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IGF & Insulin System in Physiology & Disease
Gordon Research Conference

IGF/Insulin Signaling: New Discoveries in Metabolism and Growth, Stem Cells and Epigenetics, Aging, Cancer, and Neurological Disease

Dates

March 12-17, 2017

Location

Ventura Beach Marriott
Ventura, CA Site Information

Organizers

Chair:
Cunming Duan

Vice Chairs:
Claire M. Perks & Shin-Ichiro Takahashi

Application Deadline

The application deadline for this meeting was February 12, 2017. You may still submit an application, which may be considered by the conference chair if there is still room available.

Meeting Description

The 2017 Gordon Conference on the Insulin-Like Growth Factor (IGF) and Insulin System in Physiology and Disease will present cutting-edge research on the roles of IGFs and insulin and their signaling pathways in normal physiology and in major diseases. IGFs and insulin are structurally related and evolutionarily ancient peptides. They play essential roles in the development, growth, and metabolism in major organs such as brain, cardiovascular system, muscle, bone, and gonads. The IGF and insulin system is also implicated in stem cell biology, aging, neurodegenerative diseases, diabetes, cancer, and are therefore being actively explored as points of therapeutic intervention for these pathological conditions. This conference will cover the organismal, cellular, and molecular aspects of IGFs and insulin, their receptors, IGF binding proteins, and signaling pathways.

The program has two keynote addresses from two prominent scientists, Dr. Thomas C. Südhof and Dr. Gary Ruvkun. The remainder of the program will bring together investigators around the globe who are at the forefront of this exciting field to discuss key aspects of the IGF and insulin biology. The program will provide opportunities for junior scientists, postdoctoral fellows, and graduate students to present their work and exchange ideas with leaders in the field. The collegial atmosphere of this conference, with programmed discussion sessions as well as opportunities for informal gatherings will provide a great avenue for scientists of all levels in basic, translational, and clinical research fields to brainstorm and promote collaborations ultimately aimed at understanding and potentially manipulating IGF and insulin systems to enhance normal tissue function or to suppress disease progression.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Regulation of IGF and Insulin Expression and Secretion
Discussion Leaders: Cunming Duan (University of Michigan, USA) and Claire Perks (University of Bristol, United Kingdom)
7:40 pm - 8:25 pmThomas Sudhof (Stanford University, USA)
"IGF-1 Exocytosis in Pancreas and Brain"
8:25 pm - 8:45 pmDiscussion
8:45 pm - 9:00 pmAnna Petrashen (Brown University, USA)
"Tissue-Specific Translational Regulation of Insulin-Like Growth Factor 1 by MYC"
9:00 pm - 9:05 pmDiscussion
9:05 pm - 9:20 pmJoanna Stanicka (University College Cork, Ireland)
"The Adhesion Regulated FER Non-Receptor Tyrosine Kinase Enhances the Stability, Auto-Activation and Trafficking of IGF-1R"
9:20 pm - 9:25 pmDiscussion
9:25 pm - 9:30 pmGeneral Discussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmmTOR in IGF/Insulin Signaling and Nutrient Sensing
Discussion Leader: Derek Leroith (Icahn School of Medicine at Mount Sinai, USA)
9:00 am - 9:25 amMichael Hall (Biozentrum, University of Basel, Switzerland)
"mTOR Signaling in Growth and Metabolism"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amKun-Liang Guan (University of California, San Diego, USA)
"Cross Talk Between mTOR and Hippo Pathways"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:05 amJohn Blenis (Weill Cornell Medicine, USA)
"mTOR Regulation of mRNA Biogenesis, Metabolism and Cell Growth"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amPan Zheng (Children's National Medical Center, USA)
"Expansion of Innate Myelolymphoblastoid Effector Cells by Inactivation of mTOR Complex 1"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmGuang Yang (The University of Sydney, Australia)
"Identifying Novel Regulatory Roles of Rag GTPases and Rapamycin on mTOR Complex1 Pathway"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmPeter Stralfors (Linkoping University, Sweden)
"Insulin-Signaling Network, Normally and in Type 2 Diabetes - Mechanisms of Insulin Resistance"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Briony Forbes (Flinders Medical Centre, Flinders University, Australia) and Cheryl Conover (Mayo Clinic, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmIGF/Insulin Signaling in Aging
Discussion Leader: Cheryl Conover (Mayo Clinic, USA)
7:30 pm - 7:55 pmDiana Van Heemst (Leiden University Medial Center, The Netherlands)
"The Somatotropic Axis in Human Longevity and Old Age Survival"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmLuigi Fontana (University of Brescia, Italy / Washington University in St. Louis, USA)
"Dietary Modulation of the Insulin/IGF-1 Pathway"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmPinchas Cohen (University of Southern California, USA)
"Interface Between the IGF System and Mitochondrial Biology"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmLaurie Bale (Mayo Clinic, USA)
"Inducible Knock-Down of Pregnancy-Associated Plasma Protein-A Gene Expression in Adult Mice Extends Lifespan"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmIGF/Insulin Signaling in Cancer
Discussion Leader: Rosemary O'Connor (University College Cork, Ireland)
9:00 am - 9:25 amCarlos Lopez-Otin (University of Oviedo, Spain)
"Loss of Proteostasis Causes IGF1R-Mediated Myeloid Transformation"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amEmily Gallagher (Icahn School of Medicine at Mount Sinai, USA)
"Hyperinsulinemia and Breast Cancer Progression"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:05 amJeff Holly (University of Bristol, United Kingdom)
"New Insights into the Role of IGFBPs in Human Cancers"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amThomas Bogenrieder (Boehringer Ingelheim RCV GmbH, Austria)
"Targeting the IGF Signaling Network with the IGF-1/-2 Ligand Neutralizing Antibody BI 836845"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmAsia Matthew (University of Massachusetts Medical School, USA)
"Beclin 1 Regulates IGF1 and Insulin Signaling to Promote Breast Cancer Progression"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmAlison Nagle (University of Pittsburgh, USA)
"A Proteomic Screen Reveals E-Cadherin as a Repressor of IGF1R Activity and a Potential Role for IGF1R in E-Cadherin-Low Breast Cancers"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmIGF Binding Proteins
Discussion Leader: Robert Baxter (University of Sydney, Australia)
7:30 pm - 7:55 pmYihong Wan (University of Texas Southwestern Medical Center, USA)
"IGFBP-1 Is a Pro-Osteoclastogenic Liver Hormone"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmWendie Cohick (Rutgers University, USA)
"Role for Nuclear IGFBP-3 in Intrinsic Apoptosis"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmLester Lau (University of Illinois at Chicago, USA)
"CCN1 in Wound Healing and Tissue Repair"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmRudiger Schulz (Utrecht University, The Netherlands)
"IGF Binding Proteins Protect Spermatogonia Against Excessive Differentiation in the Zebrafish Testis"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNeural Stem Cells, Neurological Diseases/Regeneration
Discussion Leader: John Pintar (Robert Wood Johnson Medical School, Rutgers University, USA)
9:00 am - 9:25 amTerri Wood (New Jersey Medical School, Rutgers University, USA)
"Insulin and IGF Receptor Signaling in Neural Stem Cell Homeostasis"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amTzumin Lee (Janelia Research Campus, Howard Hughes Medical Institute, USA)
"Targets of IGF-II mRNA-Binding Protein in Neural Stem Cells"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:05 amMasahiro Tomioka (University of Tokyo, Japan)
"Role of the Insulin-Like Signaling Pathway in Learning in C. elegans"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amZhigang He (Harvard University, USA)
"Differential IGF-1 Responses of Injured Neurons in the Adult CNS"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmTali Gidalevitz (Drexel University, USA)
"Misfolding of IGF Protein Induces Selective Neuronal Dysfunction Through a Bystander Mechanism"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmAndreas Hoeflich (Leibniz-Institute for Farm Animal Biology, Germany)
"Phenotype Analysis of Transgenic Mice Overexpressing a Mutant IGFBP-2 Lacking the Cardin-Weintraub Sequence Motif: Reduced Expression of Synaptic Markers and Myelin Basic Protein in the Brain"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmIGF/Insulin Signaling in Metabolism, Growth, and Disease
Discussion Leader: Peter Rotwein (Texas Tech University Health Sciences Center at El Paso, USA)
7:30 pm - 7:55 pmThomas Clemens (Johns Hopkins University, USA)
"Bone Cell Bioenergetics and Skeletal Energy Homeostasis"
7:55 pm - 8:05 pmDiscussion
8:05 pm - 8:30 pmHongxia Ren (Indiana University-Purdue University Indianapolis, USA)
"The FoxO1 Target Gene Gpr17 Regulates Appetite and Glucose Metabolism"
8:30 pm - 8:40 pmDiscussion
8:40 pm - 9:05 pmFrancois Leulier (Universite de Lyon, France)
"Influence of the Intestinal Microbiota on Juvenile Growth and the GH/IGF-1 Axis"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmGen He (Ocean University of China, China)
"Modulation of Nutritional Sensing and Its Applications in Aquaculture"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmEpigenetics and Stem Cells/Cell Differentiation
Discussion Leaders: Briony Forbes (Flinders Medical Centre, Flinders University, Australia) and Linheng Li (Stowers Institute for Medical Research, USA)
9:00 am - 9:25 amMarisa Bartolomei (University of Pennsylvannia, USA)
"Regulation of Igf2 Imprinting During Development and Under Adverse Environmental Conditions"
9:25 am - 9:35 amDiscussion
9:35 am - 10:00 amJoseph Avruch (Massachusetts General Hospital, USA)
"The Igf2 mRNA Binding Proteins in IGF2 Production and Action"
10:00 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:05 amMarie-Liesse Asselin-Labat (Walter and Eliza Hall Institute of Medical Research, Australia)
"Elucidating the Role of IGF-1 in the Regulation of Lung Stem Cells in Development and Disease"
11:05 am - 11:15 amDiscussion
11:15 am - 11:40 amDavid Clemmons (University of North Carolina at Chapel Hill, USA)
"Role of IRS-1 in Regulating IGF-I and Insulin Induced Differentiation"
11:40 am - 11:50 amDiscussion
11:50 am - 12:05 pmColin Delaney (University of Michigan, USA)
"The Insulin-Like Peptide INS-9 Controls Stress-Induced Developmental Plasticity in C. elegans"
12:05 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmDavid Arnosti (Michigan State University, USA)
"Complex cis-Regulatory Landscape of the Insulin Receptor Gene"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: New Lessons from Model Organisms
Discussion Leaders: Andrzej Bartke (Southern Illinois University School of Medicine, USA) and Shin-Ichiro Takahashi (University of Tokyo, Japan)
7:30 pm - 7:45 pmChunyang Zhang (Indiana University Bloomington, USA)
"Drosophila as a Model for Metabolic Regulation During Oogenesis"
7:45 pm - 7:50 pmDiscussion
7:50 pm - 8:05 pmJennifer Hill (University of Oregon, USA)
"Uncovering the Mechanism by Which a Conserved Bacterial Protein Induces Pancreatic Beta Cell Expansion"
8:05 pm - 8:10 pmDiscussion
8:10 pm - 8:25 pmTakafumi Miyamoto (Institute of Medical Science, University of Tokyo, Japan)
"Deconvoluting AMPK Dynamics"
8:25 pm - 8:30 pmDiscussion
8:30 pm - 9:15 pmGary Ruvkun (Harvard University, USA)
"C. elegans Surveillance of Core Cellular Components to Detect and Defend from Microbial Attacks"
9:15 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1 R13 DK 112660-01 from the National Institute of Diabetes and Digestive and Kidney Diseases. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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