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Barriers of the CNS
Gordon Research Conference

Key Interfaces Between the Nervous System and the Rest of the Body in Health and Disease

Dates

June 19-24, 2016

Location

Colby-Sawyer College
New London, NH

Organizers

Chair:
Robert G. Thorne

Vice Chair:
Britta Engelhardt

Meeting Description

The Barriers of the CNS GRC has been running since 1999 and brings together a truly unique, multidisciplinary group of scientists and clinicians from around the world. The meeting is focused on the structure, function, and regulation of the specialized barriers that exist between the CNS and the bloodstream, alterations to these barriers that occur with disease and injury, as well as the science of crossing or bypassing these barriers for CNS drug delivery. The goal of the Barriers of the CNS GRC is to bring together international experts, junior investigators, postdoctoral fellows and students working at the forefront of the field in a collegial, supportive environment for the purpose of exchanging new ideas and brainstorming novel solutions to existing challenges. The 2016 meeting will present cutting edge research and provide new perspectives on all aspects of CNS barriers science. Concepts surrounding the neurovascular unit and major barrier systems such as the blood-brain barrier, blood-cerebrospinal fluid barriers and blood-retinal barriers will be comprehensively explored in featured talks and daily poster sessions. Specific themes for the meeting will cover the following topics: transport, signaling and junctions at the CNS barriers and beyond; barrier function in stroke, brain trauma, and epilepsy; barrier function in neurodegenerative disease, brain cancer, and drug abuse; immunology of the CNS barriers and related systems; imaging, model systems, and technology; CNS drug delivery and distribution; and new perspectives on the future of the field and academic-industrial partnerships.

The Barriers of the CNS GRC aims to foster interactions between investigators at all career stages and to bring new people and fresh ideas into the field. As such, we are excited to welcome new participants to attend and present their research at the Barriers of the CNS GRC as well as the companion Barriers of CNS GRS that is being organized by Drs. Roosmarijn Vandenbroucke and Holly Johnson. Content from our highly successful GRS, to be held for the fourth time, and selected poster presentations from junior scientists and new GRC attendees will also be featured in short highlight talks at the main conference, facilitating interactions and dialogue across the two related meetings as well as presenting fresh, new perspectives. Please join us at the wonderful and well-equipped Colby-Sawyer College site for a highly enjoyable, interactive, and impactful meeting on the barriers of the CNS and related science.

Related Meeting

This GRC was held in conjunction with the "Barriers of the CNS" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: New Perspectives on the CNS Barriers
Discussion Leader: Robert Thorne (University of Wisconsin-Madison, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:25 pmFiona Doetsch (University of Basel, Switzerland)
"Regulation of Adult Neural Stem Cells: Life at the Interface of Two Barriers"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmCostantino Iadecola (Weill Cornell Medicine, USA)
"Neurovascular Regulation and Dysfunction in Disease States"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmTransport, Signaling, and Junctions at the CNS Barriers and Beyond
Discussion Leaders: Martha O'Donnell (University of California, Davis, USA) and Lester Drewes (University of Minnesota, USA)
9:00 am - 9:20 amGeoffrey Chang (University of California, San Diego, USA)
"P-Glycoprotein: New Insights on Structure/Function"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amTetsuya Terasaki (Tohoku University, Japan)
"Transporter Proteomics at the CNS Barriers"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amNathalie Strazielle (Brain-i / BIP - Lyon Neuroscience Research Center, INSERM U1028, France)
"Neuroprotective Functions of the Blood-CSF Barrier in Young Animals: Enzymes and Transporters"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amErin Schuetz (St. Jude Children's Research Hospital, USA)
"Species Differences in Drug Transporters at the Blood-CSF Barriers"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amSabina Hrabetova (SUNY Downstate Medical Center, USA)
"Diffusive Spread of Substances Through Brain Extracellular Space: Modulatory Role of Astroglia"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmMelanie-Jane Hannocks (University of Muenster, Germany)
"Molecular Characterization of the Perivascular Space and Its Relationship to the CSF"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: N. Joan Abbott (King's College London, United Kingdom), Reina Bendayan (University of Toronto, Canada) and Chenghua Gu (Harvard Medical School, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLate-Breaking Topics
Session in honor of the contributions of David Miller.
Discussion Leaders: Stefan Liebner (University of Frankfurt, Germany) and Xavier Decleves (Université Paris Descartes, France)
7:30 pm - 7:50 pmChenghua Gu (Harvard Medical School, USA)
"Molecular Mechanisms Governing the Formation and Function of the Blood-Brain Barrier"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMartin Lauritzen (University of Copenhagen, Denmark)
"Modification of Brain Microvascular Function In Vivo by Pericytes"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmBenjamin Deverman (California Institute of Technology, USA)
"CREATEing AAV Vectors that Cross CNS Barriers"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmRoosmarijn Vandenbroucke (VIB, Ghent University, Belgium)
"CNS Barriers Science: New Work and Concepts"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCNS Barrier Function in Stroke, Brain Trauma, and Epilepsy
Discussion Leaders: Zena Vexler (University of California, San Francisco, USA) and Richard Daneman (University of California, San Diego, USA)
9:00 am - 9:20 amDavid Antonetti (University of Michigan, USA)
"Retinal Ischemia Reperfusion: A Model of Blood-Retinal Barrier Loss, Neuroinflammation, and Resolution"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amGregory Bix (University of Kentucky, USA)
"A Role for α5β1 Integrin in Blood-Brain Barrier Permeability in the Context of Stroke"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amRichard Keep (University of Michigan, USA)
"Controversies over the Pathways Underlying Early Disruption in Ischemic and Hemorrhagic Stroke"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amGroup Photo / Coffee Break
11:00 am - 11:20 amJerome Badaut (CNRS, France)
"CNS Barrier Function in Juvenile Traumatic Brain Injury"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amBjoern Bauer (University of Kentucky, USA)
"Blood-Brain Barrier Function in Epilepsy"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmPatricia Dickson (Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, USA)
"Intrathecal Enzyme Delivery for MPS Disorders: New Insights"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCNS Barrier Function in Neurodegenerative Disease, Brain Cancer, and Drug Abuse
Discussion Leaders: Elizabeth De Lange (Leiden University, The Netherlands) and Jeffrey Iliff (Oregon Health and Science University, USA)
7:30 pm - 7:50 pmAnika Hartz (University of Kentucky, USA)
"ABCb1 News: The Transporter and the Amyloid"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmHelga De Vries (VU University Medical Center, The Netherlands)
"Inflammation of the CNS Barriers in Multiple Sclerosis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmRichard Egleton (Marshall University, USA)
"Opioid Regulation of Brain Endothelial Cell Function"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmWilliam Elmquist (University of Minnesota, USA)
"Impact of Focal Changes in the BBB in Treating Brain Tumors: Where, When, and How?"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmImmunology of the CNS Barriers and Related Systems
Discussion Leaders: Britta Engelhardt (University of Bern, Switzerland) and Lydia Sorokin (University of Muenster, Germany)
9:00 am - 9:20 amAleksandra Deczkowska (Weizmann Institute of Science, Israel)
"Immune Regulation at the Choroid Plexus and Implications to Brain Ageing and Alzheimer's Disease"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amRoxana Carare (University of Southampton, United Kingdom)
"The Perivascular Spaces and Cerebral Lymphatic Drainage Pathways"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amZsuzsanna Fabry (University of Wisconsin-Madison, USA)
"Discontinuous Distribution of Immune Cell Migration in Response to CNS Autoimmunity, Infection, and Trauma"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amErlend Nagelhus (University of Oslo, Norway)
"Roles of Aquaporins at the Brain-Blood Interface"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amJorge Alvarez (University of Pennsylvania, USA)
"The Blood-Meningeal Barrier and Its Role During Homeostasis and Neuroinflammation"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amMaria Rosito (University of Bern, Switzerland)
"Investigating the Cellular and Molecular Mechanisms Mediating the Migration of Human T Cell Subsets Across the Human Brain Barriers In Vitro"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSunit Singh (Banaras Hindu University, India)
"HIV Tat Exploits Cellular microRNA to Hit the Blood-Brain Barrier"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmNovel Approaches: Imaging, Model Systems, and Technology
Discussion Leaders: Michael Taylor (University of Wisconsin-Madison, USA) and Ethan Lippmann (Vanderbilt University, USA)
7:30 pm - 7:50 pmAngela Gelli (University of California, Davis, USA)
"Fungi at the Gate: How Does Cryptococcus neoformans Breach the BBB?"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMaria Deli (Biological Research Centre, Hungarian Academy of Sciences, Hungary)
"New Applications of Integrated Microelectronic Lab-on-a-Chip Devices in BBB Research"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmDaniela Virgintino (Bari University School of Medicine, Italy)
"Cell-to-Cell Communication During Cortical Vascularization"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmMaarja Andaloussi Mae (Uppsala University, Sweden)
"Transcriptomic and Proteomic Analysis of the Role of Pericytes at the Blood-Brain Barrier"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmBrian Chow (Harvard Medical School, USA)
"Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCNS Drug Delivery and Distribution: New Concepts
Discussion Leaders: Danica Stanimirovic (National Research Council / University of Ottawa, Canada) and Eric Shusta (University of Wisconsin-Madison, USA)
9:00 am - 9:20 amMargareta Hammarlund-Udenaes (Uppsala University, Sweden)
"CNS Drug Delivery and Distribution: Across the BBB and into the Cells"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amFrederic Calon (Laval University, Canada)
"To Cross or Not to Cross the BBB: The Journey of Antibodies Targeting Transferrin Receptors"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amReina Bendayan (University of Toronto, Canada)
"Regulation of ABC Drug Transporters by Nuclear Receptors: New Ways of Tightening or Opening the BBB"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amJoseph Nicolazzo (Monash University, Australia)
"The Role of Intracellular Proteins in Facilitating Molecular Transport Across the Blood-Brain Barrier and Implications for Alzheimer's Disease"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amVijaya Gopal (Centre for Cellular and Molecular Biology, CSIR, India)
"Targeted Delivery of Short Interfering RNA Across the Blood-Brain Barrier"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amDionna Williams (Johns Hopkins University, USA)
"Novel Flow Cytometric Analysis of the Blood-Brain Barrier"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmDebayon Paul (UConn Health, USA)
"Extracellular Vesicles as Conveyors of Tight Junction Protein to Leukocytes in Neuroinflammation"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: Evolving Perspectives in CNS Barriers Science: Anticipating the Next Ten Years in Academic and Industrial Partnerships
Discussion Leaders: N. Joan Abbott (King's College London, United Kingdom) and Axel Meyer (AbbVie Deutschland GmbH & Co KG, Germany)
7:30 pm - 8:05 pmRita Balice-Gordon (Sanofi, USA)
"Academic/Industrial Partnerships in CNS Barriers Science: Challenges and Opportunities"
8:05 pm - 8:20 pmDiscussion
8:20 pm - 8:30 pmSaileta Prabhu (Genentech, USA)
"Industrial Perspective on CNS Barriers Science: Considerations for Publishing"
8:30 pm - 8:35 pmDiscussion
8:35 pm - 8:45 pmAnne Christiansen (Shire, USA)
"Industrial Perspective on CNS Barriers Science: Successful Collaborations"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:00 pmQuentin Smith (Texas Tech University Health Sciences Center, USA)
"Academic Perspective on CNS Barriers Science: Developing Collaborations Between Institutions and Industry"
9:00 pm - 9:05 pmDiscussion
9:05 pm - 9:15 pmGeneral Discussion
9:15 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS098650. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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