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DNA Damage, Mutation & Cancer
Gordon Research Conference

Genome Instability from Environmental and Inherent Sources of DNA Damage

Dates

March 13-18, 2016

Location

Ventura Beach Marriott
Ventura, CA

Organizers

Chair:
Sergei M. Mirkin

Vice Chair:
Richard D. Wood

Meeting Description

The 2016 Gordon Conference on DNA Damage, Mutation & Cancer will present cutting-edge research on the molecular mechanisms responsible for the recognition and processing of environmental DNA damage as well as inherently unstable DNA sequences. Multiple biochemical mechanisms recognize DNA lesions or difficult to unravel DNA structures, ultimately yielding a choice of pathways for resolution. Competing and collaborating DNA repair mechanisms are at heart of a delicate balance between inherent genomic stability and instability in health and disease. Understanding these mechanisms is crucial for developing next generation anti-cancer therapies that will take advantage of genotypic differences between normal cells and tumor cells. The conference will feature many front-line scientific topics as outlined in the session titles.  

Our invited speakers represent a variety of scientific disciplines, including molecular genetics, biochemistry, structural biology and molecular oncology. The Conference will bring together a diverse group of researchers with broad backgrounds and interests stimulating new research and collaborations. It will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field, as well as the possibility to attend the associated Gordon Research Seminar. Some poster presenters will be selected for late-breaking short talks.  

This conference has been over-subscribed in the past, so early application with submission of abstracts is strongly encouraged.

Related Meeting

This GRC was held in conjunction with the "DNA Damage, Mutation & Cancer" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Inherent Genomic Stability and Instability
Discussion Leader: Sergei Mirkin (Tufts University, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:30 pmPhilip Hanawalt (Stanford University, USA)
"From Repair Replication to R-Loops in Half-a-Century"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:20 pmStephen Kowalczykowski (University of California, Davis, USA)
"Molecular Functions of BRCA1, BRCA2, and RAD51 Paralogs in Homologous Recombination"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmGenome Weak Links
Discussion Leader: Richard Wood (University of Texas MD Anderson Cancer Center, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amRichard Wood (University of Texas MD Anderson Cancer Center, USA)
"Expanding the Repertoire of Replicative DNA Polymerases"
9:30 am - 9:35 amDiscussion
9:35 am - 9:55 amCatherine Freudenreich (Tufts University, USA)
"Transcriptional Effects on CAG Repeat Instability and Fragility"
9:55 am - 10:00 amDiscussion
10:00 am - 10:20 amKaren Vasquez (The University of Texas at Austin, USA)
"Replication-Dependent and Replication-Independent Models of DNA Structure-Induced Genetic Instability"
10:20 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:15 amSusan Lovett (Brandeis University, USA)
"Template-Switch Mutagenesis and Genetic Rearrangements During DNA Repair"
11:15 am - 11:20 amDiscussion
11:20 am - 11:40 amThomas Petes (Duke University, USA)
"DNA Structure-Based Determinants of Mutation Rates in Yeast"
11:40 am - 11:45 amDiscussion
11:45 am - 12:05 pmNancy Maizels (University of Washington, USA)
"Repair at DNA Nicks"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmSelected from Poster Abstracts: Sheroy Minocherhomji (University of Copenhagen, Denmark)
"Mitotic DNA Repair Synthesis Protects Against Chromosome Fragility"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Catherine Freudenreich (Tufts University, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEnvironmental and Endogenous DNA Damage
Discussion Leader: Nicholas Geacintov (New York University, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmNicholas Geacintov (New York University, USA)
"Removal of Environmental DNA Damage by Competing BER and NER Pathways"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmIsao Kuraoka (Osaka University, Japan)
"Function of Human Endonuclease V: From DNA to RNA"
8:20 pm - 8:25 pmDiscussion
8:25 pm - 8:35 pmSelected from Poster Abstracts: Xiaohua Wu (The Scripps Research Institute, USA)
"Repair of DNA Double-Strand Breaks Associated with Re-Replication"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmJohn Tainer (University of Texas MD Anderson Cancer Center, USA)
"Nucleases Sculpt DNA to Control Outcomes at Replication Forks and Double-Strand Breaks"
9:00 pm - 9:05 pmDiscussion
9:05 pm - 9:25 pmDavid Pellman (Dana-Farber Cancer Institute, USA)
"Nuclear Organization and Genome Stability"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmRNA-DNA Interplay in Genome Instability
Discussion Leader: Hannah Klein (New York University School of Medicine, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amHannah Klein (New York University School of Medicine, USA)
"Ribonucleotide-Promoted Genome Instability"
9:30 am - 9:35 amDiscussion
9:35 am - 9:55 amMark Bedford (University of Texas MD Anderson Cancer Center, USA)
"The Link Between Arginine Methylation and R-Loop Resolution"
9:55 am - 10:00 amDiscussion
10:00 am - 10:20 amFrancesca Storici (Georgia Institute of Technology, USA)
"DNA Self-Repair by Transcript RNA"
10:20 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:15 amKarlene Cimprich (Stanford University School of Medicine, USA)
"RNA Meets DNA: Mechanisms for Transcription-Associated Genome Instability"
11:15 am - 11:20 amDiscussion
11:20 am - 11:40 amAndres Aguilera (University of Seville, Spain)
"Role of Chromatin and the DNA Damage Response in Transcription-Associated Genome Instability"
11:40 am - 11:45 amDiscussion
11:45 am - 12:05 pmEvgeny Nudler (New York University School of Medicine, USA)
"New Principles of Transcription-Coupled DNA Repair"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmSelected from Poster Abstracts: Giordano Liberi (L'Istituto di Genetica Molecolare (IGM), CNR, Italy)
"Mechanisms that Rescue Replication Forks Arrested by Transcription"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmOxidative DNA Damage and Base Excision Repair
Discussion Leader: Samuel Wilson (National Institute of Environmental Health Sciences, NIH, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmSamuel Wilson (National Institute of Environmental Health Sciences, NIH, USA)
"Mechanistic Studies of Base Excision Repair"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmCynthia McMurray (Lawrence Berkeley National Laboratory, USA)
"Death by DNA Repair"
8:20 pm - 8:25 pmDiscussion
8:25 pm - 8:45 pmYuan Liu (Florida International University, USA)
"DNA Base Lesion Repair and Trinucleotide Repeat Instability"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmGuoliang Xu (Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China)
"Enzymatic DNA Oxidation in Epigenetic Regulation of Mammalian Development"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: James Cleaver (University of California, San Francisco, USA)
"Why Cockayne Patients Do Not Get Cancer Despite Their DNA Repair Deficiency"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMutagenesis in Response to Arrested Replication
Discussion Leader: Wei Yang (National Institutes of Health, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amWei Yang (National Institutes of Health, USA)
"Tripartite DNA Lesion Recognition and Verification by XPC, TFIIH and XPA in Nucleotide Excision Repair"
9:30 am - 9:35 amDiscussion
9:35 am - 9:55 amSimon Boulton (The Francis Crick Institute, United Kingdom)
"Genome Stability and the Control of Homologous Recombination"
9:55 am - 10:00 amDiscussion
10:00 am - 10:20 amMassimo Lopes (University of Zurich, Switzerland)
"Replication Fork Remodelling upon DNA Replication Stress"
10:20 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:15 amNaoko Shima (University of Minnesota, USA)
"Functional Interactions Between Dormant Origins and BRCA2 in Genome Stability and Mouse Development"
11:15 am - 11:20 amDiscussion
11:20 am - 11:40 amFrederick Alt (Harvard Medical School, USA)
"Chromosomal Loop Domains, DNA Breaks and Translocations in Lymphoid and Neural Cells"
11:40 am - 11:45 amDiscussion
11:45 am - 12:05 pmKirill Lobachev (Georgia Institute of Technology, USA)
"Mechanism of Endogenous and Damage-Induced Mutagenesis in Palindrome-Proximal Regions"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:20 pmSelected from Poster Abstracts: Duncan Smith (New York University, USA)
"Pif1 Helicases Suppress Widespread Replisome Pausing at tRNA Genes in S. cerevisiae"
12:20 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmCheckpoints and Strand-Break Repair
Discussion Leader: Karlene Cimprich (Stanford University School of Medicine, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmLee Zou (Massachusetts General Hospital Cancer Center, Harvard University, USA)
"New Insights into the Functions of ATR in DNA Repair"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmDale Ramsden (University of North Carolina, Lineberger Comprehensive Cancer Center, USA)
"The Contribution of DNA Polymerases to Double Strand Break Repair"
8:20 pm - 8:25 pmDiscussion
8:25 pm - 8:45 pmSylvie Doublie (University of Vermont, USA)
"When the 3'-End Justifies the Means, or How a Family A Polymerase Solves a Major Challenge"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmMitch McVey (Tufts University, USA)
"Meaningful Mistakes: Using Translesion Polymerases During Double-Strand Break Repair"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Richard Pomerantz (Temple University Lewis Katz School of Medicine, USA)
"New Mechanisms of Polymerase Theta-Mediated End-Joining"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFoSTeS, Kataegis and Chromothripsis
Discussion Leader: Anna Malkova (University of Iowa, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amAnna Malkova (University of Iowa, USA)
"Genetic Instability Resulting from DNA Synthesis Associated with Double-Strand Break Repair"
9:30 am - 9:35 amDiscussion
9:35 am - 9:55 amJames Lupski (Baylor College of Medicine, USA)
"Mechanisms for Disease Associated Genomic Rearrangements"
9:55 am - 10:00 amDiscussion
10:00 am - 10:20 amThanos Halazonetis (University of Geneva, Switzerland)
"Mechanisms of Oncogene-Induced DNA Replication Stress"
10:20 am - 10:25 amDiscussion
10:25 am - 10:35 amSelected from Poster Abstracts: Jane Kim (Tufts University, USA)
"Break-Induced Replication Drives Large-Scale CAG Repeat Expansion in Budding Yeast"
10:35 am - 10:40 amDiscussion
10:40 am - 11:10 amCoffee Break
11:10 am - 11:30 amYouri Pavlov (UNMC Eppley Cancer Center, University of Nebraska, USA)
"En Route to APOBEC-Induced Mutation Clusters"
11:30 am - 11:35 amDiscussion
11:35 am - 11:55 amLawrence Loeb (University of Washington, USA)
"Extensive Subclonal Mutations Characterize Many Human Cancers; Origin and Consequences"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Ashok Bhagwat (Wayne State University, USA)
"DNA Damage at the Replication Fork: The Role of APOBEC Enzymes"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmSelected from Poster Abstracts: Robert P. Fuchs (CNRS UMR7258, France)
"Gymnastics Between Sister Chromatids and Timing of Events at the Replication Fork Upon Encounter of a Replication-Blocking Lesion in E. coli"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEmerging Therapies Based on Cancer Genomics
Discussion Leader: Thomas Helleday (Karolinska Institutet, Sweden)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 7:55 pmThomas Helleday (Karolinska Institutet, Sweden)
"Targeting DNA Repair to Poison Cells with Damaged Nucleosides"
7:55 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmZvi Livneh (Weizmann Institute of Science, Israel)
"Harnessing DNA Repair for Cancer Prevention and Early Detection"
8:20 pm - 8:25 pmDiscussion
8:25 pm - 8:45 pmTarun Kapoor (The Rockefeller University, USA)
"Chemical Proteomics: Shining Light on Phosphorylation-Dependent Protein-Protein Interactions Required for Genome Stability"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:10 pmJames Ford (Stanford University School of Medicine, USA)
"Chemoprevention Targeting BRCA1-Mutation Associated DNA Repair Defects"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Menachem Rubinstein (Weizmann Institute of Science, Israel)
"Programmed DNA Damage: Potential Clinical Implications"
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13CA203164-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health & Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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