulation of S-Nitrosation in the Cardiovascular System"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmJennifer Van Eyk (Cedars-Sinai Medical Center, USA)
"NO and Arginine Based Post-Translational Modifications of the Heart"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmFrancisco Schopfer (University of Pittsburgh, USA)
"Reactions of Nitrated Fatty Acids: Formation, Conjugation and Degradation"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTaking the NO Pathway to the Clinic: Current Clinical Trials
Discussion Leader: Timothy Billiar (University of Pittsburgh, USA)
7:30 pm - 7:50 pmMark Gladwin (University of Pittsburgh, USA)
"Taking Nitrite to the Clinic"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmTodd Milne (Ironwood Pharmaceuticals, USA)
"Application of sGC Stimulators to Human Disease"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmDavid Rodman (Nivalis Therapeutics, Inc., USA)
"GSNO Reductase Inhibitors in the Clinic"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmDiane Jorkasky (Complexa, Inc., USA)
"Development of Nitrolipids for the Clinic"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNO Production and Crosstalk with Other Gasotransmitters
Discussion Leaders: Christopher Kevil (Louisiana State University, USA) and Peter Ford (University of California, Santa Barbara, USA)
9:00 am - 9:20 amJohn Calvert (Emory University, USA)
"Regulation of Cardiac Mitochondria by Hydrogen Sulfide"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJon Fukuto (Sonoma State University, USA)
"Interaction and Crosstalk Between Hydrogen Sulfide and Nitrogen Oxide Species"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amBindu Paul (Johns Hopkins School of Medicine, USA)
"Gasotransmitter Signaling in Neurodegenerative States"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amMegan Frost (Michigan Technological University, USA)
"Toward a Better Understanding of Targeted Dose and Duration of NO Needed and the Development of Controlled NO Delivery Materials"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amHiroshi Takagi (Graduate School of Biological Sciences, Nara Institute of Science and Technology, Japan)
"Synthetic Mechanism and Physiological Role of Nitric Oxide in Yeast"
11:40 am - 11:45 amDiscussion
11:45 am - 12:05 pmDominic Paari (LSU Health Sciences Center Shreveport, USA)
"Role of NO and H2S in the Pathogenesis of Atrial Fibrillation"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmTakaaki Akaike (Tohoku University Graduate School of Medicine, Japan)
"Persuflide Regulation of Mitochondrial Number and Function"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmNO Modulation of Cancer Progression
Discussion Leaders: Katrina Miranda (University of Arizona, USA) and David Wink (National Cancer Institute, NIH, USA)
7:30 pm - 7:50 pmDebashree Basudhar (National Cancer Institute, NIH, USA)
"Cross Talk Between Inflammation Associated Proteins NOS2 and COX2 as a Driver of Breast Cancer Progression in Tumor Microenvironment"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJenny Chang (Houston Methodist Cancer Center at Texas Medical Center, USA)
"Targeting iNOS in Cancer"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmSharon Glynn (National University of Ireland Galway, Ireland)
"Is There a Role for Nitric Oxide in Prostate Carcinogenesis?"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmDouglas Thomas (University of Illinois at Chicago, USA)
"Nitric Oxide Is an Epigenetic Driver of Cancer"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNovel Paradigms of NO-Dependent Cardiovascular Signaling
Discussion Leaders: Amrita Ahluwalia (Queen Mary University of London, United Kingdom) and William Montfort (University of Arizona, USA)
9:00 am - 9:20 amYe Chen-Izu (University of California, Davis, USA)
"NO Mediates Mechano-Chemo-Transduction During Cardiac Myocyte Contraction"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAnnarita Di Lorenzo (Weill Cornell Medicine, USA)
"Nogo-B Regulates S1P/S1PR1/NO Pathway to Impact Cardiovascular Functions"
9:50 am - 10:00 amDiscussion
10:00 am - 10:15 amNathan Bryan (Baylor College of Medicine, USA)
"Nitrite, the Microbiome and Blood Pressure"
10:15 am - 10:20 amDiscussion
10:20 am - 10:35 amJose Tanus-Santos (University of Sao Paulo, Brazil)
"Evidence Supporting S-Nitrosothiols Formation as a Possible Mechanism Involved in the Blood Pressure Effects of Oral Nitrite"
10:35 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:30 amChristine Helms (University of Richmond, USA)
"The In Vitro Effect of Fibrin Modification Due to NO Exposure"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amPaola Corti (University of Pittsburgh, USA)
"Globin X Is a Nitrite Reductase"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmDan Jones (William Harvey Research Institute, Queen Mary University of London, United Kingdom)
"Nitrite and Inflammatory Signaling in Acute Myocardial Infarction"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: Biochemical NO Signaling Mechanisms
Discussion Leader: Neil Hogg (Medical College of Wisconsin, USA)
7:30 pm - 8:30 pmRafael Radi (University of the Republic, Uruguay)
"Nitric Oxide, Peroxynitrite and Protein Tyrosine Nitration: Facts, Unknown and Challenges"
8:30 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmGeneral Discussion
9:20 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13HL135874-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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