SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Signaling and Cancer |
| Discussion Leader: Chris Marshall (Institute for Cancer Research) |
7:40 pm - 8:05 pm | David Tuveson (Cambridge Research Institute) "Oncogenic Kras pancreatic tumourigenesis" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Channing Der (University of North Carolina at Chapel Hill) "Mechanisms of aberrant Ras and Rho signal deregulation in cancer" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Somasekar Seshagiri (Genentech) "Identifying, understanding and targeting cancer somatic mutations" |
9:15 pm - 9:25 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Cell polarity |
| Discussion Leader: Diane Barber (University of California, San Francisco) |
9:00 am - 9:25 am | Shuh Narumiya (Kyoto University) "Phenotype analysis of mDia-deficient mice; impaired neuroblast migration and disordered proliferation of neural stem cells" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Ian Macara (University of Virginia School of Medicine) "Polarity proteins and metastasis- a STAT3 connection" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | Phillip Hawkins (Babraham Institute) "PI3K signalling in neutrophils" |
11:05am - 11:15 am | Discussion |
11:15 am - 11:40 am | Keith Mostov (University of California, San Francisco) "Formation of multicellular epithelial structures" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Ziqiang Yang (Ontario Cancer Institute) "The role of the Gab1-PARs complex in regulation of epithelial cell polarization and scattering" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Paul Frankel (University College London) "PDGF-mediated mesenchymal cell invasion is dependent on DOK1 tyrosine phosphorylation via a p130Cas-CRKL signalling pathway in glioma cells" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Cytoskeletal dynamics & migration |
| Discussion Leader: Peter Devreotes (Johns Hopkins University) |
7:30 pm - 7:55 pm | Klaus Hahn (University of North Carolina at Chapel Hill) "Peeking and poking at rapid GTPase signaling in vivo" |
7:55 pm - 8:05pm | Discussion |
8:05 pm - 8:30 pm | Marcelo Kazanietz (University of Pennsylvania) "ErbB signaling in breast cancer" |
8:30 pm - 8:40pm | Discussion |
8:40 pm - 9:05 pm | Diane Barber (University of California, San Francisco) "pH Sensors: Design principles and functional significance" |
9:05 pm - 9:15 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Engineering principles of signaling cascades I |
| Discussion Leader: Paul Sternweis (University of Texas Southwestern Medical Center) |
9:00 am - 9:25 am | Douglas Lauffenburger (Massachusetts Institute of Technology) "From illustrative pathway maps to computable network models" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Rama Ranganathan (University of Texas Southwestern Medical Center) |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break / Group Photo |
10:40 am - 11:05 am | Tobias Meyer (Stanford University) "A two-dimensional signaling code decides between differentiation and proliferation" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Rafaella Sordella (Cold Spring Harbor Laboratory) "Mechanisms of resistance to EGFR tyrosine kinase inhibitors" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Michael Ochs (Johns Hopkins University) "Improved inference of signaling activity through genomic and epigenetic data integration" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Kimberly Reynolds (University of Texas Southwestern Medical Center) "A structural model for the emergence of allosteric control in proteins" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Engineering principles of signaling cascades II |
| Discussion Leader: Paul Sternweis (University of Texas Southwestern Medical Center) |
7:30 pm - 7:55 pm | Michael Yaffe (Massachusetts Institute of Technology) "Integration of growth factor, MAP kinase, and DNA damage signaling networks" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:55 pm | Chris Marshall (Institute for Cancer Research) Keynote Lecture: "Rho-family GTPase signalling in tumour cell migration" |
8:55 pm - 9:20 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Organismal Biology |
| Discussion Leader: Ian Macara (University of Virginia School of Medicine) |
9:00 am - 9:25 am | Xosé Bustelo (CSIC-University of Salamanca) "Pleiotropic control of cancer growth by Vav family proteins" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Peter Devreotes (Johns Hopkins University) "Signaling networks in chemotactic cells" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | Stefan Offermanns (Max Planck Institute for Heart and Lung Research) "Cardiovascular regulation through GPCRs in physiology and pathology" |
11:05am - 11:15 am | Discussion |
11:15 am - 11:40 am | Anna Huttenlocher (University of Wisconsin-Madison) "Imaging neutrophil chemotaxis in vivo" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Silvia Cappello (Helmholtz Center Munich) "A new mouse model of 'double cortex' - the role of RhoA in cortical development"
|
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Todd Strochlic (Fox Chase Cancer Center) "A novel role for Ack1 in flies and mammals" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Neuronal development |
| Discussion Leader: John Colicelli (University of California, Los Angeles) |
7:30 pm - 7:55 pm | Magdalena Götz (Helmholtz Center & University of Munich) "Signalling in neural stem cells in embryonic and adult neurogenesis" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | Heidi Welch (Babraham Institute) "New functional roles and mechanisms of regulation of P-Rex family Rac-GEFs" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Linda Van Aelst (Cold Spring Harbor Laboratory) "Role of Rho regulators in neuronal development and disease" |
9:05 pm - 9:15 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Trafficking and post-translational modifications |
| Discussion Leader: Jeff Peterson (Fox Chase Cancer Center) |
9:00 am - 9:25 am | Adrienne Cox (University of North Carolina at Chapel Hill) "Local control of Ras and Rho family signaling" |
9:25 am - 9:35 am | Discussion |
9:35 am - 10:00 am | Mark Philips (NYU Cancer Institute, NYU School of Medicine) "Regulation of Ras trafficking" |
10:00 am - 10:10 am | Discussion |
10:10 am | Coffee Break |
10:40 am - 11:05 am | Keith Burridge (University of North Carolina at Chapel Hill) "Signaling pathways from mechanical force to RhoA activation" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Angeliki Malliri (Cancer Research UK Paterson Institute for Cancer Research) "Post-translational modifications of Rac and the Rac activator Tiam1 and their biological roles" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Peter Hordijk (University of Amsterdam) "Limiting Rac1 signaling through ubiquitylation and internalization" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Krishnaraj Rajalingam (Goethe University) "IAPs directly regulate Rho GTPases and cell motility"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Structural biology of signaling nodes |
| Discussion Leader: Matthias Buck (Case Western Reserve University) |
7:30 pm - 7:55 pm | David Barford (Chester Beatty Laboratories, Institute of Cancer Research) "Structural analysis of proteins of the Ras-Raf signalling pathway" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:30 pm | John Tesmer (University of Michigan Life Sciences Institute) "Allosteric activation of effectors by heterotrimeric G proteins" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Fred Wittinghofer (Max Planck Institute of Molecular Physiology) "Ras and Arl, an unexpected connection" |
9:05 pm - 9:15 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |