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Stress Proteins in Growth, Development & Disease
Gordon Research Conference

From Protein Folding to Misfolding Disorders: The Importance of Maintaining Proteostasis over a Lifetime

Dates

July 9-14, 2017

Location

Grand Summit Hotel at Sunday River
Newry, ME

Organizers

Chair:
Kevin Morano

Vice Chair:
Elke Deuerling

Meeting Description

The cellular proteome is constantly exposed to a wide variety of proteotoxic stress conditions. These include external stresses, such as elevated temperatures and radiation damage as well as physiological stresses encountered during cellular proliferation and differentiation, such as oxidative stress, or challenges to protein folding caused by inherited gene mutations. Moreover, a number of common stimuli, such as pharmacological agents, infection, and inflammation also negatively impact the cellular proteome. In all organisms, deployment of a comprehensive stress response is essential for the maintenance of protein homeostasis in response to proteotoxic stress. A hallmark of stressed cells and organisms is the increased synthesis of molecular chaperones that aid in the folding of nascent polypeptides and prevent protein misfolding and aggregation. Chaperones are also important for protein degradation and translocation of proteins across membranes as well as for the correct formation of macromolecular assemblies. The protein quality control and stress protection machineries require strict signaling modalities and transcriptional programs, many of which are altered in a number of disease states, including cancer, cardiovascular disease, metabolic disease (e.g., diabetes) and liver disease. Modulation of the stress response also plays a critical role in life-span regulation and aging-related disorders such as Alzheimer's, Parkinson's, Huntington's diseases as well as prion-based disease.

The Gordon Conference on "Stress Proteins in Growth, Development and Disease" will highlight the most recent advances in stress biology and biomedical research of stress-related diseases. Special emphasis is on a multitude of model systems that are being used to investigate stress sensing, signaling and regulation of gene expression, including epigenetic mechanisms. Cutting-edge work on spatial quality control and management of protein misfolding at the ribosome will be highlighted. Connections between compartmental protein folding status and disease will be explored. The Conference's collegial and scholarly environment encourages vigorous discussions of exciting developments related to several areas of stress research. The meeting also provides excellent opportunities for graduate students, postdoctoral fellows and junior group leaders to present their work either in posters or short talks. We will continue recent meetings innovations of poster teaser talks and career tables, and will be adding for the first time a Power Hour focused on women investigators in the field. The formal scientific program, limited attendance and organized but informal opportunities for interaction make this meeting a preeminent conference promoting deeper understanding of the versatile roles of stress proteins in human health, aging and disease.

Related Meeting

This GRC was held in conjunction with the "Stress Proteins in Growth, Development & Disease" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Protein Quality Control and Aging
Discussion Leaders: Kevin Morano (University of Texas Medical School at Houston, USA) and Elke Deuerling (University of Konstanz, Germany)
7:40 pm - 8:20 pmJudith Frydman (Stanford University, USA)
"Proteostasis Function and Dysfunction: The Delicate Art of Maintaining a Healthy Proteome"
8:20 pm - 8:35 pmDiscussion
8:35 pm - 9:15 pmJonathan Weissman (University of California, San Francisco / Howard Hughes Medical Institute, USA)
"Monitoring Translation in Space and Time with Ribosome Profiling"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFolding and Misfolding
Discussion Leader: James Bardwell (University of Michigan / Howard Hughes Medical Institute, USA)
9:00 am - 9:20 amBernd Bukau (University of Heidelberg, Germany)
"Chaperone Action in Folding and Disaggregation of Proteins"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amElizabeth Craig (University of Wisconsin-Madison, USA)
"How Do J-Proteins Get Hsp70 to Do So Many Different Things?"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amUlrich Hartl (Max-Planck Institute of Biochemistry, Germany)
"Chaperone Functions in Protein Folding and Proteostasis Maintenance"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amManajit Heyer-Hartl (Max Planck Institute of Biochemistry, Germany)
"A New Twist in the Mechanism of the GroEL/GroES Chaperonin System"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amSelected from Poster Abstracts: Stephanie Gates (University of Michigan, USA)
"Translocation Mechanism of the Hsp104 Disaggregase Determined by Cryo-EM"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Shelli McAlpine (University of New South Wales, Australia)
"Small Molecules that Control Cell Survival Pathways Through Inhibiting Hsp70"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Carolyn Sevier (Cornell University, USA)
"Molecular Mechanisms to Maintain Cellular Redox Homeostasis"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:20 pmGeneral Discussion
12:20 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Elke Deuerling (University of Konstanz, Germany)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmSensing and Signaling: the Ribosome and Beyond
Discussion Leader: Harm Kampinga (University Medical Center Groningen, The Netherlands)
7:30 pm - 7:50 pmOnn Brandman (Stanford University, USA)
"Ribosome Associated Protein Quality Control"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmClaudio Joazeiro (University of Heidelberg, Germany)
"Ribosome-Associated Protein Quality Control (RQC)"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmSelected from Poster Abstracts: Olga Sin (Max Planck Institute for Molecular Biomedicine, Germany)
"Aggregation-Prone Proteins that Require Ssb1 and Ssb2 Molecular Chaperones Are Not Translated Slower than Non-Aggregation-Prone Proteins"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 8:55 pmSelected from Poster Abstracts: Anat Ben-Zvi (Ben-Gurion University of the Negev, Israel)
"The Dynamic Landscape of Molecular Chaperones Across Tissues"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmJohannes Buchner (Technische Universitaet Muenchen, Germany)
"The Structure and Function of an Essential Co-Chaperone of Hsp90"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmQuality Control and Disease
Discussion Leader: Jonathan Weissman (University of California, San Francisco / Howard Hughes Medical Institute, USA)
9:00 am - 9:20 amAndrew Lieberman (University of Michigan Medical School, USA)
"Proteasome Dysfunction in Polyglutamine Disease"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJan Hoeijmakers (Erasmus University Medical Center, The Netherlands)
"The Contribution of Aging to Neurodegeneration: From DNA Damage to Protein Aggregates"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amMagdalini Polymenidou (University of Zurich, Switzerland)
"The Intertwined Roles of RNA Misregulation and Protein Aggregation in ALS and FTD"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amAnne Bertolotti (MRC Laboratory of Molecular Biology, United Kingdom)
"Surviving Protein Quality Control Failure in Cells and Organisms"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amSelected from Poster Abstracts: Peter Douglas (University of Texas Southwestern Medical Center, USA)
"Uncovering the Cellular Response to Mechanical Stress: What Can a Worm Teach Us About Traumatic Brain Injury?"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Nadinath Nillegoda (Center for Molecular Biology (ZMBH), Heidelberg University and German Cancer Research Center (DKFZ), Germany)
"Evolution of an Intricate J-Protein Network Driving Protein Disaggregation in Eukaryotic Cells"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Anniina Vihervaara (Cornell University, USA)
"Transcriptional Response to Stress Is Pre-Wired by Promoter and Enhancer Architecture"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:20 pmGeneral Discussion
12:20 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmAggregates, Assemblies and Depots
Discussion Leader: Judith Frydman (Stanford University, USA)
7:30 pm - 7:50 pmSimon Alberti (Max Planck Institute of Molecular Cell Biology and Genetics, Germany)
"Organizing Living Matter in Stressed Cells: Phase Transitions as a Survival Strategy"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmDavid Allan Drummond (University of Chicago, USA)
"How Cells Use Quinary Regulation to Sense and Respond to Stress"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmPaul Herman (Ohio State University, USA)
"P-Bodies, RNP Granules and Protein Quality Control"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmSelected from Poster Abstracts: Frederick Stull (University of Michigan / Howard Hughes Medical Institute, USA)
"Acid-Induced Chloride Accumulation Leads to Cytotoxic Protein Aggregation"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Daniel Jarosz (Stanford University, USA)
"Quality Control and Aggregation in the Aging Vertebrate Proteome"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmProtein Homeostasis in the Endoplasmic Reticulum
Discussion Leader: Andrew Dillin (University of California, Berkeley / Howard Hughes Medical Institute, USA)
9:00 am - 9:20 amLinda Hendershot (St. Jude Children's Research Hospital, USA)
"Protein Folding and Quality Control via the Hsp70 System"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amKazuhiro Nagata (Kyoto Sangyo University, Japan)
"Regulation of ER Homeostasis by Redox Signaling"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amMaho Niwa (University of California, San Diego, USA)
"ER Stress Response During the Cell Cycle"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amDavid Ron (University of Cambridge, United Kingdom)
"Early Events in the Endoplasmic Reticulum Unfolded Protein Response"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amSelected from Poster Abstracts: Teresa Buck (University of Pittsburgh, USA)
"Regulation of ENaC (Epithelial Sodium Channel) by the ER Lumenal Chaperone, GRP170"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Ashley Frakes (University of California, Berkeley, USA)
"Glial Regulation of ER Stress Resistance and Longevity"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Jan Reiling (BioMed X Innovation Center, Germany)
"TRAPPC13 Modulates Autophagy and the Response to Golgi Stress"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:20 pmGeneral Discussion
12:20 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmProteinopathies: Aging and Defense Strategies
Discussion Leader: Jeffrey Brodsky (University of Pittsburgh, USA)
7:30 pm - 7:50 pmUrsula Jakob (University of Michigan, USA)
"Role of Polyphosphate in Amyloidogenic Processes"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmRichard Morimoto (Northwestern University, USA)
"Resetting Organismal Proteostasis Through Epigenetic and Mitochondrial Remodeling"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmMartin Duennwald (University of Western Ontario, Canada)
"Hsp90 and Its Co-Chaperones Regulate ALS-Related Proteinopathies"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmSelected from Poster Abstracts: Alex Jaeger (Whitehead Institute for Biomedical Research, MIT, USA)
"Limiting the Buffer Function of HSP90 Markedly Enhances Tumor Immunogenicity"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmSelected from Poster Abstracts: Carmen Nussbaum-Krammer (University of Heidelberg, Germany)
"C. elegans Model for Prion-Like Spreading of a-Syn Reveals New Genetic Modifiers of Cell to Cell Transmission"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
8:30 am - 9:00 amBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pmProtein Triage and Degradation
Discussion Leader: Lea Sistonen (Abo Akademi University, Finland)
9:00 am - 9:20 amAndreas Matouschek (The University of Texas at Austin, USA)
"How the Proteasome Selects Proteins for Degradation"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amThomas Nystrom (University of Gothenburg, Sweden)
"Regulation of Protease vs. Co-Chaperone Activity of a Metacaspase - Turning an Executioner into a Protector"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amKylie Walters (National Cancer Institute, NIH, USA)
"Substrate Recognition by the Proteasome"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amVeena Prahlad (University of Iowa, USA)
"Sensory Experience and Learning Modulate the Expression of Molecular Chaperones in C. elegans"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amSelected from Poster Abstracts: Rachel Cliffe (University of Cambridge, United Kingdom)
"Filamentous Aggregates Are Disassembled by the Proteasome in a Ubiquitin-Independent Manner"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amSelected from Poster Abstracts: Liming Li (Northwestern University, USA)
"Heritable Switches in Conformation and Transcriptional Regulation"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmSelected from Poster Abstracts: Hugo Tapia (University of California, Berkeley, USA)
"Hsp12 and Trehalose: Necessary and Sufficient Desiccation Stress Effectors"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:20 pmGeneral Discussion
12:20 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmControl of Stress Protein Expression
Discussion Leader: Jason Gestwicki (University of California, San Francisco, USA)
5:30 pm - 5:50 pmBrian Freeman (University of Illinois at Urbana-Champaign, USA)
"Molecular Chaperones Regulate the Chromatin Landscape - Is It Time to Move?"
5:50 pm - 6:00 pmDiscussion
6:00 pm - 6:20 pmDavid Gross (LSU Health Sciences Center New Orleans, USA)
"Hsf1 Restructures the Yeast Genome in Response to Heat Shock"
6:20 pm - 6:30 pmDiscussion
6:30 pm - 6:50 pmDennis Thiele (Duke University School of Medicine, USA)
"The Atypical Regulation of Heat Shock Factors in Disease"
6:50 pm - 7:00 pmDiscussion
7:00 pm - 7:10 pmSelected from Poster Abstracts: Sara Peffer (The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, USA)
"Defining the Regulatory Interaction of Ssa1/Hsp70 with Hsf1"
7:10 pm - 7:15 pmDiscussion
7:15 pm - 7:25 pmSelected from Poster Abstracts: David Pincus (Whitehead Institute for Biomedical Research, MIT, USA)
"Essential Function and Dynamic Regulation of Yeast Heat Shock Factor"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13AG057030-01 from the NIA. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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