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Synaptic Transmission
Gordon Research Conference

From Nanostructures to Microcircuits in Health and Disease

Dates

August 14-19, 2016

Location

Waterville Valley
Waterville Valley, NH

Organizers

Chair:
Ege Kavalali

Vice Chair:
Kristen M. Harris

Meeting Description

Synapses are the main sites of communication in the nervous system and are also critically involved in several major brain diseases. The conference aims to increase our understanding of the fundamental molecular and cellular mechanisms of synaptic transmission, to elucidate how synaptic transmission shapes neuronal network activity, and to link basic science on synapses to disease aspects. Several brain diseases, such as neurodegenerative diseases, mood disorders, schizophrenia, addiction and autism spectrum disorders, are emerging as synaptopathies, but the precise mechanisms are unknown. We will bring together a group of scientists who all are highly interested in synaptic function, but examine synapses at multiple levels, look at them from distinct perspectives, and use different approaches (molecular biology, super resolution imaging, electron microscopy, optogenetics, subcellular electrophysiology and many others). The program will have two keynote lectures in a session entitled "Synaptic transmission: From nanostructures to microcircuits" and eight sessions that address aspects of synaptic signaling, including mechanisms of presynaptic function, postsynaptic function, presynaptic as well as postsynaptic forms of plasticity, synaptic circuits, synaptic diseases, synapse development and synapse evolution. The conference will bring together a diverse group of investigators who are at the forefront of their field, and will provide ample opportunities for junior scientists to present their work. Furthermore, some poster presenters will be selected for short talks. The Gordon Research Seminar (GRS) directly preceding the GRC will make this meeting particularly attractive for graduate students, enabling them to directly exchange ideas with world-class leading scientists. Past participants have lauded this GRC for the uniquely high quality of unpublished data being presented and for the collegial and interactive atmosphere where scientists at all levels felt welcome to join in the discussion of most recent advances in the field.

Related Meeting

This GRC was held in conjunction with the "Synaptic Transmission" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Synaptic Transmission: From Nanostructures to Microcircuits
Discussion Leader: Ege Kavalali (University of Texas Southwestern Medical Center, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:30 pmAlexander M. Cruickshank Lecture: Xiaowei Zhuang (Harvard University / Howard Hughes Medical Institute, USA)
"Illuminating Neurobiology with Super-Resolution Imaging, from Sub-Neuronal Structures to Neural Circuits"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:20 pmCornelia Bargmann (Rockefeller University, USA)
"Bridging Timescales with Synaptic Transmission"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPresynaptic Structure and Mechanisms
Discussion Leader: Erwin Neher (Max Planck Institute for Biophysical Chemistry, Germany)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amKatalin Toth (Laval University, Canada)
"What Triggers the Detonator? Presynaptic Mechanisms of Synaptic Facilitation at Hippocampal Mossy Fibre Terminals"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amVladan Lucic (Max Planck Institute for Biochemistry, Germany)
"A Detailed Look at Synaptic Structure"
9:55 am - 10:05 amDiscussion
10:05 am - 10:25 amAxel Brunger (Stanford University, USA)
"How Do SNAREs, Synaptotagmin, and Complexin Cooperate in Calcium-Triggered Synaptic Vesicle Fusion?"
10:25 am - 10:35 amDiscussion
10:35 am - 11:15 amGroup Photo / Coffee Break
11:15 am - 11:35 amLu-Yang Wang (SickKids Research Institute / University of Toronto, Canada)
"The Underpinnings of Synaptic Heterogeneity at a Central Synapse"
11:35 am - 11:45 amDiscussion
11:45 am - 12:05 pmDavid Zenisek (Yale University School of Medicine, USA)
"Ribeye and Ribbon Synapses: Does Structure Predict Physiology?"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmVitaly Klyachko (Washington University in St. Louis, USA)
"Spatio-Temporal Regulation of Release Sites in Central Synapses"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Kristen Harris (University of Texas at Austin, USA), Indira Raman (Northwestern University, USA) and Alison Barth (Carnegie Mellon University, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPresynaptic Plasticity
Discussion Leader: Thomas Sudhof (Stanford University, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmAlain Marty (CNRS, France)
"Studying Vesicular Release in Single Synapses"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmYishi Jin (University of California, San Diego, USA)
"New Insights into Synaptic Transmission in C. elegans"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmDavid Sulzer (Columbia University Medical School, USA)
"Synaptic Selection in Dopamine Axons"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmJianyuan Sun (Institute of Biophysics, Chinese Academy of Sciences, China)
"Neuronal Signaling at Single Active Zones"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmRichard Cho (Massachusetts Institute of Technology, USA)
"ADAR-Dependent RNA Editing of Complexin Regulates Activity-Dependent Miniature Neurotransmission and Structural Synaptic Plasticity"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPostsynaptic Structure and Mechanisms
Discussion Leader: Robert Malenka (Stanford University School of Medicine, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amThomas Blanpied (University of Maryland School of Medicine, USA)
"Nanoscale Functional Organization of Single Synapses"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amThomas Biederer (Tufts University, USA)
"Topography and Dynamics of the Synaptic Cleft"
9:55 am - 10:05 amDiscussion
10:05 am - 10:15 amAlison Barth (Carnegie Mellon University, USA)
"State-Dependent Reconfiguration of Synaptic Circuits in the Neocortex"
10:15 am - 10:20 amDiscussion
10:20 am - 11:00 amCoffee Break
11:00 am - 11:20 amPablo Castillo (Albert Einstein College of Medicine, USA)
"Presynaptic Protein Synthesis in Long-Term Plasticity"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amKimberly Huber (University of Texas Southwestern Medical Center, USA)
"MEF2 Transcription Factors, Synapse Development and Plasticity"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmKenneth Kosik (University of California, Santa Barbara, USA)
"Matching Local Translation and Synapse Number"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPostsynaptic Plasticity
Discussion Leader: Julie Kauer (Brown University, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmInna Slutsky (Tel Aviv University, Israel)
"IGF-1 Receptor: From Synaptic Transmission to Alzheimer's Degeneration"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmGina Turrigiano (Brandeis University, USA)
"Pharmacological Rescue of Synaptic Scaling in 'Shankopathies'"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmMarina Wolf (Rosalind Franklin University of Medicine and Science, USA)
"Synaptic Mechanisms Underlying the Persistence of Drug Craving"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:25 pmHenrique Von Gersdorff (Vollum Institute, USA)
"Postsynaptic Plasticity in the Retina Mediated by via Ca2-Permeable AMPA Receptors"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSynaptic Circuits
Discussion Leader: Kimberly Huber (University of Texas Southwestern Medical Center, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amHaruhiko Bito (University of Tokyo Graduate School of Medicine, Japan)
"lIluminating Activity-Dependent Signaling and Circuits"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amLu Chen (Stanford University, USA)
"Retinoic Acid Signaling and Synaptic Metaplasticity"
9:55 am - 10:05 amDiscussion
10:05 am - 10:30 amCoffee Break
10:30 am - 10:50 amRichard Tsien (New York University School of Medicine, USA)
"Synaptic Ca2+ Influx Pathways: Partners in Plasticity"
10:50 am - 11:00 amDiscussion
11:00 am - 11:20 amMin Zhuo (University of Toronto, Canada)
"Cortical Potentiation for Pain and Anxiety"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amLi-Huei Tsai (Picower Institute for Learning and Memory, Massachusetts Institute of Technology, USA)
"Next Generation Whole Brain Imaging Reveals Synaptically Connected Subcortical Structures in the Vulnerability of Neurodegeneration"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmIlya Bezprozvanny (University of Texas Southwestern Medical Center, USA)
"Neuronal Store Operated Calcium Entry as Novel Therapeutic Target for Treatment of Alzheimer's Disease"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmNicole Calakos (Duke University Medical Center, USA)
"Striatal Circuit-Level Plasticity Mechanisms in Habit and Compulsion"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmSynaptic Circuits and Plasticity
Discussion Leader: Kristen Harris (University of Texas at Austin, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmIndira Raman (Northwestern University, USA)
"Inhibition and Excitation in the Mouse Cerebellar Nuclei"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:45 pmThomas Sudhof (Stanford University, USA)
"Towards a Molecular Logic of Neural Circuits"
8:45 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmJulie Kauer (Brown University, USA)
"Potentiation of Glycinergic Synapses"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSynapse Development
Discussion Leader: Erik Jorgensen (Howard Hughes Medical Institute / University of Utah, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:25 amVivian Budnik (University of Massachusetts Medical School, USA)
"Trans-Synaptic Signaling Through Exosomes"
9:25 am - 9:35 amDiscussion
9:35 am - 9:55 amChinfei Chen (Boston Children's Hospital, Harvard Medical School, USA)
"A Role for Cortical Feedback in Feedforward Refinement"
9:55 am - 10:05 amDiscussion
10:05 am - 10:15 amPeri Kurshan (Stanford University, USA)
"How Are New Synapses Added to Existing Circuits? Diverse Roles for Two Cell Adhesion Molecules"
10:15 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:10 amCagla Eroglu (Duke University Medical Center, USA)
"Control of Synaptic Connectivity by Glia"
11:10 am - 11:20 amDiscussion
11:20 am - 11:40 amKaren Zito (University of California, Davis, USA)
"Mechanisms of Spine Structural Plasticity During Excitatory Synapse Development"
11:40 am - 11:50 amDiscussion
11:50 am - 12:00 pmIsabel Llano (CNRS, France)
"Parallel Fiber Mediated Intracellular Calcium Rises in Cerebellar Molecular Layer Interneurons In Vivo"
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:15 pmLarry Trussell (Oregon Hearing Research Center, Oregon Health and Science University / Vollum Institute, USA)
"A Slow AMPAR-Mediated EPSC Mediated by 'Desensitized' Receptors"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmSynaptic Transmission: New Perspectives
Discussion Leader: Richard Tsien (New York University School of Medicine, USA)
5:30 pm - 5:35 pmIntroduction by Discussion Leader
5:35 pm - 5:55 pmLeonid Moroz (University of Florida, USA)
"How Many Time Synapses Evolved? Early Origins and Convergent Evolution of Synapses"
5:55 pm - 6:05 pmDiscussion
6:05 pm - 6:25 pmErik Jorgensen (Howard Hughes Medical Institute / University of Utah, USA)
"Ultrafast Endocytosis: An Evolutionary Perspective"
6:25 pm - 6:35 pmDiscussion
6:35 pm - 6:45 pmStefan Hallermann (Leipzig University, Germany)
"Fast, Temperature-Sensitive and Clathrin-Independent Endocytosis at Central Synapses"
6:45 pm - 6:50 pmDiscussion
6:50 pm - 7:00 pmJada Vaden (University of Alabama at Birmingham, USA)
"Regulation of Multivesicular Release by cAMP-Dependent Signaling"
7:00 pm - 7:05 pmDiscussion
7:05 pm - 7:15 pmJason Shepherd (University of Utah, USA)
"Arc - Building a Bridge from Viruses to Memory"
7:15 pm - 7:20 pmDiscussion
7:20 pm - 7:30 pmClosing Remarks
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS096779. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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