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Chemotactic Cytokines
Gordon Research Conference

From Molecular Mechanisms of Chemokine Biology and Pathophysiology to Progress and Challenges in the Development of Therapeutics

Dates

May 29 - June 3, 2016

Location

PGA Catalunya Business and Convention Centre
Girona, Spain

Organizers

Chair:
Tracy M. Handel

Vice Chair:
Reinhold J. Forster

Meeting Description

Chemokines were first identified as small soluble proteins that orchestrate leukocyte migration during immune surveillance, inflammation and wound repair. However it is now well known that they do much more, and also control cell migration in the context of many developmental processes such as lymphopoiesis, cardiogenesis and development in the CNS. As a consequence they attract interest from researchers from diverse areas of study including immunology, developmental biology, and neurobiology. Because of the importance of chemokines to the immune system and host defense, many viruses have developed mechanisms to exploit or hijack the chemokine system; thus chemokines have attracted the interest of virologists. Moreover, they are involved in numerous inflammatory diseases such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel diseases and asthma, in addition to many other therapeutic areas. In 1996, two chemokine receptors were discovered to be the coreceptors that facilitate the entry of HIV into cells. In 2001, the connection between chemokines and cancer metastasis was established. Because of their unusually broad clinical significance, they are studied not only by basic research scientists but also by clinical scientists and researchers in the pharmaceutical industry. Thus the 2016 Chemotactic Cytokines Gordon Research Conference (GRC) will draw scientists from a variety of disciplines and as implied in the subtitle, will feature studies involving basic mechanisms of chemokine biology and pathophysiology, to progress and challenges in the development of new drugs and disease treatments. The 2014 meeting was held in West Dover Vermont, and based on a unanimous decision to alternate every other conference between Europe and the US, the 2016 GRC will take place 5/29/2016 - 6/3/2016 at the PGA Catalunya Business and Convention Centre near Girona, Spain, which should be a fantastic site with many options for tours and activities during free time.

To ensure that the GRC captures the most recent breakthroughs in chemokine research, 24 speaking slots for "short talks" have been reserved for late breaking presentations selected from abstracts to complement the 29 "long talks" from invited speakers. To educate, integrate, empower and give visibility to the next generation of chemokine scientists, the Chemotactic Cytokine GRC will also be linked for the third time with a satellite Gordon Research Seminar (GRS): Emerging Concepts in Chemokine Biology, which will take place during the 1.5 days immediately preceding the GRC. In summary, we plan to bring together the most passionate and engaged researchers in the field working in different biomedical disciplines and disease areas, coming from different countries and representing different age and experience groups. The focus of this conference will be to advance our understanding of the mechanistic functions of chemokines and their role in human disease, and to provide a forum for novel uncharted aspects of chemokine research to be presented, discussed and assessed, and to seed ideas that will lead to clinical breakthroughs.

We look forward to seeing you in Spain in May 2016 and hope that the combination of cutting edge science, friendly scientific debate and the relaxing atmosphere of the site will be conducive to a hugely successful meeting. Apply early as we expect the meeting to be oversubscribed!

Comenzar a practicar tu español!

Tracy Handel and Reinhold Forster

Related Meeting

This GRC was held in conjunction with the "Chemotactic Cytokines" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Visualizing Cancer Invasion to Chemokine Therapeutics
Discussion Leader: Tracy Handel (University of California, San Diego, USA)
7:40 pm - 7:55 pmOpening Remarks
7:55 pm - 8:45 pmPeter Friedl (The University of Texas MD Anderson Cancer Center, USA)
"Cancer Invasion, Metastasis and CTL Function Controlled by the Tumor Microenvironment"
8:45 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmAmanda Proudfoot (Chemokine Biologist, Freelance Consultant, France)
"Retrospective Analyses of Drug Successes and Failures and Perspectives on the Future of Chemokine Targeted Therapies"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAtypical Receptors and Atypical Interactions in Chemokine Function and in Disease
Discussion Leader: Massimo Locati (University of Milan, Italy)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amMarcus Thelen (Institute for Research in Biomedicine, Università Della Svizzera Italiana, Switzerland)
"ACKR3: A Marker for B Cell Populations in Health and Disease"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amAntal Rot (University of York, United Kingdom)
"New Physiological Role of ACKR1"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amRalf Stumm (Jena University Hospital, Germany)
"CXCL12 Receptors in Development and Repair of the Cerebral Cortex: Highlighting Atypical Functions and Cell Fate"
10:30 am - 10:40 amDiscussion
10:40 am - 11:00 amCoffee Break
11:00 am - 11:20 amKathleen Caron (University of North Carolina, USA)
"Atypical Modulation of Chemokine Receptor Function by RAMP Proteins"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amNikolaus Heveker (University of Montreal, Canada)
"CXCR7/ACKR3 Chemokine Binding and Activation"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amChris Hansell (University of Glasgow, United Kingdom)
"The Atypical Chemokine Receptor, ACKR2, Constrains NK Cell Activity and Promotes Metastasis"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmScott Mueller (The University of Melbourne, Australia)
"Neural Regulation of Lymphocyte Migration"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmJames Pease (Imperial College London, United Kingdom)
"Cell Surface Binding of CXCL8 by Neutrophil Glycosaminoglycans Is Required for Efficient Navigation of Chemokine Gradients"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmChemokines in Immunity, Host Defense and Inflammation
Discussion Leader: Sergio Lira (Mount Sinai School of Medicine, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:30 pmHeather Hickman (National Institute of Allergy and Infectious Disease, NIH, USA)
"CXCR3 Chemokine Receptor Facilitates CD8(+) T Cell Migration for the Destruction of Virus-Infected Cells"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:00 pmFederica Sallusto (Institute for Research in Biomedicine, Università della Svizzera Italiana, Switzerland)
"Human T Cell Subsets in Immunity, Autoimmunity, and Allergy"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:30 pmAlberto Mantovani (Istituto Clinico Humanitas, Italy)
"Chemokines and Complement-Derived Chemoattractants in Tumor Promoting Inflammation"
7:30 pm - 7:40 pmDiscussion
7:40 pm - 7:55 pmMaud Deruaz (Massachusetts General Hospital, Harvard Medical School, USA)
"HIV Hitches a Ride with Leukocytes to Exit the Genital Mucosa and Establish Systemic Infection"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmTherapeutic Targeting of Chemokine Receptors
Discussion Leader: Timothy Williams (Imperial College London, United Kingdom)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amThomas Schall (ChemoCentryx, USA)
"Chemokine Receptor Inhibitors as New Medicines: The Revolution Returns"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amJohn Westwick (Imperial College London, United Kingdom)
"CXCR2 Antagonists as Therapies for Pulmonary Arterial Hypertension"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amOla Winqvist (Karolinska Institutet, Sweden)
"Chemokine Receptor Targeted Leukapheresis for Inflammatory Diseases"
10:30 am - 10:40 amDiscussion
10:40 am - 11:00 amCoffee Break
11:00 am - 11:20 amPhilip Murphy (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Targeting CXCR4 in WHIM Syndrome Immunodeficiency"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amOliver Hartley (University of Geneva, Switzerland)
"Anti-HIV Chemokine Analogs: Discovery, Optimization and Unusual Pharmacology"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amMette Rosenkilde (University of Copenhagen, Denmark)
"Rationally Designed Protein-Based and Small Molecule Ligands for US28"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmChristian Weber (Ludwig Maximilian University of Munich, Germany)
"Chemokine Interactome Mapping for Tailored Intervention in Acute and Chronic Inflammation"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSam Hwang (University of California, Davis, USA)
"An Engineered Mutant of the Chemokine CCL20 Prevents Psoriasiform Dermatitis in an IL-23-Dependent Murine Model"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmMechanisms of Cell Migration and Gradient Sensing
Discussion Leader: Ronen Alon (The Weizmann Institute of Science, Israel)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:30 pmMichael Sixt (Institute of Science and Technology Austria, Austria)
"Interpretation of Chemokine Gradients In Vitro and In Vivo"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:00 pmTim Lammermann (Max Planck Institute of Immunobiology and Epigenetics, Germany)
"Chemokines and Chemoattractants Controlling Neutrophil Swarming"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:30 pmSussan Nourshargh (William Harvey Research Institute, United Kingdom)
"Neutrophil-Vessel Wall Interactions: Novel Insights and Complexities"
7:30 pm - 7:40 pmDiscussion
7:40 pm - 7:55 pmDaniel Irimia (Massachusetts General Hospital, Harvard Medical School, USA)
"Ex Vivo Assays Help Elucidate Chemokine Signaling During Human Neutrophil Swarming"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmChemokines, Inflammation and Cancer
Discussion Leader: Adit Ben-Baruch (Tel Aviv University, Israel)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amJeffrey Pollard (University of Edinburgh, United Kingdom)
"Chemokine Cascades Promote Pulmonary Metastatic Colonization by Breast Cancer Cells"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amAndrew Luster (Massachusetts General Hospital, USA)
"Chemokines in Cancer Immunotherapy"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amAnn Richmond (Vanderbilt University, USA)
"Chemokines as Mediators of Cancer Immunotherapy"
10:30 am - 10:40 amDiscussion
10:40 am - 11:00 amCoffee Break
11:00 am - 11:20 amGerry Graham (University of Glasgow, United Kingdom)
"A Pro-Metastatic Role for the Atypical Chemokine Receptor ACKR2"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amLeandros Moschovakis (Institute of Immunology, Hannover Medical School, Germany)
"The CXCR5-Dependent Co-Localization of T Cells and B Cells in Joint Draining Lymph Nodes and Spleen Is Essential for the Induction of Rheumatoid Arthritis"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amShiri Klein (Hebrew University of Jerusalem, Israel)
"CXCR4 Controls BCL-2 Expression and Function by Regulating Mir-15a/16-1 Expression in Tumor Cells"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmAngela Hughson (University of Rochester, USA)
"Leishmania Dissemination Is Held in Check by CCL7"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmTamara Girbl (Queen Mary University of London, United Kingdom)
"Sequential Chemotactic Cues Guide Neutrophils Through Distinct Cellular Barriers of Blood Vessel Walls During Inflammation"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmControl of Cell Function by Chemokines in the Microenvironment
Discussion Leader: Ann Richmond (Vanderbilt University, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:30 pmMatthew Albert (Genentech, USA)
"Post-Translational Modification of Chemokines Impacts Endogenous Tumor Immunity and Success of Immunotherapy"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:00 pmRobert Insall (Cancer Research UK Beatson Institute, University of Glasgow, United Kingdom)
"Cells Steering Themselves: Self-Generated Chemotactic Gradients, Why They're Important, and How They're Different from the Usual Type"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:30 pmSwarnali Acharyya (Columbia University, USA)
"Understanding the Systemic Effects of Metastasis"
7:30 pm - 7:40 pmDiscussion
7:40 pm - 7:55 pmKeehoon Jung (Harvard Medical School / Massachusetts General Hospital, USA)
"Targeting the Immune Microenvironment to Improve Colorectal Cancer Anti-Angiogenic Therapy"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmNovel Mechanisms for Regulating Chemokine Function
Discussion Leader: Mario Mellado (Centro Nacional de Biotecnología, CSIC, Spain)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amEleanor Fish (University of Toronto / University Health Network, Canada)
"CCL5 Activation of CCR5 Regulates Cell Metabolism to Promote Breast Cancer Cell Proliferation"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amRichard Ransohoff (Biogen, USA)
"Fractalkinomics - What, Why, How?"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amCoffee Break
10:30 am - 10:50 amMartine Smit (VU University Amsterdam, The Netherlands)
"Chemokine Receptor-Targeting Nanobodies"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amDaniel Legler (University of Konstanz, Germany)
"Control of CCR7-Driven Cell Migration by Distinct Signaling Complexes"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amCaroline Sokol (Massachusetts General Hospital, USA)
"CCR8 Directs the Initiation of Th2 Cell Differentiation"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amWei-Jen Tang (The University of Chicago, USA)
"Structural Basis of Oligomerization, Glycosaminoglycan Binding, and Proteolysis of Chemokines, CCL3 and CCL5"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSimi Ali (Newcastle University, United Kingdom)
"Nitration Is a Negative Regulator of Chemokine-Mediated Inflammation"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmAndrew Kleist (Medical College of Wisconsin, USA)
"Structural Basis for Balanced Signaling of the Chemokine Receptor CXCR4 by Constitutively Monomeric CXCL12"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmMechanisms of Immune System Development and Homeostasis
Discussion Leader: Marcus Thelen (Institute for Research in Biomedicine, Università Della Svizzera Italiana, Switzerland)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:30 pmReina Mebius (VU University Medical Center, The Netherlands)
"Molecular and Cellular Mechanisms Underlying the Differentiation of Chemokine-Producing B- and T-Zone Stromal Cells"
6:30 pm - 6:40 pmDiscussion
6:40 pm - 7:00 pmReinhold Forster (Hannover Medical School, Germany)
"A Novel Mechanism Allowing Activated T Cells to Home from Lymph Node Subcapsular Sinus into the Paracortex"
7:00 pm - 7:10 pmDiscussion
7:10 pm - 7:25 pmJoanna Groom (Walter and Eliza Hall Institute of Medical Research, Australia)
"Migration and Transcriptional Regulation of TFH Cell Differentiation"
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:40 pmBernhard Moser (Cardiff University, United Kingdom)
"CXCL14 Targets Novel Immune Cell Subset"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmJoshua Farber (National Institute of Allergy and Infectious Diseases, NIH, USA)
"C/EBPdelta Enables Human CCR2+ MAIT Cells to Excel at Multiple Steps Required for Extravasation"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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