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Angiogenesis
Gordon Research Conference

New Frontiers of Angiogenesis in Health, Regeneration and Disease: Building Durable and Adaptable Vascular Networks

Dates

August 6-11, 2017

Location

Salve Regina University
Newport, RI Site Information

Organizers

Chair:
Shahin Rafii

Vice Chair:
Hellmut G. Augustin

Application Deadline

Applications for this meeting must be submitted by July 9, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

The 2017 Angiogenesis Gordon Conference will explore the very latest innovative and translational research on the cellular principles and molecular regulation of vasculogenesis and angiogenesis in development, adulthood, aging, disease processes, and tumorigenesis. Recent studies have uncovered the pathways dictating vascular heterogeneity, plasticity and adaptability of the tissue-specific endothelial cell populations to respond to injury, including chemical and radiation insults. This meeting will aim to integrate newly identified angiogenic pathways that enable endothelial cells to coordinate signaling and adaptive behavior to establish functional, stable and durable organotypic capillary networks for therapeutic regeneration of injured organs without provoking fibrosis. The instructive contribution of the endothelial cells to hematopoiesis, immune cell regulation as well as regeneration of heart, lung, liver and other organs will also be discussed. Presentations from fields of developmental, computational, bioengineering, biophysical, Imaging and regenerative medicine will be employed to bring together the multipronged approaches for repairing, microfabricating and engineering long-lasting blood vessels. We will also seek to highlight new insights and approaches towards translation of angiogenic concepts into the clinic, including regenerative medicine and cancer therapy. This conference is organized to stimulate rich and constructive interactions among, trainees, experts, senior and junior faculty, industry, National Institutes of Health experts, funding resources, clinicians and basic scientists and importantly provide educational opportunity for students in training, graduate students and post-doctoral and clinical fellows.

Related Meeting

This GRC will be held in conjunction with the "Angiogenesis" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: New Frontiers in Angiogenesis and Endothelial Cell Physiology
Discussion Leader: Shahin Rafii (Weill Cornell Medicine, USA)
7:40 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:10 pmGregg Semenza (Johns Hopkins University, USA)
"Hypoxia/HIF: From Basic Mechanisms to Therapeutics"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmPeter Carmeliet (VIB-KU Leuven Center for Cancer Biology, Belgium)
"Metabolic Regulation of Angiogenesis: Therapeutic Implications"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmDidier Stainier (Max Planck Institute for Heart and Lung Research, Germany)
"Endothelial Cell Differentiation and Behavior in Zebrafish"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTranscriptional Regulation of Vasculogenesis and Angiogenesis
Discussion Leader: Anne Eichmann (Yale School of Medicine, USA)
9:00 am - 9:20 amElisabetta Dejana (IFOM - The FIRC Institute of Molecular Oncology, Italy)
"Transcriptional Regulation of the Blood Brain Barrier Differentiation"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAnna Randi (Imperial College London, United Kingdom)
"Transcriptional Control of Endothelial Homeostasis and Lineage Specification"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amShort Talk Selected from Poster Abstracts
10:10 am - 10:15 amDiscussion
10:15 am - 10:35 amNathan Lawson (University of Massachusetts Medical School, USA)
"Epigenetic Regulation of Vascular Development"
10:35 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:35 amGou Young Koh (Institute for Basic Science / Korea Advanced Institute of Science and Technology, South Korea)
"Regulation of the Hippo-YAP Pathway in Angiogenesis and Vascular Maturation"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmLate-Breaking Topic
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmBuilding and Remodeling Stable Endothelial Cell Tubular Networks
Discussion Leader: Donald McDonald (University of California, San Francisco, USA)
7:30 pm - 7:50 pmHolger Gerhardt (Vesalius Research Center, KU Leuven, Germany)
"Shaping and Remodelling Vascular Networks in Development"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmChrister Betsholtz (Integrated Cardio Metabolic Centre (ICMC), Karolinska Institutet, Sweden)
"Single Cell Transcriptomics of the Vasculature"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmShort Talk Selected from Poster Abstracts
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmLuisa Iruela-Arispe (University of California, Los Angeles, USA)
"Critical Signaling Nodes in Vascular Homeostasis"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmIntegration of Signaling Pathways in Angiogenesis
Discussion Leader: Victoria Bautch (The University of North Carolina at Chapel Hill, USA)
9:00 am - 9:20 amJan Kitajewski (University of Illinois at Chicago, USA)
"Cell Fate Mechanisms that Drive the Angiogenic Process"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amNapoleone Ferrara (University of California, San Diego, USA)
"Novel Pathways in Angiogenic Signaling"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amShort Talk Selected from Poster Abstracts
10:10 am - 10:15 amDiscussion
10:15 am - 10:35 amLena Claesson-Welsh (Uppsala University, Sweden)
"VEGF Receptors and Signaling Crosstalk"
10:35 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:35 amDavid Cheresh (University of California, San Diego, USA)
"Reprogramming the Endothelium During Tissue Remodeling"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amShort Talk Selected from Poster Abstracts
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmSusan Quaggin (Northwestern University, USA)
"High Tek Treatment of Ocular Maladies"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmHomeostasis and Metabolism in Angiogenesis
Discussion Leader: Michael Potente (Max Planck Institute for Heart and Lung Research, Germany)
7:30 pm - 7:50 pmKari Alitalo (Wihuri Research Institute / University of Helsinki, Finland)
"Structuring Angiopoietin-Tie Signaling Functions"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:10 pmShort Talk Selected from Poster Abstracts
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmMichael Simons (Yale School of Medicine, USA)
"Metabolic Control of Development"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmShort Talk Selected from Poster Abstracts
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmLate-Breaking Topic
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTissue-Specific Endothelial Instructive Function in Regeneration
Discussion Leader: Hellmut Augustin (Heidelberg University / German Cancer Research Center, Germany)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amEli Keshet (The Hebrew University of Jerusalem, Israel)
"Vascular Stem Cell Niches"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amJason Butler (Weill Cornell Medicine, USA)
"Regulation of the Hematopoietic Stem Cell Lifecycle by the Endothelial Niche"
9:55 am - 10:05 amDiscussion
10:05 am - 10:15 amShort Talk Selected from Poster Abstracts
10:15 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:10 amOndine Cleaver (University of Texas Southwestern Medical Center, USA)
"Heterogeneity of Blood Vessel Tubulogenesis"
11:10 am - 11:20 amDiscussion
11:20 am - 11:40 amMichael Detmar (ETH Zurich, Switzerland)
"Cutaneous Lymphatic Vessel Contribution to Regeneration and Immunity"
11:40 am - 11:50 amDiscussion
11:50 am - 12:10 pmLate-Breaking Topic
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmEndothelial Plasticity and Adapative Response to Mechanotransduction and Patterning
Discussion Leader: Timothy Hla (Harvard Medical School, USA)
7:30 pm - 7:50 pmTatiana Byzova (Cleveland Clinic, USA)
"Vascular Patterning Control by Resident Immune Cells"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMartin Schwartz (Yale School of Medicine, USA)
"Regulation of the Endothelial Phenotype by Fluid Shear Stress"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmShort Talk Selected from Poster Abstracts
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmChristopher Chen (Boston University / Wyss Institute for Biologically Inspired Engineering, Harvard University, USA)
"Forces, Adhesions, and the Regulation of Vascular Form and Function: Insights from Engineered Cultures"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMaladaptive Angiogenesis in Tumor Growth and Inflammation
Discussion Leader: Harold Dvorak (Beth Israel Deaconess Medical Center, USA)
9:00 am - 9:20 amRobert Kerbel (Sunnybrook Research Institute / University of Toronto, Canada)
"Impact of Vessel Co-Option in Metastases on Antiangiogenic Efficacy"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amGabriele Bergers (VIB-KU Leuven Center for Cancer Biology, Belgium)
"Trimming the Vascular Tree in Tumors: Metabolic and Immune Adaptations"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amShort Talk Selected from Poster Abstracts
10:10 am - 10:15 amDiscussion
10:15 am - 10:35 amGavin Thurston (Regeneron Pharmaceuticals, Inc, USA)
"Novel Approaches in Anti-Angiogenesis Therapies"
10:35 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:35 amBi-Sen Ding (Weill Cornell Medicine, USA)
"Maladapted Endothelial Niche Provokes Lung Fibrosis"
11:35 am - 11:45 amDiscussion
11:45 am - 11:55 amShort Talk Selected from Poster Abstracts
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmMasataka Majima (Kitasato University School of Medicine, Japan)
"Prostaglandinds as Regulators of Neovascularization"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTranslational Vascular Medicine: Organ Repair and Tumor Targeting
Discussion Leader: Laura Benjamin (KatahdinRx, USA)
7:30 pm - 7:50 pmDouglas Hanahan (Swiss Institute for Experimental Cancer Research, Switzerland)
"Molecular and Metabolic Pathways Involved in Anti-Angiogenesis Resistance"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmRakesh Jain (Harvard Medical School / Massachusetts General Hospital, USA)
"Overcoming Resistance to Antiangiogenesis Therapy of Cancer"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmWeilan Ye (Genentech, Inc., USA)
"Modulating EC-ECM Adhesion to Alter Drug Delivery and Lymphocyte Trafficking"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmRaghu Kalluri (University of Texas MD Anderson Cancer Center, USA)
"EMT and Regulation of Tumor Angiogenesis"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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