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Ligand Recognition & Molecular Gating
Gordon Research Conference

Molecular Basis of Ligand Recognition and Gating in Transmembrane Signaling and Transport

Dates

January 31 - February 5, 2016

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chair:
Crina Nimigean

Vice Chair:
Edmund Kunji

Meeting Description

The goal of the Gordon Research Conference on Ligand Recognition and Molecular Gating is to share the latest knowledge and expertise on the mechanism of function of three important classes of membrane proteins: receptors, transporters, and ion channels. These integral membrane proteins have crucial physiological roles and are targets for more than 50% of the available drugs on the market. Specifically, we will cover topics ranging from understanding the molecular conformational changes these proteins undergo in response to binding of ligands and substrates to the downstream signaling in a cellular context. Novel, emerging techniques as well as more established techniques that have been applied to these problems, will be highlighted in this conference.

All participants are asked to submit abstracts and bring posters - providing opportunities for people at different stages in their careers to meet, mix, learn and establish new interdisciplinary collaborations. The organizers will select additional speakers to give short talks from the submitted abstracts. In 2016, the GRC will be immediately preceded by a Gordon Research Seminar, which will provide young scientists with unique opportunities for interaction with peers from different research and geographical areas and for presentation of their research in a "safe" and approachable environment. We strongly encourage graduate students and post-doctoral fellows to apply for this GRS as well as the GRC that follows. We also encourage conference applications by both junior and senior scientists, by minorities and people with disabilities, and we are applying for funds to support in part those with financial constraints.

Related Meeting

This GRC was held in conjunction with the "Ligand Recognition & Molecular Gating" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmG Protein Coupled Receptors
Discussion Leader: Gebhard Schertler (Paul Scherrer Institute / ETH Zürich, Switzerland)
7:40 pm - 8:00 pmKlaus-Peter Hofmann (Charite Institute for Medical Physics and Biophysics, Germany)
"Versatility and Precision of GPCR Interactions"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmAndreas Pluckthun (University of Zurich, Switzerland)
"Evolving Stable Receptors: Principles, Structural Studies and Use in Drug Discovery"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:55 pmChris Tate (Medical Research Council, United Kingdom)
"Crystal Structure of the Human Adenosine A2a Receptor Bound to an Engineered G Protein"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmEhud Isacoff (University of California, Berkeley, USA)
"An Optical View of mGluR Gating Mechanism"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPhysiology of Transporters and Channels
Discussion Leader: Edmund Kunji (MRC - Mitochondrial Biology Unit, United Kingdom)
9:00 am - 9:20 amGeoffrey Abbott (University of California, Irvine, USA)
"Potassium Channel-Solute Transporter Co-Regulation"
9:20 am - 9:30 amDiscussion
9:30 am - 9:45 amStephan Pless (University of Copenhagen, Denmark)
"Atomic Basis for Therapeutic Activation of Neuronal Potassium Channels"
9:45 am - 9:50 amDiscussion
9:50 am - 10:10 amFrances Ashcroft (University of Oxford, United Kingdom)
"KATP Channels and Neonatal Diabetes: When Ligand Recognition Goes Wrong"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:10 amNancy Carrasco (Yale School of Medicine, USA)
"The Sodium/Iodide Symporter (NIS): An Unending Source of Surprises"
11:10 am - 11:20 amDiscussion
11:20 am - 11:35 amAndres Jara-Oseguera (National Institute of Neurological Disorders and Stroke, NIH, USA)
"Extracellular Sodium Is Required for Temperature-Dependent Gating in TRPV1 Channels"
11:35 am - 11:40 amDiscussion
11:40 am - 11:55 amIsabelle Mus-Veteau (CNRS, France)
"The Human Hedgehog Receptor Patched Is a Cholesterol and a Drug Efflux Pump"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmBenjamin Kaupp (Center of Advanced European Studies and Research, Germany)
"Chemotactic Signaling by Exotic Ion Channels"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Teresa Giraldez (La Laguna University, Spain)
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmCalcium Release and Calcium-Gated Channels
Discussion Leader: Teresa Giraldez (La Laguna University, Spain)
6:00 pm - 6:20 pmSteve Long (Memorial Sloan Kettering Cancer Center, USA)
"Structure and Insights into the Mechanism of the Bestrophin Calcium-Activated Chloride Channel"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:40 pmBrad Rothberg (Temple University School of Medicine, USA)
"An Intersubunit Ca2+ Bridge Contributes to BK Channel Gating"
6:40 pm - 6:45 pmDiscussion
6:45 pm - 7:05 pmIrina Serysheva (The University of Texas Medical School, USA)
"Cryo-EM Structure of the IP3R1 Channel: Insights into the Gating Mechanism"
7:05 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmManuel Arcangeletti (International School for Advanced Studies (SISSA), Italy)
"Interactions Between the C-Linker and the S4-S5 Linker Mediate Gating in CNGA1 Channels"
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:50 pmNieng Yan (Tsinghua University, China)
"Molecular Visualization of the Excitation-Contraction Coupling"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmLigand-Gated Ion Channels
Discussion Leader: Anna Moroni (University of Milan, Italy)
9:00 am - 9:20 amPierre-Jean Corringer (Pasteur Institute, France)
"Gating Mechanism of a Bacterial Homolog of Pentameric Ligand-Gated Ion Channel"
9:20 am - 9:30 amDiscussion
9:30 am - 9:45 amJorg Grandl (Duke University, USA)
"Mechanism of Activation and Modulation of Piezo Ion Channels"
9:45 am - 9:50 amDiscussion
9:50 am - 10:10 amPeter Hegemann (Humboldt-Universitaet zu Berlin, Germany)
"Operation of Light as Ligand for Channel and Enzyme Activation"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:05 amAndrea Saponaro (University of Milan, Italy)
"HCN Channel Modulation: The Competition Between cAMP and TRIP8b Explained in Molecular Detail"
11:05 am - 11:10 amDiscussion
11:10 am - 11:30 amHenning Stahlberg (University of Basel, Switzerland)
"A Prokaryotic Potassium Channel in Lipid Membranes Studied by Electron Crystallography"
11:30 am - 11:40 amDiscussion
11:40 am - 11:55 amMartina Rangl (INSERM U1006, France)
"Real-Time Visualization of Conformational Changes in Ion Channels and Transporters by High-Speed Atomic Force Microscopy"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmEduardo Perozo (University of Chicago, USA)
"On Symmetry and the Gating Mechanism of Ion Channels"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmTechnique Innovation
Discussion Leader: Simon Scheuring (INSERM U1006 / Aix-Marseille Université, France)
6:00 pm - 6:20 pmGebhard Schertler (Paul Scherrer Institute / ETH Zürich, Switzerland)
"The Application of Free Electron Lasers to Biology: A New Age of Time-Resolved Crystallography"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmCarol Robinson (Oxford University, United Kingdom)
"Membrane Proteins - The Lipid Connection"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:10 pmMarina Casiraghi (IBPC Institut de Biologie Physico-Chimique, France)
"Functional Remodelling of a GPCR Conformational Landscape in a Lipid Bilayer"
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:35 pmMaxime Dahan (Institut Curie, France)
"Unraveling the Diffusivity and Energy Landscapes of Membrane Proteins with High Density Single Molecule Imaging"
7:35 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmHervé Rémigy (FEI Company, The Netherlands)
"Cryo-TEM: A Third Member Joins the High Resolution Band"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPermeation and Gating Mechanisms in Ion Channels and Transporters
Discussion Leader: Kenton Swartz (National Institutes of Health, USA)
9:00 am - 9:20 amAnn McDermott (Columbia University, USA)
"Allosteric Coupling in KcsA: Ion Affinities by SSNMR"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amBert de Groot (Max Planck Institute for Biophysical Chemistry, Germany)
"The Molecular Dynamics of Selective Permeation Across Biological Channels"
9:50 am - 10:00 amDiscussion
10:00 am - 10:15 amColin Nichols (Washington University School of Medicine in St. Louis, USA)
"Lipid Control of Ion Channels: smFRET and Crystallography Reveal the Intimate and Moving Details"
10:15 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:10 amFrancisco Bezanilla (University of Chicago, USA)
"Following the Movement of the Charges in Voltage Sensors"
11:10 am - 11:20 amDiscussion
11:20 am - 11:35 amThomas Baukrowitz (University of Kiel, Germany)
"A Non-Canonical Voltage Sensor Controls Gating in K2P K+ Channels"
11:35 am - 11:40 amDiscussion
11:40 am - 12:00 pmJian Payandeh (Genentech, USA)
"Cryo-What? Engineering Human Voltage-Gated Sodium Channels for Crystallography and Structure-Based Drug Design"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSimon Berneche (Swiss Institute of Bioinformatics, Switzerland)
"The Proton Pathway in a ClC H+/Cl- Antiporter"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmDual Function and Exotic Channels and Transporters
Discussion Leader: Poul Nissen (Aarhus University, Denmark)
6:00 pm - 6:20 pmChristopher Miller (Brandeis University, USA)
"Binding of Two Funky Ligands to One Weird Channel"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:40 pmJulia Preobraschenski (Max Planck Institute for Biophysical Chemistry, Germany)
"Vesicular Glutamate Transporters (VGLUTs) Use Flexible Anion and Cation Binding Sites for Efficient Accumulation of Neurotransmitter"
6:40 pm - 6:45 pmDiscussion
6:45 pm - 7:05 pmAlessio Accardi (Weill Cornell Medical College, USA)
"Ion and Lipid Transport by TMEM16 Phospholipid Scramblases"
7:05 pm - 7:15 pmDiscussion
7:15 pm - 7:35 pmJean-Ju Chung (Yale University, USA)
"Ca2+ Signaling Components in Sperm Motility and Fertility"
7:35 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmJoel Meyerson (Brandeis University, USA)
"Structural Mechanism of Glutamate Receptor Activation and Desensitization"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmTransporter Mechanism
Discussion Leader: Cristina Paulino (University of Zurich, Switzerland)
9:00 am - 9:20 amOlga Boudker (Weill Cornell Medical College, USA)
"Controlling Transporter Dynamics and Function"
9:20 am - 9:30 amDiscussion
9:30 am - 9:45 amOezkan Yildiz (Max Planck Institute of Biophysics, Germany)
"Citrate Recognition, Binding, and Transport by the Sodium-Dependent Citrate Symporter"
9:45 am - 9:50 amDiscussion
9:50 am - 10:10 amJose Faraldo-Gomez (National Institutes of Health, USA)
"Molecular Mechanism of the Na+/Ca2+ Exchanger: Insights from Computations and Experiments"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:10 amWerner Kuhlbrandt (Max-Planck-Institute for Biophysics, Germany)
"Structure and Mechanisms of Archaeal Sodium/Proton Antiporters"
11:10 am - 11:20 amDiscussion
11:20 am - 11:35 amHoma Majd (MRC Mitochondrial Biology Unit, United Kingdom)
"A High Throughput Method for Identification of Orphan Mitochondrial Transporters"
11:35 am - 11:40 amDiscussion
11:40 am - 12:00 pmDirk Jan Slotboom (University of Groningen, The Netherlands)
"Toppling Mechanism of Energy Coupling Factor Vitamin Transporters"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmAndrea Brueggemann (Nanion Technologies, Germany)
"Novel Approaches to Study Ion Channels and Transporters"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmLate-Breaking Topics
Discussion Leader: Chris Ahern (University of Iowa, USA)
6:00 pm - 6:20 pmDimitrios Stamou (University of Copenhagen, Denmark)
"Insights Gained from the First Measurements of Transport at the Single Molecule Level"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:40 pmMarcel Goldschen-Ohm (University of Wisconsin-Madison, USA)
"Single Molecule Ligand Binding Dynamics at Micromolar Concentrations in Zero-Mode Waveguides"
6:40 pm - 6:45 pmDiscussion
6:45 pm - 7:05 pmFilippo Mancia (Columbia University, USA)
"Structure of a Micronutrient Transporter"
7:05 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmJiafei Mao (Biomolecular Magnetic Resonance Center (BMRZ), Goethe-University Frankfurt, Germany)
"Understanding Ligand Selectivity of GPCR Subtypes – A View of Peptide Ligands from Solid-State Nuclear Magnetic Resonance (SSNMR) Spectroscopy Enhanced by Dynamic Nuclear Polarization (DNP)"
7:25 pm - 7:30 pmDiscussion
7:30 pm - 7:50 pmPaul Shaffer (Amgen, Inc., USA)
"Crystal Structures of the Glycine Receptor"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS095582. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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