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Signal Transduction by Engineered Extracellular Matrices
Gordon Research Conference

Integration of Systems Biology with Tissue Engineering for Development of Molecular and Regenerative Therapies

Dates

June 26 - July 1, 2016

Location

University of New England
Biddeford, ME

Organizers

Chair:
Linda G. Griffith

Vice Chair:
Sarah C. Heilshorn

Meeting Description

The Gordon Research Conference (GRC) on Signal Transduction by Engineered Extracellular Matrices was established in 2000 to enhance the intersection of bioengineering and stem cell biology with an aim to foster translation of cell-based technologies into practice. For example: How does a single human iPS cell grow into an intestinal or brain organoid, and how can engineers make the process more efficient, less costly, and more adaptable to in vitro assays in drug development or for studies of disease state? The 2016 meeting retains the classic foundations of stem cell biology, bioengineering, and biomaterials design while emphasizing emerging new directions. A greater emphasis is placed on using systems biology approaches to interpret complex morphogenic phenomena across multiple length and time scales, so that translation of engineered systems into clinical or pharmaceutical/biotechnology practice becomes more robust. Systems biology approaches in the context of this conference involve engineering/computational analysis and interpretation of high content / high throughput multiscale measurements of intracellular and extracellular signaling molecules, including matrix, with corresponding phenotypic measurements. Emerging efforts involve not just single-cell models, but multiscale population models to inform the design of matrix and scaffolds to direct cell behaviors as they proliferate, migrate, and undergo morphogenesis processes. From the applications perspective, the conference includes a new emphasis on mucosal barriers as an exciting frontier for regenerative therapies and targeted interventions against chronic inflammation. Understanding and controlling the properties of mucus as a matrix, and even synthesizing synthetic mucus, is crucial to regulation of mucosal immunity and healing. There is also an emphasis on engineering organoids for "organs on chips" type applications. This conference should be of interest to a wide range of basic scientists, engineers, and practitioners in regenerative medicine and pharmaceutical development. Invited speakers span a spectrum including cell and developmental biology, chemistry, materials, applied math, bioengineering, and practice. Several short talks will be selected from submitted abstracts. Activities at the conference will be designed to encourage interactions between established investigators and young investigators, including students and postdocs.

"3D Models and Organs-on-Chips in Drug Development" discussion group: Several invited speakers, discussion leaders, and other participants will host an informal discussion group/workshop on the topic of 3D models and organs on chips in drug development on Wednesday afternoon. The group includes a mix of academic and industry participants involved in creating or using these technologies. All GRC participants are invited to take part. This activity is not an official part of the program or sponsored by the GRC – it is an ad hoc activity for anyone interested in this topic, with logistical details to be provided at check-in.

Related Meeting

This GRC was held in conjunction with the "Signal Transduction by Engineered Extracellular Matrices" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Frontiers in Integration of Matrix and Systems Biology in Understanding and Control of Stem Cell Differentiation
Discussion Leader: Linda Griffith (Massachusetts Institute of Technology, USA)
7:40 pm - 7:50 pmIntroduction by Discussion Leader
7:50 pm - 8:25 pmFiona Watt (King's College London, United Kingdom)
"Multiscale Analysis of Extrinsic Cues Regulating the Epidermal Stem Cell Compartment"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmDavid Schaffer (University of California, Berkeley, USA)
"Should I Stay or Should I Go: Integration of Matrix and Growth Factor Cues in iPS Expansion and Escape from the Pluripotent State"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAnalysis and Control of Early Stem Cell Fate Decisions
Discussion Leader: David Mann (Cellular Dynamics International, USA)
9:00 am - 9:25 amTodd McDevitt (Gladstone Institute of Cardiovascular Disease / University of California, San Francisco, USA)
"Integration of Matrix and Growth Factor Cues in Directing Pluripotent Morphogenesis"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amMatthias Lutolf (École Polytechnique Fédérale de Lausanne, Switzerland)
"Tissue Engineering Through Matrix-Guided Stem Cell-Based Self-Organisation"
10:05 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amMadeline Lancaster (MRC Laboratory of Molecular Biology, United Kingdom)
"The Influence of Micropatterning on Brain Organoids in Normal and Diseased Conditions"
11:15 am - 11:30 amDiscussion
11:30 am - 11:55 amRandolph Ashton (University of Wisconsin-Madison, USA)
"Recapitulating CNS Tissue Development In Vitro Using Engineered Biomaterials"
11:55 am - 12:10 pmDiscussion
12:10 pm - 12:25 pmBenjamin Cosgrove (Cornell University, USA)
"Biomimetic Self-Assembled Scaffolds Enhance Muscle Stem Cell-Driven Regeneration in Mice"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMatrix Cues Regulating Morphogenesis and Regeneration
Discussion Leader: Shelly Peyton (University of Massachusetts Amherst, USA)
7:30 pm - 7:55 pmBrendan Harley (University of Illinois at Urbana-Champaign, USA)
"Harnessing the Biology of the Placenta and Endometrium in Biomaterial Design"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmPenney Gilbert (University of Toronto, Canada)
"Spatio-Temporal Control of Skeletal Muscle Stem Cell Self-Renewal"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmCeleste Nelson (Princeton University, USA)
"Matrix Dynamics and Epithelial Morphogenesis"
9:15 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmThe Other Extracellular Matrix: Understanding and Engineering Mucosal Barriers
Discussion Leader: Fiona Watt (King's College London, United Kingdom)
9:00 am - 9:25 amAndrea Cerutti (Mount Sinai School of Medicine, USA)
"Mucus Orchestrates Complex Gut-Immune-Microbe Communication Networks"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amKatharina Ribbeck (Massachusetts Institute of Technology, USA)
"Physical Biology of Native and Synthetic Mucus as a Regulator of Cellular Function"
10:05 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amRebecca Carrier (Northeastern University, USA)
"Engineering the Gut Mucosal Barrier in Health and Disease"
11:15 am - 11:30 amDiscussion
11:30 am - 11:55 amThaddeus Stappenbeck (Washington University in St. Louis, USA)
"Regulation of Gut Mucosal Healing by Transplanted Stem Cells"
11:55 am - 12:10 pmDiscussion
12:10 pm - 12:25 pmCole DeForest (University of Washington, USA)
"Photoreversible Patterning of Hydrogel Biomaterials with Site-Specifically-Modified Proteins"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmDynamic Multiscale Matrices for Engineering 3D Tissue Function
Discussion Leader: Kevin Healy (University of California, Berkeley, USA)
7:30 pm - 7:55 pmJean Schwarzbauer (Princeton University, USA)
"Metabolic Parameters Influencing Matrix Assembly and Function"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmJason Burdick (University of Pennsylvania, USA)
"Multiscale Engineering of Hydrogels for Controlling Cell Behavior"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmKamil Godula (University of California, San Diego, USA)
"Glycoengineering of Extracellular Matrix for Stem Cell Differentiation and Tissue Morphogenesis"
9:15 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSystems Biology Approaches to Signaling in Morphogenesis, Homeostasis, and Remodeling
Discussion Leader: Mark Powers (Thermo Fisher Scientific, Inc., USA)
9:00 am - 9:25 amKevin Janes (University of Virginia, USA)
"Heterogeneous Regulation and Misregulation of an ECM-Resident Ligand in Normal and Transformed Basal-Like Breast Epithelia"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amStanislav Shvartsman (Princeton University, USA)
"Quantitative Reconstructions of Developmental Dynamics"
10:05 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amClaus Jorgensen (Cancer Research UK Manchester Institute, University of Manchester, United Kingdom)
"Analysis of Reciprocal Tumor-Stroma Signaling by Cell-Specific Phosphoproteomics"
11:15 am - 11:30 amDiscussion
11:30 am - 11:55 amKatja Schenke-Layland (Fraunhofer IGB, Germany)
"In Situ Minimally Invasive Spectroscopic Approaches to Discerning Cell and Tissue States"
11:55 am - 12:10 pmDiscussion
12:10 pm - 12:25 pmFan Yang (Stanford University, USA)
"Microribbon-Based Hydrogels as Cell Niche: A Lego Building Approach"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmEngineering Microenvironments to Probe and Control Immune Responses
Discussion Leader: Shannon Hughes (Division of Cancer Biology, National Cancer Institute, NIH, USA)
7:30 pm - 7:55 pmSilvia Goldoni (Novartis Institutes for BioMedical Research, USA)
"Next Generation Assays for Next Generation Oncology Targets: Modeling Immuno-Oncology In Vitro"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmLonnie Shea (University of Michigan, USA)
"Immune Cell- and Material-Mediated Transcription Factor Activation Driving Cell Fate Decisions"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmPrincess Imoukhuede (University of Illinois at Urbana-Champaign, USA)
"Computational Analysis of Growth Factor Regulation of Inflammatory and Regenerative Remodeling"
9:15 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCells and Matrix on the Move
Discussion Leader: Serena Silver (Novartis Institutes for BioMedical Research, USA)
9:00 am - 9:25 amDaniel Hammer (University of Pennsylvania, USA)
"Understanding and Controlling Immune Cell Trafficking by Matrix and Growth Factor Cues"
9:25 am - 9:40 amDiscussion
9:40 am - 10:05 amUlrik Nielson (Torque Therapeutics, Inc., USA)
"Engineering T-Cells to Carry Therapy-Loaded Backpacks to a Therapeutic Target In Vivo"
10:05 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:15 amManu Platt (Georgia Institute of Technology, USA)
"Quantitative Dissection of Protease Networks Governing Matrix Remodeling"
11:15 am - 11:30 amDiscussion
11:30 am - 11:55 amPam Kreeger (University of Wisconsin-Madison, USA)
"Experimental and Computational Analysis of Multi-Cellular Interactions"
11:55 am - 12:10 pmDiscussion
12:10 pm - 12:25 pmAnjelica Gonzalez (Yale University, USA)
"Microvascular Basement Membrane Remodeling Facilitates Neutrophilic Dermatoses"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTranslation to Drug Development and the Clinic
Discussion Leader: Brendan Harley (University of Illinois at Urbana-Champaign, USA)
7:30 pm - 7:55 pmElliot Chaikof (Beth Israel Deaconess Medical Center, Harvard Medical School, USA)
"Controlling Thromboinflammatory Responses at Interfaces"
7:55 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmKeith Isaacson (Newton-Wellesley Hospital, Harvard Medical School, USA)
"Harnessing the Merger of Systems Biology and Tissue Engineering to Improve Women's Reproductive Health"
8:35 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmJohn Hambor (Boehringer Ingelheim, USA) and Erick Young (Boehringer Ingelheim, USA)
"The Boehringer Ingelheim SHINE Program: An Example of Academic-Industry Partnership"
9:15 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13 HL95217-01 from the National Institutes of Health, National Heart, Lung and Blood Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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