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Malaria
Gordon Research Conference

The Basic Science of Malaria: A Springboard for New Approaches to Control and Elimination

Dates

July 2-7, 2017

Location

Les Diablerets Conference Center
Les Diablerets, Switzerland Site Information

Organizers

Chair:
Maria Mota

Vice Chair:
Peter D. Crompton

Application Deadline

Applications for this meeting must be submitted by June 4, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

New tools and strategies are needed to accelerate progress toward malaria control and elimination. To successfully meet this challenge we need a clearer understanding of the complex interplay between the Plasmodium parasite, its mosquito vector and the vertebrate host it infects. The 2017 Gordon Research Conference (GRC) on Malaria will focus on the biology of Plasmodium infection at every stage of the parasite's life cycle. To set the stage for a thought-provoking meeting, the program is composed of both malaria and non-malaria scientists at the forefront of their fields. We hope to stimulate innovative ideas and collaborations by providing a forum to discuss cutting edge basic malaria research as well as recent advances in non-malaria fields with potential relevance to malaria. The conference will be preceded by the Malaria Gordon Research Seminar (GRS) from July 1-2, 2017 targeted at graduate students, post-docs and junior scientists.

Related Meeting

This GRC will be held in conjunction with the "Malaria" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Progress and Next Steps in Understanding the Parasite, Vector and Host
This session will be composed by lectures of leaders in the field that will put in perspective the past achievements and present challenges of malaria research, setting the tone for the entire conference and scientific discussions.
Discussion Leader: Maria Mota (Instituto de Medicina Molecular, University of Lisbon, Portugal)
7:40 pm - 7:45 pmIntroduction by Discussion Leader
7:45 pm - 8:05 pmChris Karp (Bill & Melinda Gates Foundation, USA)
"How Understanding Basic Parasite Biology Helps Us to Find New Anti-Malaria Solutions"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:30 pmCarolina Barillas-Mury (National Institutes of Health, USA)
"Can a Pfs47-Based Vaccine Recruit the Mosquito Immune System to Disrupt Malaria Transmission?"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:55 pmFidel Zavala (Johns Hopkins Malaria Research Institute, USA)
"Dissecting Protective Immune Mechanisms Against PE Stages"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmAlan Cowman (Walter and Eliza Hall Institute of Medical Research, Australia)
"Understanding Red Blood Cell Infection and Pathogenicity"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmWithin the Mosquito Vector, Basic Biology
Discussion Leader: Carolina Barillas-Mury (National Institutes of Health, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amAnandasankar Ray (University of California, Riverside, USA)
"Molecular Basis of Insect Olfaction"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amFlaminia Catteruccia (Harvard T.H. Chan School of Public Health, USA)
"Studying Anopheles-Plasmodium Interactions: From Basic Research to Applications for Malaria Control"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amElena Levashina (Max Planck Institute for Infection Biology, Germany)
"Environmental and Genetic Factors in Mosquito Resistance to Plasmodium"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amOliver Billker (Wellcome Trust Sanger Institute, United Kingdom)
"Regulation of Sexual Development in P. berghei"
11:30 am - 11:40 amDiscussion
11:40 am - 11:50 amShort Talk Selected from Poster Abstracts
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk Selected from Poster Abstracts
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmGroup Photo / Lunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmBeyond the Bench of the Plasmodium-Anopheles Interactions
Discussion Leader: Flaminia Catteruccia (Harvard T.H. Chan School of Public Health, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:30 pmDavid Sacks (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Sand Fly Molecules Controlling the Development of Transmissible Infections"
6:30 pm - 6:35 pmDiscussion
6:35 pm - 6:55 pmGeorge Dimopolous (Johns Hopkins Bloomberg School of Public Health, USA)
"Exploring Strategies for Plasmodium Suppression in the Mosquito"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmAlessandra della Torre (Sapienza University of Rome, Italy)
"The Cryptic Genetic Heterogeneity Within Malaria Vectors and Its Impact on Malaria Transmission and Control"
7:20 pm - 7:25 pmDiscussion
7:25 pm - 7:45 pmLate-Breaking Topic
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBasic Biology of the Pre-Erythrocytic Stages
Discussion Leader: Stefan Kappe (Center for Infectious Disease Research, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amLate-Breaking Topic
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amOlivier Silvie (Centre d'Immunologie et des Maladies Infectieuses, France)
"New Insights into Host Cell and Parasite Determinants of Plasmodium Sporozoite Entry into Hepatocytes"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amIan Cockburn (Australian National University, Australia)
"Why Don't We Make Better Antibody and B Cell Responses to the Circumsporozoite Protein?"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amPhotini Sinnis (Johns Hopkins Bloomberg School of Public Health, USA)
"Establishment of Malaria Infection: Transmission Dynamics and Roadblocks"
11:30 am - 11:40 amDiscussion
11:40 am - 11:50 amShort Talk Selected from Poster Abstracts
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk Selected from Poster Abstracts
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmThe Pre-Erythrocytic Stages, Beyond the Bench
Discussion Leader: Photini Sinnis (Johns Hopkins Bloomberg School of Public Health, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:30 pmCharles Rice (The Rockefeller University, USA)
"New Insights into Cell-Specific Innate Immunity"
6:30 pm - 6:35 pmDiscussion
6:35 pm - 6:55 pmStefan Kappe (Center for Infectious Disease Research, USA)
"Preventing Pre-Erythrocytic Malaria Infection"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmElizabeth Winzeler (University of California, San Diego, USA)
"Finding New Compounds that Kill Liver Stage Parasites"
7:20 pm - 7:25 pmDiscussion
7:25 pm - 7:45 pmVolker Heussler (University of Bern, Switzerland)
"Single Cell Biology of EEFs"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMalaria Blood Stage Biology
Discussion Leader: Alan Cowman (Walter and Eliza Hall Institute of Medical Research, Australia)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amJudy Lieberman (Harvard Medical School, USA)
"Killer Lymphocytes Recognize and Kill Blood Stage Falciparum Malaria and Other Protozoan Parasites"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amJohn Harty (University of Iowa, USA)
"Immune Regulation During Blood-Stage Plasmodium-Infection"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amJacquin Niles (Massachusetts Institute of Technology, USA)
"A Functional Genetics Toolkit for Human Malarial Parasites"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amLeann Tilley (University of Melbourne, Australia)
"Mechanisms of Action of and Resistance to Artemisinins"
11:30 am - 11:40 amDiscussion
11:40 am - 12:00 pmWai-Hong Tham (Walter and Eliza Hall Institute of Medical Research, Australia)
"A New Invasion Pathway for Plasmodium vivax Entry into Reticulocytes"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmShort Talk Selected from Poster Abstracts
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmBlood Stage Malaria Biology Moved Forward
Discussion Leader: Wai-Hong Tham (Walter and Eliza Hall Institute of Medical Research, Australia)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:30 pmGalit Alter (Ragon Institute, Harvard Medical School, USA)
"Using Systems Tools to Define Correlates of Humoral Immunity Against Malaria"
6:30 pm - 6:35 pmDiscussion
6:35 pm - 6:55 pmLate-Breaking Topic
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmSimon Draper (Jenner Institute, University of Oxford, United Kingdom)
"Towards a Broadly-Neutralising Vaccine Against the P. falciparum Merozoite"
7:20 pm - 7:25 pmDiscussion
7:25 pm - 7:45 pmLate-Breaking Topic
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmMalaria Is Not Alone: The Role of the Microbiome and Co-Infection in the Vector and Host
Plasmodium parasites infect hosts that are populated with many other microorganisms and are likely to impact each others' development.
Discussion Leader: Peter Crompton (National Institute of Allergy and Infectious Diseases, NIH, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amYasmine Belkaid (National Institute of Allergy and Infectious Diseases, NIH, USA)
"Control of Tissue Immunity and Inflammation by the Microbiota"
9:30 am - 9:40 amDiscussion
9:40 am - 10:00 amNathan Schmidt (University of Tennessee, USA)
"Contributions of the Intestinal Microbiota to Severe Malaria"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amMiguel Soares (Instituto Gulbenkian de Ciencia, Portugal)
"Disease Tolerance as a Defence Strategy Against Malaria"
11:00 am - 11:10 amDiscussion
11:10 am - 11:30 amLate-Breaking Topic
11:30 am - 11:40 amDiscussion
11:40 am - 11:50 amShort Talk Selected from Poster Abstracts
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk Selected from Poster Abstracts
12:10 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmEnabling Tools for Malaria Research
Discussion Leader: Oliver Billker (Wellcome Trust Sanger Institute, United Kingdom)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:30 pmLate-Breaking Topic
6:30 pm - 6:35 pmDiscussion
6:35 pm - 6:55 pmKirsten Hanson (University of Texas at San Antonio, USA)
"Single Cell Profiling of Plasmodium Phenotypic Heterogeneity"
6:55 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmSangeeta Bhatia (Massachusetts Institute of Technology, USA)
"How Bioengineering Can Help Us?"
7:20 pm - 7:25 pmDiscussion
7:25 pm - 7:35 pmShort Talk Selected from Poster Abstracts
7:35 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmGeneral Discussion
7:55 pm - 8:00 pmClosing Remarks
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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