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Excitatory Synapses & Brain Function
Gordon Research Conference

Integrating Molecules, Synapses, Neurons, Circuits and Behavior

Dates

May 28 - June 2, 2017

Location

Les Diablerets Conference Center
Les Diablerets, Switzerland Site Information

Organizers

Chairs:
Kang Shen & Christian Lüscher

Vice Chairs:
Pierre Paoletti & Kimberly M. Huber

Application Deadline

Applications are no longer being accepted for this meeting. If you have been instructed to apply by the Conference Chair, please contact Alexis Laraway for further instructions.

Meeting Description

The synapse is central to our understanding of circuit function and behavior. In the central nervous system, excitatory synapses represent the primary means of information processing by local circuits and communication between brain regions. Synapses serve as the site of action for many commonly prescribed medications and their disruption contributes to many neurological and psychiatric disorders. These include schizophrenia, autism, depression, substance abuse and addiction, Parkinson's disease, Alzheimer's disease, traumatic brain injury, stroke and epilepsy. In some cases, synaptic dysfunction is causal in disease, whereas in other cases it represents the downstream sequelae of one or more underlying molecular defects. In either case, a fundamental understanding of the formation, structure, molecular organization, signaling function, and plasticity of synapses is essential to progress in lessening the burden of human neurological disease and for predicting and improving mental health.

This conference is unique in its focus on the excitatory synapse, and in its multidisciplinary group of participants including structural biologists, molecular and developmental biologists, cell biologists, biochemists, cell/molecular imagers, biophysicists and neurophysiologists. The conference is intended to relate fundamental insights in excitatory synaptic function to the impairments in synaptic function that occur in disease, as well as the maladaptive plasticity that occurs in substance abuse. The goal of the conference is to identify and highlight fundamental new insights into synaptic function, neural circuit dynamics and dysfunction from a thematic approach. The program has been designed to also highlight cutting edge approaches and to stimulate new concepts, methods and technologies within a sound biological framework of fundamental neuroscience.

Special note: To promote young scientists at the doctoral and postdoctoral level, several slots for oral presentation have been reserved. We also have funds to support travel and registration for these junior scientists. Please clearly indicate in your application if you wish to be considered for an oral presentation. Please send all requests for financial support, along with a CV (bio-sketch of maximally two pages, including all your publications), to catherine.pham@unige.ch.

Related Meeting

This GRC will be held in conjunction with the "Excitatory Synapses & Brain Function" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: From Synapses to Circuits and Behavior
This session will include our two keynote speakers.
Discussion Leader: Christian Lüscher (University of Geneva, Switzerland)
7:40 pm - 8:20 pmSilvia Arber (Biozentrum, University of Basel, Switzerland)
"Organization and Function of Descending Motor Control Circuits"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmKarl Deisseroth (Stanford University, USA)
"How the Discovery of Structural Principles in a Microbial Protein Helped Illuminate Psychiatry"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSynapses in Autism and Dementia
Discussion Leader: Kang Shen (Stanford University, USA)
9:00 am - 9:20 amCamilla Bellone (University of Geneva, Switzerland)
"Synaptic Basis of Social Motivation"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amClaudia Bagni (University of Lausanne, Switzerland)
"Synaptic Molecular Pathways Regulating Brain Wiring and Social Behavior"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amBrittney Cox (University of California, Irvine, USA)
"Episodic Memory Impairment in a Mouse Model of Autism Is Due to Defects in a Novel, Pathway Specific Form of Hippocampal Plasticity"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amSergio Valbuena Alvarez (Instituto de Neurociencias, Universidad Miguel Hernández de Elche, CSIC, Spain)
"Contribution of Kainate Receptors to Synaptic Phenotype in Down Syndrome"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amSuzanne Zukin (Albert Einstein College of Medicine, USA)
"Dysregulation of Synaptic AMPARs in Fragile X Syndrome"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amLucas Pozzo-Miller (University of Alabama at Birmingham, USA)
"Dysfunction of Hippocampal Synapses in Rett Syndrome"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmMary Phillips (University of Alabama at Birmingham, USA)
"Atypical Hippocampal Afferent Inputs to the Medial Prefrontal Cortex Alter Social Behaviors in the Mecp2 Mouse Model of Rett Syndrome"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmVincent Pascoli (University of Geneva, Switzerland)
"Synaptic Correlates of Individual Vulnerability for Cocaine Addiction"
12:25 pm - 12:30 pmDiscussion
12:30 pmGroup Photo / Lunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmSynapses in Addiction and Depression
Discussion Leader: Kimberly Huber (University of Texas Southwestern Medical Center, USA)
6:00 pm - 6:20 pmManuel Mameli (The University of Lausanne, Switzerland)
"Habenular Circuits for Aversion Encoding"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmStephan Lammel (University of California, Berkeley, USA)
"Neural Circuit Mechanisms Underlying Drug-Induced Changes in Motivated Behavior"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmGarret Stuber (University of North Carolina at Chapel Hill, USA)
"Frontal Cortical Circuits Guide Reward Seeking Through Divergent Cue Encoding"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:50 pmBo Li (Cold Spring Harbor Laboratory, USA)
"The Central Amygdala Circuits in Aversive Learning"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNovel Methods
Discussion Leader: Richard Huganir (Johns Hopkins University, USA)
9:00 am - 9:20 amValentin Nagerl (University of Bordeaux / CNRS, France)
"Super-Resolution Shadow Imaging of Brain Structure Based on 3D-STED Microscopy"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amSandeep Robert Datta (Harvard Medical School, USA)
"Using Motion Sequencing to Link Brain to Behavior"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amHyungbae Kwon (Max Planck Florida Institute for Neuroscience, USA)
"Light-Inducible Labeling and Manipulation of Behaviorally Relevant Circuits"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amRyohei Yasuda (Max Planck Florida Institute for Neuroscience, USA)
"Biochemical Computation in Single Dendritic Spines"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amGraham Ellis-Davies (Icahn School of Medicine at Mount Sinai, USA)
"New Optical Probes for Neurophysiology"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmK. Ulrich (Ulli) Bayer (University of Colorado School of Medicine, USA)
"GluN2B: A Tail for Two CaM Kinases"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmXiang Cai (Southern Illinois University, USA)
"The Essential Roles of GluR1 Phosphorylation and Presynaptic HCN Channels in Fast-Acting Antidepressant Responses of Ketamine"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmPhysiology of Synaptic Transmission
Discussion Leader: Christophe Mulle (CNRS / University of Bordeaux, France)
6:00 pm - 6:20 pmJeremy Dittman (Weill Cornell Medical College, USA)
"A Novel Inhibitory Function of Munc13 Regulates Calcium-Dependent Fusion"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmPascal Kaeser (Harvard Medical School, USA)
"Assembly and Function of the Presynaptic Active Zone"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmRichard Huganir (Johns Hopkins University, USA)
"Regulation of AMPA Receptor Function and Synaptic Plasticity in Cognitive Disorders"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:50 pmNathalie Rouach (College de France, France)
"A Role for Perisynaptic Astroglial Processes in Shaping Synaptic Strength and Circuits"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmStructural Plasticity of Synapses
Discussion Leader: Pablo Castillo (Albert Einstein College of Medicine, USA)
9:00 am - 9:20 amAnthony Holtmaat (University of Geneva, Switzerland)
"Probing Synaptic Plasticity in the Mouse Somatosensory Cortex"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amKaren Zito (University of California, Davis, USA)
"Mechanisms of Spine Structural Plasticity During Excitatory Synapse Development"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amMartin Mueller (University of Zurich, Switzerland)
"Dysbindin Links Synaptic Proteasome Function to Homeostatic Recruitment of Low Release Probability Vesicles"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amGiordano Lippi (University of California, San Diego, USA)
"MicroRNAs Constrain the Development of the Excitatory Input to Produce Balanced Networks in the Adult"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amThomas Blanpied (University of Maryland School of Medicine, USA)
"How Does Nanostructure Regulate Synaptic Function?"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amHaruo Kasai (The University of Tokyo, Japan)
"Dopamine Actions on the Structural Plasticity of Dendritic Spines"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmMatthew Dalva (Thomas Jefferson University, USA)
"Synaptic Nanomodules Underlie the Organization and Plasticity of Spine Synapses"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmYanjun Li (Nanjing University, China)
"GluA1 Signal Peptide Determines the Spatial Assembly of Heteromeric AMPA Receptors"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmSynaptic Receptor Signaling
Discussion Leader: Camilla Bellone (University of Geneva, Switzerland)
6:00 pm - 6:20 pmDaniel Choquet (CNRS, France)
"Various Pathways of AMPA Receptor Trafficking to Set Up Long Term Potentiation of Excitatory Synapses"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmPablo Castillo (Albert Einstein College of Medicine, USA)
"Presynaptic Long-Term Plasticity in the Dentate Gyrus"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmSusumu Tomita (Yale School of Medicine, USA)
"Molecular Signaling to Regulate Receptors at Synapses"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:50 pmMarina Picciotto (Yale University, USA)
"Molecular Mechanisms Underlying Nicotinic Receptor Control of Synaptic Development and Maintenance"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmPlasticity of Synaptic Transmission
Discussion Leader: Pierre Paoletti (Ecole Normale Superieure (ENS), CNRS, INSERM, France)
9:00 am - 9:20 amJean-Louis Bessereau (University of Lyon, France)
"Control of Postsynaptic Organization by the Synaptomatrix"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amChristophe Mulle (CNRS / University of Bordeaux, France)
"Plasticity of Hippocampal Synaptic Circuits In Vivo"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amJason Shepherd (University of Utah, USA)
"Retroviral Origins of Synaptic Plasticity of Excitatory Synapses"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amJochen Schwenk (University of Freiburg, Germany)
"AMPA-Receptor Specific Biogenesis Complexes Control Synaptic Transmission and Intellectual Ability"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amHailan Hu (Zhejiang University, China)
"Bidirectional Modulation of Depression State by Astrocyte-Neuron Interaction in Lateral Habenula"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amMegan Carey (Champalimaud Neuroscience Programme, Champalimaud Foundation, Portugal)
"Locomotor Modulation of Associative Learning in Mouse Cerebellum"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmCeline Maeder (Stanford University, USA)
"THO Complex: A Master Regulator of Presynaptic Gene Expression and Synapse Assembly in Dopamine Neurons"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmJoris de Wit (VIB Center for Brain and Disease Research, KU Leuven, Belgium)
"A Modular Organization of Synaptic Adhesion Defines Synapse Identity"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmSynapse Formation and Circuit Development
Discussion Leader: Marina Picciotto (Yale University, USA)
6:00 pm - 6:20 pmJulia Kaltschmidt (Memorial Sloan Kettering Cancer Center, USA)
"Mechanisms of Synaptic Specificity Underlying Neuronal Circuit Formation"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmDenis Jabaudon (University of Geneva, Switzerland)
"Transcriptional Control of Cortical Circuit Assembly"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmMegan Williams (University of Utah, USA)
"Selective Cell Adhesion in Hippocampal Synapse Specificity"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:50 pmKendal Broadie (Vanderbilt University, USA)
"Activity-Dependent Circuit Refinement During the Initial Sensory Input Developmental Critical Period"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13NS101855-01 from the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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