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Viruses & Cells
Gordon Research Conference

Biology, Pathogenesis, and Treatment of Viral Infections

Dates

May 14-19, 2017

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chair:
Blossom Damania

Vice Chair:
Julie Pfeiffer

Meeting Description

The 2017 Viruses and Cells GRC, the premier conference in the field of virology, will cover seminal topics in virology ranging from viral entry and structure to virus-host interactions, viral replication, immune responses to viral infection, and viral therapeutics.

The 2017 meeting will be held at Renaissance Tuscany, Il Ciocco, Lucca (Barga), Italy, from May 14-19, 2017. The conference is an interactive forum which brings together investigators at the forefront of the field, junior investigators launching their independent research careers, graduate students and postdoctoral fellows, and investigators from NIH and industry. The conference strives to represent a collegial environment that supports the discussion of novel ideas and fosters new collaborations.

Invited speakers will present novel and cutting edge findings in the field of virology. Topics will include: viral structure and entry, the immune response to viral infection, viral evasion of host immunity, viral replication and persistence, viral pathogenesis, virus-host interactions, modulation of cellular pathways by viruses, viruses and cancer, and viral therapeutics. Session chairs who are experts on the topic covered in each session will lead interactive, lively, and open discussions following each presentation.

In addition to each of the invited speakers, short talks will be chosen from the abstracts that are submitted to the meeting at the time of registration. Abstracts that highlight the most exciting and new developments in the field of virology will be selected for short talks, and the remainder of the abstracts will be selected as posters. The evening poster sessions are a prominent and important aspect of this conference providing yet another opportunity for participants to interact and discuss their research findings in an informal, friendly atmosphere.

Related Meeting

This GRC was held in conjunction with the "Viruses & Cells" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmVirus Structure and Entry
Discussion Leaders: Michael Imperiale (University of Michigan, USA) and Roberto Cattaneo (Mayo Clinic College of Medicine, USA)
7:40 pm - 8:00 pmSean Whelan (Harvard Medical School, USA)
"Structure and Inhibition of the Replication Machinery of Negative Sense RNA Viruses"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmRichard Longnecker (Northwestern University, USA)
"Epstein-Barr Virus Entry"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmFelix Rey (Institut Pasteur, France)
"Class II Membrane Fusion Proteins in Viruses and Cells: Implications for Eukaryotic Evolution"
9:00 pm - 9:05 pmDiscussion
9:05 pm - 9:25 pmAri Helenius (ETH Zurich, Switzerland)
"Influenza Virus Capsid Uncoating"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Immune Response to Viral Infection
Discussion Leaders: Carolina Lopez (University of Pennsylvania, USA) and Mark Denison (Vanderbilt University Medical Center, USA)
9:00 am - 9:20 amHerbert Virgin (Washington University School of Medicine, USA)
"Role of the Virome in Control of Immunity, and Vice Versa"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAna Fernandez-Sesma (Icahn School of Medicine at Mount Sinai, USA)
"Immune Evasion Mechanisms by Flaviviruses and Beyond"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amCharles Rice (The Rockefeller University, USA)
"Unraveling Nature's Intrinsic and Innate Antiviral Defenses"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amMichael Gale (University of Washington, USA)
"Targeting RIG-I for Antiviral Therapy and Vaccine Adjuvant Against RNA Virus Infection"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amBenjamin Fulton (Icahn School of Medicine at Mount Sinai, USA)
"Mutagenesis of the Zika Virus Genome Defines Regions with Essential Replication and Immune Evasion Functions"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amRyan Langlois (University of Minnesota, USA)
"Mechanisms Dictating Cellular Susceptibility and Resistance to Influenza A Virus Infections In Vivo"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmNadia Martinez (Genentech, USA)
"Virus-Host Receptome Characterization for Discovery of Novel Mechanisms of Immunoregulation"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmJacob Yount (The Ohio State University, USA)
"IFITM3 Restriction of Virus Infection Requires an Amphipathic Helix"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmViral Replication and Persistence
Discussion Leaders: Andrew Pekosz (Johns Hopkins University, USA) and Laurie Krug (Stony Brook University, USA)
6:00 pm - 6:20 pmRonald Desrosiers (University of Miami, USA)
"Evidence for an Actual Cure of a SHIV-Infected Monkey"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmStacey Schultz-Cherry (St. Jude Children's Research Hospital, USA)
"Defining the Cellular Factors Regulating Astrovirus Replication"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmRolf Renne (University of Florida, USA)
"Long and Short Non-Coding RNAs in KSHV Biology and Pathogenesis"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:50 pmCarolyn Coyne (University of Pittsburgh, USA)
"Breaking Barriers: Viral Infections of Polarized Cells"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmViral Pathogenesis
Discussion Leaders: Lynn Enquist (Princeton University, USA) and Matthew Evans (Icahn School of Medicine at Mount Sinai, USA)
9:00 am - 9:20 amJulie Overbaugh (Fred Hutchinson Cancer Research Center, USA)
"Immune Responses to HIV in Mothers and Their Infants"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amLisa Ng (Singapore Immunology Network (SIgN), A*STAR, Singapore)
"Cell and Molecular Mechanisms of Alphavirus Pathogenesis"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amMartha Clokie (University of Leicester, United Kingdom)
"Bacteriophages to Treat Antibiotic Resistant Bacteria"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amChristiane Wobus (University of Michigan Medical School, USA)
"Modulation of Cellular Deubiquitinases Alters Macrophage Functions and Blocks Norovirus Infection"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amAndrew Mehle (University of Wisconsin-Madison, USA)
"Repurposing Canonical Antiviral Responses to Promote Viral Infection"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amCraig McCormick (Dalhousie University, Canada)
"Translation of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Lytic Gene Products Is Resistant to mTORC1 Inhibition"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmEnzo Poirier (Pasteur Institute, France)
"Defective Genome Production Tunes Viral Load and Persistence Through RNA Interference Activation in Arthropods"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmPaul Duprex (Boston University, USA)
"Delineating Morbillivirus Entry, Dissemination and Transmission by Studying In Vivo Competition of Multicolor Canine Distemper Viruses in Ferrets"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmVirus-Host Interactions
Discussion Leaders: Chris Sullivan (University of Texas at Austin, USA) and Donna Neumann (LSU Health Sciences Center New Orleans, USA)
6:00 pm - 6:20 pmKanta Subbarao (WHO Collaborating Centre for Reference and Research on Influenza, Australia)
"Viral and Host Determinants of Influenza Virus Transmission"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmRozanne Sandri-Goldin (University of California, Irvine, USA)
"Structure-Function Analysis of a Signature Multifunctional Herpesvirus Protein"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmNels Elde (University of Utah, USA)
"Viral Adaptation Through Retrotransposition"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:40 pmMarta Gaglia (Tufts University School of Medicine, USA)
"Transcriptome-Wide Analysis of Targets of the Influenza RNase PA-X Reveals Specificity for Functional and Structural Classes of RNAs"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmRossana Colon-Thillet (Fred Hutchinson Cancer Research Center, USA)
"An Unbiased Approach to Evaluate the Contribution of Rapidly Evolving Sites at Antiviral Interfaces"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmVirus Biology
Discussion Leaders: Britt Glaunsinger (University of California, Berkeley, USA) and Micah Luftig (Duke University Medical Center, USA)
9:00 am - 9:20 amJoan Steitz (Yale University, USA)
"Viral Noncoding RNAs: More Surprises"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amCarla Saleh (Pasteur Institute, France)
"Small RNA Pathways and Arboviral Persistence in Mosquitoes"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amFelicia Goodrum (University of Arizona, USA)
"Cytomegalovirus Regulation of Membrane Trafficking and Signaling"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:10 amAdam Lauring (University of Michigan, USA)
"A Speed-Fidelity Trade-Off Determines the Mutation Rate and Virulence of an RNA Virus"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amEmma Abernathy (Stanford University, USA)
"Poliovirus Utilizes Key Components of the Autophagy Pathway While Bypassing Others"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amAndreas Puschnik (Stanford University, USA)
"Genetic Dissection of Flaviviridae Host Factors Through Genome-Scale CRISPR Screens"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amEmmanuelle Genoyer (University of Pennsylvania, USA)
"Mechanisms and Consequences of Intracellular Distribution of Sendai Virus Genome Species"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSeema Lakdawala (University of Pittsburgh, USA)
"Genome-Wide Analysis of Influenza Viral RNA and Nucleoprotein Architecture"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmGisa Gerold (Institute for Experimental Virology, TWINCORE, Germany)
"Identification of Two Host Enzymes as Entry Factors for Hepatitis C Virus and Plasmodium Sporozoites"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmViral Modulation of Host Immunity
Discussion Leaders: Melanie Brinkmann (Helmholtz Centre for Infection Research, Germany) and Stacy Horner (Duke University Medical Center, USA)
6:00 pm - 6:20 pmSoren Paludan (University of Aarhus, Denmark)
"Evasion of Innate Immune Responses by Viruses"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmRalph Baric (University of North Carolina at Chapel Hill, USA)
"Identification of Novel Viral and Host Genetic Elements Impacting Coronavirus Pathogenesis"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmJoanna Shisler (Univeristy of Illinois at Urbana-Champaign, USA)
"Comparative Biology of Poxvirus Immune Evasion Genes to Learn About Virus Biology"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:40 pmJudy Brown (Vanderbilt University / University of Pittsburgh, USA)
"Reovirus Abrogates Immunological Tolerance to Orally Fed Antigen"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmChristine Vazquez (Duke University, USA)
"Identification of a Riplet-Dependent, RIG-I-Independent Antiviral Response Regulated by Hepatitis C Virus"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmViruses and Cancer
Discussion Leaders: Robert Yarchoan (National Cancer Institute, NIH, USA) and Jae Jung (University of Southern California, USA)
9:00 am - 9:20 amYuan Chang (University of Pittsburgh, USA)
"MCV Small T Antigen and the Mitotic Environment"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amErle Robertson (University of Pennsylvania, USA)
"EBV Regulation of Bcl6: Insights into Viral Mediated Lymphomagenesis"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amLaimonis Laimins (Northwestern University, USA)
"Human Papillomaviruses and DNA Damage Responses"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amEthel Cesarman (Weill Cornell Medicine, USA)
"Targeting Viral Oncogenic Signals"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amJessica Tucker (University of California, Berkeley, USA)
"The Role of Retrotransposon Stimulation During Reactivation of Latent Gammaherpesvirus"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amCary Moody (University of North Carolina at Chapel Hill, USA)
"Trimethylation of Histone H3 on Lysine 36 Is Required for Productive Replication of HPV-31"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmBenjamin Gewurz (Brigham and Women's Hospital, USA)
"CRISPR/Cas9 Screens for Synthetic Lethal Targets in EBV-Transformed B-Cells"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmDean Kedes (University of Virginia, USA)
"The KSHV Episome-Host Chromatin Synapse: Elucidation of Nanoscale Architecture"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmViral Therapeutics and Vaccines
Discussion Leaders: Terence Dermody (University of Pittsburgh, USA) and Sankar Swaminathan (University of Utah, USA)
6:00 pm - 6:20 pmMatthais Gromeier (Duke University Medical Center, USA)
"Cytotoxic and Immunogenic Mechanisms of Oncolytic Poliovirus"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmMatthew Frieman (University of Maryland, USA)
"Pathogenesis and Therapeutic Treatment of the MERS Coronavirus"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:10 pmDavid Bloom (University of Florida College of Medicine, USA)
"In Vivo Knock-Down of the Herpes Simplex Virus Type 1 Latency-Associated Transcript Reduces Reactivation from Latency"
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmMatthew Pennington (Cornell University, USA)
"Exploring the Antiviral Mechanism and Anti-Angiogenic Effects of Raltegravir During Feline Herpesvirus (FHV-1) Infection of Primary Feline Corneal Epithelial Cells"
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:50 pmGeneral Discussion
7:50 pm - 8:00 pmClosing Remarks
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible [in part] by 1-R13-AI129344-01 from the National Institute of Allergy and Infectious Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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