Gordon Research Conferences
Meeting Details

Ligand Recognition and Molecular Gating
Gordon Research Conference

Molecular Mechanisms of Transporters, Ion Channels, and G-Protein Coupled Receptors


March 4-9, 2018


Ventura Beach Marriott
Ventura, CA Site Information


Edmund Kunji

Vice Chair:
Alessio Accardi

Application Deadline

Applications for this meeting must be submitted by February 4, 2018. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

The 2018 Gordon Research Conference on Ligand Recognition and Molecular Gating will address the molecular mechanisms and physiological roles of three important classes of membrane proteins: ion channels, transporters and G-protein coupled receptors. These membrane proteins play key roles in human physiology and they have been implicated in a large number of neuromuscular, endocrine, cardiac and metabolic diseases. They are also major drug targets, accounting for more than 50% of the currently available drugs on the market. Several new and medically important structures of transporters, channels and signalling complexes will be presented at this GRC. We will also discuss the latest scientific progress in understanding the fundamental principles of their action, such as proton and substrate coupling in transport, gating mechanisms of channels, and the formation of different signalling complexes. We will also present techniques that can be applied to study the mechanism of these membrane proteins. Finally, we will get updates on their roles in human physiology and their exploitation as drug targets.

All participants are asked to submit abstracts and bring posters, from which we will select additional speakers for short talks. A Gordon Research Seminar (GRS) will precede the GRC and will provide young scientists with an opportunity to present their work and to meet experienced scientists in an informal setting. We strongly encourage graduate students and post-doctoral fellows to apply to the GRS and to stay for the GRC. We would also like to invite scientists from industry, as the membrane proteins discussed at this GRC/GRS are major drug targets. We would like to encourage minorities and people with disabilities to apply. We are trying to secure funding to support in part those with financial constraints.

Related Meeting

This GRC will be held in conjunction with the "Ligand Recognition and Molecular Gating" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.


Gordon Research Conferences
Actelion Pharmaceuticals Ltd.
Heptares Therapeutics
Avanti Polar Lipids, Inc.

Preliminary Program

The topics and speakers for the conference sessions are displayed below (italics denote discussion leaders). The Conference Chair is currently developing their detailed program, which will include the complete meeting schedule, as well as the talk titles for all speakers. The detailed program will be available by November 4, 2017. Please check back for updates.

  • New Membrane Protein Structures
    (Edmund Kunji / Eric Gouaux / Kaspar Locher / Nieng Yan / Randy Stockbridge)
  • Mechanistic Studies
    (Kaspar Locher / Lucy Forrest / Daniel Mueller / Simon Scheuring / Janice Robertson)
  • G-Protein Coupled Receptor-Mediated Signalling
    (Chris Tate / Brian Kobilka / Daniel Oprian / Patrick Sexton / Roger Sunahara / Ali Jazayeri)
  • Cation Channels
    (Poul Nissen / Henry Colecraft / Richard Hite / Crina Nimigean / Bonnie Wallace / Ming Zhou / Liz Carpenter)
  • Primary Active Transporters
    (Susan Buchanan / Poul Nissen / John Walker / Zhe Zhang)
  • Channel Diversity
    (Nieng Yan / Raimund Dutzler / Mei Hong / Cristina Paulino / Jian Yang / Irina Serysheva)
  • Physiology and Pharmacology
    (Dirk Jan Slotboom / Lily Jan / Amy Newman)
  • Secondary Active Transporters
    (Liz Carpenter / David Drew / H. Ronald Kaback / Hartmut Luecke)
  • Selected Poster Presentations
    (Alessio Accardi)
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