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Environmental Endocrine Disruptors
Gordon Research Conference

The Next Generation of Endocrine Disruption: Emerging Contaminants, Tools and Research Approaches for Assessing Multigenerational Effects

Dates

June 19-24, 2016

Location

Grand Summit Hotel at Sunday River
Newry, ME

Organizers

Chair:
Heather B. Patisaul

Vice Chairs:
Daniel Zalko & Jerrold J. Heindel

Meeting Description

2016 is a landmark year for the endocrine disruption (EDC) field. It is the 25th anniversary of the Wingspread Conference on environmental endocrine disruption, the meeting which first codified the concept of endocrine disruption and comprehensively described how environmental chemicals could modulate the endocrine system and produce long term consequences in wildlife and humans. It is also the 20th anniversary of Our Stolen Future, the bellwether book that drew widespread attention to the endocrine disruption field and the potential for multi-generational impacts. The Environmental Endocrine Disruptors Gordon Research Conference (EED-GRC) will also celebrate its own 10th anniversary in 2016. The 2016 EED-GRC will mark these collective milestones by focusing on the next generation of questions, chemicals, tools, approaches, challenges, investigative strategies and EDC-related effects. Featured themes include understanding inter-individual sensitivity, mechanisms of transgenerational inheritance, and emerging chemicals of concern. A primary goal of this meeting is to feature new investigators, new technology, and new areas of concern, including potential effects on pollinators. An associated Gordon Research Seminar (GRS) will be held in conjunction, led and organized by trainees, and featuring work in the area of genes, genetics and genomics. Focusing on emerging ideas and transformative approaches will be a unifying basis from which participants working on every level from molecule to man can converge and discuss the past, present and future of the EDC field.

Related Meeting

This GRC was held in conjunction with the "Environmental Endocrine Disruptors" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Our Stolen Future? Reflections on the Past, Present and Future of EDC Research
Reflections on the past, present and future of EDC research as the EED-GRC Celebrates its 10th anniversary.
Discussion Leader: Heather Patisaul (North Carolina State University, USA)
7:40 pm - 8:10 pmJerrold Heindel (National Institute of Environmental Health Sciences, NIH, USA)
"Endocrine Disruption: History and Reflections"
8:10 pm - 8:25 pmDiscussion
8:25 pm - 9:15 pmMelissa Perry (George Washington University, USA)
"The New EDC Frontier: What Is Known About the Endocrine Disrupting Properties of Neonicotinoid Pesticides?"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEvidence for and Mechanisms of Transgenerational Inheritance of EDC Effects
Discussion Leaders: Vasantha Padmanabhan (University of Michigan, USA) and David Crews (University of Texas at Austin, USA)
9:00 am - 9:30 amPiroska Szabo (Van Andel Institute, USA)
"Germline Epigenetic Remodeling and Endocrine Disruptors"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amJodi Flaws (University of Illinois, USA)
"Effects of Endocrine Disrupting Chemicals on Female Reproduction"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amFolami Ideraabdullah (University of North Carolina at Chapel Hill, USA)
"Use of Mouse Models to Identify and Characterize Gene-Epigenome Interactions that Influence Epigenetic Stability and Inheritance"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmPatrick Allard (University of California, Los Angeles, USA)
"Multi-Model Approaches for the Investigation of Epigenetic and Transgenerational Effects"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Heather Stapleton (Duke University, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEDC Impacts on the Global Community
Discussion Leaders: Joe Braun (Brown University, USA) and Jane Muncke (Food Packaging Forum Foundation, Switzerland)
7:30 pm - 8:00 pmLeonardo Trasande (New York University School of Medicine, USA)
"Health and Economic Costs of Endocrine Disrupting Chemical Exposures"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmDavid Aylor (North Carolina State University, USA)
"Genetic Susceptibility to Diethylstilbestrol (DES) Exposure in Mice"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmFrank von Hippel (Northern Arizona University, USA)
"Protecting the Health of Future Generations: Assessing and Preventing Exposures to Endocrine Disrupting Chemicals in Two Alaska Native Arctic Communities on St. Lawrence Island"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNeural and Behavioral Impacts
Discussion Leaders: Andrea Gore (University of Texas at Austin, USA) and Thaddeus Schug (National Institute of Environmental Health Sciences, NIH, USA)
9:00 am - 9:30 amDeborah Kurrasch (University of Calgary, Canada)
"Hormone Control of Neural Progenitors During Embryonic Brain Development, and Interference by EDCs"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amValerie Hu (George Washington University, USA)
"An Integrative Genomics Approach Towards Understanding Sex Bias and Gene-Environment Interactions in Autism"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amJoe Braun (Brown University, USA)
"Neurotoxicity of Endocrine Disrupting Chemicals: Beyond BPA and the Prenatal Window"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmRoss Gillette (The University of Texas at Austin, USA)
"The Effects of Low Dose Fetal PCB Exposure on Social and Anxiety Behavior and Gene Expression in the Stress Neural Circuit of Male and Female Rats"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLate-Breaking Topics
Discussion Leaders: Folami Ideraabdullah (University of North Carolina at Chapel Hill, USA) and Scott Belcher (North Carolina State University, USA)
7:30 pm - 7:50 pmChristopher Kassotis (Duke University, USA)
"Characterization of Potential Obesogens In Vitro and Implications for Reproducibility"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmJustin Conley (U.S. Environmental Protection Agency, USA)
"EDC Mixtures: Synergy or Dose Additivity"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 9:15 pmSheldon Krimsky (Tufts University, USA)
"The Legacy of Wingspread '91 on Science, Policy, and the Media"
9:15 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmEndocrine Disruption of Cellular Energy Balance and Metabolism
Discussion Leaders: Daniel Zalko (INRA, France) and Ana Soto (Tufts University, USA)
9:00 am - 9:30 amRobert Sargis (University of Chicago, USA)
"Metabolic Disruption by the Phenylsulfamide Fungicide Tolylfluanid"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amAndrea Baccarelli (Columbia University Mailman School of Public Health, USA)
"Environmental Mitochondriomics: Missing Link Between Environmental Exposures and Disease?"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amPaloma Alonso-Magdalena (Universidad Miguel Hern√°ndez de Elche, Spain)
"The Diabesogenic Behaviour of Endocrine Disruptor Chemicals: Windows of Susceptibility"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmFabien Jourdan (TOXALIM Research Centre in Food Toxicology, INRA, France)
"Metabolic Network Modeling: Assessing and Deciphering the Modulatory Impact of EDC on Metabolism"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmAssessing the Risks: New Directions in EDC Assessment and Public Policy
Discussion Leaders: Carol Kwiatkowski (TEDX - The Endocrine Disruption Exchange, USA) and Patience Browne (U.S. Environmental Protection Agency, USA)
7:30 pm - 8:00 pmRussell Thomas (U.S. Environmental Protection Agency, USA)
"Developments in the EPA Computational Toxicology Program to Identify Environmental Endocrine Disruptors"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmDouglas Bell (National Institute of Environmental Health Sciences, NIH, USA)
"Integrating Data from 1000 Genomes Project, GWAS, ENCODE and eQTL Databases to Explore the Functional Link Between Genetic Variation and Endocrine Associated Diseases"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmTracey Woodruff (University of California, San Francisco, USA)
"How to Make Science Matter in the Real World"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSurveying the Landscape: Emerging EDCs
Discussion Leaders: Jerrold Heindel (National Institute of Environmental Health Sciences, NIH, USA) and Suzanne Fenton (National Toxicology Program, National Institute of Environmental Health Sciences, NIH, USA)
9:00 am - 9:30 amSusan Nagel (University of Missouri, USA)
"Health Effects After Developmental Exposure to a Mixture of Chemicals Associated with Oil and Gas Extraction"
9:30 am - 9:45 amDiscussion
9:45 am - 10:15 amKim Anderson (Oregon State University, USA)
"Bridging Passive Sampling Technology to Measure External Chemical Mixtures"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amHeather Stapleton (Duke University, USA)
"Brominated Flame Retardants in Placenta Tissues and Associations with Thyroid Deiodinase and Sulfotransferase Activities"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmSagi Gillera (National Institute of Environmental Health Sciences, NIH, USA)
"Latent Health Outcomes Following TBBPA Developmental Exposures: Focus on Female Reproductive Tissues"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmKeynote Session: Our Reclaimed Future? Precedents and Priorities
Discussion Leader: Ann Petersen (Oregon State University, USA)
5:30 pm - 6:15 pmFrederica Perera (Columbia University, USA)
"The Role of Endocrine Disruptors in Children's Heath and Development"
6:15 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmMegan Romano (Brown University School of Public Health, USA)
"Variability and Predictors of Urinary Concentrations of Replacement Flame Retardants Among Pregnant Women in Rhode Island"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmTegan Horan (Washington State University, USA)
"The Kids Are (Not) Alright: Multiple Generational Estrogen Exposures Disrupt Meiosis and Reproductive Tract Morphology in Male Mice"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1 R13 ES 026865 - 01 from the National Institute of Environmental Health Sciences. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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