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Assisted Circulation
Gordon Research Conference

Overcoming the Remaining Obstacles Limiting the Field of Mechanically Assisted Circulatory Support

Dates

June 25-30, 2017

Location

Stoweflake Conference Center
Stowe, VT

Organizers

Chairs:
Karen D. May-Newman & Mark S. Slaughter

Vice Chairs:
Bart Meyns & Trevor A. Snyder

Meeting Description

The success of Mechanical Circulatory Support (MCS) is now supported by large multinational companies that can leverage complementary technologies to advance this therapy for heart failure. However, many fundamental challenges remain, including the adverse effects on the vascular system and the right heart. Innovations in medicine, science, engineering, and patient management can help to address these problems, and, if coordinated across the community, will have the greatest potential to impact the field.

Related Meeting

This GRC was held in conjunction with the "Assisted Circulation" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmCurrent Direction of Mechanical Circulatory Support (MCS) – What We Have Learned Since REMATCH (Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure)
This opening session will summarize recent clinical trial successes and failures, and provide a critical analysis of the remaining obstacles limiting the growth of MCS.
Discussion Leader: Robin Bostic (Abbott, USA)
7:40 pm - 7:50 pmOpening Remarks
7:50 pm - 8:05 pmIntroduction by Discussion Leader: State of the VAD Nation
8:05 pm - 8:20 pmMandeep Mehra (Brigham and Women's Hospital, USA)
"Remaining Obstacles Limiting the Field of MCS: A Frank Assessment of Where We Are Now with Adverse Events (and Where We Would Be Without Them)"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmMark Carlson (Abbott, USA)
"Growth of MCS Within the Larger Medical Device Field"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:00 pmLisa Ensz (Medtronic, USA)
"The Impact of Next Generation Devices on Physicians and Patients"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion: Recent Evolution of MCS Industry
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmOptimizing MCS Patient and Lifestyle Management
Determinants of exercise tolerance and capacity and how they can be coordinated for efficacy and patient compliance. Insight into MCS physiology from the Total Artificial Heart community. Home health monitoring as well as decision-making tools for patient management.
Discussion Leaders: Lynne Warner Stevenson (Brigham and Women's Hospital, USA) and Kartik Sundareswaran (Abbott, USA)
9:00 am - 9:15 amDonna Mancini (Mount Sinai Hospital, USA)
"Exercise Tolerance and Capacity"
9:15 am - 9:20 amDiscussion
9:20 am - 9:35 amLibera Fresiello (KU Leuven, Belgium)
"Exercise Hemodynamics, Analysis and Modeling"
9:35 am - 9:40 amDiscussion
9:40 am - 10:00 amGeneral Discussion: Exercise and MCS
10:00 am - 10:30 amCoffee Break
10:30 am - 10:45 amKeyur Shah (Virginia Commonwealth University, USA)
"Clinical Considerations and Patient Selection for the Total Artificial Heart"
10:45 am - 10:50 amDiscussion
10:50 am - 11:00 amDaniel Tang (Virginia Commonwealth University, USA)
"Surgical Challenges of the Total Artificial Heart"
11:00 am - 11:05 amDiscussion
11:05 am - 11:15 amGeneral Discussion: Total Artificial Heart
11:15 am - 11:30 amAmrut Ambardekar (University of Colorado, USA)
"Decision-Making Tools for LVAD Patient Management"
11:30 am - 11:40 amDiscussion
11:40 am - 11:50 amKathleen Grady (Northwestern University, USA)
"VAD Self-Care: Providing a Patient and Caregiver-Centric Focus"
11:50 am - 11:55 amDiscussion
11:55 am - 12:05 pmMichael Petty (University of Minnesota Medical Center, USA)
"Psychosocial Risk Factors and Implications for VAD Self-Care"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:30 pmGeneral Discussion: Patient Case Studies
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmPhysiology of Adverse Events that Are Limiting the Growth of Assisted Circulation
The obstacles of hemocompatibility and right ventricular failure are discussed from a wide range of perspectives.
Discussion Leaders: Ulrich Jorde (Montefiore Medical Center / Albert Einstein College of Medicine, USA) and Salim Olia (University of Pittsburgh, USA)
7:30 pm - 7:45 pmGabriel Sayer (University of Chicago Medical Center, USA)
"RV Failure Post Device Implantation; Assessment and Novel Therapies"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmDavid Farrar (Abbott, USA)
"RV Function, RV Failure, and RVADs"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:20 pmGeneral Discussion: Right Ventricular MCS
8:20 pm - 8:35 pmGeorg Wieselthaler (University of California, San Francisco, USA)
"The Next Generation of VADs: How Much Better Will They Be?"
8:35 pm - 8:40 pmDiscussion
8:40 pm - 8:55 pmLisa Baumann Kreuziger (BloodCenter of Wisconsin, USA)
"Balancing Bleeding and Clotting in MCS Patients: A Mechanistic View"
8:55 pm - 9:00 pmDiscussion
9:00 pm - 9:15 pmNir Uriel (University of Chicago, USA)
"Angiogenesis in Patients Supported with Continuous Flow Pumps"
9:15 pm - 9:20 pmDiscussion
9:20 pm - 9:30 pmGeneral Discussion: Hemocompatibility
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSelecting and Managing the Right Patient for the Right Outcome
Discussion Leaders: Thorsten Siess (Abiomed Europe GmbH, Germany) and Victor Pretorius (University of California, San Diego, USA)
9:00 am - 9:15 amO. H. Frazier (Texas Heart Institute, USA)
"The Future Role of MCS in Advanced Heart Failure"
9:15 am - 9:30 amDiscussion
9:30 am - 9:45 amJames Kirklin (University of Alabama at Birmingham, USA)
"InterMACS"
9:45 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:45 amJennifer Conway (University of Alberta, Canada)
"Selection and Treatment: Pediatric HF Patients Are Not Small Adult HF Patients"
10:45 am - 11:00 amDiscussion
11:00 am - 11:15 amStavros Drakos (University of Utah, USA)
"Recent Developments in Myocardial Recovery"
11:15 am - 11:20 amDiscussion
11:20 am - 11:35 amEduardo Rame (University of Pennsylvania, USA)
"Myocardial Recovery May Be a Dead-End Target"
11:35 am - 11:40 amDiscussion
11:40 am - 12:00 pmGeneral Discussion: Myocardial Recovery
12:00 pm - 12:15 pmEric Adler (University of California, San Diego, USA)
"Bi-VADs"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmThe Future of Intelligent Pumping
Discussion Leaders: Heinrich Schima (Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria) and James Kirklin (University of Alabama at Birmingham, USA)
7:30 pm - 7:45 pmFrancesco Moscato (Medical University of Vienna, Austria)
"24/7 Beat-to-Beat Monitoring of VAD-Patients: Clinical Data Underline the Importance of Smart Pumps"
7:45 pm - 8:00 pmDiscussion
8:00 pm - 8:15 pmBryan Lynch (ReliantHeart Inc., USA)
"Experiences with Remote Home Monitoring with the Reliant Heart"
8:15 pm - 8:30 pmDiscussion
8:30 pm - 8:45 pmKevin Bourque (Abbott, USA)
"Integration of CardioMEMS Pressure Sensor into VAD Systems"
8:45 pm - 9:00 pmDiscussion
9:00 pm - 9:15 pmShaun Gregory (Griffith University, Australia)
"Smart Pump Control - What Has Been Done, How to Optimize, and What Are the Open Questions"
9:15 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAcademic Innovations and Prognostic Indicators
Novel approaches to overcoming the obstacles of MCS from academic labs in a variety of areas.
Discussion Leaders: Steven Koenig (University of Louisville, USA) and Francis Pagani (University of Michigan, USA)
9:00 am - 9:15 amDaniel Tamez (Medtronic, USA)
"Next Generation Ventricular Assist Devices and Diagnostics, Industry's Collaboration with Academia"
9:15 am - 9:30 amDiscussion
9:30 am - 9:45 amEllen Bass (Drexel University, USA)
"Human Factors in MCS Design"
9:45 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:45 amKaren Christman (University of California, San Diego, USA)
"Biomaterials for Improving Myocardial Function"
10:45 am - 11:00 amDiscussion
11:00 am - 11:15 amDaniel Zimpfer (Medical University of Vienna, Austria)
"Minimally Invasive Access"
11:15 am - 11:30 amDiscussion
11:30 am - 11:45 amAmy Prieto (Colorado State University, USA)
"Novel Battery Design"
11:45 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmShort Talk Selected from Poster Abstracts
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmIndustry Innovations: New Advances in LVAD Pulsatility, Miniaturized MCS Devices, and Total Artificial Heart Design
Many small companies have developed novel designs that may be game-changers in the reduction of serious adverse events, short technical overviews of late-breaking innovations will be presented.
Discussion Leaders: Kurt Dasse (HBeat Medical, USA), Changfu Wu (Food and Drug Administration, USA) and Michael Ashenuga (Medtronic, USA)
7:30 pm - 7:40 pmRichard Wampler (Oregon Health and Science University, USA)
"Current Innovations in Device Design"
7:40 pm - 7:50 pmDiscussion
7:50 pm - 8:00 pmCarl Botterbusch (CorWave SA, France)
"Corwave LVAD - the 'Fishtail' Membrane, a Novel Approach to Pumping, Promises to Reduce Adverse Events"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:20 pmSonna Patel-Raman (NuPulseCV, USA)
"NuPulse iVAS - A Minimally Invasive Long-Term Counterpulsation Device for Treatment of CHF"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmVegard Tuseth (NuHeart, Norway)
"The Nuheart Fully Percutaneous LVAD"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:00 pmMichael Zilbershlag (Leviticus Cardio, Israel)
"Coplanar Wireless Energy Transfer (CET) System for Fully Implanted VAD"
9:00 pm - 9:10 pmDiscussion
9:10 pm - 9:30 pmGeneral Discussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Global Future of MCS
What opportunities are there for growing the application of MCS in health care? What are the economics of MCS and heart failure predicted to be over the next 10-15 years?
Discussion Leaders: Timothy Baldwin (National Heart, Lung, and Blood Institute, NIH, USA) and Emma Birks (University of Louisville, USA)
9:00 am - 9:15 amJerry Heatley (St. Jude Medical / Thoratec, USA)
"Clinical Trial Design"
9:15 am - 9:30 amDiscussion
9:30 am - 9:45 amRobert Kormos (University of Pittsburgh Medical Center, USA)
"Global Initiatives in Standardization of MCS Therapy"
9:45 am - 10:00 amDiscussion
10:00 am - 10:30 amCoffee Break
10:30 am - 10:45 amKurt Dasse (HBeat Medical, USA)
"Emerging Markets for MCS: Pediatrics"
10:45 am - 10:50 amDiscussion
10:50 am - 11:05 amChristina Vanderpluym (Boston Children's Hospital, USA)
"How PediMACS Will Enlighten Us"
11:05 am - 11:10 amDiscussion
11:10 am - 11:30 amGeneral Discussion: Pediatric MCS
11:30 am - 11:45 amJames Long (INTEGRIS Advanced Cardiac Care, USA)
"Emerging Markets for MCS: India"
11:45 am - 12:00 pmDiscussion
12:00 pm - 12:15 pmYuriy Pya (National Research Center for Cardiac Surgery, Kazakhstan)
"Emerging Markets for MCS: Kazakhstan"
12:15 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCatalyzing the Next Steps to Solving Major MCS Challenges
Wide-ranging perspectives from experiences investigators will challenge the assisted circulation community to define priorities for immediate study as well as long-term direction.
Discussion Leader: John Watson (University of California, San Diego, USA)
7:30 pm - 7:45 pmTom Vassiliades (Medtronic, USA)
"Role of MCS in an Integrated Health Care System"
7:45 pm - 8:15 pmDiscussion
8:15 pm - 8:30 pmDawn Christensen (Innovative Program Solutions, LLC, USA)
"Social Media as Support for MCS Patients"
8:30 pm - 8:45 pmDiscussion
8:45 pm - 9:00 pmJames Antaki (Carnegie Mellon University, USA)
"MCS Moonshot"
9:00 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture
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