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Protein Folding Dynamics
Gordon Research Conference

Folding: The Landscapes of Natural and Synthetic Life

Dates

January 10-15, 2016

Location

Hotel Galvez
Galveston, TX

Organizers

Chair:
Peter Wolynes

Vice Chair:
Benjamin Schuler

Meeting Description

The protein folding problem has long been regarded as a fundamental mystery blocking our understanding of how the genetic information locked in DNA is transformed into a dynamic living organism. In the last decades, however, a basic understanding of the folding process has been achieved. The keys to this progress include borrowing theoretical ideas about energy landscapes from condensed matter physics and physical chemistry, employing powerful computer simulation techniques and bringing to bear new experimental tools such as single molecule methods and ultrafast spectroscopy, as well as elaborating the classical kinetic techniques of biophysical chemistry while exploiting the capabilities of protein engineering. Thus many communities from physics, chemistry and biology have merged to form the discipline of protein folding dynamics. Many of the fundamental issues about how proteins fold remain under intense investigation. New frontiers include understanding the diversity and basic time scales of folding larger proteins building on what has been learned in small model systems. Also we can now enquire how folding behavior has evolved in natural history, using huge quantities of genomic data. Folding is now known to be an emergent property. Recognizing this, to test our understanding, the community is now also exploring whether folding can be instantiated in completely novel designed systems, so-called "foldamers". Folding is not just a preliminary step to biological function but is intimately involved in functional processes such as allosteric change and molecular recognition. Furthermore the evolution of these capabilities has shown its mark on protein folding dynamics, an area of great ferment bringing together a new group of biologists. The misfolding of some proteins seems central to the progress of many diseases such as Alzheimer's and here the new tools of the folding community are bringing new insights. Finally we now can ask whether the hard won paradigms of protein folding dynamics gleaned from studying small globular proteins can be applied to membrane protein folding in which other biological actors are implicated as chaperones. Also can folding concepts be applied to studying how the very largest structures in the cell are organized, such as chromosomes? Sessions covering both new developments in the basic areas as well as applications of folding dynamics to more complex biology are planned.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: The Atomistic Basis of Folding Energy Landscapes
Discussion Leader: Angel Garcia (Los Alamos National Laboratory, USA)
7:40 pm - 8:25 pmRobert Best (National Institutes of Health, USA)
"Molecular Origins of Internal Friction in Protein Folding Dynamics"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 9:20 pmKlaus Schulten (University of Illinois, USA)
"What Can Be Learnt from the Molecular Dynamics View of Protein Translocation, Folding and Aggregation?"
9:20 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmThe Rights and Wrongs of Folding
Discussion Leader: Jose Onuchic (Rice University, USA)
9:00 am - 9:45 amSheena Radford (University of Leeds, United Kingdom)
"Stopping the Amyloid Cascade: New Molecular Insights and Some New Opportunities"
9:45 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:15 amPaul Whitford (Northeastern University, USA)
"The Role of Disorder in Biomolecular Assemblies"
11:15 am - 11:30 amDiscussion
11:30 am - 12:15 pmSusan Marqusee (University of California, Berkeley, USA)
"Touring the Landscape: The View Depends on How You Look"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Jane Clarke (University of Cambridge, United Kingdom) and Sheena Radford (University of Leeds, United Kingdom)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFast Folding
Discussion Leader: Martin Gruebele (University of Illinois at Urbana-Champaign, USA)
7:30 pm - 8:15 pmGerhard Hummer (Max Planck Institute of Biophysics, Germany)
"Fast Folding: Mechanisms from Simulations"
8:15 pm - 8:30 pmDiscussion
8:30 pm - 9:15 pmVictor Munoz (University of California, Merced, USA)
"Gradual Disorder of Fast Folding Proteins Monitored at Atomic Resolution"
9:15 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFolding the Chromosome
Discussion Leader: Bin Zhang (Rice University, USA)
9:00 am - 9:45 amAndrew Belmont (University of Illinois, USA)
"Boundary Conditions for Chromosome Folding Models from Direct Visualization of Native and Reconstituted Chromosomes"
9:45 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:15 amErez Lieberman Aiden (Baylor College of Medicine, USA)
"How the Genome Folds: Now Inside the Loop"
11:15 am - 11:30 amDiscussion
11:30 am - 12:15 pmMasaki Sasai (Nagoya University, Japan)
"Fluctuating Three-Dimensional Genome Architecture and Gene Regulation"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTowards Synthetic Life: The World of Foldamers
Discussion Leader: Jeffrey Hartgerink (Rice University, USA)
7:30 pm - 8:15 pmJeffrey Hartgerink (Rice University, USA)
"Design Criteria for Collagen Triple Helices"
8:15 pm - 8:30 pmDiscussion
8:30 pm - 9:15 pmIvan Huc (Université de Bordeaux / CNRS, France)
"Designing Foldamers with Predictable Structures"
9:15 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFolding One Molecule at a Time
Discussion Leader: William Eaton (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
9:00 am - 9:45 amJane Clarke (University of Cambridge, United Kingdom)
"Folding Proteins On and Off the Ribosome"
9:45 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 11:15 amAshok Deniz (The Scripps Research Institute, USA)
"Single-Molecule Folding Biophysics of Disordered Proteins"
11:15 am - 11:30 amDiscussion
11:30 am - 12:15 pmMichael Woodside (University of Alberta, Canada)
"Observing Transition Paths in the Folding of Proteins and Nucleic Acids with Single-Molecule Force Spectroscopy"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmFolding Membrane Proteins
Discussion Leader: Daniel Otzen (Aarhus University, Denmark)
7:30 pm - 8:15 pmPaula Booth (King's College London, United Kingdom)
"Helical Membrane Proteins and Lipid Bilayer Mechanics"
8:15 pm - 8:30 pmDiscussion
8:30 pm - 9:15 pmJames Bowie (University of California, Los Angeles, USA)
"Folding Membrane Proteins One at a Time"
9:15 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmMisfolding Landscapes
Discussion Leader: Yaakov Levy (Weizmann Institute of Science, Israel)
9:00 am - 9:45 amTuomas Knowles (University of Cambridge, United Kingdom)
"Kinetics of Protein Aggregations"
9:45 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:40 amSelected from Poster Abstracts: Mingchen Chen (Rice University, Center for Theoretical Biological Physics, USA)
"Dynamics of Prion"
10:40 am - 10:45 amDiscussion
10:45 am - 10:55 amSelected from Poster Abstracts: Sarah Shammas (University of Cambridge, United Kingdom)
"Role of Residual Structure in Coupled Folding and Binding of Transcription Factors"
10:55 am - 11:00 amDiscussion
11:00 am - 11:10 amSelected from Poster Abstracts: Edward O'Brien (Pennsylvania State University, USA)
"Accurate Prediction of Co-Translational Folding in Living Cells and the Physical Origins of Critical Codon Positions"
11:10 am - 11:15 amDiscussion
11:15 am - 11:25 amSelected from Poster Abstracts: William Jacobs (Harvard University, USA)
"Theoretical Prediction of Protein-Folding Pathways"
11:25 am - 11:30 amDiscussion
11:30 am - 12:15 pmMartin Zanni (University of Wisconsin-Madison, USA)
"Humans but Not Rats? Cats but Not Dogs? A Study into the Molecular Mechanism of Type 2 Diabetes Using 2D IR Spectroscopy"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFrustration and the Evolution of the Folding Landscape
Discussion Leader: Elizabeth Komives (University of California, San Diego, USA)
7:30 pm - 8:15 pmFaruck Morcos (University of Texas at Dallas, USA)
"Investigating Co-Evolutionary Landscapes of Interaction Specificity in Signaling Proteins"
8:15 pm - 8:30 pmDiscussion
8:30 pm - 9:15 pmDiego Ferreiro (University of Buenos Aires, Argentina)
"Frustration and the Energy Landscapes of Repeat- Proteins"
9:15 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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