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Molecular Basis of Microbial One-Carbon Metabolism
Gordon Research Conference

Exploring, Understanding and Applying the Diversity of One-Carbon Metabolism

Dates

July 31 - August 5, 2016

Location

Waterville Valley
Waterville Valley, NH

Organizers

Chair:
Stephane Vuilleumier

Vice Chair:
Victoria J. Orphan

Meeting Description

Metabolism of one-carbon (C1) compounds is shared by all living organisms today, yet microorganisms growing on one-carbon compounds established C1 metabolism as a major driver of global elemental cycles in the biosphere. Microbial C1 metabolism involves transformations of key molecules such as methane, methanol, formic acid, and carbon dioxide; metabolic intermediates including formaldehyde and corrinoid and tetrahydrofolate derivatives; and organic compounds without carbon-carbon bonds, such as methylated amines and dimethyl sulfide. Several of these molecules (in particular methane) are important energy sources, some (e.g. carbon dioxide and methane) are potent greenhouse gases, and others (e.g. chlorinated methanes, carbon monoxide, and methanethiol) are toxic chemicals, produced and used naturally and industrially in large quantities.

The conference will highlight the most recent research on all aspects of microbial one-carbon metabolism, spanning natural and synthetic systems, under oxic and anoxic conditions, and at scales from molecules to ecosystems. It will feature the wide-ranging metabolic diversity of autotrophic microbes, methanogens, acetogens, methylotrophs and methanotrophs. Complementary cross-disciplinary perspectives on C1 metabolism from microbiology, biochemistry, molecular biology, structural biology, microbial ecology, and systems and synthetic biology will be provided. Innovative applications of C1 metabolism for production of biofuels and high added value chemicals, as well as for remediation of environmental contamination, will be presented.

As in previous editions of this long-running meeting, the 2016 conference, with its associated GRS, will bring together junior and senior investigators from the open and vibrant research C1 community. The time-proven GRC format, with extensive discussions, interactive poster sessions, and informal gatherings in the afternoons and evenings, will provide an ideal setting for researchers from different fields and generations, to exchange ideas, brainstorm, and discuss opportunities for collaboration.

Related Meeting

This GRC was held in conjunction with the "Molecular Basis of Microbial One-Carbon Metabolism" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmStructure and Mechanism in C1 Enzymes
Discussion Leader: Stephen Ragsdale (University of Michigan Medical School, USA)
7:40 pm - 7:55 pmIntroduction by Discussion Leader
7:55 pm - 8:20 pmRolf Thauer (Max-Planck-Institute for Terrestrial Microbiology, Germany)
"Function and Structure of an Electron-Bifurcating Transhydrogenase Involved in Acetogenesis from CO2"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmJohn Peters (Montana State University, USA)
"New Insights into the Mechanism of Electron Bifurcating NADH-Dependent Reduced Ferredoxin:NADP Oxidoreductase"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmCatherine Drennan (Massachusetts Institute of Technology, USA)
"Capturing Carbon, One Crystallographic Snapshot at a Time"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMicrobial C1 Metabolism in the Environment
Discussion Leader: Harold Drake (University of Bayreuth, Germany)
9:00 am - 9:15 amIntroduction by Discussion Leader
9:15 am - 9:40 amMichael Wagner (University of Vienna, Austria)
"Nitrification 2.0: Growth on Cyanate and Complete Nitrification by One Organism"
9:40 am - 9:50 amDiscussion
9:50 am - 10:15 amMarina Kalyuzhnaya (San Diego State University, USA)
"A Drop of Water in the Desert"
10:15 am - 10:25 amDiscussion
10:25 am - 10:55 amGroup Photo / Coffee Break
10:55 am - 11:15 amJennifer Pratscher (University of East Anglia, United Kingdom)
"Atmospheric Methane Oxidisers and the Soil Methane Sink"
11:15 am - 11:25 amDiscussion
11:25 am - 11:50 amAnne-Marie Delort (Institut de Chimie de Clermont-Ferrand, Université Blaise Pascal, France)
"Microbial C1 Metabolism in Clouds: Potential Impact on Atmospheric Chemistry"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmHang Yu (California Institute of Technology, USA)
"The Mechanism of Direct Interspecies Electron Transfer in Anaerobic Oxidation of Methane"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Lisa Stein (University of Alberta, Canada)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Human C1 Microbiome
Discussion Leader: Michael Rother (Technische Universität Dresden, Germany)
7:30 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:10 pmRuth Schmitz-Streit (University of Kiel, Germany)
"Methanoarchaea as Part of the Human Microbiome: Friends or Foes?"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmEmily Balskus (Harvard University, USA)
"Chemical Discovery in the Human Microbiota"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:00 pmIntroduction by Discussion Leader
9:00 pm - 9:15 pmTristan Wagner (Max Planck Institute for Terrestrial Microbiology, Germany)
"Crystal Structures of Formyl-Methanofuran Dehydrogenase and Heterodisulfide Reductase: Methanogen's Trick to Couple Methane Formation to CO2 Fixation"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNew C1 Reactions, Pathways and Organisms
Discussion Leader: Joseph Krzycki (Ohio State University, USA)
9:00 am - 9:15 amIntroduction by Discussion Leader
9:15 am - 9:40 amIvan Berg (University of Freiburg, Germany)
"Autotrophic CO2 Fixation in Thermophilic Bacteria: Surprising Variations on Old Pathways"
9:40 am - 9:50 amDiscussion
9:50 am - 10:15 amJulia Vorholt (ETH Zurich, Switzerland)
"From C1 to C35 or the Extended Age of Coenzymes"
10:15 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:15 amHiroya Yurimoto (Kyoto University, Japan)
"Methanol Sensing and Signaling Pathway in the Methylotrophic Yeast Pichia pastoris"
11:15 am - 11:25 amDiscussion
11:25 am - 11:50 amThomas Hanson (University of Delaware, USA)
"Insights into the Utilization of Insoluble S(0) to Drive Photosynthetic Growth in Chlorobaculum tepidum"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmXiuzhu Dong (Institute of Microbiology, Chinese Academy of Sciences, China)
"The Archaeal RNA Chaperone TRAM Modulates CO2 Reductive Methanogenesis in Methanococcus maripaludis"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmC1 Microbiology of Climate Change
Discussion Leader: Lisa Stein (University of Alberta, Canada)
7:30 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:10 pmPaul Bodelier (Netherlands Institute of Ecology, The Netherlands)
"An Ecologist's Climate Change Experiments on Microbial C1 Cycling: Controls, Traits and Life Strategies"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmBeth Orcutt (Bigelow Laboratory for Ocean Sciences, USA)
"The Role of Methanotrophs and Methanogens in Methane Flux from Ice-Covered Arctic Lakes"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmPatricia Yager (University of Georgia, USA)
"Melting Ice and Green Oceans: Climate Sensitive Carbon Cycling in the Amundsen Sea Polynya, Antarctica"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmApplications of Microbial C1 Metabolism
Discussion Leader: J. Colin Murrell (University of East Anglia, United Kingdom)
9:00 am - 9:15 amIntroduction by Discussion Leader
9:15 am - 9:40 amMike Manefield (University of New South Wales, Australia)
"Chloroform Respiration by Dehalobacter restrictus UNSWDHB, and Subsequent Dichloromethane Fermentation by a New Kid on the Block"
9:40 am - 9:50 amDiscussion
9:50 am - 10:15 amMarkus Buchhaupt (DECHEMA-Forschungsinstitut (DFI), Germany)
"Methanol-Based Biotechnology - Engineering Methylobacterium extorquens for Production of Dicarboxylic Acids and Terpenes"
10:15 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:15 amAllison Pieja (Mango Materials, USA)
"From Methane to Bioplastic - Challenges of Engineering and Fermentation at Scale"
11:15 am - 11:25 amDiscussion
11:25 am - 11:50 amMichael Koepke (LanzaTech, USA)
"Commercial Scale Production of Low Carbon Fuels and Chemicals from Waste Gases by the Acetogen Clostridium autoethanogenum"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmJung-Kul Lee (Konkuk University, South Korea)
"Hybrid Rational Design of Methane Monooxygenase"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmSpecialized Microbial C1 Metabolism
Discussion Leader: Cornelia Welte (Radboud University Nijmegen, The Netherlands)
7:30 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:10 pmYin Chen (University of Warwick, United Kingdom)
"New Insights on Bacterial Methylated Amine Metabolism - From Ecology to Enzymology"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmHuub Op Den Camp (Radboud University Nijmegen, The Netherlands)
"Methanethiol, a Smelly but Exciting C1 Sulfur Compound"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmGary King (Louisiana State University, USA)
"Carbon Monoxide as Survival Substrate in Water-Stressed Extreme Terrestrial and Extraterrestrial Systems"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEngineering New C1 Metabolisms
Discussion Leader: F. Robert Tabita (Ohio State University, USA)
9:00 am - 9:15 amIntroduction by Discussion Leader
9:15 am - 9:40 amTobias Erb (Max-Planck-Institute for Terrestrial Microbiology, Germany)
"We Do It Our (Path)way - Bringing Inorganic Carbon to Life"
9:40 am - 9:50 amDiscussion
9:50 am - 10:15 amJustin Siegel (University of California, Davis, USA)
"Designing Novel Metabolic Pathways and Integrative Genomic Mining"
10:15 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:20 amJonathan Parquette (Ohio State University, USA)
"Immobilization of RubisCO by Self-Assembled Nanotubes"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amChristopher Marx (University of Idaho, USA)
"Towards Engineering (and Evolving) New C1 Metabolisms: The Good, the Bad, and the Toxic"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmNorma Cecilia Martinez-Gomez (Michigan State University, USA)
"Recycling Rare Earths by Biometallurgy"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmMicrobial C1 Metabolism in Associations
Discussion Leader: Yasuyoshi Sakai (Kyoto University, Japan)
5:30 pm - 5:45 pmIntroduction by Discussion Leader
5:45 pm - 6:10 pmAndreas Brune (Max Planck Institute for Terrestrial Microbiology, Germany)
"Acetogenesis in Termite Guts - Variations on a Theme"
6:10 pm - 6:20 pmDiscussion
6:20 pm - 6:45 pmYahai Lu (Peking University, China)
"Direct Interspecies Electron Transfer in Methanogenic Syntrophy"
6:45 pm - 6:55 pmDiscussion
6:55 pm - 7:20 pmLudmila Chistoserdova (University of Washington, USA)
"Social Life of Microbes: Who Is Eating Methane?"
7:20 pm - 7:30 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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