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Cannabinoid Function in the CNS
Gordon Research Conference

A New Dawn in Cannabinoid Neurobiology: The Road from Molecules to Therapeutic Discoveries

Dates

August 20-25, 2017

Location

Waterville Valley
Waterville Valley, NH

Organizers

Chairs:
Joseph F. Cheer & Yasmin Hurd

Vice Chairs:
Istvan Katona & Zsolt Lenkei

Meeting Description

There is likely no greater hot-button topic in biomedical and clinical research today than discussions surrounding the utility of active chemicals found in marijuana and how they interact within the body's endocannabinoid system to elicit beneficial or deleterious effects. Although the chemical isolation of the two most widely studied phytocannabinoids (delta-9-THC and cannabidiol) occurred in the 1960s, there is a renewed need for more mechanistic understanding on how these lipid molecules impact neuronal functions in the brain. In this meeting, we will provide a recent view of endocannabinoid signaling as it pertains to a number of neurobiological processes.

This Gordon Research Conference on "Cannabinoid Function in the CNS" will explore topics including the neurochemical control of learning and memory, reward, motor activity and pain as well as the regulatory role of cannabinoids in feeding behavior and energy balance. We will also explore the impact of cannabinoids on neuronal development and survival as well as on glial cells. Speakers will also comment on the control by cannabinoid receptors of neural circuits involved in a number of neurological and psychiatry conditions ranging from addiction and anxiety to epilepsy and Huntington's disease amongst others. The implications of the widespread recreational use of marijuana as well as its prescription will also be discussed. Our goal is to stimulate a collegial and informal atmosphere that generates fruitful discussions and exchanges of ideas among established leaders of the field, younger scientists and newcomers.

Related Meeting

This GRC was held in conjunction with the "Cannabinoid Function in the CNS" Gordon Research Seminar (GRS). Refer to the associated GRS program page for more information.

Contributors

Meeting Program

Sunday
2:00 pm - 9:00 pmArrival and Check-in
6:00 pmDinner
7:30 pm - 7:40 pmWelcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pmKeynote Session: Endocannabinoids Maketh the Male: EDCs and the Sculpting of Brain Sex Differences
Discussion Leader: Ken Mackie (Indiana University, USA)
7:40 pm - 9:15 pmMargaret McCarthy (University of Maryland School of Medicine, USA)
"Endocannabinoids Maketh the Male: EDCs and the Sculpting of Brain Sex Differences"
9:15 pm - 9:30 pmDiscussion
Monday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmAdvances in the Neurobiology of Cannabinoid Use Disorders
Discussion Leader: Marco Pistis (University of Cagliari, Italy)
9:00 am - 9:30 amMichael Taffe (The Scripps Research Institute, USA)
"Self-Administration of THC via Vapor Inhalation in Rats"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amCarl Lupica (National Institute on Drug Abuse Intramural Research Program, NIH, USA)
"Altered Endocannabinoid Function and Synaptic Remodeling of Brain Reward Pathways by Tetrahydrocannabinol"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amGroup Photo / Coffee Break
10:50 am - 11:20 amZuzana Justinova (National Institute on Drug Abuse Intramural Research Program, NIH, USA)
"Involvement of Dopamine D3 and D4 Receptors in the Abuse-Related Effects of THC in Squirrel Monkeys"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmMargaret Haney (Columbia University, USA)
"Cyclooxygenase-2 Inhibition for Cannabis Withdrawal and Relapse: A Human Laboratory Study"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmDaniela Neuhofer (Medical University of South Carolina, USA)
"The Neurobiology Mediating THC Seeking Behavior"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
3:00 pm - 4:00 pmPower Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Allyn Howlett (Wake Forest University, USA)
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmEnduring Neural Effects of Cannabinoids: Molecular Mechanisms
Discussion Leader: Hui-Chen Lu (Indiana University Bloomington, USA)
7:30 pm - 8:00 pmOlivier Manzoni (Institut de Neurobiologie de la Méditerranée (INMED), INSERM, France)
"Cannabis Along Lifetime: Looking at the Prefrontal Cortex"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmMiriam Melis (University of Cagliari, Italy)
"Prenatal THC Exposure Affects Dopamine Function and Neuropsychiatric Outcome in the Offspring"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmKent Hutchison (University of Colorado Boulder, USA)
"Flowers, Edibles and Dabs: Cognitive Effects of THC and CBD in the Real World"
9:20 pm - 9:30 pmDiscussion
Tuesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmRegulation of Emotional Memories by the Endocannabinoid System
Discussion Leader: Matthew Hill (Hotchkiss Brain Institute, Canada)
9:00 am - 9:30 amDavid Finn (National University of Ireland Galway, Ireland)
"Reciprocal Interactions Between Pain and Negative Affect: Role of the Endocannabinoid System"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amSachin Patel (Vanderbilt University, USA)
"2-Arachidonoylglycerol as a Homeostatic Signal Counteracting the Adverse Effects of Stress"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amFrancis Lee (Weill Cornell Medicine, USA)
"Role of Genetic Variation in the Endocannabinoid System on Adolescent Brain Development"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmPatrizia Campolongo (Sapienza University of Rome, Italy)
"Endocannabinoids and the Regulation of Memory for Emotionally Arousing Experiences"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmHanna Molla (Chicago Medical School, Rosalind Franklin University of Medicine and Science, USA)
"Developmental Regulation of Prefrontal Plasticity by Endocannabinoid-CB1R Signaling In Vivo"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:30 pm - 9:30 pmA Ray of Hope: Battling Pain Through Cannabinoid Pharmacotherapy
Discussion Leader: Aron Lichtman (Virginia Commonwealth University, USA)
7:30 pm - 8:00 pmAndrea Hohmann (Indiana University, USA)
"The Therapeutic Potential of Nonpsychotropic Cannabinoid Analgesics"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmRebecca Craft (Washington State University, USA)
"Sex Differences in Cannabinoid Analgesia"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmVolker Neugebauer (Texas Tech University Health Sciences Center, USA)
"Corticolimbic CB1 Receptor Function in Arthritic Pain"
9:20 pm - 9:30 pmDiscussion
Wednesday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmDamage, Neuroadaptation and the Role of Cannabinoid Receptors
Discussion Leader: Mary Abood (Temple University, USA)
9:00 am - 9:30 amDavid Sulzer (Columbia University Medical Center, USA)
"Selection of Striatal Synapses by Cannabinoids and L-DOPA"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amLynn Raymond (University of British Columbia, Canada)
"Corticostriatal Synaptic Activity-Dependent Depression Mediated by Anandamide Is Impaired While 2-AG Signaling Is Preserved in Early Huntington's Disease"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amDebra Kendall (University of Connecticut, USA)
"Allosteric, Biased Signaling Modulators of CB1: Taking a Different Path"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmEster Aso (Centro de Investigación Biomédica en Red (CIBERNED), Spain)
"THC and CBD Combination for Treating Alzheimer's Disease: First Steps Toward the Clinic"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmAndrea Ruiz (Universidad Complutense de Madrid, Spain)
"Cannabinoid CB1 Receptors Located on Corticostriatal Terminals Dictate a Dissimilar Vulnerability of Direct-Pathway and Indirect-Pathway Medium Spiny Neurons"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 6:00 pmPoster Session
6:00 pmDinner
7:00 pm - 7:30 pmBusiness Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pmOrchestrating Hippocampal Function Through Cannabinoid Signaling
Discussion Leader: Raffaella Tonini (Istituto Italiano di Tecnologia (IIT), Italy)
7:30 pm - 8:00 pmIvan Soltesz (Stanford University, USA)
"Control of Neuronal Excitability by Postsynaptic CB1 Receptors in Normal and Epileptic Circuits"
8:00 pm - 8:10 pmDiscussion
8:10 pm - 8:40 pmDietmar Schmitz (Charité - Universitätsmedizin Berlin, Germany)
"CB2-Receptors Mediate Cellular Plasticity via Two Different Mechanisms"
8:40 pm - 8:50 pmDiscussion
8:50 pm - 9:20 pmPablo Castillo (Albert Einstein College of Medicine, USA)
"Presynaptic Molecular Mechanisms Underlying Endocannabinoid LTD"
9:20 pm - 9:30 pmDiscussion
Thursday
7:30 am - 8:30 amBreakfast
9:00 am - 12:30 pmCannabinoids and Mental Health: New Insights from Basic and Clinical Studies
Discussion Leader: Robin Murray (Kings College London, United Kingdom)
9:00 am - 9:30 amKuei-Yuan Tseng (Rosalind Franklin University, USA)
"Timing Is Everything When Cannabinoids Meet Your Frontal Lobe"
9:30 am - 9:40 amDiscussion
9:40 am - 10:10 amMarta Di Forti (King's College London, United Kingdom)
"Cannabis Use Across the EU: Psychosis Polygenic Risk Scores Shape Individual Risk to Develop Psychosis"
10:10 am - 10:20 amDiscussion
10:20 am - 10:50 amCoffee Break
10:50 am - 11:20 amCyril Deepak D'Souza (Yale University, USA)
"Cannabinoids and Acute Psychotic States"
11:20 am - 11:30 amDiscussion
11:30 am - 12:00 pmAnissa Abi-Dargham (State University of New York at Stony Brook, USA)
"Timing and Location of Cannabis' Effects on Dopamine in the Striatum May Offer Clues to Its Negative Effects"
12:00 pm - 12:10 pmDiscussion
12:10 pm - 12:25 pmMitchell Farrell (University of California, Irvine, USA)
"The DREADDed Weed: Chemogenetic Dissection of Dopamine Function After Adolescent Cannabinoid Receptor Stimulation"
12:25 pm - 12:30 pmDiscussion
12:30 pmLunch
1:30 pm - 4:00 pmFree Time
4:00 pm - 5:30 pmPoster Session
5:30 pm - 7:30 pmKeynote Session: Endocannabinoid Signaling / Late-Breaking Topics
Discussion Leader: David Lovinger (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
5:30 pm - 5:45 pmMario van der Stelt (Leiden University, The Netherlands)
"Activity-Based Protein Profiling Reveals Off-Target Proteins of the FAAH Inhibitor BIA 10-2474"
5:45 pm - 5:50 pmDiscussion
5:50 pm - 6:10 pmMichael Bruchas (Washington University in St. Louis School of Medicine, USA)
"Modern Approaches for Studying G-Protein Coupled Receptor Function in Behavior"
6:10 pm - 6:15 pmDiscussion
6:15 pm - 6:35 pmMarisela Morales (National Institute on Drug Abuse, NIH, USA)
"Cannabinoid Receptors and Neuronal Diversity"
6:35 pm - 6:40 pmDiscussion
6:40 pm - 7:25 pmCecilia Hillard (Medical College of Wisconsin, USA)
"Endocannabinoid Signaling: A Wealth of Therapeutic Potential"
7:25 pm - 7:30 pmDiscussion
8:00 pmDinner
Friday
7:30 am - 8:30 amBreakfast
9:00 amDeparture

Funding for this conference was made possible (in part) by 5 R13 DA39610-03 from the National Institute on Drug Abuse. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.
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