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Cancer Genetics & Epigenetics
Gordon Research Conference

Cancer Epigenetics: Mutations, Functions, and Therapies

Dates

April 23-28, 2017

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chairs:
X. Shirley Liu & Saverio Minucci

Vice Chair:
Jonathan D. Licht

Meeting Description

There has been increasing awareness of the interplay between mutations and epimutations in driving the initiation and progression of cancer. Specific genetic mutations of epigenetic regulators may cause widespread epigenetic alterations, and epimutations similarly predispose to genetic alterations either locally or across the genome. The field has seen a dramatic shift in the past decade from a pure genetic to a mixed genetic/epigenetic explanation of cancer. From the discovery of the alterations, along with significant structural biology and chemistry, new agents with therapeutic potential have arisen. This GRC series focuses on the discovery and functional characterization of novel recurrent genetic and epigenetic alterations, the molecular mechanisms underlying epigenetic mutations and epigenetic changes in cancer, as well as the development and applications of epigenetic therapies in cancer. Recent discoveries on tumor heterogeneity and tumor immunity as well as their interactions with cancer epigenetics also bring new excitement to the field. The development of high throughput "omics" techniques, such as mutational and epigenetic profiling, chemical and genetic screens, proteomics, has greatly accelerated research in this area. Need for computational algorithms and analyses integrating such "omics" data to model epigenetic regulation in cancer also becomes critical. Developments and discoveries on cancer genetics and epigenetics will have far-reaching implications to our capacity to understand tumor initiation and progression, to decipher the pathways and molecules involved, as well as to devise new strategies for prevention and treatment. We hope to attract leaders from academia and industry for stimulating discussions on cancer genetics and epigenetics, from mutation profiles, to mechanistic and functional characterization, to cancer therapies.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: From Epigenetic Mechanism to Epigenetic Therapy
Discussion Leader: Peggy Goodell (Baylor College of Medicine, USA)
7:40 pm - 7:45 pmOpening Remarks
7:45 pm - 8:15 pmShelley Berger (University of Pennsylvania, USA)
"Epigenetic Pathways as Targets in Human Disease"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:50 pmScott Armstrong (Dana Farber Cancer Institute, USA)
"Targeting Chromatin Associated Complexes in Leukemia"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:25 pmPeter Jones (Van Andel Research Institute, USA)
"Activating Endogenous Retroviruses for Therapy"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenetic and Epigenetic Changes in Hematological Malignancies
Discussion Leader: Chi Wai Eric So (King's College London, United Kingdom)
9:00 am - 9:25 amPier Giuseppe Pelicci (European Institute of Oncology, Italy)
"Genetic and Biological Heterogeneity in AMLs"
9:25 am - 9:30 amDiscussion
9:30 am - 9:40 amSelected from Poster Abstracts: Lev Kats (Peter MacCallum Cancer Centre, Australia)
"A Pharmocogenomic Approach Identifies Key Oncogenic Dependencies of Mutant IDH in Acute Myeloid Leukemia"
9:40 am - 9:45 amDiscussion
9:45 am - 10:10 amPeggy Goodell (Baylor College of Medicine, USA)
"DNA Methyltransferase 3A in Normal and Malignant Hematopoiesis"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amSelected from Poster Abstracts: Alexander Murison (Princess Margaret Cancer Centre, Canada)
"Chromatin Rearrangements Observed over the Earliest Stages of Hematopoiesis Are Co-Opted to Drive Leukemogenesis in NPM1c Acute Myeloid Leukemia"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amJonathan Licht (The University of Florida, USA)
"Gain of Function NSD2 Histone Methyltranferase Mutation Drives Therapy Resistance of Acute Lymphocytic Leukemia"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amSelected from Poster Abstracts: Christopher Oakes (The Ohio State University, USA)
"Mutations in EGR2 Direct Aberrant Epigenetic Programming in Chronic Lymphocytic Leukemia"
11:40 am - 11:45 amDiscussion
11:45 am - 12:10 pmRoss Dickins (Monash University, Australia)
"PU.1 Controls Reversible Transitions Between Tumourigenic and Differentiated States in Acute Myeloid Leukemia"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Jean-Francois Couture (University of Ottawa, Canada)
"Emerging Paradigms Controlling the Activity of Mixed Lineage Leukemia Proteins"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmMutations of Chromatin Regulators in Cancer
Discussion Leader: Kristian Helin (University of Copenhagen, Denmark)
6:00 pm - 6:25 pmCigall Kadoch (Dana-Farber Cancer Institute, USA)
"Mammalian SWI/SNF(BAF) Complex Structure and Function in Human Cancer"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:40 pmSelected from Poster Abstracts: Albert Jeltsch (University of Stuttgart, Germany)
"The DNMT3A R882H Mutant Is Catalytically Active and Displays Altered Flanking Sequence Preferences"
6:40 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmChi Wai Eric So (King's College London, United Kingdom)
"Cells-of-Origin Transcriptional Memory Governs B-Catenin Dependence and Treatment Responses in MLL Stem Cells"
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmSelected from Poster Abstracts: Florian Grebien (Ludwig Boltzmann Institute for Cancer Research, Austria)
"MLL Fusion-Driven Leukemia Requires SETD2 to Safeguard Genomic Integrity"
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:55 pmSuming Huang (University of Florida College of Medicine, USA)
"The Role of HOX Gene Associated lincRNA HoxBlinc in Normal Hematopoiesis and Leukemogenesis"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmChromatin Altered Function in Cancer
Discussion Leader: Sharon Dent (University of Texas MD Anderson Cancer Center, USA)
9:00 am - 9:25 amEmily Bernstein (Icahn School of Medicine at Mount Sinai, USA)
"Epigenetic Players in Malignant Melanoma"
9:25 am - 9:30 amDiscussion
9:30 am - 9:40 amSelected from Poster Abstracts: Michael Chan (National Chung Cheng University, Taiwan)
"Epigenetic Silencing of the Dual-Role Signal Mediator, ANGPTL4 in Tumor Tissues and Its Overexpression in the Urothelial Carcinoma Microenvironment"
9:40 am - 9:45 amDiscussion
9:45 am - 10:10 amKristian Helin (University of Copenhagen, Denmark)
"Histone Methylation in Transcriptional Regulation and Cancer"
10:10 am - 10:15 amDiscussion
10:15 am - 10:45 amCoffee Break
10:45 am - 10:55 amSelected from Poster Abstracts: Elisabeth Hessmann (University Medical Center Goettingen, Germany)
"Functional and Mechanistic Characterization of Oncogenic EZH2 Activity in Pancreatic Cancer Cell Plasticity"
10:55 am - 11:00 amDiscussion
11:00 am - 11:25 amLuciano Di Croce (Centre for Genomic Regulation (CRG), Spain)
"Defining Mechanisms that Regulate Polycomb Functions in Stem Cell Differentiation and Cancer"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amSelected from Poster Abstracts: Ranjan Perera (Sanford Burnham Prebys Medical Discovery Institute, USA)
"Genome-Wide Methylated CpG Island Profiles of Melanoma Cells Reveal a Melanoma Coregulation Network"
11:40 am - 11:45 amDiscussion
11:45 am - 12:10 pmGeorge Muscat (The University of Queensland, Australia)
"Epigenetic Protein Arginine Methyltransferase 6 Signaling Regulates Breast Carcinogenesis"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Claudia Benavente (University of California, Irvine, USA)
"Chromatin Remodeler HELLS Mediates the Epigenetic Deregulation of Genes that Drive Retinal Degeneration and Retinoblastoma Following Rb Loss"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmAnimal Models for Cancer Epigenetics
Discussion Leader: Mathieu Lupien (Princess Margaret Cancer Centre, Canada)
6:00 pm - 6:25 pmSharon Dent (University of Texas MD Anderson Cancer Center, USA)
"A Saga of USPs"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:40 pmSelected from Poster Abstracts: Adele Murrell (University of Bath, United Kingdom)
"Genomic Imprinting as a Model System for Studying the Epigenetic Regulation of Tumour Suppressors and Oncogenes"
6:40 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmJohannes Zuber (Research Institute of Molecular Pathology (IMP), Austria)
"Exploring and Exploiting Aberrant Cell Fate Programs in Leukemia"
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmSelected from Poster Abstracts: Jason Huse (University of Texas MD Anderson Cancer Center, USA)
"ATRX Deficiency Modulates Differentiation State and Migratory Behavior by Way of Global Epigenomic Remodeling in Glioma Cells of Origin"
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:55 pmIannis Aifantis (New York University School of Medicine, USA)
"Genetic and Pharmacological Targeting of TET Activity in Hematopoiesis and Leukemia"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRegulatory Genomics and Epigenomics of Cancer
Discussion Leader: Benjamin Ebert (Brigham and Women's Hospital, USA)
9:00 am - 9:25 amMathieu Lupien (Princess Margaret Cancer Centre, Canada)
"Identifying Epigenetic Vulnerabilities in Cancer"
9:25 am - 9:30 amDiscussion
9:30 am - 9:40 amSelected from Poster Abstracts: Dong Wang (Tsinghua University School of Medicine, China)
"Epigenetically Reprogramming Tissue-Specific Transcription Promotes Colorectal Cancer Liver Metastasis"
9:40 am - 9:45 amDiscussion
9:45 am - 10:10 amOmar I. Abdel-Wahab (Memorial Sloan Kettering Cancer Center, USA)
"Understanding and Targeting RNA Splicing Factor Mutations in Cancer"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amSelected from Poster Abstracts: Edward Curry (Imperial College London, United Kingdom)
"Compensatory DNA Methylation at Amplified Genomic Regions in Ovarian Cancer Reveals Epigenetic Silencing of Genes Involved in Growth Suppression"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amTing Wang (Washington University School of Medicine, USA)
"Transposable Elements in Normal and Cancer Epigenome"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amSelected from Poster Abstracts: Luca Magnani (Imperial College London, United Kingdom)
"Epigenetic Mapping of Breast Cancer Patients Reveals Principles and Drivers of Functional Heterogeneity"
11:40 am - 11:45 amDiscussion
11:45 am - 12:10 pmWei Li (Baylor College of Medicine, USA)
"Homeobox Oncogene Activation by Pan-Cancer Gene-Body DNA Hypermethylation"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Aristotelis Tsirigos (New York University School of Medicine, USA)
"Chromatin Organization Alterations in Critical Oncogenic Loci in Leukemia"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmFunctional Genomics, Epigenomics and Proteomics of Cancer
Discussion Leader: Ricky Johnstone (Peter MacCallum Cancer Centre, Australia)
6:00 pm - 6:25 pmBenjamin Ebert (Brigham and Women's Hospital, USA)
"The Genetics and Biological Consequences of Clonal Hematopoiesis"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:40 pmSelected from Poster Abstracts: Henry Long (Dana-Farber Cancer Institute, USA)
"Applications of FiT-Seq to Cancer Epigenetic Studies"
6:40 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmChristopher Vakoc (Cold Spring Harbor Laboratory, USA)
"Transcriptional Coactivators as Cancer Dependencies"
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmSelected from Poster Abstracts: Daniel Liefwalker (Stanford University School of Medicine, USA)
"Disruption of Epigenetic Drivers in MYC-Addicted Lymphomas"
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:55 pmTiziana Bonaldi (European Institute of Oncology, Italy)
"Quantitative Mapping of Epigenetic Marks by MS-Proteomics in Breast Cancer Samples, for Patient Stratification and Novel Drug Target Identification"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmCancer Epigenetic Therapies
Discussion Leader: Stephen Baylin (Johns Hopkins University, USA)
9:00 am - 9:25 amMark Dawson (Peter MacCallum Cancer Centre, Australia)
"Mechanisms of Response and Resistance to Epigenetic Therapies"
9:25 am - 9:30 amDiscussion
9:30 am - 9:40 amSelected from Poster Abstracts: Galina Selivanova (Karolinska Institutet, Sweden)
"p53 Controls a Global Epigenetic Program to Suppress Tumour Development"
9:40 am - 9:45 amDiscussion
9:45 am - 10:10 amTatiana Kutateladze (University of Colorado School of Medicine, USA)
"Targeting Epigenetic Readers"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amSelected from Poster Abstracts: Georg Mellitzer (INSERM, France)
"Short Talk Selected from Poster Abstract"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amJacques Neefjes (Leiden University Medical Center, The Netherlands)
"DNA Breaks or Epigenetic Modifications as the Mechanism of Action of the Anti-Cancer Drug Doxorubicin"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amSelected from Poster Abstracts: Paola Scaffidi (The Francis Crick Institute, United Kingdom)
"The Linker Histone H1.0 Generates Epigenetic and Functional Intratumor Heterogeneity"
11:40 am - 11:45 amDiscussion
11:45 am - 12:10 pmSaverio Minucci (University of Milan, Italy)
"Tackling Mechanisms of Drug Resistance in Cancer"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Daliang Wang (Tsinghua University, China)
"The Role of JMJD5 in Tumorigenesis and Chemosensitivity"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmInterplay Between Cancer Epigenetics and Cancer Immunity
Discussion Leader: Jacques Neefjes (Leiden University Medical Center, The Netherlands)
6:00 pm - 6:25 pmRicky Johnstone (Peter MacCallum Cancer Centre, Australia)
"Epigenetic Regulation of Cancer Immune Surveillance Processes"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:40 pmSelected from Poster Abstracts: Burkhard Kleuser (University of Potsdam, Germany)
"Decitabine and Vitamin C Act Synergistically in Reactivating Epigenetic Silenced Tumor Suppressors and 5-hmdC-Increase in Colon Cancer Cells"
6:40 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmStephen Baylin (Johns Hopkins University, USA)
"Epigenetics or Genetic Modifications Other than Those in DNA that Can Affect Cell Behavior"
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmSelected from Poster Abstracts: Steven Johnsen (University Medical Center Goettingen, Germany)
"Histone Deacetylase Class-I Inhibition Promotes Epithelial Gene Expression in Pancreatic Cancer Cells in a BRD4- and MYC-Dependent Manner"
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:55 pmX. Shirley Liu (Harvard T.H. Chan School of Public Health, USA)
"Using CARE to Model Cancer Therapy Resistance"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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