SUNDAY |
4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 7:50 pm | Welcome / Meeting Overview by GRC Chair, Linda Nicholson |
7:50 pm - 9:30 pm | Single Molecule Dynamics |
| Discussion Leader: Susan Marqusee (UC Berkeley) |
7:50 pm - 8:00 pm | Susan Marqusee (UC Berkeley)
"Session Introduction"
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8:00 pm - 8:35 pm | Yann Chemla (University of Illinois at Urbana - Champagne)
"High-resolution optical trap with single fluorophore sensitivity"
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8:35 pm - 8:45 pm | Discussion |
8:45 pm - 9:20 pm | Susan Marqusee (UC Berkeley)
"Walking the landscape one step at a time"
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9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Thermodynamics and Kinetics |
| |
9:00 am - 9:10 am | Babis Kalodimos (Rutgers University)
"Session Introduction"
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9:10 am - 9:35 am | Bertrand Garcia-Moreno (Johns Hopkins)
"Charges in hydrophobic environments"
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9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Kevin Gardner (UT Southwest Medical Center)
"Ligand-regulated protein/protein interactions: Role in environmental sensors"
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10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Anthony Kossiakoff (University of Chicago)
"Modifying biological function using conformational trapping by synthetic antibodies"
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11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Babis Kalodimos (Rutgers University)
"Proline molecular switches in cell signaling"
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11:40 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Herschel Wade (Johns Hopkins)
"Dissecting the code of MD recognition by the MDR gene regulator, BmrR"
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12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Justin Hall (Pfizer)
"Biophysical and mechanistic insights into a novel allosteric inhibitor of spleen tyrosin kinase"
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12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Advances in Biophysical and Computational Methods |
| Discussion Leader: Sarah Teichmann (MRC - Laboratory of Molecular Biology) |
7:30 pm - 7:40 pm | Sarah Teichmann (MRC - Laboratory of Molecular Biology)
"Session Introduction"
|
7:40 pm - 8:05 pm | Mei Hong (Iowa State University)
"Elucidating protein-drug interactions in lipid membranes by solid-state NMR"
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8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Madan Babu (MRC - Laboratory of Molecular Biology)
"Molecular principles of tissue-specific protein interactions mediated by alternatively spliced exons"
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8:35 pm - 8:40 pm | Discussion |
8:40 pm - 9:05 pm | Sarah Teichmann (MRC - Laboratory of Molecular Biology)
"Evolution and assembly of protein complexes"
|
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Darryl Bornhop (Vanderbilt University)
"Quantification of GPCR-ligand Binding Affinity Using Back-scattering Interferometry"
|
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Green Biophysics |
| Discussion Leader: John Golbeck (Penn State University) |
9:00 am - 9:10 am | John Golbeck (Penn State University)
"Session Introduction"
|
9:10 am - 9:45 am | Ken Nealson (University of Southern California)
"New vistas in extracellular electron transport (EET): processes and (some) mechanisms"
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9:45 am - 9:55 am | Discussion |
9:55 am - 10:30 am | Chris Moser (University of Pennsylvania)
"Design blueprints for efficient photochemical energy conversion"
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10:30 am - 10:40 am | Discussion |
10:40 am - 11:00 am | Coffee Break |
11:00 am - 11:35 am | Fraser Armstrong (Oxford University)
"Instructive experiments and devices in the development of green fuel technology"
|
11:35 am - 11:45 am | Discussion |
11:45 am - 12:20 pm | John Golbeck (Penn State University)
"Hybrid biological/organic nanoconstructs for solar biofuel generation"
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12:20 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Advances in Biophysical and Computational Methods |
| Karen Fleming (Johns Hopkins) |
7:30 pm - 7:40 pm | Karen Fleming (Johns Hopkins)
"Session Introduction"
|
7:40 pm - 8:05 pm | Sandro Keller (University of Kaiserslautern)
"A new ITC assay for measuring ultratight and low-affinity protein-ligand interactions"
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8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:40 pm | Gideon Schreiber (Weizmann Institute of Science)
"Structural and biochemical linkage between ligand binding and differential receptor activation by Type I Interferons"
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8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Karen Fleming (Johns Hopkins)
"Monitoring membrane protein folding using fluorescence"
|
9:15 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Macromolecular Machines and Assemblages |
| Discussion Leader: Peter Rosenthal (MRC - National Institute for Medical Research) |
9:00 am - 9:10 am | Peter Rosenthal (MRC - National Institute for Medical Research)
"Session Introduction"
|
9:10 am - 9:35 am | Thomas Marlovits (Institute of Molecular Biotechnology, Austria)
"Dissection of the Injectisome"
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9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Carolyn Moores (Birkbeck University of London)
"Molecular strategies for regulating microtubule dynamics"
|
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 11:05 am | Jacqueline Matthews (University of Sydney)
"Assembling a hematopoietic transcription factor complex"
|
11:05 am - 11:15 am | Discussion |
11:15 am - 11:30 am | Roberto DeGuzman (University of Kansas)
"NMR determination of the protein-protein interactions involved in the assembly of the type 3 secretion system needle and tip proteins"
|
11:30 am - 11:35 am | Discussion |
11:35 am - 11:50 am | Blake Hill (Johns Hopkins)
"A Dull Mitochondrial Knife: How disease-causing mutations in Drp1 affect mitochondrial fission"
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11:50 am - 11:55 am | Discussion |
11:55 am - 12:20 pm | Peter Rosenthal (MRC - National Institute for Medical Research)
"High resolution imaging of assemblies inside and outside the cell"
|
12:20 am - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Molecular Network Dynamics |
| Discussion Leader: Justin Molloy (MRC) |
7:30 pm - 7:40 pm | Justin Molloy (MRC)
"Session Introduction"
|
7:40 pm – 8:20 pm | Marc Wilkins (University of New South Wales)
"The Dynamics of Protein Interaction Networks" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Andy LiWang (UC - Merced)
"The Oscillating Mechanism of a Circadian Clock"
|
9:15 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Protein Interactions and Disease |
| Discussion Leader: Susan Lea (University of Oxford) |
9:00 am - 9:10 am | Susan Lea (University of Oxford)
"Session Introduction"
|
9:10 am - 9:35 am | Titia Sixma (Netherlands Cancer Institute)
"Protein:protein interactions modulate ubiquitin signaling"
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9:35 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Gavin Wright (Wellcome Trust Sanger Institute)
"Systematic extracellular protein interaction screens identify a host
receptor essential for erythrocyte invasion by P. falciparum"
|
10:10 am - 10:20 am | Discussion |
10:20 am - 10:40 am | Coffee Break |
10:40 am - 10:55 am | Samy Meroueh (Indiana University School of Medicine)
"Targeting Multiple Conformations Leads to Small Molecule Inhibitors of the uPAR•uPA Protein-Protein Interaction That Block Cancer Cell Invasion"
|
10:55 am - 11:00 am | Discussion |
11:00 am - 11:15 am | Sophia Kenrick (Wyatt Technology Corporation)
"Composition-Gradient Multi-Angle Light Scattering: a multifaceted tool for use in biopharmaceutical development"
|
11:15 am - 11:20 am | Discussion |
11:20 am - 11:45 am | Susan Lea (University of Oxford)
"Weak protein:protein interactions underlying pathogensis"
|
11:45 am - 11:55 am | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Speaker |
| Discussion Leader: Linda Nicholson (Cornell University) |
7:30 pm - 7:40 pm | Linda Nicholson (Cornell University)
"Introduction of Keynote Speaker"
|
7:40 pm - 8:40 pm | Lewis Kay (University of Toronto)
"Seeing the Invisible by Solution NMR Spectroscopy"
|
8:40 pm - 9:00 pm | Discussion |
9:00 pm | Closing Party |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |