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Cancer Genetics & Epigenetics
Gordon Research Conference

Cancer Epigenetics: Mutations, Functions, and Therapies

Dates

April 23-28, 2017

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy Site Information

Organizers

Chairs:
X. Shirley Liu & Saverio Minucci

Vice Chair:
Jonathan D. Licht

Application Deadline

Applications for this meeting must be submitted by March 26, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

There has been increasing awareness of the interplay between mutations and epimutations in driving the initiation and progression of cancer. Specific genetic mutations of epigenetic regulators may cause widespread epigenetic alterations, and epimutations similarly predispose to genetic alterations either locally or across the genome. The field has seen a dramatic shift in the past decade from a pure genetic to a mixed genetic/epigenetic explanation of cancer. From the discovery of the alterations, along with significant structural biology and chemistry, new agents with therapeutic potential have arisen. This GRC series focuses on the discovery and functional characterization of novel recurrent genetic and epigenetic alterations, the molecular mechanisms underlying epigenetic mutations and epigenetic changes in cancer, as well as the development and applications of epigenetic therapies in cancer. Recent discoveries on tumor heterogeneity and tumor immunity as well as their interactions with cancer epigenetics also bring new excitement to the field. The development of high throughput "omics" techniques, such as mutational and epigenetic profiling, chemical and genetic screens, proteomics, has greatly accelerated research in this area. Need for computational algorithms and analyses integrating such "omics" data to model epigenetic regulation in cancer also becomes critical. Developments and discoveries on cancer genetics and epigenetics will have far-reaching implications to our capacity to understand tumor initiation and progression, to decipher the pathways and molecules involved, as well as to devise new strategies for prevention and treatment. We hope to attract leaders from academia and industry for stimulating discussions on cancer genetics and epigenetics, from mutation profiles, to mechanistic and functional characterization, to cancer therapies.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: From Epigenetic Mechanism to Epigenetic Therapy
Discussion Leader: Jonathan Licht (The University of Florida, USA)
7:40 pm - 7:45 pmOpening Remarks
7:45 pm - 8:15 pmShelley Berger (University of Pennsylvania, USA)
"Regulation of the Nuclear Genome in Mammals and Model Organisms"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 8:50 pmScott Armstrong (Dana Farber Cancer Institute, USA)
"Development of New Therapeutics that Target Chromatin Based Mechanisms"
8:50 pm - 8:55 pmDiscussion
8:55 pm - 9:25 pmPeter Jones (Van Andel Research Institute, USA)
"Activating Endogenous Retroviruses for Therapy"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenetic and Epigenetic Changes in Hematological Malignancies
Discussion Leader: Chi Wai Eric So (The University of London, United Kingdom)
9:00 am - 9:25 amPier Giuseppe Pelicci (European Institute of Oncology, Italy)
"Molecular Mechanisms of Cancer and Ageing"
9:25 am - 9:30 amDiscussion
9:30 am - 9:40 amShort Talk Selected from Poster Abstracts
9:40 am - 9:45 amDiscussion
9:45 am - 10:10 amOmar I. Abdel-Wahab (Memorial Sloan Kettering Cancer Center, USA)
"The Role of Disordered Epigenetic Modifiers in the Pathogenesis of Hematopoietic Malignancies"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amShort Talk Selected from Poster Abstracts
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amPeggy Goodell (Baylor College of Medicine, USA)
"DNA Methyltransferase 3A in Normal and Malignant Hematopoiesis"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amShort Talk Selected from Poster Abstracts
11:40 am - 11:45 amDiscussion
11:45 am - 12:10 pmLate-Breaking Topic
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmMutations of Chromatin Regulators in Cancer
Discussion Leader: Kristian Helin (University of Copenhagen, Denmark)
6:00 pm - 6:25 pmRoss Dickins (Monash University, Australia)
"PU.1 Controls Reversible Transitions Between Tumourigenic and Differentiated States in Acute Myeloid Leukemia"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:40 pmShort Talk Selected from Poster Abstracts
6:40 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmCigall Kadoch (Dana-Farber Cancer Institute / Harvard Medical School, USA)
"Mammalian SWI/SNF(BAF) Complex Structure and Function in Human Cancer"
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmShort Talk Selected from Poster Abstracts
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:55 pmChi Wai Eric So (The University of London, United Kingdom)
"Characterize the Mechanisms of Transcriptional Regulation that Are Corrupted in Leukemia"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmChromatin Altered Function in Cancer
Discussion Leader: Sharon Dent (University of Texas MD Anderson Cancer Center, USA)
9:00 am - 9:25 amEmily Bernstein (Mount Sinai School of Medicine, USA)
"Mechanisms that Alter the Chromatin Template, Including Histone Modifications, Histone Variants and Their Dedicated Chaperones, and Non-Coding RNAs"
9:25 am - 9:30 amDiscussion
9:30 am - 9:40 amShort Talk Selected from Poster Abstracts
9:40 am - 9:45 amDiscussion
9:45 am - 10:10 amKristian Helin (University of Copenhagen, Denmark)
"Elucidate the Molecular Mechanisms Leading to Cancer and to Transform This Knowledge into Novel Anti-Cancer Therapies"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amShort Talk Selected from Poster Abstracts
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amLuciano Di Croce (Centre for Genomic Regulation (CRG), Spain)
"Defining Mechanisms that Regulate Polycomb Functions in Stem Cell Differentiation and Cancer"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amShort Talk Selected from Poster Abstracts
11:40 am - 11:45 amDiscussion
11:45 am - 12:25 pmLate-Breaking Topic
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmAnimal Models for Cancer Epigenetics
Discussion Leader: Mathieu Lupien (Princess Margaret Cancer Centre, Canada)
6:00 pm - 6:25 pmSharon Dent (University of Texas MD Anderson Cancer Center, USA)
"A Saga of USPs"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:40 pmShort Talk Selected from Poster Abstracts
6:40 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmJohannes Zuber (Research Institute of Molecular Pathology (IMP), Austria)
"Exploring and Exploiting Aberrant Cell Fate Programs in Leukemia"
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmShort Talk Selected from Poster Abstracts
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:55 pmIannis Aifantis (NYU School of Medicine / Howard Hughes Medical Institute, USA)
"Molecular Mechanisms Driving Normal Stem Cell Differentiation and Malignant Transformation"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRegulatory Genomics and Epigenomics of Cancer
Discussion Leader: Saverio Minucci (University of Milan, Italy)
9:00 am - 9:25 amMathieu Lupien (Princess Margaret Cancer Centre, Canada)
"Identifying the Molecular Biology Underlying Cancer Initiation and Progression by Exploiting the Power of Functional Epigenomics"
9:25 am - 9:30 amDiscussion
9:30 am - 9:40 amShort Talk Selected from Poster Abstracts
9:40 am - 9:45 amDiscussion
9:45 am - 10:10 amBen Lehner (Centre for Genomic Regulation (CRG), Spain)
"Understanding Rare Inherited Variants and Somatic Mutation in Human Tumors"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amShort Talk Selected from Poster Abstracts
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amTing Wang (Washington University School of Medicine, USA)
"Transposable Elements in Normal and Cancer Epigenome"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amShort Talk Selected from Poster Abstracts
11:40 am - 11:45 amDiscussion
11:45 am - 12:10 pmWei Li (Baylor College of Medicine, USA)
"Homeobox Oncogene Activation by Pan-Cancer Gene-Body DNA Hypermethylation"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmShort Talk Selected from Poster Abstracts
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmFunctional Genomics, Epigenomics and Proteomics of Cancer
Discussion Leader: Ricky Johnstone (Peter MacCallum Cancer Centre, Australia)
6:00 pm - 6:25 pmBenjamin Ebert (Brigham and Women's Hospital, USA)
"The Genetics and Biological Consequences of Clonal Hematopoiesis"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:40 pmShort Talk Selected from Poster Abstracts
6:40 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmChristopher Vakoc (Cold Spring Harbor Laboratory, USA)
"Transcriptional Coactivators as Cancer Dependencies"
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmShort Talk Selected from Poster Abstracts
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:55 pmTiziana Bonaldi (European Institute of Oncology, Italy)
"Elucidation of the Molecular Mechanisms that Regulate Gene Expression Using a Combination of Functional Genomic Approaches"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmCancer Epigenetic Therapies
Discussion Leader: Stephen Baylin (Johns Hopkins University, USA)
9:00 am - 9:25 amMark Dawson (Peter MacCallum Cancer Centre, Australia)
"Mechanisms of Response and Resistance to Epigenetic Therapies"
9:25 am - 9:30 amDiscussion
9:30 am - 9:40 amShort Talk Selected from Poster Abstracts
9:40 am - 9:45 amDiscussion
9:45 am - 10:10 amAri Melnick (Weill Cornell Medicine, USA)
"Understanding the Mechanisms Through Which Transcriptional and Epigenetic Regulation Occur"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amShort Talk Selected from Poster Abstracts
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amJacques Neefjes (Netherlands Cancer Institute, The Netherlands)
"Cell Biology of MHC Class I and II Antigen Presentation"
11:25 am - 11:30 amDiscussion
11:30 am - 11:40 amShort Talk Selected from Poster Abstracts
11:40 am - 11:45 amDiscussion
11:45 am - 12:25 pmLate-Breaking Topic
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmInterplay Between Cancer Epigenetics and Cancer Immunity
Discussion Leader: X. Shirley Liu (Harvard T.H. Chan School of Public Health, USA)
6:00 pm - 6:25 pmWeiping Zou (University of Michigan Health System, USA)
"Epigenetics Regulate the Cancer Immune Microenvironment"
6:25 pm - 6:30 pmDiscussion
6:30 pm - 6:40 pmShort Talk Selected from Poster Abstracts
6:40 pm - 6:45 pmDiscussion
6:45 pm - 7:10 pmStephen Baylin (Johns Hopkins University, USA)
"Epigenetics or Genetic Modifications Other than Those in DNA that Can Affect Cell Behavior"
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmShort Talk Selected from Poster Abstracts
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:55 pmRicky Johnstone (Peter MacCallum Cancer Centre, Australia)
"Integrating Epigenetic- and Immune-Based Therapeutics to Provide More Potent and Durable Therapeutic Outcomes"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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