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Lymphatics
Gordon Research Conference

Basic Science and Disease Mechanisms in Multiple Organ Systems

Dates

March 20-25, 2016

Location

Four Points Sheraton / Holiday Inn Express
Ventura, CA

Organizers

Chair:
Gwendalyn J. Randolph

Vice Chairs:
Mihaela Skobe & Gou Young Koh

Meeting Description

The Gordon Conference on Lymphatics has been running since 2004 and uniquely brings together scientists who think about lymphatic vessels and interstitial fluid clearance from multiple perspectives. The meeting involves and attracts physiologists, engineers, developmental biologists, immunologists, cancer biologists, geneticists, and clinicians, allowing for a high level of cross fertilization between disciplines. The 2016 conference builds on the rapid growth in the field of lymphatic biology that the first decade of conferences fostered. Sessions have been designed to center around a theme that integrates speakers from various disciplines to further promote cross-disciplinary interactions. For example, a session on the lymph node in lymphatic biology will bring together presentations from the field of immunology to physiological analysis of how the organization of a lymph node and where it is placed in a chain of lymphangions affects lymph flow within the lymphatic system. Whereas the skin has been the traditional organ in which work in the field has focused, the 2016 conference will also bring in talks and even whole sessions that consider interstitial flow and lymphatic vessels in different organ systems. These include a talk on glymphatics in the brain and a session devoted solely to mesenteric lymphatic development, function, and roles in intestinal disease. New disease perspectives will be discussed, including a session devoted to the molecular and clinical features of lymphangioleiomyomatosis (LAM) a disease that primarily involves the pulmonary system. Throughout the conference, talks will consider the emerging connections between lymphatics and the cardiovascular system, from platelets to arterial disease and lipid metabolism.

Many speakers will be first time participants to this conference, representing the growth in the scope of lymphatics research and the number of scientists focusing on lymphatics. The meeting remains, as always, committed to fostering interactions between international scientists at all career stages. Following on the success of the 2014 Gordon Research Seminar, the 2016 conference will also have a companion GRS, being organized by Drs. Joshua Scallan and Amelie Sabine, and the incorporation of seelected short talks into the sessions of the main conference. Please join me in Ventura, CA for a wonderfully interactive and impactful meeting on the lymphatic vasculature.

Related Meeting

This GRC was held in conjunction with the "Lymphatics" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Final Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmBuilding Lymphatics
Discussion Leader: Anne Eichmann (Yale School of Medicine, USA)
7:40 pm - 7:45 pmOpening Remarks
7:45 pm - 8:05 pmBenjamin Hogan (University of Queensland, Australia)
"New Mechanisms of Lymphatic Vascular Development from Zebrafish"
8:05 pm - 8:15 pmDiscussion
8:15 pm - 8:35 pmMark Kahn (University of Pennsylvania, USA)
"Molecular Regulation of Lymphatic Development"
8:35 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmGuillermo Oliver (Northwestern University, USA)
"The Specification of Lymphatic Fate, a Key Step in Lymphatic Development"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmStefan Schulte-Merker (Westfälische Wilhelms-Universität Münster, Germany)
"Novel Genes Essential for Lymphangiogenesis in Fish and Mice"
9:25 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmThe Interstitial Microenvironment and Recent Focus on Interstitial Flow in the Brain
Discussion Leader: Melody Swartz (University of Chicago, USA)
9:00 am - 9:20 amKari Alitalo (Wihuri Research Institute / University of Helsinki, Finland)
"Are Dural Lymphatics Involved in Neuropathology?"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amJonathan Kipnis (University of Virginia, USA)
"Lymphatics in the Central Nervous System"
9:50 am - 10:00 amDiscussion
10:00 am - 10:10 amSamia Bachmann (ETH Zurich, Switzerland)
"In Vivo Regulation of Lymphatic Vessel Function by the Autonomous Nervous System"
10:10 am - 10:15 amDiscussion
10:15 am - 10:25 amMasataka Majima (Kitasato University School of Medicine, Japan)
"Roles of RAMP-1 Signalling as a Neuronal Cue of Lymphangiogenesis"
10:25 am - 10:30 amDiscussion
10:30 am - 11:00 amCoffee Break
11:00 am - 11:20 amJens Titze (Vanderbilt University, USA)
"Sodium and the Microenvironment Inside and Outside the Lymphatics"
11:20 am - 11:30 amDiscussion
11:30 am - 11:50 amHelge Wiig (University of Bergen, Norway)
"On the New Role of the Interstitium and Lymphatics in the Development of Hypertension"
11:50 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmCathryn Kolka (Cedars-Sinai Medical Center, USA)
"The Lymphatic System as a Tool for the Study of Insulin Trafficking in Interstitial Fluid of Skeletal Muscle"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmHector Peinado (Spanish National Cancer Research Centre (CNIO), Spain)
"Exosomes Shed by Tumor Cells into the Interstitium Transit to LNs and Reprogram the Microenvironment"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Laura Santambrogio (Albert Einstein College of Medicine, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmCollecting Lymphatic Vessels and Mechanics
Discussion Leader: David Zawieja (Texas A&M University, USA)
7:30 pm - 7:50 pmTatiana Petrova (Lausanne University Hospital / University of Lausanne, Switzerland)
"Biomechanical and Transcriptional Regulation of Lymphatic Vessel Function"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmMichael Davis (University of Missouri School of Medicine, USA)
"KATP Channels Are an Important Component of Lymphatic Dysfunction in Cantu Syndrome"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmBrandon Dixon (Georgia Institute of Technology, USA)
"Lymphatic Remodeling as a Driving Force in Collecting Vessel Pump Failure in Lymphedema"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmNiklas Telinius (Aarhus University Hospital, Denmark)
"Voltage-Gated Sodium Channels Contribute to Action Potentials and Spontaneous Contractility in Isolated Human Lymphatic Vessels"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmJoshua Scallan (University of South Florida, USA)
"Regulation of Collecting Lymphatic Vessel Permeability by Dendritic Cells Expressing CCR7 and IRF4"
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmThe Lymph Node and Lymphatics in Immunity
Discussion Leader: Nancy Ruddle (Yale School of Public Health, USA)
9:00 am - 9:20 amJason Cyster (University of California, San Francisco, USA)
"Lymph Node Lymphatic Sinuses and Immunity"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amReinhold Forster (Hannover Medical School, Germany)
"Migration of Lymphocytes into and Within Lymph Nodes"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amJames Moore (Imperial College London, United Kingdom)
"Analysis of Fluid Flow Through Lymph Nodes"
10:20 am - 10:30 amDiscussion
10:30 am - 10:50 amCoffee Break
10:50 am - 11:10 amLijun Xia (Oklahoma Medical Research Foundation, USA)
"Signals Governing Lymph Node Integrity"
11:10 am - 11:20 amDiscussion
11:20 am - 11:40 amShannon Turley (Genentech, USA)
"Podoplanin Function in Lymphoid Stroma"
11:40 am - 11:50 amDiscussion
11:50 am - 12:10 pmMelody Swartz (University of Chicago, USA)
"Lymphatics in Immune Modulation"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmBeth Tamburini (University of Colorado Anschutz Medical Campus, USA)
"Contraction of the Hypertrophic Lymph Node and Death of Lymphatic Endothelial Cells as a Process for Antigen Exchange"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmGenetics and Lymphedema
Discussion Leader: Stanley Rockson (Stanford University School of Medicine, USA)
7:30 pm - 7:50 pmMiikka Vikkula (de Duve Institute, Université Catholique de Louvain, Belgium)
"Genes Implicated in the VEGFR3 Signaling Pathway Explain 30% of Primary Lymphedema"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmSahar Mansour (St. George's, University of London, United Kingdom)
"Two New Genetic Disorders Presenting with Lymphatic-Related Hydrops Fetalis"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmBabak Mehrara (Memorial Sloan-Kettering Cancer Center, USA)
"Cellular Mechanisms of Lymphatic Regeneration and Dysfunction in Lymphedema"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:10 pmMarco Borri (CR-UK Cancer Imaging Centre / Royal Marsden NHS Foundation Trust / Institute of Cancer Research, United Kingdom)
"Magnetic Resonance for Improved Understanding of Collecting Lymphatic Vessels Morphology and Tissue Composition in Breast Cancer Related Lymphedema"
9:10 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmBarbara Garmy-Susini (Inserm, France)
"Beneficial Effect of Estrogen on Lymphatic System Is Inhibited by Hormone Therapy to Promote Lymphedema"
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSignals that Regulate the Lymphatic Vasculature in Development, Health, and Cancer / Advances in Imaging
Discussion Leader: Gou Young Koh (Korea Advanced Institute of Science and Technology, South Korea)
9:00 am - 9:20 amKarina Yaniv (Weizmann Institute of Science, Israel)
"Building Lymphatic Vessels in Vertebrates: Insights from Zebrafish"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amAnne Eichmann (Yale School of Medicine, USA)
"Neuropilin Regulation of Lymphatics"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amSteve Watson (Birmingham University, United Kingdom)
"CLEC-2 and Podoplanin Crosstalk Between Platelets and Lymphatics"
10:20 am - 10:30 amDiscussion
10:30 am - 10:40 amNatasha Harvey (Centre for Cancer Biology, University of South Australia, Australia)
"Control of Lymphatic Valve Morphogenesis by Gata2"
10:40 am - 10:45 amDiscussion
10:45 am - 11:05 amCoffee Break
11:05 am - 11:25 amMichael Detmar (ETH Zurich, Switzerland)
"Important Roles of Lymphatic Vessels in the Control of Inflammation and the Promotion of Distant Cancer Metastasis"
11:25 am - 11:35 amDiscussion
11:35 am - 11:55 amMihaela Skobe (Icahn School of Medicine at Mount Sinai, USA)
"Lymphatic Metastasis and Metastatic Efficiency"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmEelco Meijer (Massachusetts General Hospital, USA)
"In Vivo Label-Free Measurement of Lymph Flow Velocity and Volumetric Flow Rates Using Doppler Optical Coherence Tomography"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmRene Haegerling (Max Planck Institute for Molecular Biomedicine, Germany)
"A Novel Imaging Approach for the 3D Visualization of Blood and Lymphatic Vasculature in Healthy and Lymphoedema Affected Humans"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmLymphangioleiomyomatosis (LAM) and mTOR in Lymphatic Biology
Discussion Leader: Mark Kahn (University of Pennsylvania, USA)
7:30 pm - 7:50 pmFrank McCormack (University of Cincinnati, USA)
"Lymphatic Manifestations of Lymphangioleiomyomatosis"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmKuniaki Seyama (Juntendo University, Japan)
"Isolation and Characterization of LAM Cells"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:50 pmLisa Henske (Harvard Medical School, USA)
"Role of Cellular Metabolism and Autophagy in Lymphangioleiomyomatosis (LAM): From Pathogenesis to Targeted Therapy"
8:50 pm - 9:00 pmDiscussion
9:00 pm - 9:20 pmDonald McDonald (University of California, San Francisco, USA)
"Rapamycin Reversal of Lymphangiectasia in a Mouse Model"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmLymphatics in the Intestine, Mesentery, and Visceral Fat
Discussion Leader: Gwendalyn Randolph (Washington University in St. Louis, USA)
9:00 am - 9:20 amTaija Makinen (Uppsala University, Sweden)
"Organ-Specific Origins of the Lymphatic Vasculature"
9:20 am - 9:30 amDiscussion
9:30 am - 9:50 amNatasza Kurpios (Cornell University, USA)
"Dual Origin of Intestinal Lymphatic Vasculature Is Established via Integration of Pitx2 and Cxcl12/Cxcr4 Chemotaxis"
9:50 am - 10:00 amDiscussion
10:00 am - 10:20 amGou Young Koh (Korea Advanced Institute of Science and Technology, South Korea)
"Intestinal Lymphatic Lacteals"
10:20 am - 10:30 amDiscussion
10:30 am - 10:40 amJeremiah Bernier-Latmani (University of Lausanne, Switzerland)
"Mechanisms of Notch Signaling in Adult Intestinal Lacteals"
10:40 am - 10:45 amDiscussion
10:45 am - 11:00 amCoffee Break
11:00 am - 11:20 amJean-Frederic Colombel (Mount Sinai School of Medicine, USA)
"Clinical and Experimental Observations Implicating a Role for Lymphatic Vessels in Crohn's Disease"
11:20 am - 11:30 amDiscussion
11:30 am - 11:40 amSonia Rehal (University of Calgary, Canada)
"Intestinal Lymphatic Pathology and Lymph Transport in Mouse Crohn's Disease-Like Ileitis"
11:40 am - 11:45 amDiscussion
11:45 am - 11:55 amReema Davis (University of North Carolina at Chapel Hill, USA)
"Lymphatic Vessels in Intestinal Inflammation and Repair"
11:55 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmJoseph Rutkowski (Texas A&M Health Science Center, USA)
"Adipose Tissue VEGF-D Overexpression Induces Local Lymphangiogenesis and Altered Lipid Handling"
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:25 pmJerome Breslin (University of South Florida, USA)
"Remodeling of Mesenteric Collecting Vessels in Juvenile, Obese Zucker Rats"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmLymphatics in the Cardiovascular System
Discussion Leader: Natasha Harvey (Centre for Cancer Biology, University of South Australia, Australia)
7:30 pm - 7:50 pmPaul Riley (University of Oxford, United Kingdom)
"Heterogeneity of Lymphatics in the Heart and Its Implications"
7:50 pm - 8:00 pmDiscussion
8:00 pm - 8:20 pmKathleen Caron (University of North Carolina, USA)
"Adrenomedullin in Cardiac and Lymphatic Development"
8:20 pm - 8:30 pmDiscussion
8:30 pm - 8:40 pmMichael Dellinger (University of Texas Southwestern Medical Center, USA)
"Overexpression of VEGF-C in Bone Induces a Gorham-Stout Disease-Like Phenotype"
8:40 pm - 8:45 pmDiscussion
8:45 pm - 9:05 pmSeppo Yla-Herttuala (University of Eastern Finland, Finland)
"Lymphatics and Atherosclerosis"
9:05 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmElizabeth Haining (University of Birmingham, United Kingdom)
"A Novel Knock-In Mouse Reveals an Essential Role for the CLEC-2 hemITAM in Development"
9:25 pm - 9:30 pmDiscussion
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 1 R13 DK 109553 - 01 from NIDDK, NIAD and NHLBI. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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