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High Throughput Chemistry and Chemical Biology
Gordon Research Conference

New Modalities, Methods and Mechanisms for Chemical Biology

Dates

June 25-30, 2017

Location

Proctor Academy
Andover, NH

Organizers

Chair:
Andrew J. Phillips

Vice Chair:
Ivan Cornella-Taracido

Meeting Description

Dear Colleagues

The 2017 High-Throughput Chemistry and Chemical Biology (HTCCB) Gordon Research Conference, carries forward the torch of cutting-edge science at the ever-evolving interface of chemistry and chemical biology. The 2017 edition will be held at the Proctor Academy in Andover, NH and will gather invited speakers and attendees from industry, academia and other research institutions for collegial and dynamic discussions of the latest methods, modalities, and mechanisms from chemistry and their use to impact chemistry, chemical biology, and medicine. Afternoon poster sessions will also contribute to the scientific and social exchange at the HTCCB GRC and all conferees are encouraged to participate through the presentation of a poster.

Betsy Parkinson (University of Illinois at Urbana-Champaign) and Cynthia Chio (University of California, San Francisco) are organizing the 5th Gordon Research Seminar (GRS) on High-Throughput Chemistry and Chemical Biology. This GRS will be held on Saturday and Sunday June 13-14, immediately prior to the GRC and will provide an opportunity for trainees to share science and interact with leading researchers in an intimate setting. Graduate students and post-docs are encouraged to apply to both the GRS and GRC.

We invite you to apply to what we expect will be an exciting, stimulating, and memorable meeting.

Andy Phillips, C4 Therapeutics and Ivan Cornella-Taracido, Merck and Co.
Chair and Vice-Chair, 2017 GRC on High-Throughput Chemistry and Chemical Biology

Related Meeting

This GRC was held in conjunction with the "High Throughput Chemistry and Chemical Biology" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: The Vanguard of Chemical Biology
Discussion Leader: Jennifer Prescher (University of California, Irvine, USA)
7:40 pm - 8:10 pmRandy Peterson (Massachusetts General Hospital / Harvard University, USA)
"Behavior-Based Discovery of New Optochemical Genetic Tools"
8:10 pm - 8:15 pmDiscussion
8:15 pm - 8:45 pmDaria Hazuda (Merck Research Laboratories, USA)
"Novel Approaches to Infectious Disease Targets"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:25 pmDirk Trauner (New York University, USA)
"Optical Control of the Cytoskeleton"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSmall Molecule Probes, Drug Candidates and New Approaches in Chemical Biology
Discussion Leader: Betsy Parkinson (University of Illinois at Urbana-Champaign, USA)
9:00 am - 9:30 amAnna Mapp (University of Michigan, USA)
"Small Molecule Modulators of Conformationally Dynamic Protein Complexes"
9:30 am - 9:35 amDiscussion
9:35 am - 10:05 amRichard Sparks (Incyte Corporation, USA)
"Fragment to Pharmacophore to Candidate: Invention of INCB054329, a Potent and Selective BRD Inhibitor in Clinical Trials for Oncology"
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amJonathan Morris (University of New South Wales, Australia)
"Developing Small Molecule Inhibitors of RNA Splicing Kinases for the Modulation of Protein Isoforms"
10:40 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:45 amEmily Balskus (Harvard University, USA)
"Deciphering the Human Microbiome Using Chemistry"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmBenjamin Spangler (Novartis Institutes for Biomedical Research, USA)
"Molecular Probes for Determination of Sub-Cellular Compound Exposure in Gram-Negative Bacteria"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmJustin Rettenmaier (Whitehead Institute for Biological Research, USA)
"DELs in Cells: Phenotypic Screening with DNA-Encoded Cyclic Peptides"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmChemical Biology with Proteins, Mini-Proteins, and Peptides
Discussion Leader: Joshua Kritzer (Tufts University, USA)
7:30 pm - 8:05 pmAlbert Bowers (UNC Eshelman School of Pharmacy, USA)
"Chemoenzymatic Platforms for the Discovery of New Peptide Therapeutics"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:45 pmBrad Pentelute (Massachusetts Institute of Technology, USA)
"Homogenous Antibody Drug Conjugates Enabled by Cysteine Arylation"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:25 pmAlan Saghatelian (Salk Institute for Biological Studies, USA)
"Discovery and Characterization of Novel Microproteins"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmNovel Chemistries and Methods for Chemical Biology and Therapeutics
Discussion Leader: Aaron Wright (Pacific Northwest National Laboratory, USA)
9:00 am - 9:30 amMarcus Bantscheff (Cellzome / GlaxoSmithKline, Germany)
"Comprehensive Drug Target Profiling Using Complementary (Chemo-)proteomics Approaches"
9:30 am - 9:35 amDiscussion
9:35 am - 10:05 amCorey Nislow (Genetic Networks, USA)
"The Cellular Response to Drugs Quantified by Fitness Profiling: A Genetic Networks' Perspective"
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amEmily Parker (Victoria University of Wellington, New Zealand)
"Unravelling and (Re)engineering Biosynthetic Pathways"
10:40 am - 10:45 amDiscussion
10:45 am - 11:15 amCoffee Break
11:15 am - 11:45 amJennifer Prescher (University of California, Irvine, USA)
"Spying on Cellular Communication"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmAlison Narayan (University of Michigan, USA)
"Biocatalysis for Complex Molecule Synthesis"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmShigeki Kiyonaka (Kyoto University, Japan)
"Chemogenetic Approach for Allosteric Activation of Neurotransmitter Receptors on Living Cells"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmChemical Biology: Phenotype, Target Engagement, and Mechanism of Action
Discussion Leader: Cynthia Chio (University of California, San Francisco, USA)
7:30 pm - 8:05 pmStewart Fisher (C4 Therapeutics, Inc., USA)
"It's About Time: Mechanistic PK-PD Models for Time-Dependent Inhibitors"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:45 pmLyn Jones (Jnana Therapeutics, USA)
"Drug-Target Engagement in Live Cells"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:25 pmChristopher Vakoc (Cold Spring Harbor Laboratory, USA)
"Generating Resistance Alleles of Epigenetic Drug Targets"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNovel Chemistries and Methods for Chemical Biology and High-Throughput Experimentation
Discussion Leader: Samuel Gerritz (Bristol-Myers Squibb, USA)
9:00 am - 9:30 amStevan Djuric (AbbVie, USA)
"Enabling Chemistry Technologies - Accelerators of Drug Discovery"
9:30 am - 9:35 amDiscussion
9:35 am - 10:05 amAlexander Satz (Roche, Switzerland)
"Design and Application of DNA Encoded Libraries at Roche"
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amMelodie Christensen (Merck, USA)
"High Throughput Experimentation in the Optimization of Metallaphotoredox Catalyzed Alpha-Hydroxy Arylation Reactions"
10:40 am - 10:45 amDiscussion
10:45 am - 11:20 amCoffee Break
11:20 am - 11:50 amAleksandra Baranczak (AbbVie, USA)
"Approaches to Cellular Characterization of Small Molecule Protein Binders"
11:50 am - 11:55 amDiscussion
11:55 am - 12:25 pmAnthony Keefe (X-Chem Pharmaceuticals, USA)
"Drug Discovery for Challenging Targets Using DNA-Encoded Chemistry"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmChemistry and Biology of Natural Products
Discussion Leader: Tarek Sammakia (University of Colorado Boulder, USA)
7:30 pm - 8:05 pmCorinna Schindler (University of Michigan, USA)
"New Methods for the Synthesis of Biologically Active Molecules"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:45 pmMichael Burkart (University of California, San Diego, USA)
"Directing Biosynthesis Through Protein-Protein Interactions"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:25 pmCorey Stephenson (University of Michigan, USA)
"Redox Catalysis for Complex Molecule Synthesis"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmBivalent Molecules and Other Novel Approaches to Control of Function
Discussion Leader: Lyn Jones (Jnana Therapeutics, USA)
9:00 am - 9:30 amJingwen Zhang (AstraZeneca, USA)
"Clinical Candidate AZD5153 Is a Novel Bivalent Inhibitor of BET Bromodomains"
9:30 am - 9:35 amDiscussion
9:35 am - 10:05 amRhamy Zeid (C4 Therapeutics, USA)
"Targeted Protein Degradation as a Novel Therapeutic Approach"
10:05 am - 10:10 amDiscussion
10:10 am - 10:40 amDavid Spiegel (Yale University, USA)
"Bifunctional Molecules for Modulating Human Immune Responses"
10:40 am - 10:45 amDiscussion
10:45 am - 11:20 amCoffee Break
11:20 am - 11:50 amYimon Aye (Cornell University / Weill Cornell Medicine, USA)
"'Stay on Target' — Targeting Kinetically Privileged First Responders in Electrophile Signaling"
11:50 am - 11:55 amDiscussion
11:55 am - 12:25 pmM.G. Finn (Georgia Institute of Technology, USA)
"Low Throughput Studies of Reactivity to Enable High Throughput Applications"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: Novel Therapeutics
Discussion Leader: Alan Saghatelian (Salk Institute for Biological Studies, USA)
7:30 pm - 8:05 pmPhil Chamberlain (Celgene, USA)
"Expanding the Druggable Genome with Cereblon Modulators"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:45 pmNathanael Gray (Dana Farber Cancer Institute, USA)
"Targeting Transcription Addiction in Cancer"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:25 pmSteve Haggarty (Harvard Medical School / Massachusetts General Hospital, USA)
"Probing Neurogenetic Disorders Using Patient-Specific Stem Cells and Chemogenomics"
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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