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Protein Folding Dynamics
Gordon Research Conference

Order, Disorder, and Aggregation in Protein Folding Dynamics

Dates

January 7-12, 2018

Location

Hotel Galvez
Galveston, TX Site Information

Organizers

Chair:
Benjamin Schuler

Vice Chair:
Margaret S. Cheung

Application Deadline

Applications for this meeting must be submitted by December 10, 2017. Please apply early, as some meetings become oversubscribed (full) before this deadline. If the meeting is oversubscribed, it will be stated here. Note: Applications for oversubscribed meetings will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

The concepts and methods of protein folding have diversified from the original "protein folding problem" into many rapidly advancing areas in physics, chemistry, and biology. A main purpose of this conference is to bring together researchers from these areas and in particular to foster the contact between experiment, theory, and simulation, since many of the key challenges in the field of protein folding dynamics can only be resolved in close collaboration between these disciplines.

Conceptually, the areas covered will range from elementary mechanisms, such as fast events in folding and the behavior of unfolded and intrinsically disordered proteins, to processes involving large molecular machinery, such as folding on the ribosome. The program will also address many of the resulting complex phenomena, including protein aggregation, intracellular phase transitions, and regulatory and evolutionary processes. Addressing these questions requires a versatile toolbox of techniques, and the methodological advances will be another important topic of the conference, both from the experimental and the theoretical side: from single-molecule techniques, spectroscopic methods with high time resolution, and experiments in live cells on the experimental side, to the latest developments in large-scale computing, models at different levels of coarse-graining, and analytical theory for describing biomolecular structure and dynamics. These developments have a large impact far beyond the protein folding field itself and fertilize many other areas of research. The conference will encourage interactions between junior scientists and established leaders in the field, e.g. through abstract-selected presentations and posters, and by means of the Gordon Research Seminar preceding the conference.

Related Meeting

This GRC will be held in conjunction with the "Protein Folding Dynamics" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Gordon Research Conferences
National Science Foundation

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Bridging Theory and Experiment
Discussion Leader: Jane Clarke (University of Cambridge, United Kingdom)
7:40 pm - 8:15 pmPeter Wolynes (Rice University, USA)
"Harvesting the Fruits of the Energy Landscape Theory of Protein Folding"
8:15 pm - 8:25 pmDiscussion
8:25 pm - 9:00 pmWilliam Eaton (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA)
"Aggregation of Sickle Cell Hemoglobin"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:25 pmLate-Breaking Topic
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmProtein Dynamics: Unfolded to Folded
Discussion Leader: Victor Munoz (University of California, Merced, USA)
9:00 am - 9:25 amStefano Piana (D. E. Shaw Research, USA)
"Atomistic Models for the Simulation of Protein Folding"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amRoland Netz (Fachbereich Physik, Freie Universität Berlin, Germany)
"Barrier Crossing in the Presence of Solvent and Internal Memory Effects"
10:00 am - 10:10 amDiscussion
10:10 am - 10:35 amCoffee Break
10:35 am - 10:45 amShort Talk Selected from Poster Abstracts
10:45 am - 10:50 amDiscussion
10:50 am - 11:15 amCharles Matthews (University of Massachusetts Medical School, USA)
"Frustration and Folding: A Case Study of a TIM Barrel Protein"
11:15 am - 11:25 amDiscussion
11:25 am - 11:45 amGregory Bowman (Washington University in St. Louis, USA)
"Enzyme Dynamics"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pmGaregin Papoian (University of Marlyland, USA)
"Physics and Biology of Nucleosomal Assembly and Dynamics"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Jane Clarke (University of Cambridge, United Kingdom)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmFolding In Vivo and on the Ribosome
Discussion Leader: Susan Marqusee (University of California, Berkeley, USA)
7:30 pm - 7:55 pmJohn Christodoulou (University College London, United Kingdom)
"Structure and Dynamics in Co-Translational Protein Folding"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmEdward O'Brien (Pennsylvania State University, USA)
"Non-Equilibrium Coupling of Protein Structure and Function to Translation Kinetics"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:55 pmSimon Ebbinghaus (Ruhr-Universitat Bochum, Germany)
"Protein Unfolding and Aggregation Kinetics in Cells"
8:55 pm - 9:05 pmDiscussion
9:05 pm - 9:25 pmLate-Breaking Topic
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDisordered Proteins: Dynamics and Function
Discussion Leader: Robert Best (National Institutes of Health, USA)
9:00 am - 9:25 amJulie Forman-Kay (The Hospital for Sick Children, Canada)
"Effects of Post-Translational Modification of Disordered Proteins on Binding and Self-Association"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amPeter Wright (The Scripps Research Institute, USA)
"Function of Intrinsically Disordered Proteins in Regulation of Cellular Stress Response"
10:00 am - 10:10 amDiscussion
10:10 am - 10:35 amCoffee Break
10:35 am - 10:55 amHagen Hofmann (Weizmann Institute of Science, Israel)
"IDP Dynamics"
10:55 am - 11:05 amDiscussion
11:05 am - 11:30 amTeresa Head-Gordon (University of California, Berkeley, USA)
"Simulations of IDPs"
11:30 am - 11:40 amDiscussion
11:40 am - 12:05 pmMartin Blackledge (Institute of Structural Biology, CNRS, France)
"Conformational Ensembles from NMR"
12:05 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmLate-Breaking Topic
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmIntracellular Phase Separation: A New Paradigm of Protein Assembly
Discussion Leader: Rohit Pappu (Washington University in St. Louis, USA)
7:30 pm - 7:50 pmTanja Mittag (St. Jude Children's Research Hospital, USA)
"Phase Separation in Cancer and Neurodegenerative Disease"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:25 pmMichael Rosen (University of Texas Southwestern Medical Center / Howard Hughes Medical Institute, USA)
"Physical Mechanisms of Cell Organization on Micron Length Scales"
8:25 pm - 8:35 pmDiscussion
8:35 pm - 8:45 pmShort Talk Selected from Poster Abstracts
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:15 pmNed Wingreen (Princeton University, USA)
"Magic Numbers in Protein Phase Separation"
9:15 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmFolding Transitions and Folding Paths
Discussion Leader: Michael Woodside (University of Alberta, Canada)
9:00 am - 9:25 amDave Thirumalai (University of Texas at Austin, USA)
"Transitions in Folding"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amDmitrii Makarov (University of Texas at Austin, USA)
"Transition Path Times Reveal Multi-Dimensionality and Memory Effects in the Dynamics of Protein Folding"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 10:50 amShort Talk Selected from Poster Abstracts
10:50 am - 10:55 amDiscussion
10:55 am - 11:15 amPietro Faccioli (University of Trento, Italy)
"Ab Initio Calculation of Time-Resolved CD Spectra in Near UV Region Reveal the Folding Mechanism in Full Atomistic Detail"
11:15 am - 11:25 amDiscussion
11:25 am - 11:50 amEmanuele Paci (University of Leeds, United Kingdom)
"Folding Proteins from Decoys"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:20 pmLate-Breaking Topic
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmMisfolding and Aggregation
Discussion Leader: George Makhatadze (Rensselaer Polytechnic Institute, USA)
7:30 pm - 7:55 pmJoan-Emma Shea (University of California, Santa Barbara, USA)
"Simulations of Amyloid Formation"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmPernilla Wittung-Stafshede (Chalmers University of Technology, Sweden)
"In Vitro Cross-Reactivity of Parkinson's Disease Protein, Alpha-Synuclein: Consequences for Amyloid Formation"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmDaniel Raleigh (State University of New York at Stony Brook, USA)
"The Biophysics of Amyloidosis Induced Cell Death"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSingle-Molecule Folding
Discussion Leader: Jin Wang (State University of New York at Stony Brook, USA)
9:00 am - 9:25 amMatthias Rief (Technical University of Munich, Germany)
"Force Spectroscopy of Protein Folding"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amOlga Dudko (University of California, San Diego, USA)
"Distinguishing Signatures of Folding Mechanisms"
10:00 am - 10:10 amDiscussion
10:10 am - 10:35 amCoffee Break
10:35 am - 10:45 amShort Talk Selected from Poster Abstracts
10:45 am - 10:50 amDiscussion
10:50 am - 11:10 amHoi Sung Chung (National Institutes of Health, USA)
"Probing Folding and Conformational Dynamics of Intrinsically Disordered Proteins by Single Molecule FRET"
11:10 am - 11:20 amDiscussion
11:20 am - 11:45 amGilad Haran (Weizmann Institute of Science, Israel)
"Sub-Millisecond Large-Scale Conformational Changes: Flexibility at the Service of Function"
11:45 am - 11:55 amDiscussion
11:55 am - 12:20 pmSander Tans (FOM Institute AMOLF, The Netherlands)
"Chaperone-Guided Folding of Single Proteins"
12:20 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmRegulation and Evolution
Discussion Leader: Jose Onuchic (Rice University, USA)
7:30 pm - 7:40 pmShort Talk Selected from Poster Abstracts
7:40 pm - 7:45 pmDiscussion
7:45 pm - 8:10 pmVincent Hilser (Johns Hopkins University, USA)
"Dynamic Allostery Can Direct Cold Adaptation in Enzymes"
8:10 pm - 8:20 pmDiscussion
8:20 pm - 8:45 pmRama Ranganathan (University of Texas Southwestern Medical Center, USA)
"Coevolution in Protein Structure"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:20 pmEugene Shakhnovich (Harvard University, USA)
"Evolution of Protein Homeostasis"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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