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Antimicrobial Peptides
Gordon Research Conference

How Animals and Plants Use Antimicrobial Peptides, How They Work, and How to Design Interesting New Molecules

Dates

February 26 - March 3, 2017

Location

Four Points Sheraton / Holiday Inn Express
Ventura, CA

Organizers

Chairs:
Wuyuan Lu & Michael A. Zasloff

Vice Chairs:
Donald J. Davidson & Henk P. Haagsman

Meeting Description

The 2017 Antimicrobial Peptides GRC takes place 35 years after the pioneering report in Nature by Hans Boman and his colleagues of the discovery of cecropins (Steiner H, Hultmark D, Engström A, Bennich H, Boman HG. Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature 1981; 292:246-8). This simple study taught us that when an insect is challenged by a pathogen it protects its inner milieu by elaborating high concentrations of antimicrobial peptides. Since that landmark publication, AMPs are now known to be widely expressed in both plants and animals, have been studied in states of human health and disease, and have been developed as human therapeutics. Because of the diverse scientific and medical fields in which AMPs are studied, it is difficult to grasp the "larger picture" in which they now are positioned. The purpose of this meeting is to provide a broad overview of our current state of knowledge regarding AMPs.

Related Meeting

This GRC was held in conjunction with the "Antimicrobial Peptides" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: AMPs at the Interface of Chemistry and Biology
Discussion Leaders: Pieter Hiemstra (Leiden University Medical Center, The Netherlands) and Julia Dorin (University of Edinburgh, United Kingdom)
7:40 pm - 7:45 pmOpening Remarks
7:45 pm - 8:20 pmWilliam Degrado (University of California, San Francisco, USA)
"Design, Characterization and Mechanisms of Bacterial Response to Small Molecule Mimics of Antimicrobial Peptides"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 9:05 pmDavid Schneider (Stanford University School of Medicine, USA)
"Measuring and Altering the Shape of Infections"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmLee Schnaider (Tel Aviv University, Israel)
"Design and Development of Self-Assembling Stereo-Specific Antibacterial Peptides and Nano-Structures"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmEvolution of AMPs Within Invertebrates
Discussion Leaders: Jens Rolff (Free University of Berlin, Germany) and Delphine Destoumieux-Garzon (French National Centre for Scientific Research (CNRS), France)
9:00 am - 9:20 amRoland Regoes (ETH Zurich, Switzerland)
"Resistance Evolution: Antimicrobial Peptides vs. Antibiotics"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amAbdelaziz Heddi (University of Lyon, France)
"Antimicrobial Peptide Function and Regulation in Insect Endosymbiosis"
9:55 am - 10:10 amDiscussion
10:10 am - 10:25 amGuangshun Wang (University of Nebraska Medical Center, USA)
"A Database View of Vertebrate and Invertebrate Antimicrobial Peptides"
10:25 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:25 amNichole Broderick (University of Connecticut, USA)
"Probing Immune and Non-Immune Roles of AMPs in Drosophila melanogaster"
11:25 am - 11:40 amDiscussion
11:40 am - 12:00 pmRobert Unckless (University of Kansas, USA)
"Balancing Selection and Convergence in Insect AMPs and/or the Role of Gene Duplication in AMP Evolution"
12:00 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAMPs as Components of Plant Immune Defense
Discussion Leaders: Karin Thevissen (KU Leuven, Belgium) and Octavio Franco (Catholic University of Brasilia, Brazil)
7:30 pm - 7:50 pmDavid Craik (The University of Queensland, Australia)
"Gene Co-Evolution and Regulation Locks Cyclic Plant Peptides to Their Targets"
7:50 pm - 8:05 pmDiscussion
8:05 pm - 8:20 pmAttila Kereszt (Hungarian Academy of Sciences, Hungary)
"Non-Antimicrobial Roles of AMPs in Nitrogen-Fixing Symbiosis: Tools to Dominate a Theoretically Mutualistic Interaction"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmMarilyn Anderson (La Trobe University, Australia)
"Evolution, Function and Applications of Plant Defensins"
8:50 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmBarbara De Coninck (Katholieke Universiteit Leuven, Belgium)
"Plant Defensins: Multifunctionality in Relation to Their In Planta Role(s)"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAMPs in Human Health and Disease
Discussion Leaders: Charles Bevins (University of California, Davis, USA) and Nita Salzman (Medical College of Wisconsin, USA)
9:00 am - 9:20 amRobert Moir (Harvard Medical School / Massachusetts General Hospital, USA)
"The Aβ Peptide of Alzheimer's Disease: A Model for the Role of Soluble Oligomers in Antimicrobial Peptide Activities"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amMichael Selsted (University of Southern California, USA)
"Macrocyclic Peptides: Retroevolutionary Bioinspiration"
9:55 am - 10:10 amDiscussion
10:10 am - 10:25 amBrice Sperandio (Pasteur Institute, France)
"Deciphering the Regulation of Antimicrobial Peptides to Develop Innovative Anti-Infectious Drugs"
10:25 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:25 amRichard Gallo (University of California, San Diego, USA)
"Discovering AMPs from the Super-Organism that Is Human Skin"
11:25 am - 11:40 amDiscussion
11:40 am - 11:55 amEthan Stolzenberg (Nassau County, NY Medical Examiner, USA)
"Parkinson's Disease and Innate Immunity"
11:55 am - 12:05 pmDiscussion
12:05 pm - 12:15 pmDan Xu (Xi'an Jiaotong University, China)
"Pathogenic Role of Human Enteric Alpha-Defensin 5 in Shigella Infection"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAMPs from the Pathogen's Perspective
Discussion Leaders: Victor Nizet (University of California, San Diego, USA) and Jason Smith (University of Washington, USA)
7:30 pm - 7:50 pmRupert Kaul (University of Toronto, Canada)
"In Vivo Associations of Genital Antimicrobial Peptides with HIV Susceptibility"
7:50 pm - 8:05 pmDiscussion
8:05 pm - 8:20 pmJennifer Bomberger (University of Pittsburgh, USA)
"Simultaneous Antibiofilm and Antiviral Activities of an Engineered Antimicrobial Peptide During Virus-Bacterium Co-Infection"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmMolly Hughes (University of Virginia, USA)
"Understanding Microbial Susceptibility to Host Chemokines: A Pathway to New Strategies to Combat Drug Resistant Pathogens?"
8:50 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmAndrew Koh (University of Texas Southwestern Medical Center, USA)
"Activation of LL-37 by Commensal Bacteria Inhibits Candida albicans Gastrotinestinal Colonization and Dissemination"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHow Do AMPs Interact with Their Targets?
Discussion Leaders: Karl Lohner (University of Graz, Austria) and Burkhard Bechinger (University of Strasbourg / CNRS, France)
9:00 am - 9:20 amGerard Wong (University of California, Los Angeles, USA)
"Antimicrobial Peptides and Their Roles in Immune Activation"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amJames Mason (King's College London, United Kingdom)
"Membranes and Metabolomics: Distinctive Mechanisms and Bacterial Responses in Related AMPs"
9:55 am - 10:10 amDiscussion
10:10 am - 10:25 amSascha Jung (Technical University of Berlin, Germany)
"Catching Bacteria - A Biophysics Story"
10:25 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:25 amLorenzo Stella (University of Rome Tor Vergata, Italy)
"AMP Interaction with Target and Host Cells: A Complex Interplay of Multiple Equilibria"
11:25 am - 11:40 amDiscussion
11:40 am - 12:00 pmJoshy Jacob (Emory University, USA)
"Urumin, an Amphibian Antimicrobial Peptide Is Virucidal for Influenza Viruses"
12:00 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCritical Design Features and Novel Synthesis of AMPs
Discussion Leaders: David Craik (The University of Queensland, Australia) and James Tam (Nanyang Technological University, Singapore)
7:30 pm - 7:50 pmJohn Vederas (University of Alberta, Canada)
"Antimicrobial Mechanisms of Tridecaptins and Lantibiotics that Interact with Lipid II"
7:50 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmJulio Camarero (University of Southern California, USA)
"Using Antimicrobial Cys-Rich Polypeptides as Scaffolds to Target Protein-Protein Interactions in Cancer"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmSonia Henriques (The University of Queensland, Australia)
"Redesigned Spider Toxin with Improved Antimicrobial, Anticancer and Cell Penetration Properties"
9:00 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmEdith Porter (California State University, Los Angeles, USA)
"Synergistic Activities of Antimicrobial Peptides and Antimicrobial Lipids"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmAMPs at the Interface of Innate and Adaptive Immunity
Discussion Leaders: Joost Oppenheim (National Cancer Institute, NIH, USA) and Aaron Weinberg (Case Western Reserve University, USA)
9:00 am - 9:20 amFeng Shao (National Institute of Biological Sciences, China)
"The Pore-Forming Activity of Gasdermin D in Anti-Bacterial Defenses"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amOliver Soehnlein (Institute for Cardiovascular Prevention (IPEK), LMU Munich, Germany)
"Neutrophil-Platelet Cooperation During Monocyte Recruitment"
9:55 am - 10:10 amDiscussion
10:10 am - 10:25 amErik de Leeuw (University of Maryland, Baltimore, USA)
"Defensin-Derived Small Molecule Agonists of Tumor Necrosis Factor Receptor 1"
10:25 am - 10:35 amDiscussion
10:35 am - 11:05 amCoffee Break
11:05 am - 11:25 amGe Jin (Case Western Reserve University, USA)
"Role of Human β-Defenisns in Head and Neck Cancer Progression"
11:25 am - 11:40 amDiscussion
11:40 am - 12:00 pmDe Yang (National Cancer Institute, NIH, USA)
"Antimicrobial Alarmins and Anti-Tumor Immunity"
12:00 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLatest Developments with AMPs / Late-Breaking Topics
Discussion Leaders: Robert Lehrer (University of California, Los Angeles, USA) and Andre Ouellette (University of Southern California, USA)
7:30 pm - 7:50 pmDominik Filipp (Institute of Molecular Genetics, ASCR, Czech Republic)
"Enteric Alpha-Defensins, Thymus and Microbiota: Essential Players of Intestinal Autoimmunity"
7:50 pm - 8:05 pmDiscussion
8:05 pm - 8:20 pmElizabeth Nolan (Massachusetts Institute of Technology, USA)
"Host-Defense Peptides and Metal Ions"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmManuela Raffatellu (University of California, Irvine, USA)
"Bacterial Competition in the Gut: A Role for Microcins"
8:50 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmDmitri Kudryashov (The Ohio State University, USA)
"Destabilization of Pathogen Effector Proteins by Human Defensins"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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