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Oxidative Stress & Disease
Gordon Research Conference

Redox Biology in Disease and Translational Medicine

Dates

March 19-24, 2017

Location

Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy

Organizers

Chairs:
LaDora V. Thompson & Giuseppe Poli

Vice Chairs:
Dean P. Jones & Helen R. Griffiths

Meeting Description

The theme for 2017 Oxidative Stress and Disease GRC is "Redox Biology in Disease and Translational Medicine". Its focus is on questions and approaches at the forefront of the field of redox biology with particular emphasis on cutting edge basic research with high translational potential to eliminate disease, improve quality of life and promote healthy longevity. A special effort has been made to highlight important research areas not recently emphasized at other meetings. Topics of emphasis at the 2017 meeting will include: (1) recent insights into ROS/RNS signaling and its translational potential, (2) advances in our understanding of proteostasis and mitochondrial quality in longevity, (3) the role of ROS/RNS in human health, inflammation and disease progression, and (4) initial strategies currently being applied for translation of basic redox biology research discoveries into the clinical realm.

Related Meeting

This GRC was held in conjunction with the "Oxidative Stress & Disease" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: The Redox Language in Medical Research
Discussion Leader: Helmut Sies (Heinrich Heine University Dusseldorf, Germany)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:25 pmRafael Radi (University of the Republic, Uruguay)
"Interplay of Oxygen Radicals, Nitric Oxide and Redox-Active Compounds: Relevance to Human Physiology, Disease and Aging"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmHarald Schmidt (Maastricht University, The Netherlands)
"NOX, NOS and sGC as Therapeutic Targets Within a Cluster of Redox-Related Diseases"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmProteostasis, Autophagy and Longevity
Discussion Leader: Kelvin Davies (University of Southern California, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amRichard Morimoto (Northwestern University, USA)
"Proteostasis in Aging and Disease"
9:35 am - 9:50 amDiscussion
9:50 am - 10:15 amAna Maria Cuervo (Albert Einstein College of Medicine, USA)
"Selective Autophagy in the Fight Against Age-Related Disease"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:15 amSelected from Poster Abstracts: George Rodney (Baylor College of Medicine, USA)
"Nox2 ROS: Putting a Break on Autophagy"
11:15 am - 11:20 amDiscussion
11:20 am - 11:35 amSelected from Poster Abstracts: Wei-Xing Zong (Rutgers University, USA)
"TRIM21 as a Negative Regulator of the p62-Keap1-Nrf2 Pathway"
11:35 am - 11:40 amDiscussion
11:40 am - 11:50 amIntroduction by Discussion Leader
11:50 am - 12:05 pmSelected from Poster Abstracts: Mariapaola Nitti (University of Genoa, Italy)
"Differentiation Impairs Bach1 Dependent HO-1 Activation and Increases Sensitivity to Oxidative Stress in Neuroblastoma Cells"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Steen Vang Petersen (Aarhus University, Denmark)
"Dynamics of SOD3 Secretion by Stimulated Macrophages"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Grazia Isaya (Mayo Clinic College of Medicine, USA) and Carmen Gomez-Cabrera (University of Valencia, Spain)
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmRevisiting: The Cross-Talk Between ROS Signaling and Cell Homeostasis
Discussion Leader: Deborah Ferrington (University of Minnesota, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:35 pmGerald Shadel (Yale School of Medicine, USA)
"Mitochondrial Stress Signaling in Disease and Immunity"
6:35 pm - 6:50 pmDiscussion
6:50 pm - 7:15 pmNoriko Noguchi (Doshisha University, Japan)
"Regulation of Cell Signaling by Lipid Oxidation Products and Antioxidants"
7:15 pm - 7:30 pmDiscussion
7:30 pm - 7:45 pmTilman Grune (German Institute of Human Nutrition, Germany)
"Redox Regulation of Proteostasis"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmROS/RNS in Vascular Aging
Discussion Leader: Giovanni Mann (King's College London, United Kingdom)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amAnne Negre-Salvayre (INSERM, France)
"Angiogenesis and Oxidized Lipids in Atherosclerosis"
9:35 am - 9:50 amDiscussion
9:50 am - 10:15 amAnna Csiszar (University of Oklahoma Health Sciences Center, USA)
"Vascular Aging in the Brain"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amFrancisco Laurindo (Heart Institute (InCor), University of Sao Paulo School of Medicine, Brazil)
"Intra and Extracellular Thiol Isomerases in Disease-Associated Vascular Remodeling"
11:25 am - 11:40 amDiscussion
11:40 am - 11:55 amSelected from Poster Abstracts: Susan Scheibe (University of Giessen, Germany)
"The Role of Mitochondrial Reactive Oxygen Species in the Response of the Pulmonary Vasculature to Hypoxia and Right Heart Remodeling"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmSelected from Poster Abstracts: Judit Marsillach Lopez (University of Washington, USA)
"Paraoxonase-1 Inactivation by Oxidative Stress in Cardiovascular Disease"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmMitochondrial Quality and Control in the Diseased Brain
Discussion Leader: Enrique Cadenas (University of Southern California, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:35 pmMarzia Perluigi (Sapienza University of Rome, Italy)
"Decoding Alzheimer-Like Neurodegeneration from Mitochondrial Defects"
6:35 pm - 6:50 pmDiscussion
6:50 pm - 7:15 pmGrazia Isaya (Mayo Clinic College of Medicine, USA)
"Mitochondrial Fe-S Cluster Dysfunction in Neurodegenerative Disease"
7:15 pm - 7:30 pmDiscussion
7:30 pm - 7:45 pmSelected from Poster Abstracts: Christian Gonzalez-Billault (University of Chile, Chile)
"Novel Mechanisms Involving Redox Biology Are Essential to Support Axonal Growth"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEmerging Challenges: Inflammation and Diseases of the Gut, Lung, Pancreas, Liver
Discussion Leader: Juan Sastre (University of Valencia, Spain)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amPatricia Oteiza (University of California, Davis, USA)
"Dietary Flavonoids in the Treatment of the Inflamed and Leaky Gut"
9:35 am - 9:50 amDiscussion
9:50 am - 10:15 amSuzanne Cloonan (Weill Cornell Medicine, USA)
"Mitochondrial Iron Metabolism in COPD"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amTony Tiganis (Monash University, Australia)
"ROS in Liver Disease and Type2 Diabetes"
11:25 am - 11:40 amDiscussion
11:40 am - 11:55 amSelected from Poster Abstracts: Ross Vlahos (RMIT University, Australia)
"ROS in Chronic Lung Diseases"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmSelected from Poster Abstracts: Nesrin Ozer (Marmara University, Turkey)
"Endoplasmic Reticulum Stress-Related Signaling and Lipid Metabolism in Non-Alcoholic Fatty Liver Disease"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmRedox Reactions in Infectious Diseases
Discussion Leader: Carroll Cross (University of California, Davis, USA)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:35 pmDavid Lembo (University of Turin, Italy)
"The Broad Antiviral Effect of Oxysterols: Molecular Aspects and Therapeutic Potential"
6:35 pm - 6:50 pmDiscussion
6:50 pm - 7:15 pmRegina Medvedev (Paul Ehrlich Institute, Germany)
"A Radical Virus Needs Radical Strategies – HCV-Induced Oxidative Stress in Viral Biology and Disease"
7:15 pm - 7:30 pmDiscussion
7:30 pm - 7:45 pmSelected from Poster Abstracts: Rao Papineni (University of Kansas Medical Center / PACT & Health, LLC, USA)
"2-Deoxyglucose and Bisphosphonate Show Common Pathways in Its Drug Repurposed Anticancer and Anti-Infection Actions"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmRedox-Orientated Biotechnology and Medicine
Discussion Leader: Cesar Fraga (University of Buenos Aires, Argentina)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:35 amElena Batrakova (University of North Carolina at Chapel Hill, USA)
"Engineering Exosomes to Deliver a Potent Redox Enzyme Catalase to the Brain"
9:35 am - 9:50 amDiscussion
9:50 am - 10:15 amGaetano Serviddio (University of Foggia, Italy)
"Therapeutic Implications of Mitochondrial Redox Impairment in Human Disease and Aging"
10:15 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amGiuseppe Valacchi (North Carolina State University, USA)
"Modulation of Oxidative Stress Response in Neurodevelopment Disorders. The Case of the Rett Syndrome Variants: MECP2 and CDKL5"
11:25 am - 11:40 amDiscussion
11:40 am - 11:55 amSelected from Poster Abstracts: Irundika Dias (Aston University, United Kingdom)
"Targeted Lipidomic Analysis of Oxysterols in Plasma from Patients with Alzheimer's Disease"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmSelected from Poster Abstracts: Laurent Paardekooper (Radboud Institute for Molecular Life Sciences, The Netherlands)
"Lipid Peroxidation Product Ethylene Is a Real-Time Respiratory Marker for Systemic Inflammation"
12:15 pm - 12:20 pmDiscussion
12:20 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:30 pmFree Time
4:30 pm - 6:00 pmPoster Session
6:00 pm - 8:00 pmCellular Mechanisms Underlying Oxidative Stress and Exercise
Discussion Leader: Jose Vina (University of Valencia, Spain)
6:00 pm - 6:10 pmIntroduction by Discussion Leader
6:10 pm - 6:35 pmCarmen Gomez-Cabrera (University of Valencia, Spain)
"Modulation of ROS Levels as a Strategy to Improve Healthy Aging: The Exercise Model"
6:35 pm - 6:50 pmDiscussion
6:50 pm - 7:15 pmMalcolm Jackson (University of Liverpool, United Kingdom)
"Neuromuscular Defects as a Regulator of Oxidative Stress in Aging Skeletal Muscle"
7:15 pm - 7:30 pmDiscussion
7:30 pm - 7:45 pmSelected from Poster Abstracts: Alex Wadley (University of Worcester, United Kingdom)
"Phenotypic Assessment of Lymphocyte Thiol Reduction Following Acute Exercise: Characterisation of a Highly Reduced CD8+ T Cell Population"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:00 pmGeneral Discussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible, in part by 1R13AG055293-01 from the National Institute on Aging. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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