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DNA Damage, Mutation and Cancer
Gordon Research Conference

Controlling Cancer by Exploiting Fundamental Knowledge of DNA Damage and Mutation

Dates

March 25-30, 2018

Location

Ventura Beach Marriott
Ventura, CA Site Information

Organizers

Chair:
Richard D. Wood

Vice Chair:
Hannah Klein

Application Deadline

Applications for this meeting must be submitted by February 25, 2018. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

The 2018 Gordon Research Conference on DNA Damage, Mutation and Cancer is developed around the theme of exploiting fundamental knowledge to advance treatment and prevention. Rich and ever-increasing information is available on the specific mutations that are the molecular basis of cancer. Many mutations can be traced to specific types of damage to the DNA, while others arise from DNA replication errors or unknown causes. Technologies are being refined to determine the origins of these mutations, and monitor the accuracy and reproducibility of cancer genomic data. Biological and structural analyses can assess which mutations are functionally relevant. Specific mutations can confer vulnerabilities, making individual cancers more responsive to treatment with DNA damaging agents.

This conference is organized to stimulate constructive interactions among an international group of experts including academic scientists, researchers from industry, and practicing clinicians. Participants will discuss the most recent and unpublished advances resulting from the current convergence of knowledge. Sessions will focus on cancer-associated mutations, foundational principles, current and developing cancer treatments based on DNA repair capability, new targets, DNA repair inhibitors and resistance, and insights into mutation and cancer from model systems.

The meeting takes place in a relaxed environment as discussions begin over breakfast, continue during the afternoon and extend into the evening through convivial gatherings after each session. Most attendees will present posters in very active discussion sessions. The program will include times for short talks to be selected from poster abstracts. For the second time, the conference will be preceded by a 1.5 day Gordon Research Seminar (GRS), to foster involvement at the graduate student and postdoctoral level. Planned by and for trainees, it will provide an opportunity for junior researchers to present their work in a supportive, interactive environment. Time will also be devoted to career and funding planning.

Related Meeting

This GRC will be held in conjunction with the "DNA Damage, Mutation and Cancer" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Gordon Research Conferences
Repare Therapeutics Inc.
Bethyl Laboratories

Preliminary Program

The topics and speakers for the conference sessions are displayed below (italics denote discussion leaders). The Conference Chair is currently developing their detailed program, which will include the complete meeting schedule, as well as the talk titles for all speakers. The detailed program will be available by November 25, 2017. Please check back for updates.

  • Epigenetic and Genetic Interplay in Cancer
    (Richard Wood / Ronny Drapkin / Paul Northcott / Sharon Plon)
  • Cancer-Associated Mutations
    (Karen Vasquez / Chris Buck / Nicola Waddell / Laurence Ettwiller / Marcin Imielinski / Janet Rader)
  • Foundations of DNA Damage, Mutation and Cancer
    (Wim Vermeulen / Susan Wallace / Cristian Tomasetti / Dmitry Gordenin)
  • Developing Cancer Treatments Based on DNA Repair Capability
    (Ronny Drapkin / Jo Morris / Natalia Tretyakova / Joann Sweasy / Helen Piwnica-Worms / Neil Johnson)
  • Current Cancer Treatments Based on DNA Repair
    (Helen Piwnica-Worms / Anna Lindstrand / Lauren Byers / Jing Wang)
  • New Targets
    (Jo Morris / Tony Huang / Wim Vermeulen / Andrew Holland / Sylvie Doublie / Sheila David)
  • DNA Damage Response Inhibitors and Resistance
    (Joann Sweasy / Christopher Bakkenist / Sharon Cantor / Paul Mischel)
  • Mutation and Cancer: New Insights from Yeast Models
    (Sharon Cantor / Yolanda Sanchez / Megan King / Polina Shcherbakova / Hannah Klein / Kara Bernstein)
  • Mutations Facilitated by DNA Damage and Structure
    (Sheila David / Hilde Nilsen / Alba Guarne / Karen Vasquez / Patricia Kannouche)
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