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Epigenetics
Gordon Research Conference

Epigenetics in Action: From Mechanisms to Biological Impacts

Dates

July 30 - August 4, 2017

Location

Holderness School
Holderness, NH Site Information

Organizers

Chairs:
Pamela K. Geyer & Frederic Berger

Vice Chairs:
Susan Strome & Maria-Elena Torres-Padilla

Application Deadline

Applications for this meeting must be submitted by July 2, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

The field of epigenetics was founded by conceptual interpretations of deviations from genetic rules. After the first mechanisms were identified, it became possible to catalog genomic landscapes of epigenetic marks. From these static views new technologies are developing that reveal the dynamics of epigenetic marks across cell division and differentiation. This meeting focuses on the impact of new experimental strategies that advance concepts of epigenetics. This meeting will provide reports of primarily unpublished data on epigenetic inheritance across cell division and generations, the relationships between environment and epigenetics, and the impact of epigenetics on disease and development.

This meeting takes place in a relaxed environment with outstanding scientists at all post-undergraduate stages. In this informal atmosphere, discussions begin over breakfast, continue during the afternoon and extend into the evening through convivial gatherings after each session. Early career scientists and students will have the occasion to discuss their unpublished data with distinguished leaders throughout the conference, and will have the opportunity to present their work in dedicated slots throughout the program.

For the second time the conference will incorporate a Gordon Research Seminar as a specific means to foster involvement by scientists at the graduate student and post doctoral level. Planned by and for trainees, it will provide an opportunity for our junior researchers to present seminars and posters in a supportive, interactive environment.

Related Meeting

This GRC will be held in conjunction with the "Epigenetics" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmEmerging Technologies and Advances in Epigenetics
Discussion Leader: Ortrun Mittelsten Scheid (Gregor Mendel Institute of Molecular Plant Biology, Austria)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:10 pmCharles Gersbach (Duke University, USA)
"Epigenome Editing for Functional Epigenomics and Cell Programming"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmTing Wu (Harvard Medical School, USA)
"An Update on Imaging the Genome"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmShort Talk Selected from Poster Abstracts
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmChromatin Modifications in Development
Discussion Leader: Sylvia Erhardt (ZMBH, Universität Heidelberg, Germany)
9:00 am - 9:35 amSusan Gasser (Friedrich Miescher Institute for Biomedical Research, Switzerland)
"Roles of Nuclear Organization in Differentiated Cells"
9:35 am - 9:45 amDiscussion
9:45 am - 10:05 amJuerg Mueller (Max Planck Institute of Biochemistry, Germany)
"Molecular Mechanisms of the Polycomb/Trithorax System for Maintaining Transcriptional OFF and ON States"
10:05 am - 10:15 amDiscussion
10:15 am - 10:35 amEdith Heard (Institut Curie, France)
"Transcriptional, Epigenetic and Chromosome Dynamics During X Inactivation"
10:35 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:35 amXin Chen (Johns Hopkins University, USA)
"Breaking Symmetry – Asymmetric Epigenetic Inheritance During Drosophila Germline Stem Cell Asymmetric Division"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Anja Groth (Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Denmark) and Susan Strome (University of California, Santa Cruz, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEpigenetic RNAs
Discussion Leader: Juerg Mueller (Max Planck Institute of Biochemistry, Germany)
7:30 pm - 7:50 pmErik Miska (University of Cambridge, United Kingdom)
"Epigenetics and Phenotypic Variation: New Insights from Nematodes and Fishes"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJohn Rinn (Harvard University, USA)
"Chromatin Environment, Transcriptional Regulation, and Splicing Distinguish lincRNAs and mRNAs"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmSylvia Erhardt (ZMBH, Universität Heidelberg, Germany)
"Centromeric tRNA Methylation Is Required for Chromosome Segregation in Mitosis"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmShiv Grewal (National Institutes of Health, USA)
"Epigenetic Genome Control by Conserved RNA Processing Factors"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEpigenetic Inheritance Between Generations
Discussion Leader: Harmit Malik (Fred Hutchinson Cancer Research Center, USA)
9:00 am - 9:20 amVincent Colot (Institut de Biologie de l'Ecole Normale Supérieure, France)
"Transposable Elements, Transgenerational Epigenetics and Heritable Phenotypic Variation"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amMarie Mirouze (Institut de Recherche pour le Développement (IRD), France)
"Mobilome-seq as a Tool for Tracking Transposable Element Mobility in Plant Epigenetic Mutants"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amAnne Ferguson-Smith (University of Cambridge, United Kingdom)
"Retrotransposons and the Heritability of Variable Epigenetic States"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amSusan Strome (University of California, Santa Cruz, USA)
"Sperm Chromatin and Paternal Contributions to Epigenetic Inheritance in C. elegans"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amShort Talk Selected from Poster Abstracts
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEnvironmental Impact on Epigenetics
Discussion Leader: Steven Jacobsen (University of California, Los Angeles / Howard Hughes Medical Institute, USA)
7:30 pm - 7:50 pmCaroline Dean (John Innes Centre, United Kingdom)
"Vernalization: A Cold-Induced Epigenetic Switch"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmVardhman Rakyan (Blizard Institute, United Kingdom)
"Inter-Individual Epigenetic Variation and the Developmental Origins of Mammalian Phenotypes"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmShort Talk Selected from Poster Abstracts
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmShort Talk Selected from Poster Abstracts
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEpigenetics and Disease
Discussion Leader: Anne Ferguson-Smith (University of Cambridge, United Kingdom)
9:00 am - 9:35 amWendy Bickmore (MRC Human Genetics Unit, United Kingdom)
"Developmental Genome Regulation and Chromatin Folding"
9:35 am - 9:45 amDiscussion
9:45 am - 10:05 amBradley Bernstein (Harvard University, USA)
"Epigenetic Plasticity in Tumor Initiation and Evolution"
10:05 am - 10:15 amDiscussion
10:15 am - 10:35 amJohn Denu (University of Wisconsin-Madison, USA)
"Metabolic Control of the Epigenome"
10:35 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:35 amJohn Greally (Albert Einstein College of Medicine, USA)
"The Second-Generation Epigenome-Wide Association Study"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEpigenetic Reprogramming
Discussion Leader: William Kelly (Emory University, USA)
7:30 pm - 7:50 pmRobert Martienssen (Cold Spring Harbor Laboratory, USA)
"Epigenetic Inheritance and Reprogramming with Small RNA"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmAzim Surani (University of Cambridge, United Kingdom)
"Epigenetics of Potency and Competency for Germ Cell Fate"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmMaria-Elena Torres-Padilla (Institute of Epigenetics and Stem Cells, Helmholtz Zentrum München, Germany)
"Epigenetic Mechanisms in Early Mammalian Development"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmShort Talk Selected from Poster Abstracts
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmEpigenetic Landscape Across Cell Division
Discussion Leader: Xin Chen (Johns Hopkins University, USA)
9:00 am - 9:20 amAnja Groth (Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Denmark)
"Chromatin Replication and Epigenome Maintenance"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amKeith Maggert (University of Arizona, USA)
"Assessing the Timing and Stability of Epigenetic Silencing"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amSteven Jacobsen (University of California, Los Angeles / Howard Hughes Medical Institute, USA)
"Mechanisms of DNA Methylation Control in Arabidopsis"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amDavid Gilbert (Florida State University, USA)
"Epigenetic vs. Sequence-Dependent Control of Replication Timing"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amShort Talk Selected from Poster Abstracts
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmShort Talk Selected from Poster Abstracts
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEpigenetics Across Evolution
Discussion Leader: Ting Wu (Harvard Medical School, USA)
7:30 pm - 7:50 pmHarmit Malik (Fred Hutchinson Cancer Research Center, USA)
"Genetic Conflict at Animal Centromeres"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmInes Drinnenberg (Institut Curie, France)
"Overcoming abCENPs: Recurrent Loss of CenH3 in Holocentric Insects"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmBenjamin Loppin (Laboratoire de Biométrie et Biologie Évolutive, University of Lyon, France)
"Evolution of Sperm Nuclear Organization: Insights from Drosophila"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmShort Talk Selected from Poster Abstracts
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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