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Cyclic Nucleotide Phosphodiesterases
Gordon Research Conference

Mechanisms of PDE Nano-Domain Control and Impacts on Disease

Dates

June 12-17, 2016

Location

PGA Catalunya Business and Convention Centre
Girona, Spain

Organizers

Chairs:
Rodolphe P. Fischmeister & David Kass

Vice Chairs:
George S. Baillie & Christopher Schmidt

Meeting Description

The GRC on Cyclic Nucleotide PDEs has a long and storied history, and engages investigators whose research covers the entire phosphodiesterases (PDE) superfamily. In addition to presentations on novel assessments of PDE compartmentalized-­targeting of cyclic nucleotides and related signaling, we progress through all the PDEs from 1 to 11, with leading research presented for each. Day one deals with basic principals and novel subcellular molecular tracking of cyclic nucleotide signaling and compartmentation. Day 2 starts with PDE1 and we move sequentially through to PDE11 by the end of the weeklong conference. Speakers will focus on general molecular and signaling aspects of PDEs and explore the role of various PDES in contributing to major diseases and identify novel therapeutic roles for their pharmacological modulation.

Related Meeting

This GRC was held in conjunction with the "Cyclic Nucleotide Phosphodiesterases" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmNon-Canonical Cyclic Nucleotides and Protein Regulators / Presentations Selected from the GRS
Discussion Leaders: David Kass (Johns Hopkins Medicine, USA), Sarah Rampersad (Queen's University, Canada) and Alessandra Ghigo (University of Torino, Italy)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:10 pmThomas Brand (Imperial College London, United Kingdom)
"Popeye-Domain Containing Proteins: cAMP-Binding and Role"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmRoland Seifert (Hannover Medical School, Germany)
"cCMP, cUMP and Other New Cyclic Nucleotides"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:05 pmDelphine Mika (INSERM U1180, University of Paris-Sud, France)
"Regulation of Pacemaker Activity by PDE4 Isoforms"
9:05 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmStefania Monterisi (University of Oxford, United Kingdom)
"PDE2A Regulates a Mitochondrial cAMP/PKA Microdomain that Affects Mitochondria Morphology and Cell Survival"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmImaging Cyclic Nucleotide/Effector Kinase Nano-Domains
Discussion Leader: Choel Kim (Baylor College of Medicine, USA)
9:00 am - 9:20 amManuela Zaccolo (University of Oxford, United Kingdom)
"Compartmentation of PDE-PKA Signaling"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amViacheslav Nikolaev (University Medical Center Hamburg-Eppendorf, Germany)
"FRET-Based Detection of Natriuretic Peptide Microdomains"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amJulia Gorelik (Imperial College London, United Kingdom)
"Nanoscale Imaging of Functional Cardiac Microdomains"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amJin Zhang (University of California, San Diego, USA)
"Imaging Local Kinase Targeting: PKA, AMPK, and Beyond"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amCarmen Dessauer (McGovern Medical School, USA)
"AKAP Regulation of Adenylyl Cyclase Signaling"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Nikhil Tulsian (National University of Singapore, Singapore)
"Two Proteins and a Ligand: Substrate Channeling in PKA-PDE Complexes Triggers cAMP Signal Termination"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Miguel Lobo (University of Oxford, United Kingdom)
"Super-Resolution Imaging of Mitochondrial PDE2A2"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmNew Insights into the Control of Cyclic AMP
Discussion Leader: William Catterall (University of Washington, USA)
6:00 pm - 6:20 pmJohn Scott (University of Washington, USA)
"Parking cAMP/PDE Signaling via AKAPs"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmChen Yan (University of Rochester, USA)
"PDE1 and cAMP vs cGMP Regulation"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmScott Soderling (Duke University, USA)
"Neural Spines and Localized Regulation"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:50 pmJoseph Beavo (University of Washington, USA)
"Roles of Synergy Among Different PDEs: New Approaches Identify New Pathways"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmPDE Regulatory Interactions with Receptors and Kinases
Discussion Leader: Emilio Hirsch (University of Torino, Italy)
9:00 am - 9:20 amYang Xiang (University of California, Davis, USA)
"Beta-Receptor Modulation by PDE4"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amGregoire Vandecasteele (INSERM U1180, University of Paris-Sud, France)
"Phenotype of Mice with Cardiac-Specific Overexpression of PDE4B"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amDavid Kass (Johns Hopkins Medicine, USA)
"PKGing Apart Heart Disease: Implications of PKG1a Redox"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amAlessandra Ghigo (University of Torino, Italy)
"Targeting PI3Kγ/PKA/PDE Interactions as a Novel Therapeutic Avenue in Respiratory Diseases"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amSelected from Poster Abstracts: Michaela Kuhn (Comprehensive Heart Failure Center, University of Wuerzburg, Germany)
"Opposite Regulation of Microvascular Endothelial Barrier Functions by ANP/cGMP Signaling via the cGMP-Stimulated Protein Kinase I and Phosphodiesterase 2"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmSelected from Poster Abstracts: Axel Kraft (University Medical Center Hamburg-Eppendorf, Germany)
"Influence of Phosphodiesterases 4B and 4D on cAMP Signaling in Calcium Handling Microdomains of Adult Mouse Cardiomyocytes"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Ibrahim Bedioune (INSERM U1180, University of Paris-Sud, France)
"Differential Regulation of Cytoplasmic and Nuclear PKA Activities by β1- and β2-Adrenoceptors in Adult Cardiac Myocytes"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmRole of PDE1 and PDE2 in Cardiac, Pulmonary, and Neurological Diseases
Discussion Leader: Claire Lugnier (CNRS / Université de Strasbourg, France)
6:00 pm - 6:20 pmLawrence Wennogle (Intra-Cellular Therapies, USA)
"PDE1 as a Neurological and Cardiovascular Target"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmAli El-Armouche (University of Dresden, Germany)
"PDE2 and Regulation of Heart Function"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmYing Xu (State University of New York at Buffalo, USA)
"PDE2 and Cognitive and Neuronal Stress Remodeling"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:50 pmAdrian Hobbs (William Harvey Research Institute, Queen Mary University of London, United Kingdom)
"PDE2 and Pulmonary Hypertension"
7:50 pm - 8:00 pmDiscussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmPDE3 and PDE4: Cardiovascular Disease and Inflammation
Session in honor of Vincent C. Manganiello.
Discussion Leader: Veronique Leblais (University of Paris-Sud, France)
9:00 am - 9:20 amMatthew Movsesian (University of Utah, USA)
"Isoform-Selective Regulation and Function of PDE3"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amSylvia Bahring (Charité - Universitätsmedizin Berlin / Max Delbruck Center for Molecular Medicine, Germany)
"Mutations of PDE3A, Identified in Mendelian Hypertension"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amJian-Dong Li (Georgia State University, USA)
"PDE4B and Inflammatory Regulation"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amDonald Maurice (Queen's University, Canada)
"PDE4 and Vascular Control"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amSelected from Poster Abstracts: Peter Backx (York University, Canada)
"Phosphodiesterase 3 (PDE3) Inhibition Attenuates Pressure Overload-Induced Cardiac Dysfunction and Hypertrophy by Antagonizing the Calcineurin-NFAT Signaling Pathway"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmSelected from Poster Abstracts: Sarah Idres (INSERM U1180, University of Paris-Sud, France)
"Key Role of BK(Ca) Channels for PDE3 and PDE4 to Regulate Coronary Tone Is Lost in Heart Failure"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Peter Wright (Imperial College London, United Kingdom)
"The Role of Cav3/Caveolar Localization of PDE4 in the Production of Regional Differences in Myocardial Cardiomyocyte β2AR Responses"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmRegulation of PDE4 Signaling and PDE5-Inhibition for Duchene Muscular Dystrophy
Discussion Leader: Susan Taylor (University of California, San Diego, USA)
6:00 pm - 6:20 pmMarco Conti (University of California, San Francisco, USA)
"PDE4 and CamKII Negative Feedback Signaling"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmGeorge Baillie (University of Glasgow, United Kingdom)
"Regulation by PDE4D Heat Shock Protein 20"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:20 pmRonald Victor (Cedars Sinai Medical Center, USA)
"PDE5 Inhibition for Treatment of Duchene Muscular Dystrophy"
7:20 pm - 7:30 pmDiscussion
7:30 pm - 7:40 pmSelected from Poster Abstracts: Chong Zhang (State University of New York at Buffalo, USA)
"Comparison of the Pharmacological Profiles of a PDE4B and a PDE4D Selective Inhibitor in the Central Nervous System"
7:40 pm - 7:45 pmDiscussion
7:45 pm - 7:55 pmSelected from Poster Abstracts: Cristina Molina (Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Germany)
"PDE8 Is a Novel Regulator of cAMP Signaling in Human Atrial Fibrillation"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmNeurological Role for PDEs: Therapeutic Implications
Discussion Leader: Rick Cote (University of New Hampshire, USA)
9:00 am - 9:20 amNikolai Artemyev (University of Iowa College of Medicine, USA)
"Regulation of PDE6 and Control of Sight"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAna Perez-Castillo (Instituto de Investigaciones Biomédicas, Spain)
"PDE7 as a Therapeutic Target in Neurodegenerative Diseases"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amCornelia Dorner-Ciossek (Boehringer Ingelheim Pharma GmbH & Co. KG, Germany)
"Inhibition of PDE9 in Alzheimer's Disease and Schizophrenia: From Animals to Human"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amMichael Russwurm (Ruhr University Bochum, Germany)
"PDE10-11 and Neurosynaptic Signaling"
11:20 am - 11:30 amDiscussion
11:30 am - 11:45 amSelected from Poster Abstracts: Neema Patel (University of South Carolina School of Medicine, USA)
"Identifying Which Subcellular Compartments in the Brain Express PDE9A and How that Expression Changes with Age"
11:45 am - 11:50 amDiscussion
11:50 am - 12:05 pmSelected from Poster Abstracts: Ellanor Whiteley (University of Glasgow, United Kingdom)
"Differential Turnover of PDE10A Splice Variants and Disease Related Mutants"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: David Paterson (University of Oxford, United Kingdom)
"Effect of B-Type Natriuretic Peptide and Phosphodiesterase 2A Is Coupled to Neurotransmitter Release in Pro-Hypertensive Rats"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmPDEs and the Central Nervous System
Discussion Leader: Christopher Schmidt (Pfizer, USA)
6:00 pm - 6:20 pmLiliana Castro (Universite Pierre et Marie Curie / CNRS, France)
"Modulation of Dopaminergic Signaling by PDE2 and PDE10 in Striatal Neurons"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmMichy Kelly (University of South Carolina School of Medicine, USA)
"To Activate or Not Activate, that Is the Question: Deletion of PDE11A4 Paradoxically Impairs Recent Long-Term Memory but Enhances Remote Long-Term Memory for Social Experiences"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:15 pmSelected from Poster Abstracts: Eamonn Sheridan (University of Leeds, United Kingdom)
"PDE10A and CNS Disease"
7:15 pm - 7:20 pmDiscussion
7:20 pm - 7:35 pmSelected from Poster Abstracts: Anthony West (Rosalind Franklin University of Medicine and Science, USA)
"Mechanisms for the Modulation of Striatonigral and Striatopallidal Neuron Activity by Phosphodiesterase 10A Inhibition in L-DOPA-Induced Dyskinesia"
7:35 pm - 7:40 pmDiscussion
7:40 pm - 7:55 pmSelected from Poster Abstracts: Si Chen (University of Rochester, USA)
"The Role of PDE10A in Pathological Cardiac Remodeling and Dysfunction"
7:55 pm - 8:00 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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