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Cardiac Arrhythmia Mechanisms
Gordon Research Conference

Model Systems, Emerging Technologies and Precision Medicine in Arrhythmia Research and Therapeutic Development

Dates

February 5-10, 2017

Location

Ventura Beach Marriott
Ventura, CA Site Information

Organizers

Chair:
Gail A. Robertson

Vice Chair:
Al George

Application Deadline

This meeting is currently oversubscribed (full). You may still submit an application. However, it will only be considered by the Conference Chair if more seats become available due to cancellations.

Meeting Description

There is an urgent need to understand the diverse mechanisms of cardiac arrhythmias that lead to sudden death and stroke, which remain major health concerns and place more than 10 million Americans at risk. The 2017 Gordon Research Conference (GRC) on Cardiac Arrhythmia Mechanisms addresses this need by emphasizing the importance of basic science discovery, the power of model systems and the new technologies that ultimately enable patient-specific, mechanistic approaches to disease diagnosis and treatment. The long-term objective of this meeting is to provide a forum for investigators – junior, mid-level and senior – to engage in focused discussion on the latest advances in the field of cardiac arrhythmia mechanisms. The meeting fosters the development of trainees by supporting an associated Gordon Research Seminar (GRS) on Cardiac Arrhythmia Mechanisms at which trainees present their research findings and engage in panel discussions with mentors on matters of career pathways and professional development.

The 2017 meeting will highlight a range of disciplines including new mechanisms of arrhythmia, the role of population variation in computational model development, and transcriptional and translational mechanisms regulating cardiac excitability. Approximately 50 speakers will be selected to present cutting-edge work that is largely unpublished. Poster sessions will provide additional opportunity for collegial interactions over refreshments. Participants are encouraged to register early as the last two offerings of this meeting were oversubscribed.

Related Meeting

This GRC will be held in conjunction with the "Cardiac Arrhythmia Mechanisms" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
4:00 pm - 8:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmThe Future of Arrhythmia Therapeutic Development
Discussion Leader: Lori Isom (University of Michigan, USA)
7:40 pm - 7:45 pmOpening Remarks
7:45 pm - 8:05 pmPeter Larsson (University of Miami, USA)
"Fatty Acid Modulators as LQT1 Therapeutics"
8:05 pm - 8:20 pmDiscussion
8:20 pm - 8:40 pmIgor Efimov (The George Washington University, USA)
"Human Organotypic Slices as a Platform for Preclinical Drug Studies"
8:40 pm - 8:55 pmDiscussion
8:55 pm - 9:15 pmRiccardo Olcese (University of California, Los Angeles, USA)
"Suppressing EADs in Single Cells and VT/VF in Isolated Hearts"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmSpecificity and Variability in Predictive Modeling
Discussion Leader: James Weiss (University of California, Los Angeles, USA)
9:00 am - 9:10 amIntroduction by Discussion Leader
9:10 am - 9:30 amBlanca Rodriguez (University of Oxford, United Kingdom)
"Experimentally Calibrated Population of Models Predicts and Explains Inter-Subject Variability"
9:30 am - 9:45 amDiscussion
9:45 am - 10:05 amDavid Christini (Weill Cornell Medicine, USA)
"Cell-Specific Models Can Produce More Robust Simulations"
10:05 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:10 amNajah Abi Gerges (AnaBios Corporation, USA)
"Proarrhythmia Predictions Using Primary Human Cardiomyocytes"
11:10 am - 11:25 amDiscussion
11:25 am - 11:45 amJamie Vandenberg (Victor Chang Cardiac Research Institute, Australia)
"Predicting Proarrhythmia - The CiPA Initiative"
11:45 am - 12:00 pmDiscussion
12:00 pm - 12:10 pmShort Talk Selected from Poster Abstracts
12:10 pm - 12:15 pmDiscussion
12:15 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmArrhythmia Triggers
Discussion Leader: Penelope Boyden (Columbia University, USA)
7:30 pm - 7:50 pmBeth Habecker (Oregon Health and Science University, USA)
"Phenotypic Switching After Infarction"
7:50 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmPeter Ruben (Simon Fraser University, Canada)
"Molecular Mechanisms of Arrhythmia in the Brugada and Long QT Syndromes"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmGlenn Fishman (New York University, USA)
"Novel Transcription Factors Regulating Cardiac Conduction"
9:00 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
8:30 amGroup Photo
9:00 am - 12:30 pmAtrial Fibrillation
Discussion Leader: Jose Jalife (University of Michigan, USA)
9:00 am - 9:20 amStanley Nattel (Montreal Heart Institute Research Center, Canada)
"The Role of Fibroblast Ion Channels in AF Pathophysiology"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amBarbara Casadei (John Radcliffe Hospital, University of Oxford, United Kingdom)
"Atrial Fibrillation Is a Dystrophinopathy of the Atria"
9:55 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amPatrick Boyle (Johns Hopkins University, USA)
"Patient-Specific Simulations of Atrial Arrhythmia Enable Precision Catheter Ablation"
11:00 am - 11:15 amDiscussion
11:15 am - 11:35 amJonathan Silva (Washington University in St. Louis, USA)
"Modulation of Sodium Channel Voltage Sensing in AF"
11:35 am - 11:50 amDiscussion
11:50 am - 12:10 pmKaren Ocorr (Sanford Burnham Prebys Medical Discovery Institute, USA)
"Channelopathies and Cardiac Remodeling in Drosophila"
12:10 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmMechano-Electrical Signaling in Arrhythmia
Discussion Leader: Robert Kass (Columbia University, USA)
7:30 pm - 7:50 pmPeter Kohl (University of Freiburg, Germany)
"Stretch Effects on Myocytes and Non-Myocytes in the Heart"
7:50 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmShelly Tzlil (Technion - Israel Institute of Technology, Israel)
"Mechanical Communication in Synchronized Beating Cardiomyocytes"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmStefan Luther (Max Planck Institute for Dynamics and Self-Organization, Germany)
"Visualizing Electrical and Mechanical Activity"
9:00 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmShort Talk Selected from Poster Abstracts
9:25 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmIlluminating Arrhythmia: Optogenetics in Research and Therapy
Discussion Leader: Natalia Trayanova (Johns Hopkins University, USA)
9:00 am - 9:20 amAdam Cohen (Harvard University, USA)
"Optical Electrophysiology in Excitable Cells: What In Vitro Measurements Can and Cannot Predict About Arrhythmia"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amEmilia Entcheva (George Washington University, USA)
"Massively Parallel All-Optical Electrophysiology"
9:55 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amPhilipp Sasse (University of Bonn, Germany)
"Novel Optogenetic Methods to Understand and Treat Cardiac Arrhythmia"
11:00 am - 11:15 amDiscussion
11:15 am - 11:35 amMatthew Kay (George Washington University, USA)
"Optogenetics for Selective Activation of Cardiac Autonomic Nerves"
11:35 am - 11:50 amDiscussion
11:50 am - 12:00 pmShort Talk Selected from Poster Abstracts
12:00 pm - 12:05 pmDiscussion
12:05 pm - 12:30 pmPoster Previews
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmTranscriptional and Translational Mechanisms in Arrhythmia
Discussion Leader: Connie Bezzina (Academic Medical Center, The Netherlands)
7:30 pm - 7:50 pmBarry London (University of Iowa, USA)
"Epigenetic and miRNA in Arrhythmia"
7:50 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmJeanne Nerbonne (Washington University in St. Louis, USA)
"RNA Regulation of Excitability"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmIvan Moskowitz (University of Chicago, USA)
"Long-Range Transcriptional Control: Connecting GWAS Hits with Biology"
9:00 pm - 9:15 pmDiscussion
9:15 pm - 9:25 pmLarisa Tereshchenko (Oregon Health and Science University, USA)
"Molecular Remodeling Is an Underlying Mechanism of Global Electrical Heterogeneity and Sudden Cardiac Death"
9:25 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmNew Targets and Macromolecular Complexes in Cardiac Excitability
Discussion Leader: Mario Delmar (New York University School of Medicine, USA)
9:00 am - 9:20 amElise Balse (Pierre and Marie Curie University / INSERM UMR1166, France)
"A New Partner of the Nav1.5 Channel in the Dystrophin-Syntrophin Complex: The Unconventional MAGUK Protein CASK"
9:20 am - 9:35 amDiscussion
9:35 am - 9:55 amTimothy Kamp (University of Wisconsin-Madison, USA)
"Regulation of Cardiac Repolarization by Caveolae"
9:55 am - 10:10 amDiscussion
10:10 am - 10:40 amCoffee Break
10:40 am - 11:00 amCalum Macrae (Harvard Medical School / Brigham and Women's Hospital, USA)
"Cardiac Connectomes and Arrhythmia"
11:00 am - 11:15 amDiscussion
11:15 am - 11:35 amNipavan Chiamvimonvat (University of California, Davis, USA)
"A Novel Transporter in the Heart and Its Functional Roles"
11:35 am - 11:50 amDiscussion
11:50 am - 12:10 pmLee Eckhardt (University of Wisconsin-Madison, USA)
"KCNJ2 as a Novel Mechanism of CPVT"
12:10 pm - 12:25 pmDiscussion
12:25 pm - 12:30 pmGeneral Discussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmKeynote Session: Old Targets, New Diseases and Mendelian Mysteries
Discussion Leader: Al George (Northwestern University, USA)
7:30 pm - 7:50 pmMohamed Chahine (IUSMQ, Laval University, Canada)
"Gating Pore Currents in SCN5A Mutations Linked to Complex Cardiac Arrhythmias and Dilated Cardiomyopathy"
7:50 pm - 8:05 pmDiscussion
8:05 pm - 8:25 pmJoseph Wu (Stanford Cardiovascular Institute, Stanford University School of Medicine, USA)
"iPSC Modeling of Cardiac Arrhythmia"
8:25 pm - 8:40 pmDiscussion
8:40 pm - 9:00 pmDan Roden (Vanderbilt University Medical Center, USA)
"Do Monogenic Arrhythmia Syndromes Exist? Musings on How Genomics Meets Mendel"
9:00 pm - 9:15 pmDiscussion
9:15 pm - 9:30 pmClosing Remarks
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Research reported in this publication was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under award Number 1R13HL136006-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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