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Lipoprotein Metabolism
Gordon Research Conference

Lipid and Lipoprotein Metabolism in Chronic Disease Pathogenesis and Treatment

Dates

June 12-17, 2016

Location

Waterville Valley
Waterville Valley, NH

Organizers

Chair:
John S. Parks

Vice Chairs:
Alan Remaley & Cheryl Wellington

Meeting Description

The Lipoprotein Metabolism GRC is one of the longest standing conferences in the 85 year history of the GRC. The program for the 2016 Lipoprotein Metabolism Conference will communicate new and exciting advances in the field and will bring together a range of established investigators, new investigators, and trainees from around the world to present and discuss a range of topics related to new developments in lipid and lipoprotein metabolism, particularly in those areas that impact chronic human diseases, such as coronary heart disease, diabetes, Alzheimer’s, and hepatosteatosis. Basic molecular and cell biological studies, animal models of metabolism, human genetic studies, and emerging therapeutics will be presented and discussed. Topics include: 1) Lipid transport and catabolism, 2) Liver and intestinal lipid/lipoprotein metabolism, 3) Keynote Address on lipoprotein metabolism and coronary heart disease by a world-renowned National Academy of Science member, 4) In vivo physiology of lipid metabolism, 5) Lipoproteins and the vascular wall, 6) HDL function, 7) Genetics of lipid/lipoprotein metabolism, 8) Therapeutics for cardiovascular and neurodegenerative diseases, and 9) Intracellular lipid metabolism. In addition to outstanding leading-edge lectures and discussion, poster presentations represent an integral part of the scientific program. Additional oral session presentations from young investigators (students, postdoctoral fellows, and junior faculty) will be selected from among submitted abstracts.

Related Meeting

This GRC was held in conjunction with the "Lipoprotein Metabolism" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Structure and Functional Role of ABCG5 and ABCG8 in Health and Disease
Discussion Leader: Russell Debose-Boyd (University of Texas Southwestern Medical Center, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:00 pmSelected from Poster Abstracts: Phillip Gordts (University of California, San Diego, USA)
"ApoC-III Modulates Clearance of Triglyceride-Rich Lipoproteins in Mice Through Low Density Lipoprotein Family Receptors"
8:00 pm - 8:05 pmDiscussion
8:05 pm - 8:15 pmSelected from Poster Abstracts: Scott Gordon (National Heart, Lung, and Blood Institute, NIH, USA)
"A High Density Lipoprotein Proteome Index Correlates with Cardiovascular Disease Severity in Humans"
8:15 pm - 8:20 pmDiscussion
8:20 pm - 9:20 pmHelen Hobbs (University of Texas Southwestern Medical Center, USA)
"Structure and Functional Role of ABCG5 and ABCG8 in Health and Disease"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLipoproteins and the Vascular Wall
Discussion Leader: Cheryl Wellington (The University of British Columbia, Canada)
9:00 am - 9:25 amYury Miller (University of California, San Diego, USA)
"Cholesterol and Oxidized Lipid Regulation of TLR4 Signaling"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amArnold von Eckardstein (University of Zurich, Switzerland)
"Transendothelial Transport of HDL"
10:00 am - 10:10 amDiscussion
10:10 am - 10:35 amKathryn Moore (New York University Medical Center, USA)
"Non-Coding RNA Regulation of Lipoprotein Metabolism"
10:35 am - 10:45 amDiscussion
10:45 am - 11:15 amGroup Photo / Coffee Break
11:15 am - 11:40 amMarco Van Der Stoep (Leiden Academic Centre for Drug Research, Leiden University, The Netherlands)
"Lipoproteins, Platelets and Thrombosis"
11:40 am - 11:50 amDiscussion
11:50 am - 12:15 pmJoachim Herz (University of Texas Southwestern Medical Center, USA)
"Vascular Biology of apoE Receptors"
12:15 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLipid Transport and Catabolism
Discussion Leader: Rosalind Coleman (University of North Carolina at Chapel Hill, USA)
7:30 pm - 7:55 pmStephen Young (University of California, Los Angeles, USA)
"GPIHBP1 and Plasma Triglyceride Lipolysis"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmRenate Schreiber (University of Graz, Austria)
"ATGL and Triglyceride Mobilization"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmIra Goldberg (NYU Langone Medical Center, USA)
"Roles of CD36 and LPL in Cellular Fatty Acid Uptake"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIn Vivo Physiology of Lipid Metabolism
Discussion Leader: Ira Goldberg (NYU Langone Medical Center, USA)
9:00 am - 9:25 amTimothy Osborne (Sanford Burnham Prebys Medical Discovery Institute, USA)
"Regulation of Lipid Metabolism by SREBP"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amKaren Reue (University of California, Los Angeles, USA)
"The Lipin Protein Family and Triglyceride Metabolism in Diverse Tissues"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amCoffee Break
10:30 am - 10:55 amSudha Biddinger (Boston Children's Hospital, USA)
"Novel Players in Diabetes-Associated Cardiovascular Disease"
10:55 am - 11:05 amDiscussion
11:05 am - 11:30 amRebecca Haeusler (Columbia University, USA)
"Regulation of Lipid and Glucose Metabolism by Hepatic FoxOs"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmRobert Farese (Harvard Medical School, USA)
"Cell Biology of Lipid Droplets"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Xin Bi (University of Pennsylvania, USA)
"C6orf106 Is a Novel Regulator of Lipoprotein Metabolism"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLiver and Intestinal Lipid/Lipoprotein Metabolism
Discussion Leader: Nancy Webb (University of Kentucky, USA)
7:30 pm - 7:50 pmMahmood Hussain (SUNY Downstate Medical Center, USA)
"Regulation of Intestinal Lipid Absorption"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmRosalind Coleman (University of North Carolina at Chapel Hill, USA)
"Acyl-CoA Synthetases and Lipid Compartmentalization"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmAnn-Hwee Lee (Weill Cornell Medical College, USA)
"CREBH-FGF21 Axis Improves Hepatic Steatosis by Suppressing Adipose Tissue Lipolysis"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmKhosrow Adeli (Hospital for Sick Children, Canada)
"CNS Control of Intestinal Lipoprotein Metabolism: Implications in Diabetic Dyslipidemia"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHDL Metabolism
Discussion Leader: Daniel Rader (Perelman School of Medicine, University of Pennsylvania, USA)
9:00 am - 9:25 amDaisy Sahoo (Medical College of Wisconsin, USA)
"Understanding SR-BI-Mediated Cholesterol Transport - One 'Segment' at a Time"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amNancy Webb (University of Kentucky, USA)
"Serum Amyloid A in Modern Chronic Inflammatory Disease: An Ancient Acute Phase Reactant Gone Rogue?"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amCoffee Break
10:30 am - 10:55 amFrank Sacks (Harvard T.H. Chan School of Public Health, USA)
"HDL Protein-Based Subspecies: Relation to HDL Metabolism and Cardiovascular Disease"
10:55 am - 11:05 amDiscussion
11:05 am - 11:30 amRussell Debose-Boyd (University of Texas Southwestern Medical Center, USA)
"Mechanisms Through Which Nonsterol Isoprenoids Modulate HMG CoA Reductase Degradation"
11:30 am - 11:40 amDiscussion
11:40 am - 11:50 amSelected from Poster Abstracts: Menno Hoekstra (Leiden Academic Centre for Drug Research, The Netherlands)
"Scavenger Receptor BI (SR-BI) Deficiency Uncouples Obesity from Glucose Intolerance in Mice"
11:50 am - 11:55 amDiscussion
11:55 am - 12:05 pmSelected from Poster Abstracts: Li-Hao Huang (Washington University in St. Louis School of Medicine, USA)
"Novel Approaches to Study Cholesterol Removal from Tissues"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmGenetics of Lipid/Lipoprotein Metabolism
Discussion Leader: Karen Reue (University of California, Los Angeles, USA)
7:30 pm - 8:00 pmKiran Musunuru (University of Pennsylvania, USA)
"Therapeutic Targeting of Human Lipid Genes with In Vivo CRISPR-Cas9 Genome Editing"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmRuth Frikke-Schmidt (Rigshospitalet, Copenhagen University Hospital, Denmark)
"Crossroad Between Dementia and Cardiovascular Disease - Shared Genes of Lipid Metabolism"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmDaniel Rader (Perelman School of Medicine, University of Pennsylvania, USA)
"New Pathways in Lipid Metabolism Revealed Through Human Genetics"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIntracellular Lipid Metabolism
Discussion Leader: Ryan Temel (University of Kentucky, USA)
9:00 am - 9:25 amSarah Cohen (National Institute of Child Health and Human Development, NIH, USA)
"Organelle Dynamics and Fatty Acid Trafficking"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amGad Asher (Weizmann Institute of Science, Israel)
"Around the Clock Lipidomics: Insight into Circadian Oscillations of Lipids in Subcellular Compartments"
10:00 am - 10:10 amDiscussion
10:10 am - 10:30 amCoffee Break
10:30 am - 10:55 amDaniel Ory (Washington University in St. Louis, USA)
"Regulation of Cholesterol Trafficking by snoRNA U17"
10:55 am - 11:05 amDiscussion
11:05 am - 11:15 amSelected from Poster Abstracts: Prakrit Jena (Memorial Sloan Kettering Cancer Center, USA)
"Non-Invasive Optical Detection of Lysosomal Lipid Accumulation In Vitro and In Vivo"
11:15 am - 11:20 amDiscussion
11:20 am - 11:30 amSelected from Poster Abstracts: Jessica Otis (Carnegie Institution for Science, USA)
"ApoA-I Localizes to the Endosomal/Lysosomal Transport System in the Liver and Intestine of Live Zebrafish"
11:30 am - 11:35 amDiscussion
11:35 am - 11:45 amSelected from Poster Abstracts: Liye Zhou (SUNY Downstate Medical Center, USA)
"MiR-1200 Differentially Modulates Plasma LDL and HDL-Cholesterol Levels to Reduce Hyperlipidemia and Atherosclerosis in Mice"
11:45 am - 11:50 amDiscussion
11:50 am - 12:00 pmSelected from Poster Abstracts: Claudio Villanueva (University of Utah School of Medicine, USA)
"Global Analysis of Plasma Lipids Identifies Liver-Derived Acyl-Carnitines as a Fuel Source for Brown Fat Thermogenesis"
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:15 pmSelected from Poster Abstracts: Jerome Robert (University of British Columbia, Canada)
"High-Density Lipoproteins Reduce Amyloid-Beta-Deposition in a Novel In Vitro Model of the Human Brain Vasculature"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmTherapeutics for Cardiovascular and Neurodegenerative Diseases
Discussion Leader: Alan Remaley (National Institutes of Health, USA)
5:30 pm - 5:50 pmDaniel Michaelson (Tel Aviv University, Israel)
"ABCA1 Directed Treatment of ApoE4 Driven Neurodegeneration in Alzheimer's Disease"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmDouglas Johns (Merck Research Laboratories, USA)
"Effects of CETP Inhibition on Lipoprotein Metabolism"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmGayathri Ramaswamy (Pfizer Neuroscience Research Unit, USA)
"Novel Mechanism for Regulating Astrocytic Apolipoprotein E"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmThomas Beyer (Eli Lilly and Company, USA)
"Increased Duration of LDL-C Reduction by a PCSK9 Antibody Which Allows Antigen Cleavage"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13HL132403-01 from the National Institutes of Health. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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