Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Apoptosis in the Larger Physiological
Context |
| Discussion Leader: Kodi S. Ravichandran (University of Virginia, USA) |
7:40 pm - 7:50 pm | Opening Remarks |
7:50 pm - 7:55 pm | Introduction by Discussion Leader |
7:55 pm - 8:50 pm | Peter Vandenabeele (University of Ghent, Belgium) "Regulated Necrosis: A Network of Cell Death Modalities with Far-Reaching Therapeutic Potential" |
8:50 pm - 9:10 pm | Discussion |
9:10 pm - 9:30 pm | General Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Lipid Alterations in
Apoptotic Cells and in Other Cells, Too |
| Discussion Leader: Peter Henson (National Jewish Health Medical Center, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Shigekazu Nagata (Kyoto University, Japan) "Flippases and Scramblases that Regulate Phosphatidylserine Exposure at the Plasma Membrane" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Xiaoping Du (University of Illinois at Chicago, USA) "A Shear-Dependent Signaling Pathway Leading to PS Exposure" |
10:10 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break |
10:55 am - 11:20 am | Coen Paulusma (Academic Medical Center, The Netherlands) "The Role of Lipid Flippases in Macrophage Function" |
11:20 am - 11:35 am | Discussion |
11:35 am - 11:45 am | Sanja Arandjelovic (University of Virginia, USA) "Engulfment Protein ELMO1 Regulates Disease Severity in Rheumatoid Arthritis" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Wonhwa Cho (University of Illinois at Chicago, USA) "In Situ Quantitative Imaging of Plasma Membrane Lipids: Transbilayer Asymmetry
and Redistribution" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Consequences of Lipid
Alterations for Apoptotic Cell Clearance |
| Discussion Leader: Christopher Gregory (University of Edinburgh, United Kingdom) |
7:30 pm - 7:55 pm | Ian Dransfield (University of Edinburgh, United Kingdom) "Protein S Binding to
Apoptotic Cells and Subsequent Phagocytosis by Macrophages" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Raymond Birge (Rutgers New Jersey Medical School, USA) "Apoptotic Cell
Recognition Receptors, Tyro3, Axl and Mer, Demonstrate Distinct Patterns of
Ligand Recognition and Biological Function" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Xianming Huang (University of Texas Southwestern Medical Center, USA) "Phosphatidylserine-Targeting
Antibodies Overcome Tumor Immunosuppression and Synergize with Immune
Checkpoint Blockade" |
9:15 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Physiological and
Pathological Consequences of Clearance Mechanisms |
| Discussion Leader: Raymond Birge (Rutgers New Jersey Medical School, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Rebecca Cook (Vanderbilt University, USA) "How Apoptotic Cell Clearance Enhances Tumor Metastasis" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:10 am | William Janssen (National Jewish Health Medical Center, USA) "Macrophages Clean Up the Mess: Clearance of Dying Cells and Debris During Resolving Inflammation" |
10:10 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break |
10:55 am - 11:05 am | Yaron Fuchs (Technion - Israel Institute of Technology, Israel) "Sept4/ARTS Regulates Stem Cell Apoptosis and Skin Regeneration" |
11:05 am - 11:10 am | Discussion |
11:10 am - 11:35 am | Patrizia Rovere-Querini (San Raffaele University, Italy) "Apoptotic Cell Recognition in Inflammatory Myopathies" |
11:35 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Ann Marie Schmidt (New York University School of Medicine, USA) "RAGE and the mDia1
Signaling Axis: Keys to Inflammatory Mechanisms in Diabetes and Beyond" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Other Apoptotic Signals in
Recognition and Clearance |
| Discussion Leader: Zheng Zhou (Baylor College of Medicine, USA) |
7:30 pm - 7:55 pm | Kodi S. Ravichandran (University of Virginia, USA) "Signals Regulating
Phagocyte Responses: Some Unexpected Observations" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Kirsten Lauber (Ludwig Maximilians University, Germany) "Dying Cell Clearance
and Its Impact on the Outcome of Cancer Radiotherapy" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Marko Radic (University of Tennesee, USA) "Histone Deimination: A Post-Translational Modification Linking Infection, Inflammation and Autoimmunity" |
9:15 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Pathogenic Subversion of
Apoptotic Processes |
| Discussion Leader: Ian Dransfield (University of Edinburgh, United Kingdom) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Nihal Altan-Bonnet (National Heart, Lung, and Bood Institute, NIH, USA) "Viral Transmission by Phosphatidylserine Vesicles: Nature's Way of Ensuring High Multiplicities of Infection" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Kouki Morizono (University of California, Los Angeles, School of Medicine, USA) "The Role of Phosphatidylserine Receptors in Enveloped Virus Infection" |
10:10 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break |
10:55 am - 11:20 am | Joao Luiz Wanderley (Federal University of Rio de Janeiro, Brazil) "Apoptotic Mimicry by
Intracellular Leishmania Parasites as
a Counteracting Sensor of Macrophage Activation" |
11:20 am - 11:35 am | Discussion |
11:35 am - 11:45 am | Gerhard Krönke (University of Erlangen, Germany) "NR4A1 as Mediator of the Anti-Inflammatory Effects of Apoptotic Cells in Tissue Resident Macrophages" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Yoshinobu Nakanishi (Kanazawa University, Japan) "Apoptosis-Dependent Phagocytosis of Virus-Infected Cells as Antiviral Immunity in Drosophila" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Immune Effects of Apoptotic
Cells |
| Discussion Leader: Kirsten Lauber (Ludwig Maximilians University, Germany) |
7:30 pm - 7:55 pm | Carla Rothlin (Yale University, USA) "TAM Receptor Tyrosine Kinase Signaling in Resolution of Inflammation" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Philip Cohen (Temple University, USA) "Clearance Abnormalities and TAM Receptors in Human Autoimmune and Inflammatory Disease" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Nathalie Franc (The Scripps Research Institute, USA) "The Roles of Pallbearer and Croquemort in Phagocytosis" |
9:15 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Insights from the Diversity
of Cell Death Mechanisms |
| Discussion Leader: Peter Vandenabeele (University of Ghent, Belgium) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Kenneth Bayles (University of Nebraska Medical Center, USA) "Tumor-Like Properties
of Bacterial Biofilm" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:10 am | Martin Herrmann (University Hospital of Erlangen, Germany) "Clearance of Apoptotic and NETotic Cells in Inflammatory Diseases" |
10:10 am - 10:25 am | Discussion |
10:25 am - 10:55 am | Coffee Break |
10:55 am - 11:20 am | Brad Cookson (University of Washington, USA) "Pyroptosis as a Host-Protective Inflammatory Alternative to Apoptosis" |
11:20 am - 11:35 am | Discussion |
11:35 am - 11:45 am | Barbara Conradt (Ludwig-Maximilians-University Munich, Germany) "How C. elegans Engulfment Pathways Promote Apoptosis" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Moritz Nowack (Flemish Institute for Biotechnology, Belgium) "License to Kill: Acquisition of PCD Competency in Plant Development" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Evolutionary Insights from
Model Organisms |
| Discussion Leader: Nathalie Franc (The Scripps Research Institute, USA) |
7:30 pm - 7:55 pm | Zheng Zhou (Baylor College of Medicine, USA) "A Giant Meal: Recognition and Engulfment of Necrotic Cells in C. elegans" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Estee Kurant (Technion - Israel Institute of Technology, Israel) "Glial Phagocytosis of Apoptotic Neurons During Drosophila CNS Development" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Carol Kim (University of Maine, USA) "Zebrafish as a Model for Phagocyte Apoptosis" |
9:15 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |