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Metals in Medicine
Gordon Research Conference

The Interplay of Creative Chemistry and Cellular Processes in Metals in Medicine

Dates

June 26 - July 1, 2016

Location

Proctor Academy
Andover, NH

Organizers

Chairs:
Katherine J. Franz & Nils Metzler-Nolte

Vice Chairs:
Seth M. Cohen & Kenneth Kam-Wing Lo

Meeting Description

Metals in Medicine is a cross-cutting field that embraces scientific advances in inorganic chemistry, cell and molecular biology, advanced spectroscopy, biophysics, nuclear medicine, medicinal chemistry, clinical medicine and other disciplines in ways that leverage knowledge of metals to advance human health. The 2016 Metals in Medicine GRC will bring together an international group of multidisciplinary scientists in the serene countryside of New Hampshire to explore the benefits that arise from a productive interplay between biological and chemical approaches to understanding, diagnosing and treating disease.

The scientific program has been especially designed to showcase this intimate interplay of biology and chemistry: sessions in this conference combine research that is uncovering the underlying metallobiology of cellular redox regulation, microbial pathogenesis, cancer, and neurodegeneration with creative chemical approaches. Molecular probes, metal complexes, and analytical techniques are combined to interrogate and/or therapeutically alter cellular processes in order to fight disease. Various strategies that may lead to commercialization of medicinal inorganic chemistry approaches will also be highlighted, including a session devoted to translating fundamental research into clinically used products.

Several early career attendees will be chosen from the submitted abstracts to give oral presentations. The collegial atmosphere of this conference is ideal for productive discussions among students, early-stage investigators, and leading researchers. In addition to poster sessions, many opportunities for informal gatherings in the afternoons and evenings provide a relaxed atmosphere conducive to initiating new connections and collaborations.

Contributors

Final Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Metal-Based Drugs and Cellular Redox Biochemistry
Discussion Leaders: Katherine Franz (Duke University, USA) and Nils Metzler-Nolte (Ruhr University Bochum, Germany)
7:40 pm - 7:55 pmOpening Remarks
7:55 pm - 8:30 pmRuma Banerjee (University of Michigan, USA)
"Redox Enzymology of H2S Metabolism and Signaling"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:15 pmThomas O'Halloran (Northwestern University, USA)
"Bioinorganic Drug Discovery: Metal-Based Drugs and Targets in the Treatment of Metastatic Cancer"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmHarnessing Metal Trafficking Pathways for Antimicrobial Drug Development
Discussion Leader: Elizabeth Nolan (Massachusetts Institute of Technology, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:35 amCelia Goulding (University of California, Irvine, USA)
"Targeting Heme/Iron Uptake Pathways in Mycobacterium tuberculosis"
9:35 am - 9:50 amDiscussion
9:50 am - 10:20 amAmanda Oglesby-Sherrouse (University of Maryland, Baltimore, USA)
"Critical Role of Iron Regulatory Pathways in Pseudomonas aeruginosa Virulence"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amJeffrey Henderson (Washington University School of Medicine, USA)
"Metals and Metabolomes in Gram Negative Bacterial Pathogenesis"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmTimothy Wencewicz (Washington University in St. Louis, USA)
"Siderophore Chemistry in Pathogenic Acinetobacter baumannii"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Angela Casini (Cardiff University, United Kingdom)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmTargeting Cancer and Infection with Photodynamic Compounds
Discussion Leader: Edith (Phoebe) Glazer (University of Kentucky, USA)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:05 pmGilles Gasser (University of Zurich, Switzerland)
"Metal Complexes as Phototoxic Anticancer Agents"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:45 pmSherri McFarland (Acadia University, Canada)
"Coordination Chemistry and Photodynamic Therapy"
8:45 pm - 8:55 pmDiscussion
8:55 pm - 9:25 pmAdah Almutairi (University of California, San Diego, USA)
"Light Stimulation to Direct Drug-Delivering Nanoparticles"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmEmerging Analytical Methods (or, What Happens to My Metallodrug In Vivo?)
Discussion Leader: Angela Casini (Cardiff University, United Kingdom)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:35 amFabio Arnesano (University of Bari Aldo Moro, Italy)
"Solution and In-Cell NMR Methods to Monitor Proteins Interacting with Inorganic Materials"
9:35 am - 9:45 amDiscussion
9:45 am - 10:15 amHugh Harris (The University of Adelaide, Australia)
"XRF and XAS Combined Yield Insight into the Biological Fate of Metallodrugs"
10:15 am - 10:25 amDiscussion
10:25 am - 10:55 amCoffee Break
10:55 am - 11:25 amChristian Hartinger (University of Auckland, New Zealand)
"Bioanalytical Studies to Elucidate Tumor-Inhibiting Action of Metal Complexes"
11:25 am - 11:40 amDiscussion
11:40 am - 11:55 amChady Stephan (PerkinElmer, Canada)
"Single Cell ICP-MS: Understanding the Uptake Mechanism of Cisplatin by Cancerous Cells"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmInorganic Chemistry and Cellular Redox Regulation
Discussion Leader: Peter Sadler (University of Warwick, United Kingdom)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:05 pmElisa Tomat (University of Arizona, USA)
"Redox-Directed Strategies Targeting the Iron Metabolism of Cancer Cells"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:45 pmMilos Filipovic (IBGC - Institut de Biochimie et Genetique Cellulaires / CNRS, France)
"Intracellular H2S Signalling and Cross-Talk with Metal Centers"
8:45 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmAlexander M. Cruickshank Lecture: Christopher Chang (University of California, Berkeley, USA)
"Chemical Probes for Studying Reactive Oxygen, Sulfur, and Carbon Species in Biology"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCreative Approaches in Imaging Agent Design
Discussion Leader: Matthew Allen (Wayne State University, USA)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:35 amElizabeth New (University of Sydney, Australia)
"Molecular Imaging Tools to Study the Interactions of Transition Metals with Cells"
9:35 am - 9:50 amDiscussion
9:50 am - 10:20 amJens Hasserodt (École Normale Supérieure de Lyon, France)
"Translating the Activity of an Enzyme Analyte into Beating the Chelate Effect"
10:20 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:30 amClotilde Policar (Ecole Normale Superieure de Paris, France)
"Re(CO) Probes as Multimodal Probes for Imaging: Fluorescence and IR-Imaging"
11:30 am - 11:45 amDiscussion
11:45 am - 12:15 pmThomas Meade (Northwestern University, USA)
"Advances in Bio-Activated and Targeted MR Imaging Probes: Are We There Yet?"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmCompound to Clinic: Not Lost in Translation
Discussion Leader: Lisa Jarvis (Chemical & Engineering News, USA)
7:30 pm - 7:40 pmIntroduction by Discussion Leader
7:40 pm - 8:00 pmChris Orvig (University of British Columbia, Canada)
"Antidiabetic Vanadium Compounds: From Concept to Clinic"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:30 pmPaul Donnelly (University of Melbourne, Australia)
"The First-Time-in-Human Trial of 64CuMeCOSar-octreotate (CuSarTATE) for Imaging Neuroendocrine Tumours"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmAmir Nashat (Polaris Partners, USA)
"How to Start a Company with Academic Research"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLate-Breaking Topics
Discussion Leader: Kenneth Kam-Wing Lo (City University of Hong Kong, Hong Kong SAR China)
9:00 am - 9:05 amIntroduction by Discussion Leader
9:05 am - 9:30 amJun-Long Zhang (Peking University, China)
"Design of NIR Emissive Metal Complexes as Biological Probes in Cell Imaging"
9:30 am - 9:40 amDiscussion
9:40 am - 9:55 amDaniela Buccella (New York University, USA)
"New Chemical Tools and Strategies for the Study of Intracellular Magnesium Mobilization: Visualizing Mg2+ Fluctuations in Apoptosis"
9:55 am - 10:05 amDiscussion
10:05 am - 10:20 amGuangyu Zhu (City University of Hong Kong, Hong Kong SAR China)
"Monochalcoplatin, a Transporter Favorable and Highly Cytotoxic Pt(IV) Anticancer Prodrug"
10:20 am - 10:30 amDiscussion
10:30 am - 11:05 amCoffee Break
11:05 am - 11:20 amBen-Zhan Zhu (State Key Laboratory of Environmental Chemistry and Ecotoxicology, Chinese Academy of Sciences, China)
"Redirecting Ru(II)-DPPZ Complex into Nucleus for Enantioselective Live-Cell DNA-Imaging and Photosensitizing via Simple 'Yin-Yang' Ion-Pairing"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amAshley Bush (Florey Institute of Neuroscience and Mental Health, Australia)
"Iron and Ferroptosis in Aging and Brain Disease"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmNeurodegeneration: Biology, Pathology, Chemistry and Collaboration
Discussion Leader: Paul Donnelly (University of Melbourne, Australia)
7:30 pm - 7:35 pmIntroduction by Discussion Leader
7:35 pm - 8:05 pmJeffrey Liddell (University of Melbourne, Australia)
"The Molecular Processes Underlying the Broad Neuroprotective Action of Metal-Complexes"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmPeter Crouch (University of Melbourne, Australia)
"Therapeutic Outcomes for the Metallo-Complex Cu(atsm) in Animal Models of Motor Neuron Disease Provide New Insight to the Mechanisms of Pathogenesis"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmBlaine Roberts (Florey Institute of Neuroscience and Mental Health, Australia)
"Application of Metalloproteomics to Define the Role of Metalloproteins in Neurodegenerative Diseases"
9:20 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1R13CA206229-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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