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Signaling by Adhesion Receptors
Gordon Research Conference

Adhesion: The Cellular Basis of Tissue Homeostasis and Dysfunction

Dates

June 19-24, 2016

Location

Bates College
Lewiston, ME

Organizers

Chair:
Alpha S. Yap

Vice Chair:
Christopher S. Chen

Meeting Description

Cell adhesion plays a vital role in many aspects of cell and tissue biology. From being first regarded as principally responsible for preserving tissue cohesion, we now appreciate that adhesion to the extracellular matrix and other cells affects processes as diverse as cell proliferation, differentiation and morphogenesis. The discovery that cell adhesion molecules are signaling receptors played a key role in this broadened understanding of the biology of adhesion. The 2016 GRC on Signaling by Adhesion Receptors aims to capture recent trends in this diverse field and focus attention on key issues that we still do not understand. The Conference will be organized in a series of thematic sessions that cover major broad topics and Focus sessions that will concentrate discussion on major open questions. Important issues for the meeting include understanding how adhesion supports tissue homeostasis; and tackling the problem of bridging the different biological scales (molecular, cellular, tissue) across which adhesion systems work. We aim to promote a multidisciplinary atmosphere that will encourage open exchange of ideas around long-standing problems and new problems in the field. Accordingly, the program includes contributions from new and established investigators in the field that span many disciplines. There will be poster sessions on the four afternoons of the conference to encourage discussion and debate and many opportunities for short talks to be chosen from submitted abstracts and from the accompanying Gordon Research Seminar on Signaling by Adhesion Receptors. Ample free time and communal meals are additional features of the conference designed to promote discussion, and facilitate new collaborations and relationships.

Related Meeting

This GRC was held in conjunction with the "Signaling by Adhesion Receptors" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Perspectives in Adhesion and Homeostasis
Discussion Leaders: Alpha Yap (The University of Queensland, Australia) and Christopher Chen (Boston University / Harvard University, USA)
7:40 pm - 8:15 pmIan Macara (Vanderbilt University Medical Center, USA)
"Unexpected Roles for Polarity Proteins in the Life and Death of Epithelial Cells"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 8:40 pmSelected from Poster Abstracts: Madeleine Oudin (Massachusetts Institute of Technology, USA)
"Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis During Metastatic Progression"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:10 pmJody Rosenblatt (Huntsman Cancer Institute, University of Utah, USA)
"Mechanical Stretch Triggers Rapid Epithelial Cell Division Through the Stretch-Activated Channel Piezo 1"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmNew Mechanisms in Cell Adhesion
Discussion Leader: Maddy Parsons (King's College London, United Kingdom)
9:00 am - 9:25 amWilliam Weis (Stanford University, USA)
"Force-Dependent Molecular Interactions in Adherens Junction Assembly"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amVinay Swaminathan (National Heart, Lung, and Blood Institute, NIH, USA)
"Actin Retrograde Flow Orients and Aligns Activated, Ligand-Engaged Integrins in Focal Adhesions"
10:00 am - 10:10 amDiscussion
10:10 am - 10:25 amSelected from Poster Abstracts: Ben Goult (University of Kent, United Kingdom)
"The Emerging Role of Talin as a Mechanosensitive Signalling Platform"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amNicholas Brown (University of Cambridge, United Kingdom)
"Integrating Adhesome Components into a Functional Machine"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmSatyajit Mayor (National Centre for Biological Sciences, India)
"Local Membrane Organization and Integrin Signaling"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Alessandra Cambi (Radboud University Medical Center, The Netherlands)
"Nanoscale Architectures and Mesoscale Dynamics of Mechanosensory Podosomes"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Jody Rosenblatt (Huntsman Cancer Institute, University of Utah, USA) and Madeleine Oudin (Massachusetts Institute of Technology, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMyosin and Adhesion: Its Roles as Force Generator and Scaffold
Discussion Leader: Kris DeMali (University of Iowa, USA)
7:30 pm - 7:55 pmJohn Hammer (National Heart, Lung, and Blood Institute, NIH, USA)
"Mixing and Matching Myosins to Drive Functional Diversity"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmMargaret Gardel (The University of Chicago, USA)
"A Mechanochemical Feedback to Regulate Cell Elasticity"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 8:55 pmVivian Tang (University of Illinois at Urbana-Champaign, USA)
"Propagating Cortical Actomyosin-Generated Tension to Intercellular Adhesion Complex by Myosin-1c"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:15 pmColleen Skau (National Institutes of Health, USA)
"An FMN2-Mediated Perinuclear Actin/Adhesion System Protects Against DNA Damage During Confined Cell Migration"
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAdvances in Adhesion Signaling
Discussion Leader: Tony Koleske (Yale University, USA)
9:00 am - 9:25 amAnn Miller (University of Michigan, USA)
"Regulation of Localized RhoA Activity and Cell-Cell Junction Remodelling in Dividing Epithelial Cells"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amJay Groves (University of California, Berkeley, USA)
"Mechanical Aspects of Signaling at Cell-Cell Junctions"
10:00 am - 10:10 amDiscussion
10:10 am - 10:25 amSelected from Poster Abstracts: Rishita Changede (Mechanobiology Institute, National University of Singapore, Singapore)
"Nascent Integrin Adhesions Form on All Matrix Rigidities After Integrin Activation"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amHilary Ashe (University of Manchester, United Kingdom)
"Enhancement of the BMP Pathway by Integrin Signalling in Drosophila"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmValerie Horsley (Yale University, USA)
"Epithelial and Stromal Players in Skin Tissue Adhesion and Matrix Deposition"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Yusuke Toyama (Mechanobiology Institute, National University of Singapore, Singapore)
"Tension-Dependent Vinculin Dynamics at Adherens Junction During Cell Boundary Oscillation"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmInside-Out Integrin Signaling: Revisiting a Controversy
Discussion Leader: Nicholas Brown (University of Cambridge, United Kingdom)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:00 pmDavid Calderwood (Yale University, USA)
"How Important Is Inside-Out Signaling in Non-Hemopoeitic Cells?"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:35 pmMartin Humphries (University of Manchester, United Kingdom)
"Primordial Connections Between the Adhesion Nexus and Cell Proliferation"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:10 pmGuy Tanentzapf (University of British Columbia, Canada)
"Regulation of Integrin-Mediated Adhesion in Tissue Development and Homeostasis"
9:10 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAdhesion and Tissue Homeostasis
Discussion Leader: Erin Cram (Northeastern University, USA)
9:00 am - 9:25 amJay Humphrey (Yale University, USA)
"Mechanoregulation of Matrix in Vascular Homeostasis and Disease"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amAnna Huttenlocher (University of Wisconsin-Madison, USA)
"Chemokines and Bidirectional Migration"
10:00 am - 10:10 amDiscussion
10:10 am - 10:25 amSelected from Poster Abstracts: Michael Smutny (Institute of Science and Technology Austria, Austria)
"E-Cadherin-Dependent Friction Force Is a Major Driver of Tissue Morphogenesis in Zebrafish Development"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amJohn Wallingford (University of Texas at Austin, USA)
"Pushing and Pulling: Understanding Cell Movement in Vertebrate Embryos"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmDidier Stainier (Max Planck Institute for Heart and Lung Research, Germany)
"Signaling, Cell Polarity and Adhesion During Cardiac Trabeculation"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Jocelyn McDonald (Kansas State University, USA)
"Detachment Versus Cohesion: Novel Roles for PDZ-GEF and Rap1 During Collective Cell Migration"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmNew Approaches to Integrate Across Biological Scales
Discussion Leader: Anand Asthagiri (Northeastern University, USA)
7:30 pm - 7:55 pmCeleste Nelson (Princeton University, USA)
"Adhesions and Forces in Tissue Origami"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmVirgile Viasnoff (Mechanobiology Institute, National University of Singapore, Singapore)
"Control of Cell-Cell Contact Polarization by Mechanical Forces"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmChristopher Chen (Boston University / Harvard University, USA)
"Forces, Adhesions and Mechanotransduction in a Multicellular Context"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDisease: Adhesion and Its Discontents
Discussion Leader: Andrew Gladden (University of Texas MD Anderson Cancer Center, USA)
9:00 am - 9:25 amPeter Friedl (Radboud University Medical Center, The Netherlands)
"Balancing Cell-Cell Interactions and Tissue Mechanics During Cancer Invasion"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amCorinne Albiges-Rizo (Institut Albert Bonniot, Université Joseph Fourier / CNRS, INSERM, France)
"Cell Contractility and Tissue Integrity"
10:00 am - 10:10 amDiscussion
10:10 am - 10:25 amSelected from Poster Abstracts: Edna Cukierman (Fox Chase Cancer Center, Temple Health, USA)
"Integrins in Epithelial Cancer Desmoplastic-to-Homeostatic Stroma Remodeling"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:25 amMartin Schwartz (Yale School of Medicine, USA)
"Mechanotransduction in Vascular Health and Disease"
11:25 am - 11:35 amDiscussion
11:35 am - 12:00 pmWeilan Ye (Genentech Inc., USA)
"Modulating Integrin a5b1 Adhesive Property to Alter Drug Delivery and Lymphocyte Trafficking"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmSelected from Poster Abstracts: Xiaoyang Wu (University of Chicago, USA)
"ACF7 Regulates Cell/Cell Junctions in Intestinal Epithelium"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSystems Approaches to Quantitative Analysis
Discussion Leader: Brenton Hoffman (Duke University, USA)
7:30 pm - 7:55 pmValerie Weaver (University of California, San Francisco, USA)
"Signaling in the 3rd Dimension: A Biophysical Perspective"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmAlexander Mogilner (Courant Institute of Mathematical Sciences, New York University, USA)
"Quantitative Adhesion Dynamics in Spontaneous and Induced Cell Motility Initiation"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmXavier Trepat (Institute for Bioengineering of Catalonia (IBEC), Spain)
"Epithelial Tissues as Active Materials Controlled by Cell-Cell Forces"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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