Applications for this meeting must be submitted by May 7, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.
The CAG Triplet Repeat Disorders are a group of
largely untreatable, heritable neurological disorders, which result from an
expansion in a CAG trinucleotide repeat in mutant genes. They include
Huntington's disease (HD), spinal and bulbar muscular atrophy (SBMA, Kennedy's
disease), several spinocerebellar ataxias, and dentatorubropallidoluysian
atrophy (DRPLA). Extended CAG repeats in the coding regions of genes result in
abnormally long polyglutamine tracts in the mutant proteins. Marked
similarities in the underlying genetics and the neurological symptoms suggest
common pathogenic mechanisms. Exciting new efforts to unravel these mechanisms
have recently been made in the area of proteostasis research, which is of high
relevance to understanding proteopathies like CAG repeat diseases. To delineate
the networks of cellular homeostasis in their entirety "-omics" approaches have
moved into the focus and have unraveled surprising new connections between the
molecules involved in disease. Seeding and spreading of misfolded protein
species have recently been recognized as perhaps highly relevant to
pathogenesis. Connected to these phenomena, innovative technologies to identify
relevant targets, disease markers and effective therapeutics are in
development. To increase the pace of molecular discovery and to accelerate
translation into the clinic, a multidisciplinary effort is required.
Gordon Research Conference on CAG Triplet Repeat Disorders and the associated Gordon
Research Seminar (GRS) will gather young investigators and established senior
scientists to deliver thought-provoking lectures on the cutting edge of
science. In keeping with the Gordon Research Conference tradition, there will
be ample time for structured discussions led by peers and for informal
discussion and social interaction. Strong emphasis is placed on training and
mentoring, and time will be devoted to career issues. All participants are
required to submit posters, based on which invitations for short talks will be issued.
Priority will be given to women, minorities and persons with disabilities when
This GRC will be held in conjunction with the "CAG Triplet Repeat Disorders" Gordon Research Seminar (GRS)
. Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page
for more information.
The topics and speakers for the conference sessions are displayed below (italics denote discussion leaders). The Conference Chair is currently developing their detailed program, which will include the complete meeting schedule, as well as the talk titles for all speakers. The detailed program will be available by February 4, 2017. Please check back for updates.
Keynote Session: Disease Mechanisms and Phenotypes
(Leslie Thompson / Henry Paulson / Ulrich Hartl)
Common Pathogenic Mechanisms in Neurodegenerative
(Diane Merry, Harry Orr / Jeffrey Rothstein / Robert Richards / Judith Frydman)
The Toxic Conformer: Does It Exist?
(Laura Ranum, Christopher Ross / Ronald Melki / Meewhi Kim / Matthew Disney / Louise Serpell)
Impairment of DNA Repair Mechanisms in CAG Repeat
(Marian Difiglia, Jang-Ho Cha / Leslie Jones / Hitoshi Okazawa / Partha Sarkar)
What Can We Learn from Large OMIC Data Sets
for Disease Research?
(Daniel Lavery, Gillian Bates / William Yang / Smita Saxena / Juan Botas)
Proteostasis and Protein Quality Control Mechanisms in Disease
(Eric Reits, Joan Steffan / Nico Dantuma / Janine Kirstein / Harm Kampinga / Ai Yamamoto)
From Molecules to Humans: Selected Poster
Presentations / Selected GRS Presentations
(Asa Petersen, Sarah Tabrizi)
Innovative Technologies, Model Systems and Quantitative Methods
(Jenny Morton, Blair Leavitt / Andreas Weiss / Elena Cattaneo / Fanny Mochel / Beatriz Alvarez-Castelao)
Innovative Therapeutic Strategies and Diagnostic Tools
(Edward Wild, Henry Paulson / Sarah Tabrizi / Albert La Spada / Beverly Davidson / Gulin Oz)